Abstract:
:The hair follicle undergoes a lifelong developmental cycle that depends on the integration between activating and inhibitory signals acting to regulate and guide the proliferation and differentiation of pluripotent epithelial stem cells. The effectors and mechanisms responsible for re-entry of quiescent telogen hair follicles into the hair-producing anagen stage in mature skin remain incompletely understood. In the June 1, 2013, issue of Genes & Development, Yucel and colleagues (pp. 1217-1222) reported the unexpected finding that CaV1.2, the pore-forming subunit in a well-characterized voltage-gated, L-type calcium channel, is expressed in hair follicle stem cells and contributes to anagen re-entry but does so in a calcium flux-independent fashion.
journal_name
Genes Devjournal_title
Genes & developmentauthors
Coulombe PA,Caterina MJdoi
10.1101/gad.223172.113subject
Has Abstractpub_date
2013-06-15 00:00:00pages
1315-7issue
12eissn
0890-9369issn
1549-5477pii
27/12/1315journal_volume
27pub_type
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journal_title:Genes & development
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journal_title:Genes & development
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journal_title:Genes & development
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