Evolution and function of genomic imprinting in plants.

abstract：:The Drosophila proteins Transformer (Tra) and Transformer2 (Tra2) regulate the sex-specific alternative splicing of Drosophila doublesex (dsx) pre-mRNA by specifically binding to a splicing enhancer (dsx repeat element; dsxRE) located 300 nucleotides (nt) downstream from a female-specific 3' splice site. In this paper...

journal_title：Genes & development

authors： Tian M,Maniatis T

更新日期：1994-07-15 00:00:00

abstract：:Genome-wide association studies (GWASs) have identified a genetic variant of moderate effect size at 6p21.1 associated with erythrocyte traits in humans. We show that this variant affects an erythroid-specific enhancer of CCND3. A Ccnd3 knockout mouse phenocopies these erythroid phenotypes, with a dramatic increase in...

journal_title：Genes & development

authors： Sankaran VG,Ludwig LS,Sicinska E,Xu J,Bauer DE,Eng JC,Patterson HC,Metcalf RA,Natkunam Y,Orkin SH,Sicinski P,Lander ES,Lodish HF

更新日期：2012-09-15 00:00:00

abstract：:Human lymphoblastoid cells derived from different healthy individuals display considerable variation in their transcription profiles. Here we show that such variation in gene expression underlies interindividual susceptibility to DNA damaging agents. The results demonstrate the massive differences in sensitivity acros...

journal_title：Genes & development

authors： Fry RC,Svensson JP,Valiathan C,Wang E,Hogan BJ,Bhattacharya S,Bugni JM,Whittaker CA,Samson LD

更新日期：2008-10-01 00:00:00

abstract：:Developmental responses to the plant hormone auxin are thought to be mediated by interacting pairs from two protein families: short-lived inhibitory IAA proteins and ARF transcription factors binding to auxin-response elements. monopteros mutants lacking activating ARF5 and the auxin-insensitive mutant bodenlos fail t...

journal_title：Genes & development

authors： Hamann T,Benkova E,Bäurle I,Kientz M,Jürgens G

更新日期：2002-07-01 00:00:00

abstract：:The growth suppression function of the retinoblastoma protein (RB) is mediated by its interaction with a variety of cellular proteins. RB contains at least two protein-binding pockets: the large A/B pocket, which interacts with E2F and the D-type cyclins, and the C pocket, which interacts with the nuclear c-Abl tyrosi...

journal_title：Genes & development

authors： Welch PJ,Wang JY

更新日期：1995-01-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is thought to be an important, possibly essential, component of the process of tumor dissemination and metastasis. About 20%-30% of Hras mutant mouse skin carcinomas induced by chemical initiation/promotion protocols have undergone EMT. Reduced exposure to TPA-induced chronic in...

journal_title：Genes & development

authors： Wong CE,Yu JS,Quigley DA,To MD,Jen KY,Huang PY,Del Rosario R,Balmain A

更新日期：2013-03-15 00:00:00

abstract：:The Rbfox proteins (Rbfox1, Rbfox2, and Rbfox3) regulate the alternative splicing of many important neuronal transcripts and have been implicated in a variety of neurological disorders. However, their roles in brain development and function are not well understood, in part due to redundancy in their activities. Here w...

journal_title：Genes & development

authors： Gehman LT,Meera P,Stoilov P,Shiue L,O'Brien JE,Meisler MH,Ares M Jr,Otis TS,Black DL

更新日期：2012-03-01 00:00:00

abstract：:The HAT4 gene from the plant Arabidopsis thaliana encodes a homeo domain protein that contains a leucine zipper motif. Homeo domain-leucine zipper (HD-Zip) proteins have not been found in animal systems, suggesting that HAT4 may define a new family of transcription factors that regulate higher plant development. To ex...

journal_title：Genes & development

authors： Schena M,Lloyd AM,Davis RW

更新日期：1993-03-01 00:00:00

abstract：:The myc family of cellular oncogenes encodes three highly related nuclear phosphoproteins (c-Myc, N-Myc, and L-Myc) that are believed to function as sequence-specific transcription factors capable of regulating genes important in cellular growth and differentiation. Current evidence indicates that Myc family proteins ...

journal_title：Genes & development

authors： Mukherjee B,Morgenbesser SD,DePinho RA

更新日期：1992-08-01 00:00:00

abstract：:To identify regions of the largest subunit of RNA polymerase that are potentially involved in transcript elongation and termination, we have characterized amino acid substitutions in the beta' subunit of Escherichia coli RNA polymerase that alter expression of reporter genes preceded by terminators in vivo. Terminatio...

journal_title：Genes & development

authors： Weilbaecher R,Hebron C,Feng G,Landick R

更新日期：1994-12-01 00:00:00

abstract：:We report the discovery of mRNA 5'-leader trans-splicing (SL trans-splicing) in the chordates. In the ascidian protochordate Ciona intestinalis, the mRNAs of at least seven genes undergo trans-splicing of a 16-nucleotide 5'-leader apparently derived from a 46-nucleotide RNA that shares features with previously charact...

journal_title：Genes & development

authors： Vandenberghe AE,Meedel TH,Hastings KE

更新日期：2001-02-01 00:00:00

abstract：:Expression of both N-myc and c-myc is induced rapidly and dramatically in normal pre-B cells after stimulation with interleukin-7 (IL-7), a pre-B cell-specific growth factor. These IL-7-induced increases in N-myc and c-myc expression are mediated at the transcriptional level; for N-myc, a major portion of the inductio...

journal_title：Genes & development

authors： Morrow MA,Lee G,Gillis S,Yancopoulos GD,Alt FW

更新日期：1992-01-01 00:00:00

abstract：:The assembly and disassembly of protein complexes at replication origins play a crucial role in the regulation of chromosomal DNA replication. The sequential binding of the origin recognition complex (ORC), Cdc6, and the minichromosome maintenance (MCM/P1) proteins produces a licensed replication origin. Before the in...

journal_title：Genes & development

authors： Jares P,Blow JJ

更新日期：2000-06-15 00:00:00

abstract：:Most eukaryotic mRNAs are translated using a cap-dependent mechanism of translation. However, approximately 10% of mammalian mRNAs initiate translation using a cap-independent mechanism that is not well understood. These mRNAs contain an internal ribosome entry site (IRES) located in the 5' untranslated region. The cr...

journal_title：Genes & development

authors： Landry DM,Hertz MI,Thompson SR

更新日期：2009-12-01 00:00:00

abstract：:During gastrulation of Xenopus embryos the prospective mesoderm is induced initially with domains of dorsal and ventral fate, then further patterned to generate somitic mesoderm by signals from the gastrula organizer. Although Xwnt-8 is expressed in future ventrolateral mesoderm and induces prospective epidermis to di...

journal_title：Genes & development

authors： Hoppler S,Brown JD,Moon RT

更新日期：1996-11-01 00:00:00

abstract：:We show the intracellular localization of the Escherichia coli replication origin (oriC) and chromosome terminus during the cell division cycle by FISH. In newborn cells, oriC is localized at the old-pole-proximal nucleoid border and the terminus at the new-pole-proximal nucleoid border. One copy of replicated oriC mi...

journal_title：Genes & development

authors： Niki H,Hiraga S

更新日期：1998-04-01 00:00:00

abstract：:Mutations that influence lin-12 activity in Caenorhabditis elegans may identify conserved factors that regulate the activity of lin-12/Notch proteins. We describe genetic evidence indicating that sel-10 is a negative regulator of lin-12/Notch-mediated signaling in C. elegans. Sequence analysis shows that SEL-10 is a m...

journal_title：Genes & development

authors： Hubbard EJ,Wu G,Kitajewski J,Greenwald I

更新日期：1997-12-01 00:00:00

abstract：:Neurofibromatosis type 1 (NF1) is a common neurodevelopmental disorder caused by impaired function of the neurofibromin RAS regulator. Using a combination of Nf1 genetically engineered mice and pharmacological/genetic inhibition approaches, we report that neurofibromin differentially controls neural stem cell (NSC) pr...

journal_title：Genes & development

authors： Chen YH,Gianino SM,Gutmann DH

更新日期：2015-08-15 00:00:00

abstract：:Transcription of the cell-cycle-regulated human histone genes increases approximately fivefold during S phase. One step toward the elucidation of the biochemical mechanisms that govern cell-cycle-regulated expression of these genes is to purify and characterize the transcription factors that regulate these promoters. ...

journal_title：Genes & development

authors： Dailey L,Roberts SB,Heintz N

更新日期：1988-12-01 00:00:00

abstract：:The kinases ATM and ATR (Tel1 and Mec1 in the yeast Saccharomyces cerevisiae) control the response to DNA damage. We report that S. cerevisiae Tel2 acts at an early step of the TEL1/ATM pathway of DNA damage signaling. We show that Tel1 and Tel2 interact, and that even when Tel1 protein levels are high, this interacti...

journal_title：Genes & development

authors： Anderson CM,Korkin D,Smith DL,Makovets S,Seidel JJ,Sali A,Blackburn EH

更新日期：2008-04-01 00:00:00

abstract：:Pre-mRNA splicing is essential for generating mature mRNA and is also important for subsequent mRNA export and quality control. The splicing history is imprinted on spliced mRNA through the deposition of a splicing-dependent multiprotein complex, the exon junction complex (EJC), at approximately 20 nucleotides upstrea...

journal_title：Genes & development

authors： Shi H,Xu RM

更新日期：2003-04-15 00:00:00

abstract：:During vascular development, endothelial platelet-derived growth factor B (PDGF-B) is critical for pericyte recruitment. Deletion of the conserved C-terminal heparin-binding motif impairs PDGF-BB retention and pericyte recruitment in vivo, suggesting a potential role for heparan sulfate (HS) in PDGF-BB function during...

journal_title：Genes & development

authors： Abramsson A,Kurup S,Busse M,Yamada S,Lindblom P,Schallmeiner E,Stenzel D,Sauvaget D,Ledin J,Ringvall M,Landegren U,Kjellén L,Bondjers G,Li JP,Lindahl U,Spillmann D,Betsholtz C,Gerhardt H

更新日期：2007-02-01 00:00:00

abstract：:Chromosomal processes related to formation and function of meiotic chiasmata have been analyzed in Sordaria macrospora. Double-strand breaks (DSBs), programmed or gamma-rays-induced, are found to promote four major events beyond recombination and accompanying synaptonemal complex formation: (1) juxtaposition of homolo...

journal_title：Genes & development

authors： Storlazzi A,Tessé S,Gargano S,James F,Kleckner N,Zickler D

更新日期：2003-11-01 00:00:00

abstract：:The RAG-1 protein plays an essential role in V(D)j recombination, but its exact function has not yet been defined. Here we report that a particular mutation in RAG-1 affects recombination by altering the specificity of target sequence usage. Recombination mediated by wild-type RAG-1 is tolerant of a wide range of codi...

journal_title：Genes & development

authors： Sadofsky MJ,Hesse JE,van Gent DC,Gellert M

更新日期：1995-09-01 00:00:00

abstract：:Using an in vitro system in which a 5' splice site (5'SS) RNA oligo (AAG decreases GUAAGUAdT) is capable of inducing formation of U2/U4/U5/U6 snRNP complex we show that this oligo specifically binds to U4/U5/U6 snRNP and cross-links to U6 snRNA in the absence of U2 snRNP. Moreover, 5'SS RNA oligo bound to U4/U5/U6 snR...

journal_title：Genes & development

authors： Konforti BB,Konarska MM

更新日期：1994-08-15 00:00:00

abstract：:Faithful inheritance of genetic information requires that DNA be copied only once each cell cycle. Initiation of DNA replication involves the establishment of a prereplication complex (pre-RC) and subsequent activation by CDK/cyclins, converting the pre-RC to a post-RC. The origin recognition complex (ORC), Cdc6p, and...

journal_title：Genes & development

authors： Liang C,Stillman B

更新日期：1997-12-15 00:00:00

abstract：:The number of known long noncoding RNA (lncRNA) functions is rapidly growing, but how those functions are encoded in their sequence and structure remains poorly understood. NORAD (noncoding RNA activated by DNA damage) is a recently characterized, abundant, and highly conserved lncRNA that is required for proper mitot...

journal_title：Genes & development

authors： Tichon A,Perry RB,Stojic L,Ulitsky I

更新日期：2018-01-01 00:00:00

abstract：:In enteric bacteria, the transcription factor σ(E) maintains membrane homeostasis by inducing synthesis of proteins involved in membrane repair and two small regulatory RNAs (sRNAs) that down-regulate synthesis of abundant membrane porins. Here, we describe the discovery of a third σ(E)-dependent sRNA, MicL (mRNA-inte...

journal_title：Genes & development

authors： Guo MS,Updegrove TB,Gogol EB,Shabalina SA,Gross CA,Storz G

更新日期：2014-07-15 00:00:00

abstract：:The yeast HO gene is transcribed transiently during G1 as cells undergo START. START-specific HO activation requires two proteins, SWI4 and SWI6, which act via a motif (CACGA4) repeated up to 10 times within the URS2 region of the HO promoter. We identified a DNA-binding activity containing SWI4 and SWI6 that recogniz...

journal_title：Genes & development

authors： Taba MR,Muroff I,Lydall D,Tebb G,Nasmyth K

更新日期：1991-11-01 00:00:00

abstract：:Genomic imprinting is an epigenetic process regulated by germline-derived DNA methylation, causing parental origin-specific monoallelic gene expression. Zinc finger protein 57 (ZFP57) is critical for maintenance of this epigenetic memory during post-fertilization reprogramming, yet incomplete penetrance of ZFP57 mutat...

journal_title：Genes & development

authors： Takahashi N,Coluccio A,Thorball CW,Planet E,Shi H,Offner S,Turelli P,Imbeault M,Ferguson-Smith AC,Trono D

更新日期：2019-01-01 00:00:00