Inflammation and Hras signaling control epithelial-mesenchymal transition during skin tumor progression.

abstract：:The gene encoding yeast U6 snRNA that is transcribed by RNA polymerase III (Pol III) contains both a TATA box upstream of the transcription start site and a downstream binding site for the factor TFIIIC. This juxtaposition of elements typical of both Pol II- and Pol III-transcribed genes raises the question of how pol...

journal_title：Genes & development

authors： Roberts S,Colbert T,Hahn S

更新日期：1995-04-01 00:00:00

abstract：:The mammalian ATF/CREB family of transcription factors comprises a large group of basic-region leucine zipper (bZIP) proteins whose members mediate diverse transcriptional regulatory functions. Here we report that expression of a specific mouse ATF gene, ATFx, is down-regulated in a variety of cells undergoing apoptos...

journal_title：Genes & development

authors： Persengiev SP,Devireddy LR,Green MR

更新日期：2002-07-15 00:00:00

abstract：:C-factor, the product of the csgA gene, is a cell-surface associated short-range intercellular signaling protein in Myxococcus xanthus. C-factor is required for at least four responses during starvation-induced fruiting body morphogenesis: rippling, aggregation, sporulation, and full expression of the csgA gene, all o...

journal_title：Genes & development

authors： Søgaard-Andersen L,Slack FJ,Kimsey H,Kaiser D

更新日期：1996-03-15 00:00:00

abstract：:In a four-cell-stage Caenorhabditis elegans embryo, Wnt signaling polarizes an endoderm precursor called EMS. The polarization of this cell orients its mitotic spindle in addition to inducing endodermal fate in one daughter cell. Reducing the function of Wnt pathway genes, including a newly identified GSK-3beta homolo...

journal_title：Genes & development

authors： Schlesinger A,Shelton CA,Maloof JN,Meneghini M,Bowerman B

更新日期：1999-08-01 00:00:00

abstract：:Lineage commitment studies in mammary glands have focused on identifying cell populations that display stem or progenitor properties. However, the mechanisms that control cell fate have been incompletely explored. Herein we show that zinc finger protein 157 (Zfp157) is required to establish the balance between luminal...

journal_title：Genes & development

authors： Oliver CH,Khaled WT,Frend H,Nichols J,Watson CJ

更新日期：2012-05-15 00:00:00

abstract：:The fission yeast telomerase RNA (TER1) precursor harbors an intron immediately downstream from its mature 3' end. Unlike most introns, which are removed from precursor RNAs by the spliceosome in two sequential but tightly coupled transesterification reactions, TER1 only undergoes the first cleavage reaction during te...

journal_title：Genes & development

authors： Kannan R,Hartnett S,Voelker RB,Berglund JA,Staley JP,Baumann P

更新日期：2013-03-15 00:00:00

abstract：:U4 and U6 small nuclear RNAs are associated by an extensive base-pairing interaction that must be disrupted and reformed with each round of splicing. U4 mutations within the U4/U6 interaction domain destabilize the complex in vitro and cause a cold-sensitive phenotype in vivo. Restabilization of the U4/U6 helix by dom...

journal_title：Genes & development

authors： Shannon KW,Guthrie C

更新日期：1991-05-01 00:00:00

abstract：:The reelin (reln) and disabled 1 (dab1) genes both ensure correct neuronal positioning during brain development. We have found that the intracellular Dab1 protein receives a tyrosine phosphorylation signal from extracellular Reln protein. Genetic analysis shows that reln function depends on dab1, and vice versa, as ex...

journal_title：Genes & development

authors： Howell BW,Herrick TM,Cooper JA

更新日期：1999-03-15 00:00:00

abstract：:A novel cysteine-rich motif, named LIM, has been identified in the homeo box genes lin-11, Isl-1, and mec-3; the mec-3 and lin-11 genes determine cell lineages in Caenorhabditis elegans. We isolated LIM class homeo box genes from Xenopus laevis that are closely related to lin-11 and mec-3 in the LIM and homeo domains....

journal_title：Genes & development

authors： Taira M,Jamrich M,Good PJ,Dawid IB

更新日期：1992-03-01 00:00:00

abstract：:Sensory organ formation in Drosophila is activated by proneural genes that encode basic-helix-loop-helix (bHLH) transcription factors. These genes are antagonized by hairy and other proline-bHLH proteins. hairy has not been shown to bind to DNA and has been proposed to form inactive heterodimers with proneural activat...

journal_title：Genes & development

authors： Ohsako S,Hyer J,Panganiban G,Oliver I,Caudy M

更新日期：1994-11-15 00:00:00

abstract：:Sequence-specific DNA-binding activators, key regulators of gene expression, stimulate transcription in part by targeting the core promoter recognition TFIID complex and aiding in its recruitment to promoter DNA. Although it has been established that activators can interact with multiple components of TFIID, it is unk...

journal_title：Genes & development

authors： Liu WL,Coleman RA,Ma E,Grob P,Yang JL,Zhang Y,Dailey G,Nogales E,Tjian R

更新日期：2009-07-01 00:00:00

abstract：:The assembly and disassembly of protein complexes at replication origins play a crucial role in the regulation of chromosomal DNA replication. The sequential binding of the origin recognition complex (ORC), Cdc6, and the minichromosome maintenance (MCM/P1) proteins produces a licensed replication origin. Before the in...

journal_title：Genes & development

authors： Jares P,Blow JJ

更新日期：2000-06-15 00:00:00

abstract：:Long understood as a bona fide tumor suppressor that safeguards the integrity of the genome via regulating numerous cellular outcomes, p53 may also exert its decisive and versatile functions by controlling DNA methylation. In this issue of Genes & Development, Tovy and colleagues (pp. 959-972) report that, in naïve mo...

journal_title：Genes & development

authors： Laptenko O,Prives C

更新日期：2017-05-15 00:00:00

abstract：:Cap-dependent translation is mediated by eIF4F, a protein complex composed of three subunits as follows: eIF4E, which recognizes the mRNA 5' cap structure; eIF4A, an RNA-helicase; and eIF4G, a scaffolding protein that binds eIF4E, eIF4A, and the eIF4E-kinase Mnk1 simultaneously. eIF4E is hypophosphorylated and cap-dep...

journal_title：Genes & development

authors： Pyronnet S,Dostie J,Sonenberg N

更新日期：2001-08-15 00:00:00

abstract：:Using an immunochemical approach, we have identified a unique antigen, PEP (protein on ecdysone puffs), which is associated in third-instar larvae with the active ecdysone-regulated loci on polytene chromosomes; PEP is not associated with most intermolt puffs and is found on some, but not all, heat shock-induced puffs...

journal_title：Genes & development

authors： Amero SA,Elgin SC,Beyer AL

更新日期：1991-02-01 00:00:00

abstract：:To investigate the relationship between splicing and polyadenylation during the production of vertebrate mRNAs, we examined the effect of mutation of a poly(A) site on splicing of upstream introns. Mutation of the AAUAAA polyadenylation consensus sequence inhibited in vitro splicing of an upstream intron. The magnitud...

journal_title：Genes & development

authors： Niwa M,Berget SM

更新日期：1991-11-01 00:00:00

abstract：:The mechanisms that control energy homeostasis and tissue growth during development are closely linked through the insulin signal transduction pathway. Changes in the level of insulin and other hormones reflect the nutritional status of the animal to control circulating sugar levels and fat metabolism. Systemic defect...

journal_title：Genes & development

authors： Teleman AA,Maitra S,Cohen SM

更新日期：2006-02-15 00:00:00

abstract：:Influenza virus unspliced NS1 mRNA, like retroviral pre-mRNAs, is efficiently exported from the nucleus and translated in the cytoplasm of infected cells. With human immunodeficiency virus (HIV), the transport of viral pre-mRNAs is facilitated by the viral Rev protein. We tested the possibility that the influenza viru...

journal_title：Genes & development

authors： Alonso-Caplen FV,Nemeroff ME,Qiu Y,Krug RM

更新日期：1992-02-01 00:00:00

abstract：:Mammalian telomeres are coated by the sequence-specific, DNA-binding protein, TRF1, a negative regulator of telomere length. Previous results showed that ADP-ribosylation of TRF1 by tankyrase 1 released TRF1 from telomeres and promoted telomere elongation. We now show that loss of TRF1 from telomeres results in ubiqui...

journal_title：Genes & development

authors： Chang W,Dynek JN,Smith S

更新日期：2003-06-01 00:00:00

abstract：:O(6)-Methylguanine ((Me)G) is a highly cytotoxic DNA modification generated by S(N)1-type methylating agents. Despite numerous studies implicating DNA replication, mismatch repair (MMR), and homologous recombination (HR) in (Me)G toxicity, its mode of action has remained elusive. We studied the molecular transactions ...

journal_title：Genes & development

authors： Mojas N,Lopes M,Jiricny J

更新日期：2007-12-15 00:00:00

abstract：:Stem cells have been identified as a source of virtually all highly differentiated cells that are replenished during the lifetime of an animal. The critical balance between stem and differentiated cell populations is crucial for the long-term maintenance of functional tissue types. Stem cells maintain this balance by ...

journal_title：Genes & development

authors： Martinez-Agosto JA,Mikkola HK,Hartenstein V,Banerjee U

更新日期：2007-12-01 00:00:00

abstract：:In this issue of Genes & Development, Wierzbicki and colleagues (pp. 1825-1836) examine the current model of RNA-directed DNA methylation (RdDM) by determining genome-wide distributions of RNA polymerase V (Pol V) occupancy, siRNAs, and DNA methylation. Their data support the key role of base-pairing between Pol V tra...

journal_title：Genes & development

authors： Zhang H,Zhu JK

更新日期：2012-08-15 00:00:00

abstract：:Myxococcus xanthus fruiting body development is induced by amino acid limitation. The decision to grow or develop is established by the RelA-dependent stringent response and A-signaling. We identified two new members of this regulatory hierarchy, socE and the C-signaling gene csgA. SocE depletion arrests growth and in...

journal_title：Genes & development

authors： Crawford EW Jr,Shimkets LJ

更新日期：2000-02-15 00:00:00

abstract：:Chemical mutagenesis in the mouse is a powerful approach for phenotype-driven genetics, but questions remain about the efficiency with which new mutations ascertained by their phenotype can be localized and identified, and that knowledge applied to a specific biological problem. During a global screen for dominant phe...

journal_title：Genes & development

authors： Fitch KR,McGowan KA,van Raamsdonk CD,Fuchs H,Lee D,Puech A,Hérault Y,Threadgill DW,Hrabé de Angelis M,Barsh GS

更新日期：2003-01-15 00:00:00

abstract：:The C-terminal domain of the Escherichia coli RNA polymerase (RNAP) alpha subunit (alphaCTD) stimulates transcription initiation by interacting with upstream (UP) element DNA and a variety of transcription activators. Here we identify specific substitutions in region 4.2 of sigma 70 (sigma(70)) and in alphaCTD that de...

journal_title：Genes & development

authors： Ross W,Schneider DA,Paul BJ,Mertens A,Gourse RL

更新日期：2003-05-15 00:00:00

abstract：:Commitment to mitosis is regulated by a protein kinase complex called MPF. MPF is inhibited by Wee1-related kinases and activated by Cdc25 phosphatase. MPF activation further boosts Cdc25 and represses Wee1. This feedback control probably involves polo kinase. A dominant cut12.s11 mutation in the Schizosaccharomyces p...

journal_title：Genes & development

authors： MacIver FH,Tanaka K,Robertson AM,Hagan IM

更新日期：2003-06-15 00:00:00

abstract：:We have analyzed pre-mRNA splicing in yeast extracts immunodepleted of the PRP18 protein. We find that while the first step of splicing (cleavage at the 5' splice site, and generation of the exon 1 and lariat intermediates) is unaffected by the absence of PRP18, the second step of splicing (excision of the lariat intr...

journal_title：Genes & development

authors： Horowitz DS,Abelson J

更新日期：1993-02-01 00:00:00

abstract：:Outward migration of epidermal progenitors occurs with induction of hundreds of differentiation genes, but the identities of all regulators required for this process are unknown. We used laser capture microdissection followed by RNA sequencing to identify calmodulin-like 5 (CALML5) as the most enriched gene in differe...

journal_title：Genes & development

authors： Sun BK,Boxer LD,Ransohoff JD,Siprashvili Z,Qu K,Lopez-Pajares V,Hollmig ST,Khavari PA

更新日期：2015-11-01 00:00:00

abstract：:Orexin A and Orexin B (also known as hypocretins) are neuropeptides that bind two related G-coupled protein receptors (OXR1 and OXR2) and thus induce wakefulness, food consumption, and locomotion. Conversely, deletion of the orexin gene in mice produces a condition similar to canine and human narcolepsy. Despite the c...

journal_title：Genes & development

authors： Sikder D,Kodadek T

更新日期：2007-11-15 00:00:00

abstract：:The transcription cofactor MAL is regulated by free actin levels and thus by actin dynamics. MAL, together with its DNA-binding partner, SRF, is required for invasive cell migration and in experimental metastasis. Although MAL/SRF has many targets, we provide genetic evidence in both Drosophila and human cellular mode...

journal_title：Genes & development

authors： Salvany L,Muller J,Guccione E,Rørth P

更新日期：2014-05-15 00:00:00