Abstract:
:The assembly of a nervous system requires the extension of axons and dendrites to specific regions where they are matched with appropriate synaptic targets. Although the cues that guide long-range outgrowth have been characterized extensively, additional mechanisms are required to explain short-range guidance in neural development. Using a complementary combination of time-lapse imaging by fluorescence confocal microscopy and serial block-face electron microscopy, we identified a novel type of presynaptic projection that participates in the assembly of the vertebrate nervous system. Synapse formation by each hair cell of the zebrafish's lateral line occurs during a particular interval after the cell's birth. During the same period, projections emerge from the cellular soma, extending toward a specific subpopulation of mature hair cells and interacting with polarity-specific afferent nerve terminals. The terminals then extend along the projections to reach appropriately matched presynaptic sites, after which the projections recede. Our results suggest that presynaptic projections act as transient scaffolds for short-range partner matching, a mechanism that may occur elsewhere in the nervous system.
journal_name
Genes Devjournal_title
Genes & developmentauthors
Dow E,Siletti K,Hudspeth AJdoi
10.1101/gad.259838.115subject
Has Abstractpub_date
2015-05-15 00:00:00pages
1087-94issue
10eissn
0890-9369issn
1549-5477pii
29/10/1087journal_volume
29pub_type
杂志文章abstract::Natural scrapie has been viewed both as a recessive trait and as a contagious disease modulated by a host locus. To address this conundrum, we determined the structure of the sheep prion protein (PrP) gene, which contains three exons and extends over 20 kb of DNA. In the United States 86.4% of scrapie cases occur in S...
journal_title:Genes & development
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journal_title:Genes & development
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doi:10.1101/gad.1025202
更新日期:2002-10-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2009-02-15 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.12.13.2073
更新日期:1998-07-01 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.12.11.1621
更新日期:1998-06-01 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.7.6.1072
更新日期:1993-06-01 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.11.16.2112
更新日期:1997-08-15 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.1934210
更新日期:2010-09-01 00:00:00
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journal_title:Genes & development
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doi:10.1101/gad.6.11.2201
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更新日期:2003-01-01 00:00:00
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pub_type: 评论,杂志文章
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更新日期:2007-11-01 00:00:00
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journal_title:Genes & development
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更新日期:1999-05-01 00:00:00
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journal_title:Genes & development
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journal_title:Genes & development
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journal_title:Genes & development
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journal_title:Genes & development
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journal_title:Genes & development
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