The Rhizobium meliloti PII protein, which controls bacterial nitrogen metabolism, affects alfalfa nodule development.

Abstract:

:Symbiotic nitrogen fixation involves the development of specialized organs called nodules within which plant photosynthates are exchanged for combined nitrogen of bacterial origin. To determine the importance of bacterial nitrogen metabolism in symbiosis, we have characterized a key regulator of this metabolism in Rhizobium meliloti, the uridylylatable P(II) protein encoded by glnB. We have constructed both a glnB null mutant and a point mutant making nonuridylylatable P(II). In free-living conditions, P(II) is required for expression of the ntrC-dependent gene glnII and for adenylylation of glutamine synthetase I. P(II) is also required for efficient infection of alfalfa but not for expression of nitrogenase. However alfalfa plants inoculated with either glnB mutant are nitrogen-starved in the absence of added combined nitrogen. We hypothesize that P(II) controls expression or activity of a bacteroid ammonium transporter required for a functional nitrogen-fixing symbiosis. Therefore, the P(II) protein affects both Rhizobium nitrogen metabolism and alfalfa nodule development.

journal_name

Genes Dev

journal_title

Genes & development

authors

Arcondéguy T,Huez I,Tillard P,Gangneux C,de Billy F,Gojon A,Truchet G,Kahn D

doi

10.1101/gad.11.9.1194

subject

Has Abstract

pub_date

1997-05-01 00:00:00

pages

1194-206

issue

9

eissn

0890-9369

issn

1549-5477

journal_volume

11

pub_type

杂志文章
  • PR72, a novel regulator of Wnt signaling required for Naked cuticle function.

    abstract::The Wnt signaling cascade is a central regulator of cell fate determination during embryonic development, whose deregulation contributes to oncogenesis. Naked cuticle is the first Wnt-induced antagonist found in this pathway, establishing a negative-feedback loop that limits the Wnt signal required for early segmentat...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.328905

    authors: Creyghton MP,Roël G,Eichhorn PJ,Hijmans EM,Maurer I,Destrée O,Bernards R

    更新日期:2005-02-01 00:00:00

  • Fgf-10 is required for both limb and lung development and exhibits striking functional similarity to Drosophila branchless.

    abstract::Fgf-10-deficient mice (Fgf-10(-/-)) were generated to determine the role(s) of Fgf-10 in vertebrate development. Limb bud initiation was abolished in Fgf-10(-/-) mice. Strikingly, Fgf-10(-/-) fetuses continued to develop until birth, despite the complete absence of both fore- and hindlimbs. Fgf-10 is necessary for api...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.12.20.3156

    authors: Min H,Danilenko DM,Scully SA,Bolon B,Ring BD,Tarpley JE,DeRose M,Simonet WS

    更新日期:1998-10-15 00:00:00

  • SCH9, a gene of Saccharomyces cerevisiae that encodes a protein distinct from, but functionally and structurally related to, cAMP-dependent protein kinase catalytic subunits.

    abstract::A new gene, SCH9, was isolated from Saccharomyces cerevisiae by its ability to complement a cdc25ts mutation. Sequence analysis indicates that it encodes a 90,000-dalton protein with a carboxy-terminal domain homologous to yeast and mammalian cAMP-dependent protein kinase catalytic subunits. In addition to suppressing...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.2.5.517

    authors: Toda T,Cameron S,Sass P,Wigler M

    更新日期:1988-05-01 00:00:00

  • Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

    abstract::Transformation of primary rodent cells by the adenovirus E1A and E1B oncogenes is a two-step process, where E1A-dependent induction of proliferation is coupled to E1B-dependent suppression of programmed cell death (apoptosis). The E1B gene encodes two distinct transforming proteins, the 19K and 55K proteins, both of w...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.7.4.546

    authors: Debbas M,White E

    更新日期:1993-04-01 00:00:00

  • Combinatorial control of Drosophila circular RNA expression by intronic repeats, hnRNPs, and SR proteins.

    abstract::Thousands of eukaryotic protein-coding genes are noncanonically spliced to produce circular RNAs. Bioinformatics has indicated that long introns generally flank exons that circularize in Drosophila, but the underlying mechanisms by which these circular RNAs are generated are largely unknown. Here, using extensive muta...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.270421.115

    authors: Kramer MC,Liang D,Tatomer DC,Gold B,March ZM,Cherry S,Wilusz JE

    更新日期:2015-10-15 00:00:00

  • SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay.

    abstract::Nonsense-mediated mRNA decay (NMD) is a quality control mechanism that detects and degrades mRNAs containing premature stop codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Degradation of PTC-containing mRNAs requires the endonucleolytic activity of SMG...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.604610

    authors: Kashima I,Jonas S,Jayachandran U,Buchwald G,Conti E,Lupas AN,Izaurralde E

    更新日期:2010-11-01 00:00:00

  • Patterns of gene action in plant development revealed by enhancer trap and gene trap transposable elements.

    abstract::The crucifer Arabidopsis thaliana has been used widely as a model organism for the study of plant development. We describe here the development of an efficient insertional mutagenesis system in Arabidopsis that permits identification of genes by their patterns of expression during development. Transposable elements of...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.9.14.1797

    authors: Sundaresan V,Springer P,Volpe T,Haward S,Jones JD,Dean C,Ma H,Martienssen R

    更新日期:1995-07-15 00:00:00

  • Bipartite stimulatory action of the Hop2-Mnd1 complex on the Rad51 recombinase.

    abstract::The HOP2 and MND1 genes are indispensable for meiotic recombination. The products of these genes associate to form a stable heterodimeric complex that binds DNA and stimulates the recombinase activity of Rad51 and Dmc1. Here we conduct molecular studies to delineate the action mechanism of the Hop2-Mnd1 complex. We pr...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.1563007

    authors: Chi P,San Filippo J,Sehorn MG,Petukhova GV,Sung P

    更新日期:2007-07-15 00:00:00

  • The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor.

    abstract::Genetic and cytologic data from Saccharomyces cerevisiae and mammals implicate the Mre11 complex, consisting of Mre11, Rad50, and Nbs1, as a sensor of DNA damage, and indicate that the complex influences the activity of ataxia-telangiectasia mutated (ATM) in the DNA damage response. Rad50(S/S) mice exhibit precipitous...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.1373705

    authors: Morales M,Theunissen JW,Kim CF,Kitagawa R,Kastan MB,Petrini JH

    更新日期:2005-12-15 00:00:00

  • Translational inactivation of ribosomal protein mRNAs during Xenopus oocyte maturation.

    abstract::Ribosomal protein synthesis ceases upon maturation of Xenopus oocytes. We find that this cessation results from the dissociation of ribosomal protein mRNAs from polysomes and is accompanied by the deadenylation of these transcripts. A synthetic mRNA encoding ribosomal protein L1, microinjected into stage VI oocytes, i...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.2.5.598

    authors: Hyman LE,Wormington WM

    更新日期:1988-05-01 00:00:00

  • Dimerization specificity of myogenic helix-loop-helix DNA-binding factors directed by nonconserved hydrophilic residues.

    abstract::The myogenic regulatory factor MyoD dimerizes with other positive and negative regulatory factors through a conserved region called the helix-loop-helix (HLH) domain. Using a non-DNA-binding MyoD mutant with a normal HLH domain as a dimerization competitor in gel mobility shift assays in conjunction with various MyoD ...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.7.12a.2456

    authors: Shirakata M,Friedman FK,Wei Q,Paterson BM

    更新日期:1993-12-01 00:00:00

  • Ovarian follicle cell enhancers from the Drosophila yolk protein genes: different segments of one enhancer have different cell-type specificities that interact to give normal expression.

    abstract::This paper examines ovarian transcription of the divergently oriented yolk protein genes 1 and 2 (yp1 and yp2) of Drosophila melanogaster. We report germ line transformation results demonstrating that yp1 and yp2 are transcribed in the same subpopulations of ovarian follicle cells. Our results show that this expressio...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.4.4.613

    authors: Logan SK,Wensink PC

    更新日期:1990-04-01 00:00:00

  • Changes in a SWI4,6-DNA-binding complex occur at the time of HO gene activation in yeast.

    abstract::The yeast HO gene is transcribed transiently during G1 as cells undergo START. START-specific HO activation requires two proteins, SWI4 and SWI6, which act via a motif (CACGA4) repeated up to 10 times within the URS2 region of the HO promoter. We identified a DNA-binding activity containing SWI4 and SWI6 that recogniz...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.5.11.2000

    authors: Taba MR,Muroff I,Lydall D,Tebb G,Nasmyth K

    更新日期:1991-11-01 00:00:00

  • Fragile X-related protein and VIG associate with the RNA interference machinery.

    abstract::RNA interference (RNAi) is a flexible gene silencing mechanism that responds to double-stranded RNA by suppressing homologous genes. Here, we report the characterization of RNAi effector complexes (RISCs) that contain small interfering RNAs and microRNAs (miRNAs). We identify two putative RNA-binding proteins, the Dro...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.1025202

    authors: Caudy AA,Myers M,Hannon GJ,Hammond SM

    更新日期:2002-10-01 00:00:00

  • sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins.

    abstract::Mutations that influence lin-12 activity in Caenorhabditis elegans may identify conserved factors that regulate the activity of lin-12/Notch proteins. We describe genetic evidence indicating that sel-10 is a negative regulator of lin-12/Notch-mediated signaling in C. elegans. Sequence analysis shows that SEL-10 is a m...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.11.23.3182

    authors: Hubbard EJ,Wu G,Kitajewski J,Greenwald I

    更新日期:1997-12-01 00:00:00

  • Critical residues for histone acetylation by Gcn5, functioning in Ada and SAGA complexes, are also required for transcriptional function in vivo.

    abstract::Several previously known transcription cofactors have been demonstrated in vitro recently to be histone acetyltransferases and deacetyltransferases, suggesting that remodeling of chromatin through histone acetylation plays a fundamental role in gene regulation. Clear evidence has not yet been obtained, however, to dem...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.12.5.640

    authors: Wang L,Liu L,Berger SL

    更新日期:1998-03-01 00:00:00

  • Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells.

    abstract::Growth of numerous cancer types is believed to be driven by a subpopulation of poorly differentiated cells, often referred to as cancer stem cells (CSCs), that have the capacity for self-renewal, tumor initiation, and generation of nontumorigenic progeny. Despite their potentially key role in tumor establishment and m...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.188292.112

    authors: Janiszewska M,Suvà ML,Riggi N,Houtkooper RH,Auwerx J,Clément-Schatlo V,Radovanovic I,Rheinbay E,Provero P,Stamenkovic I

    更新日期:2012-09-01 00:00:00

  • The SABRE gene is required for normal cell expansion in Arabidopsis.

    abstract::Regulated cell expansion is an important determinant of organ shape in higher plants. The sabre mutation results in abnormal cell expansion in Arabidopsis. There is a shift in the orientation of expansion evident primarily in root cortex cells. The SABRE gene has been cloned and found to encode a novel protein. Reduct...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.9.3.330

    authors: Aeschbacher RA,Hauser MT,Feldmann KA,Benfey PN

    更新日期:1995-02-01 00:00:00

  • Hematopoietic development of embryonic stem cells in vitro: cytokine and receptor gene expression.

    abstract::A novel system to study early hematopoietic development is described. This report documents the in vitro capacity of murine embryonic stem (ES) cells to differentiate into hematopoietic precursors of most, if not all, of the colony-forming cells found in normal bone marrow. This system is used to correlate the genetic...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.5.5.728

    authors: Schmitt RM,Bruyns E,Snodgrass HR

    更新日期:1991-05-01 00:00:00

  • The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism.

    abstract::Glucose and glutamine serve as the two primary carbon sources in proliferating cells, and uptake of both nutrients is directed by growth factor signaling. Although either glucose or glutamine can potentially support mitochondrial tricarboxylic acid (TCA) cycle integrity and ATP production, we found that glucose depriv...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.1985910

    authors: Wellen KE,Lu C,Mancuso A,Lemons JM,Ryczko M,Dennis JW,Rabinowitz JD,Coller HA,Thompson CB

    更新日期:2010-12-15 00:00:00

  • Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for the epigenetic inheritance of DNA methylation.

    abstract::Histone post-translational modifications regulate chromatin structure and function largely through interactions with effector proteins that often contain multiple histone-binding domains. While significant progress has been made characterizing individual effector domains, the role of paired domains and how they functi...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.220467.113

    authors: Rothbart SB,Dickson BM,Ong MS,Krajewski K,Houliston S,Kireev DB,Arrowsmith CH,Strahl BD

    更新日期:2013-06-01 00:00:00

  • Mutations in the Drosophila gene extradenticle affect the way specific homeo domain proteins regulate segmental identity.

    abstract::We characterized a gene, extradenticle, which seems to interact with a specific subset of Drosophila homeo domain proteins, possibly affecting their target specificity. This interpretation is based on an examination of the zygotic and maternal effect phenotypes of extradenticle mutations. In embryos with reduced level...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.4.7.1209

    authors: Peifer M,Wieschaus E

    更新日期:1990-07-01 00:00:00

  • Molecular mechanisms of Spemann's organizer formation: conserved growth factor synergy between Xenopus and mouse.

    abstract::Mesoderm induction assays in Xenopus have implicated growth factors such as activin, Vg1, Xwnt-8, and noggin as important in directing the formation of dorsal mesoderm (Spemann's organizer). Because these growth factors are structurally very different, they presumably act through distinct cell surface receptors that i...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.9.24.3038

    authors: Watabe T,Kim S,Candia A,Rothbächer U,Hashimoto C,Inoue K,Cho KW

    更新日期:1995-12-15 00:00:00

  • Purkinje cell protein-2 regulatory regions and transgene expression in cerebellar compartments.

    abstract::The Purkinje cell protein 2 (Pcp-2) is expressed in cerebellar Purkinje cells and retinal bipolar neurons. To illuminate how Pcp-2 expression is restricted to only two neuronal types and to derive tools to express heterologous genes in these neuronal subpopulations, genomic sequences of the mouse Pcp-2 gene have been ...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.5.7.1136

    authors: Vandaele S,Nordquist DT,Feddersen RM,Tretjakoff I,Peterson AC,Orr HT

    更新日期:1991-07-01 00:00:00

  • Gene encoding a morphogenic protein required in the assembly of the outer coat of the Bacillus subtilis endospore.

    abstract::Endospores of Bacillus subtilis are encased in a two-layer protein shell known as the coat, which consists of a lammellar-like inner layer and an electron-dense outer layer. We report the cloning of the structural gene (designated cotE) for an alkali-soluble coat protein of 24 kD and show that the cotE gene product is...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.2.8.1047

    authors: Zheng LB,Donovan WP,Fitz-James PC,Losick R

    更新日期:1988-08-01 00:00:00

  • The fasciated ear2 gene encodes a leucine-rich repeat receptor-like protein that regulates shoot meristem proliferation in maize.

    abstract::The ability to initiate organs throughout the lifecycle is a unique feature of plant development that is executed by groups of stem cells called meristems. The balance between stem cell proliferation and organ initiation is carefully regulated and ensures that organs can be initiated in regular geometric patterns. To ...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.208501

    authors: Taguchi-Shiobara F,Yuan Z,Hake S,Jackson D

    更新日期:2001-10-15 00:00:00

  • Interaction of the mottler of white with transposable element alleles at the white locus in Drosophila melanogaster.

    abstract::The mottler of white (mw) locus has been determined to interact with alleles of the white (w) eye color locus which are a subset of the transposable element insertion mutants. The transposable elements belong to six different types, including copia, and are located at several sites within the w gene. Three X-ray-induc...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.3.1.73

    authors: Birchler JA,Hiebert JC,Rabinow L

    更新日期:1989-01-01 00:00:00

  • piRNA-guided slicing of transposon transcripts enforces their transcriptional silencing via specifying the nuclear piRNA repertoire.

    abstract::PIWI clade Argonaute proteins silence transposon expression in animal gonads. Their target specificity is defined by bound ∼23- to 30-nucleotide (nt) PIWI-interacting RNAs (piRNAs) that are processed from single-stranded precursor transcripts via two distinct pathways. Primary piRNAs are defined by the endonuclease Zu...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.267252.115

    authors: Senti KA,Jurczak D,Sachidanandam R,Brennecke J

    更新日期:2015-08-15 00:00:00

  • Genome-wide analyses identify transcription factors required for proper morphogenesis of Drosophila sensory neuron dendrites.

    abstract::Dendrite arborization patterns are critical determinants of neuronal function. To explore the basis of transcriptional regulation in dendrite pattern formation, we used RNA interference (RNAi) to screen 730 transcriptional regulators and identified 78 genes involved in patterning the stereotyped dendritic arbors of cl...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.1391006

    authors: Parrish JZ,Kim MD,Jan LY,Jan YN

    更新日期:2006-04-01 00:00:00

  • BMP/SMAD1 signaling sets a threshold for the left/right pathway in lateral plate mesoderm and limits availability of SMAD4.

    abstract::Bistability in developmental pathways refers to the generation of binary outputs from graded or noisy inputs. Signaling thresholds are critical for bistability. Specification of the left/right (LR) axis in vertebrate embryos involves bistable expression of transforming growth factor beta (TGFbeta) member NODAL in the ...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.1682108

    authors: Furtado MB,Solloway MJ,Jones VJ,Costa MW,Biben C,Wolstein O,Preis JI,Sparrow DB,Saga Y,Dunwoodie SL,Robertson EJ,Tam PP,Harvey RP

    更新日期:2008-11-01 00:00:00