Abstract:
:The Drosophila external sensory organ forms in a lineage elaborating from a single precursor cell via a stereotypical series of asymmetric divisions. HAMLET transcription factor expression demarcates the lineage branch that generates two internal cell types, the external sensory neuron and thecogen. In HAMLET mutant organs, these internal cells are converted to external cells via an unprecedented cousin-cousin cell-fate respecification event. Conversely, ectopic HAMLET expression in the external cell branch leads to internal cell production. The fate-determining signals NOTCH and PAX2 act at multiple stages of lineage elaboration and HAMLET acts to modulate their activity in a branch-specific manner.
journal_name
Genes Devjournal_title
Genes & developmentauthors
Moore AW,Roegiers F,Jan LY,Jan YNdoi
10.1101/gad.1170904subject
Has Abstractpub_date
2004-03-15 00:00:00pages
623-8issue
6eissn
0890-9369issn
1549-5477pii
18/6/623journal_volume
18pub_type
杂志文章abstract::Protection of the stalled replication fork is crucial for responding to replication stress and minimizing its impact on chromosome instability, thus preventing diseases, including cancer. We found a new component, Abro1, in the protection of stalled replication fork integrity. Abro1 deficiency results in increased chr...
journal_title:Genes & development
pub_type: 杂志文章
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journal_title:Genes & development
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journal_title:Genes & development
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journal_title:Genes & development
pub_type: 杂志文章
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journal_title:Genes & development
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journal_title:Genes & development
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journal_title:Genes & development
pub_type: 杂志文章
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journal_title:Genes & development
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journal_title:Genes & development
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更新日期:2008-02-01 00:00:00
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journal_title:Genes & development
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journal_title:Genes & development
pub_type: 杂志文章
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更新日期:2013-02-15 00:00:00
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journal_title:Genes & development
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journal_title:Genes & development
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更新日期:2000-06-15 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.272237.115
更新日期:2016-03-01 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
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更新日期:2016-08-15 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.12.18.2831
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journal_title:Genes & development
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journal_title:Genes & development
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journal_title:Genes & development
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更新日期:2007-11-01 00:00:00
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journal_title:Genes & development
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journal_title:Genes & development
pub_type: 杂志文章,评审
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更新日期:2006-05-15 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
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journal_title:Genes & development
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journal_title:Genes & development
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更新日期:2010-07-01 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
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更新日期:1989-07-01 00:00:00