Abstract:
:The c-fos serum response element (SRE) is a multifunctional regulatory region of the c-fos promoter that responds to a variety of inducers. Recently, we have demonstrated that the SRE binds the C/EBP-related transcription factor rat NFIL-6 (rNFIL-6). In this study we show that rNFIL-6 is regulated by the cAMP second messenger pathway in the rat pheochromocytoma PC12 cell line. Following forskolin treatment, rNFIL-6 binding to the SRE is increased, and the factor becomes phosphorylated and undergoes a trans-location to the nucleus. In transient cotransfection assays, rNFIL-6 is capable of trans-activating the c-fos promoter in a manner dependent on the SRE. These data show that rNFIL-6 undergoes a novel activation in which cAMP-induced nuclear trans-location allows rNFIL-6 to bind to the SRE and contribute to c-fos activation. We propose that rNFIL-6 is an additional regulatory component of the c-fos gene, which provides cAMP responsiveness to the multifunctional SRE.
journal_name
Genes Devjournal_title
Genes & developmentauthors
Metz R,Ziff Edoi
10.1101/gad.5.10.1754subject
Has Abstractpub_date
1991-10-01 00:00:00pages
1754-66issue
10eissn
0890-9369issn
1549-5477journal_volume
5pub_type
杂志文章abstract::Medulloblastoma (MB) is the most common pediatric CNS malignancy. We identify EAG2 as an overexpressed potassium channel in MBs across different molecular and histological subgroups. EAG2 knockdown not only impairs MB cell growth in vitro, but also reduces tumor burden in vivo and enhances survival in xenograft studie...
journal_title:Genes & development
pub_type: 杂志文章
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journal_title:Genes & development
pub_type: 杂志文章
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journal_title:Genes & development
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pub_type: 杂志文章
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journal_title:Genes & development
pub_type: 杂志文章,评审
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journal_title:Genes & development
pub_type: 杂志文章
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pub_type: 评论,杂志文章
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journal_title:Genes & development
pub_type: 杂志文章
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journal_title:Genes & development
pub_type: 杂志文章
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更新日期:2003-12-15 00:00:00
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journal_title:Genes & development
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journal_title:Genes & development
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更新日期:2005-09-15 00:00:00
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journal_title:Genes & development
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更新日期:2002-10-01 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
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更新日期:1999-06-01 00:00:00