RNase E action at a distance: degradation of target mRNAs mediated by an Hfq-binding small RNA in bacteria.


:A major class of bacterial small RNAs (sRNAs), along with RNA-binding protein Hfq and endoribonuclease RNase E, acts on target mRNAs through base-pairing, leading to translational repression and rapid degradation of the mRNAs. In this issue of Genes & Development, Prévost and colleagues (pp. 385-396) demonstrate by using the well-characterized sRNA RyhB that RNase E cleavage at sites distal from the pairing region triggers degradation of target mRNAs. The study has provided an important insight into the initial events of sRNA-induced degradation of target mRNAs.


Genes Dev


Genes & development


Morita T,Aiba H




Has Abstract


2011-02-15 00:00:00














  • MVH in piRNA processing and gene silencing of retrotransposons.

    abstract::VASA is an evolutionarily conserved RNA helicase essential for germ cell development. The mouse PIWI family proteins MILI and MIWI2 are involved in production of Piwi-interacting RNAs (piRNAs) in fetal male germ cells through a ping-pong amplification cycle. Expression of retrotransposons is elevated in MILI- and MIWI...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Kuramochi-Miyagawa S,Watanabe T,Gotoh K,Takamatsu K,Chuma S,Kojima-Kita K,Shiromoto Y,Asada N,Toyoda A,Fujiyama A,Totoki Y,Shibata T,Kimura T,Nakatsuji N,Noce T,Sasaki H,Nakano T

    更新日期:2010-05-01 00:00:00

  • FGF7 is a functional niche signal required for stimulation of adult liver progenitor cells that support liver regeneration.

    abstract::The liver is a unique organ with a remarkably high potential to regenerate upon injuries. In severely damaged livers where hepatocyte proliferation is impaired, facultative liver progenitor cells (LPCs) proliferate and are assumed to contribute to regeneration. An expansion of LPCs is often observed in patients with v...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Takase HM,Itoh T,Ino S,Wang T,Koji T,Akira S,Takikawa Y,Miyajima A

    更新日期:2013-01-15 00:00:00

  • Induction of cell fate in the Drosophila retina: the bride of sevenless protein is predicted to contain a large extracellular domain and seven transmembrane segments.

    abstract::Previous genetic mosaic studies established that expression of the Drosophila bride of sevenless (boss) gene is required in photoreceptor neuron R8 for the development of photoreceptor neuron R7. This led to the proposal that boss encodes or regulates an R7-specific inductive cue. We have identified the boss gene base...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Hart AC,Krämer H,Van Vactor DL Jr,Paidhungat M,Zipursky SL

    更新日期:1990-11-01 00:00:00

  • TBP, Mot1, and NC2 establish a regulatory circuit that controls DPE-dependent versus TATA-dependent transcription.

    abstract::The RNA polymerase II core promoter is a structurally and functionally diverse transcriptional module. RNAi depletion and overexpression experiments revealed a genetic circuit that controls the balance of transcription from two core promoter motifs, the TATA box and the downstream core promoter element (DPE). In this ...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Hsu JY,Juven-Gershon T,Marr MT 2nd,Wright KJ,Tjian R,Kadonaga JT

    更新日期:2008-09-01 00:00:00

  • A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension.

    abstract::Kinetochores play an essential role in chromosome segregation by forming dynamic connections with spindle microtubules. Here, we identify a set of 10 copurifying kinetochore proteins from Caenorhabditis elegans, seven of which were previously uncharacterized. Using in vivo assays to monitor chromosome segregation, kin...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Cheeseman IM,Niessen S,Anderson S,Hyndman F,Yates JR 3rd,Oegema K,Desai A

    更新日期:2004-09-15 00:00:00

  • Genomic predictors of interindividual differences in response to DNA damaging agents.

    abstract::Human lymphoblastoid cells derived from different healthy individuals display considerable variation in their transcription profiles. Here we show that such variation in gene expression underlies interindividual susceptibility to DNA damaging agents. The results demonstrate the massive differences in sensitivity acros...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Fry RC,Svensson JP,Valiathan C,Wang E,Hogan BJ,Bhattacharya S,Bugni JM,Whittaker CA,Samson LD

    更新日期:2008-10-01 00:00:00

  • The excess microsporocytes1 gene encodes a putative leucine-rich repeat receptor protein kinase that controls somatic and reproductive cell fates in the Arabidopsis anther.

    abstract::Cell differentiation is essential for the development of multicellular organisms. In flowering plants, the haploid male gametophytes (pollen grains) are generated in the anther from reproductive cells called microsporocytes. Several types of somatic cells ensure successful pollen development, and thus reproduction. Ho...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Zhao DZ,Wang GF,Speal B,Ma H

    更新日期:2002-08-01 00:00:00

  • Time to move the fat.

    abstract::In this issue of Genes & Development, Dowen and colleagues (pp. 1515-1528) elegantly unify two previously unconnected aspects of physiology. The investigators provide significant genetic evidence to support a critical link between developmental timing decisions and the regulation of lipid mobilization at the transitio...

    journal_title:Genes & development

    pub_type: 评论,杂志文章


    authors: Weaver BP,Sewell AK,Han M

    更新日期:2016-07-01 00:00:00

  • Transabdominal, a dominant mutant of the Bithorax Complex, produces a sexually dimorphic segmental transformation in Drosophila.

    abstract::Transabdominal (Tab), a dominant mutation in the Bithorax Complex (BX-C) of Drosophila, creates a sexually dimorphic pattern of segmental transformation that has complete penetrance and expressivity. Specific regions within the notum of the second thoracic segment (T2) are transformed into abdominal-like cuticle; thus...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Celniker SE,Lewis EB

    更新日期:1987-04-01 00:00:00

  • MT1-MMP regulates the PI3Kδ·Mi-2/NuRD-dependent control of macrophage immune function.

    abstract::Macrophages play critical roles in events ranging from host defense to obesity and cancer, where they infiltrate affected tissues and orchestrate immune responses in tandem with the remodeling of the extracellular matrix (ECM). Despite the dual roles played by macrophages in inflammation, the functions of macrophage-d...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Shimizu-Hirota R,Xiong W,Baxter BT,Kunkel SL,Maillard I,Chen XW,Sabeh F,Liu R,Li XY,Weiss SJ

    更新日期:2012-02-15 00:00:00

  • RAG-1 mutations that affect the target specificity of V(D)j recombination: a possible direct role of RAG-1 in site recognition.

    abstract::The RAG-1 protein plays an essential role in V(D)j recombination, but its exact function has not yet been defined. Here we report that a particular mutation in RAG-1 affects recombination by altering the specificity of target sequence usage. Recombination mediated by wild-type RAG-1 is tolerant of a wide range of codi...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Sadofsky MJ,Hesse JE,van Gent DC,Gellert M

    更新日期:1995-09-01 00:00:00

  • Post-transcriptional down-regulation of Atoh1/Math1 by bone morphogenic proteins suppresses medulloblastoma development.

    abstract::Bone morphogenic proteins 2 and 4 (BMP2 and BMP4) inhibit proliferation and induce differentiation of cerebellar granule neuron progenitors (GNPs) and primary GNP-like medulloblastoma (MB) cells. This occurs through rapid proteasome-mediated degradation of Math1 (Atoh1), a transcription factor expressed in proliferati...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Zhao H,Ayrault O,Zindy F,Kim JH,Roussel MF

    更新日期:2008-03-15 00:00:00

  • Cas6 is an endoribonuclease that generates guide RNAs for invader defense in prokaryotes.

    abstract::An RNA-based gene silencing pathway that protects bacteria and archaea from viruses and other genome invaders is hypothesized to arise from guide RNAs encoded by CRISPR loci and proteins encoded by the cas genes. CRISPR loci contain multiple short invader-derived sequences separated by short repeats. The presence of v...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Carte J,Wang R,Li H,Terns RM,Terns MP

    更新日期:2008-12-15 00:00:00

  • Loss of TET2 in hematopoietic cells leads to DNA hypermethylation of active enhancers and induction of leukemogenesis.

    abstract::DNA methylation is tightly regulated throughout mammalian development, and altered DNA methylation patterns are a general hallmark of cancer. The methylcytosine dioxygenase TET2 is frequently mutated in hematological disorders, including acute myeloid leukemia (AML), and has been suggested to protect CG dinucleotide (...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Rasmussen KD,Jia G,Johansen JV,Pedersen MT,Rapin N,Bagger FO,Porse BT,Bernard OA,Christensen J,Helin K

    更新日期:2015-05-01 00:00:00

  • STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA.

    abstract::Multidimensional cancer genome analysis and validation has defined Quaking (QKI), a member of the signal transduction and activation of RNA (STAR) family of RNA-binding proteins, as a novel glioblastoma multiforme (GBM) tumor suppressor. Here, we establish that p53 directly regulates QKI gene expression, and QKI prote...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Chen AJ,Paik JH,Zhang H,Shukla SA,Mortensen R,Hu J,Ying H,Hu B,Hurt J,Farny N,Dong C,Xiao Y,Wang YA,Silver PA,Chin L,Vasudevan S,Depinho RA

    更新日期:2012-07-01 00:00:00

  • The epigenome and the mitochondrion: bioenergetics and the environment [corrected].

    abstract::In the July 15, 2010, issue of Genes & Development, Yoon and colleagues (pp. 1507-1518) report that, in a siRNA knockdown survey of 6363 genes in mouse C2C12 cells, they discovered 150 genes that regulated mitochondrial biogenesis and bioenergetics. Many of these genes have been studied previously for their importance...

    journal_title:Genes & development

    pub_type: 评论,杂志文章


    authors: Wallace DC

    更新日期:2010-08-01 00:00:00

  • Pit-1 binding to specific DNA sites as a monomer or dimer determines gene-specific use of a tyrosine-dependent synergy domain.

    abstract::Transcriptional activation of the prolactin and growth hormone genes, occurring in a cell-specific fashion, requires short-range synergistic interactions between the pituitary-specific POU domain factor Pit-1 and other transcription factors, particularly nuclear receptors. Unexpectedly, we find that these events invol...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Holloway JM,Szeto DP,Scully KM,Glass CK,Rosenfeld MG

    更新日期:1995-08-15 00:00:00

  • Mechanism of corepressor binding and release from nuclear hormone receptors.

    abstract::The association of transcription corepressors SMRT and N-CoR with retinoid and thyroid receptors results in suppression of basal transcriptional activity. A key event in nuclear receptor signaling is the hormone-dependent release of corepressor and the recruitment of coactivator. Biochemical and structural studies hav...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Nagy L,Kao HY,Love JD,Li C,Banayo E,Gooch JT,Krishna V,Chatterjee K,Evans RM,Schwabe JW

    更新日期:1999-12-15 00:00:00

  • Binding sites for transcription factor NTF-1/Elf-1 contribute to the ventral repression of decapentaplegic.

    abstract::The Dorsal morphogen is a transcription factor that activates some genes and represses others to establish multiple domains of gene expression along the dorsal/ventral axis of the early Drosophila embryo. Repression by Dorsal appears to require accessory proteins that bind to corepression elements in Dorsal-dependent ...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Huang JD,Dubnicoff T,Liaw GJ,Bai Y,Valentine SA,Shirokawa JM,Lengyel JA,Courey AJ

    更新日期:1995-12-15 00:00:00

  • CPSF30 and Wdr33 directly bind to AAUAAA in mammalian mRNA 3' processing.

    abstract::AAUAAA is the most highly conserved motif in eukaryotic mRNA polyadenylation sites and, in mammals, is specifically recognized by the multisubunit CPSF (cleavage and polyadenylation specificity factor) complex. Despite its critical functions in mRNA 3' end formation, the molecular basis for CPSF-AAUAAA interaction rem...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Chan SL,Huppertz I,Yao C,Weng L,Moresco JJ,Yates JR 3rd,Ule J,Manley JL,Shi Y

    更新日期:2014-11-01 00:00:00

  • The bHLH gene Hes1 is essential for expansion of early T cell precursors.

    abstract::Mice mutant for the bHLH gene Hes1, which is known to keep cells in a proliferative state, mostly lack thymus. Transfer of Hes1-null fetal liver cells into RAG2-null host mice normally reconstitutes B cells but fails to generate mature T cells in the thymus. In the reconstituted thymus, T cell differentiation is arres...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Tomita K,Hattori M,Nakamura E,Nakanishi S,Minato N,Kageyama R

    更新日期:1999-05-01 00:00:00

  • Distinct activities of the DExD/H-box splicing factor hUAP56 facilitate stepwise assembly of the spliceosome.

    abstract::The essential splicing factor human UAP56 (hUAP56) is a DExD/H-box protein known to promote prespliceosome assembly. Here, using a series of hUAP56 mutants that are defective for ATP-binding, ATP hydrolysis, or dsRNA unwindase/helicase activity, we assess the relative contributions of these biochemical functions to pr...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Shen H,Zheng X,Shen J,Zhang L,Zhao R,Green MR

    更新日期:2008-07-01 00:00:00

  • Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm.

    abstract::Dorsal mesoderm induction in arthropods and ventral mesoderm induction in vertebrates are closely related processes that involve signals of the BMP family. In Drosophila, induction of visceral mesoderm, dorsal muscles, and the heart by Dpp is, at least in part, effected through the transcriptional activation and funct...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Xu X,Yin Z,Hudson JB,Ferguson EL,Frasch M

    更新日期:1998-08-01 00:00:00

  • Selective elimination of the contact site A protein of Dictyostelium discoideum by gene disruption.

    abstract::The contact site A glycoprotein is a developmentally regulated cell-surface component expressed during the aggregation stage of Dictyostelium discoideum. This protein has been implicated in the EDTA-stable (Ca2(+)-independent) type of cell adhesion of aggregating cells. The gene coding for the contact site A protein w...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Harloff C,Gerisch G,Noegel AA

    更新日期:1989-12-01 00:00:00

  • Developmental control of the G1 to S transition in Drosophila: cyclin Eis a limiting downstream target of E2F.

    abstract::The E2F transcription factor is required for S phase in Drosophila. While it also triggers expression of replication genes at the G1-S transition, the relevance of this transcription is not clear because many of the induced gene products are sufficiently stable that new expression is not required for S phase. However,...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Duronio RJ,O'Farrell PH

    更新日期:1995-06-15 00:00:00

  • Eph signaling is required for segmentation and differentiation of the somites.

    abstract::Somitogenesis involves the segmentation of the paraxial mesoderm into units along the anteroposterior axis. Here we show a role for Eph and ephrin signaling in the patterning of presomitic mesoderm and formation of the somites. Ephrin-A-L1 and ephrin-B2 are expressed in an iterative manner in the developing somites an...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Durbin L,Brennan C,Shiomi K,Cooke J,Barrios A,Shanmugalingam S,Guthrie B,Lindberg R,Holder N

    更新日期:1998-10-01 00:00:00

  • The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and normal metaphase chromosome alignment.

    abstract::Post-translational modifications of conserved N-terminal tail residues in histones regulate many aspects of chromosome activity. Thr 3 of histone H3 is highly conserved, but the significance of its phosphorylation is unclear, and the identity of the corresponding kinase unknown. Immunostaining with phospho-specific an...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Dai J,Sultan S,Taylor SS,Higgins JM

    更新日期:2005-02-15 00:00:00

  • Inhibition of viral gene expression by the catalytic RNA subunit of RNase P from Escherichia coli.

    abstract::The catalytic RNA subunit (M1 RNA) of RNase P from Escherichia coli has been converted to an endoribonuclease that specifically cleaves the mRNA that encodes thymidine kinase (TK) of herpes simplex virus 1 (HSV-1). Covalent attachment to the 3' end of M1 RNA of a sequence complementary to TK mRNA results in very effic...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Liu F,Altman S

    更新日期:1995-02-15 00:00:00

  • Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state.

    abstract::Direct reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) provides a unique opportunity to derive patient-specific stem cells with potential applications in tissue replacement therapies and without the ethical concerns of human embryonic stem cells (hESCs). However, cellular senescence, which c...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Lapasset L,Milhavet O,Prieur A,Besnard E,Babled A,Aït-Hamou N,Leschik J,Pellestor F,Ramirez JM,De Vos J,Lehmann S,Lemaitre JM

    更新日期:2011-11-01 00:00:00

  • Role of the rasGAP-associated docking protein p62(dok) in negative regulation of B cell receptor-mediated signaling.

    abstract::Antigenic stimulation of the B-cell receptor (BCR) is a central event in the immune response. In contrast, antigen bound to IgG negatively regulates signals from the BCR by cross-linking it to the inhibitory receptor FcgammaRIIB. Here we show that upon cross-linking of BCR or BCR with FcgammaRIIB, the rasGAP-associate...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Yamanashi Y,Tamura T,Kanamori T,Yamane H,Nariuchi H,Yamamoto T,Baltimore D

    更新日期:2000-01-01 00:00:00