RNase E action at a distance: degradation of target mRNAs mediated by an Hfq-binding small RNA in bacteria.

Abstract:

:A major class of bacterial small RNAs (sRNAs), along with RNA-binding protein Hfq and endoribonuclease RNase E, acts on target mRNAs through base-pairing, leading to translational repression and rapid degradation of the mRNAs. In this issue of Genes & Development, Prévost and colleagues (pp. 385-396) demonstrate by using the well-characterized sRNA RyhB that RNase E cleavage at sites distal from the pairing region triggers degradation of target mRNAs. The study has provided an important insight into the initial events of sRNA-induced degradation of target mRNAs.

journal_name

Genes Dev

journal_title

Genes & development

authors

Morita T,Aiba H

doi

10.1101/gad.2030311

subject

Has Abstract

pub_date

2011-02-15 00:00:00

pages

294-8

issue

4

eissn

0890-9369

issn

1549-5477

pii

25/4/294

journal_volume

25

pub_type

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