当前位置： SCI文献检索 > GENES & DEVELOPMENT期刊下所有文献 > Nitric oxide directly regulates gene expression during Drosophila development: need some gas to drive into metamorphosis?

Nitric oxide directly regulates gene expression during Drosophila development: need some gas to drive into metamorphosis?

Abstract：

:Nitric oxide (NO) is an important second messenger involved in numerous biological processes, but how it regulates gene expression is not well understood. In this issue of Genes & Development, Cáceres and colleagues (pp. 1476-1485) report a critical requirement of NO as a direct regulator of gene expression through its binding to a heme-containing nuclear receptor in Drosophila. This may be an anciently evolved mechanism to coordinate behavior and metabolism during animal development.

journal_name

Genes Dev

journal_title

Genes & development

authors

Yamanaka N,O'Connor MB

doi

10.1101/gad.2080411

subject

Has Abstract

pub_date

2011-07-15 00:00:00

pages

1459-63

issue

14

eissn

0890-9369

issn

1549-5477

pii

25/14/1459

journal_volume

25

pub_type

评论,杂志文章

相关文献

GENES & DEVELOPMENT文献大全
  • Unbiased identification of signal-activated transcription factors by barcoded synthetic tandem repeat promoter screening (BC-STAR-PROM).

    abstract：:The discovery of transcription factors (TFs) controlling pathways in health and disease is of paramount interest. We designed a widely applicable method, dubbed barcorded synthetic tandem repeat promoter screening (BC-STAR-PROM), to identify signal-activated TFs without any a priori knowledge about their properties. T...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.284828.116

    authors： Gosselin P,Rando G,Fleury-Olela F,Schibler U

    更新日期：2016-08-15 00:00:00

  • A model for the abrogation of the SOS response by an SOS protein: a negatively charged helix in DinI mimics DNA in its interaction with RecA.

    abstract：:DinI is a recently described negative regulator of the SOS response in Escherichia coli. Here we show that it physically interacts with RecA and prevents the binding of single-stranded DNA to RecA, which is required for the activation of the latter. DinI also displaces ssDNA from a stable RecA-DNA cofilament, thus eli...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.862901

    authors： Voloshin ON,Ramirez BE,Bax A,Camerini-Otero RD

    更新日期：2001-02-15 00:00:00

  • Protein kinase C-zeta reverts v-raf transformation of NIH-3T3 cells.

    abstract：:We have identified protein kinase C-zeta (PKC-zeta) as a novel suppressor of neoplastic transformation caused by the v-raf oncogene. PKC-zeta overexpression drastically retards proliferation, abolishes anchorage-independent growth, and reverts the morphological transformation of v-raf-transformed NIH-3T3 cells. The mo...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.10.12.1455

    authors： Kieser A,Seitz T,Adler HS,Coffer P,Kremmer E,Crespo P,Gutkind JS,Henderson DW,Mushinski JF,Kolch W,Mischak H

    更新日期：1996-06-15 00:00:00

  • A cloned human cDNA determines expression of a mouse stage-specific embryonic antigen and the Lewis blood group alpha(1,3/1,4)fucosyltransferase.

    abstract：:The stage-specific embryonic antigen SSEA-1 is a cell-surface oligosaccharide molecule expressed with temporal precision during the murine preimplantation period and implicated in adhesive events involving the process of compaction. We used a mammalian transient expression system to isolate a cloned human cDNA that de...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.4.8.1288

    authors： Kukowska-Latallo JF,Larsen RD,Nair RP,Lowe JB

    更新日期：1990-08-01 00:00:00

  • Stages in the second reaction of pre-mRNA splicing: the final step is ATP independent.

    abstract：:We have analyzed pre-mRNA splicing in yeast extracts immunodepleted of the PRP18 protein. We find that while the first step of splicing (cleavage at the 5' splice site, and generation of the exon 1 and lariat intermediates) is unaffected by the absence of PRP18, the second step of splicing (excision of the lariat intr...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.7.2.320

    authors： Horowitz DS,Abelson J

    更新日期：1993-02-01 00:00:00

  • MT1-MMP regulates the PI3Kδ·Mi-2/NuRD-dependent control of macrophage immune function.

    abstract：:Macrophages play critical roles in events ranging from host defense to obesity and cancer, where they infiltrate affected tissues and orchestrate immune responses in tandem with the remodeling of the extracellular matrix (ECM). Despite the dual roles played by macrophages in inflammation, the functions of macrophage-d...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.178749.111

    authors： Shimizu-Hirota R,Xiong W,Baxter BT,Kunkel SL,Maillard I,Chen XW,Sabeh F,Liu R,Li XY,Weiss SJ

    更新日期：2012-02-15 00:00:00

  • Radical mutations reveal TATA-box binding protein surfaces required for activated transcription in vivo.

    abstract：:Regions on the surface of human TATA-box binding protein (TBP) required for activated transcription in vivo were defined by construction of a library of 89 surface residue mutants with radical substitutions that were assayed for their ability to support activated transcription in vivo, basal transcription in vitro, an...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.10.19.2491

    authors： Bryant GO,Martel LS,Burley SK,Berk AJ

    更新日期：1996-10-01 00:00:00

  • Lin28 sustains early renal progenitors and induces Wilms tumor.

    abstract：:Wilms Tumor, the most common pediatric kidney cancer, evolves from the failure of terminal differentiation of the embryonic kidney. Here we show that overexpression of the heterochronic regulator Lin28 during kidney development in mice markedly expands nephrogenic progenitors by blocking their final wave of differenti...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.237149.113

    authors： Urbach A,Yermalovich A,Zhang J,Spina CS,Zhu H,Perez-Atayde AR,Shukrun R,Charlton J,Sebire N,Mifsud W,Dekel B,Pritchard-Jones K,Daley GQ

    更新日期：2014-05-01 00:00:00

  • Saccharomyces cerevisiae cAMP-dependent protein kinase controls entry into stationary phase through the Rim15p protein kinase.

    abstract：:The Saccharomyces cerevisiae protein kinase Rim15p was identified previously as a stimulator of meiotic gene expression. Here, we show that loss of Rim15p causes an additional pleiotropic phenotype in cells grown to stationary phase on rich medium; this phenotype includes defects in trehalose and glycogen accumulation...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.12.18.2943

    authors： Reinders A,Bürckert N,Boller T,Wiemken A,De Virgilio C

    更新日期：1998-09-15 00:00:00

  • TALE-light imaging reveals maternally guided, H3K9me2/3-independent emergence of functional heterochromatin in Drosophila embryos.

    abstract：:Metazoans start embryogenesis with a relatively naïve genome. The transcriptionally inert, late-replicating heterochromatic regions, including the constitutive heterochromatin on repetitive sequences near centromeres and telomeres, need to be re-established during development. To explore the events initiating heteroch...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.272237.115

    authors： Yuan K,O'Farrell PH

    更新日期：2016-03-01 00:00:00

  • Inhibition of viral gene expression by the catalytic RNA subunit of RNase P from Escherichia coli.

    abstract：:The catalytic RNA subunit (M1 RNA) of RNase P from Escherichia coli has been converted to an endoribonuclease that specifically cleaves the mRNA that encodes thymidine kinase (TK) of herpes simplex virus 1 (HSV-1). Covalent attachment to the 3' end of M1 RNA of a sequence complementary to TK mRNA results in very effic...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.9.4.471

    authors： Liu F,Altman S

    更新日期：1995-02-15 00:00:00

  • Seven-up, the Drosophila homolog of the COUP-TF orphan receptors, controls cell proliferation in the insect kidney.

    abstract：:Morphogenesis of the insect kidney, the Malpighian tubules, is controlled in Drosophila by a single large cell, the tip cell. It has been postulated that this cell sends out a mitogenic signal that induces the division of neighboring cells. The signal and the molecules that receive it have remained elusive. We show th...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.12.12.1781

    authors： Kerber B,Fellert S,Hoch M

    更新日期：1998-06-15 00:00:00

  • The cloned RNA polymerase II transcription factor IID selects RNA polymerase III to transcribe the human U6 gene in vitro.

    abstract：:Although the human U2 and U6 snRNA genes are transcribed by different RNA polymerases (i.e., RNA polymerases II and III, respectively), their promoters are very similar in structure. Both contain a proximal sequence element (PSE) and an octamer motif-containing enhancer, and these elements are interchangeable between ...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.5.8.1477

    authors： Lobo SM,Lister J,Sullivan ML,Hernandez N

    更新日期：1991-08-01 00:00:00

  • The regulation of empty spiracles by Abdominal-B mediates an abdominal segment identity function.

    abstract：:The empty spiracles (ems) homeo box gene is required for the development of the Drosophila larval filzkörper, which are structural specializations of the eighth abdominal segment. Filzkörper development is also dependent on the function of the homeotic selector gene Abdominal-B (Abd-B). Here, we show that ems is a dow...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.7.2.229

    authors： Jones B,McGinnis W

    更新日期：1993-02-01 00:00:00

  • Precommitment low-level Neurog3 expression defines a long-lived mitotic endocrine-biased progenitor pool that drives production of endocrine-committed cells.

    abstract：:The current model for endocrine cell specification in the pancreas invokes high-level production of the transcription factor Neurogenin 3 (Neurog3) in Sox9(+) bipotent epithelial cells as the trigger for endocrine commitment, cell cycle exit, and rapid delamination toward proto-islet clusters. This model posits a tran...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.284729.116

    authors： Bechard ME,Bankaitis ED,Hipkens SB,Ustione A,Piston DW,Yang YP,Magnuson MA,Wright CV

    更新日期：2016-08-15 00:00:00

  • WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase.

    abstract：:Tuberous sclerosis (TSC) is an autosomal dominant disease characterized by hamartoma formation in various organs and is caused by mutations targeting either the TSC1 or TSC2 genes. TSC1 and TSC2 proteins form a functionally interdependent dimeric complex. Phosphorylation of either TSC subunit by different kinases regu...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.1624008

    authors： Hu J,Zacharek S,He YJ,Lee H,Shumway S,Duronio RJ,Xiong Y

    更新日期：2008-04-01 00:00:00

  • Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicity.

    abstract：:For all newborn mammals, mother's milk is the perfect nourishment, crucial for their postnatal development. Here we report that, unexpectedly, maternal western diet consumption in mice causes the production of toxic milk that contains excessive long chain and saturated fatty acids, which triggers ceramide accumulation...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.191031.112

    authors： Du Y,Yang M,Lee S,Behrendt CL,Hooper LV,Saghatelian A,Wan Y

    更新日期：2012-06-15 00:00:00

  • Negative regulation of FAR1 at the Start of the yeast cell cycle.

    abstract：:In budding yeast, a switch between the mutually exclusive pathways of cell cycle progression and conjugation is controlled at Start in late G1 phase. Mating pheromones promote conjugation by arresting cells in G1 phase before Start. Pheromone-induced cell cycle arrest requires a functional FAR1 gene. We have found tha...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.7.5.833

    authors： McKinney JD,Chang F,Heintz N,Cross FR

    更新日期：1993-05-01 00:00:00

  • Nuclear localization of the Arabidopsis APETALA3 and PISTILLATA homeotic gene products depends on their simultaneous expression.

    abstract：:The Arabidopsis APETALA3 (AP3) and PISTILLATA (PI) proteins are thought to act as transcription factors and are required for specifying floral organ identities. To define the nuclear localization signals within these proteins, we generated translational fusions of the coding regions of AP3 and PI to the bacterial uidA...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.10.14.1812

    authors： McGonigle B,Bouhidel K,Irish VF

    更新日期：1996-07-15 00:00:00

  • Mouse model for the lysosomal disorder galactosialidosis and correction of the phenotype with overexpressing erythroid precursor cells.

    abstract：:The lysosomal storage disorder galactosialidosis results from a primary deficiency of the protective protein/cathepsin A (PPCA), which in turn affects the activities of beta-galactosidase and neuraminidase. Mice homozygous for a null mutation at the PPCA locus present with signs of the disease shortly after birth and ...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.9.21.2623

    authors： Zhou XY,Morreau H,Rottier R,Davis D,Bonten E,Gillemans N,Wenger D,Grosveld FG,Doherty P,Suzuki K,Grosveld GC,d'Azzo A

    更新日期：1995-11-01 00:00:00

  • Reconstitution of human TFIIA activity from recombinant polypeptides: a role in TFIID-mediated transcription.

    abstract：:Human TFIIA activity is composed of three subunits (alpha, beta, gamma). Here we report the isolation of a human cDNA clone encoding the gamma-subunit and the reconstitution of TFIIA activity from recombinant polypeptides (holo-TFIIA). Protein-protein interaction analysis established that the beta and gamma subunits o...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.8.19.2336

    authors： Sun X,Ma D,Sheldon M,Yeung K,Reinberg D

    更新日期：1994-10-01 00:00:00

  • A single Hox locus in Drosophila produces functional microRNAs from opposite DNA strands.

    abstract：:MicroRNAs (miRNAs) are approximately 22-nucleotide RNAs that are processed from characteristic precursor hairpins and pair to sites in messages of protein-coding genes to direct post-transcriptional repression. Here, we report that the miRNA iab-4 locus in the Drosophila Hox cluster is transcribed convergently from bo...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.1613108

    authors： Stark A,Bushati N,Jan CH,Kheradpour P,Hodges E,Brennecke J,Bartel DP,Cohen SM,Kellis M

    更新日期：2008-01-01 00:00:00

  • The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3'UTR.

    abstract：:Caenorhabditis elegans let-7, a founding member of the microRNA family, is predicted to bind to six sites in the 3'UTR of the mRNA of its target gene, lin-41, to down-regulate LIN-41. Here, we demonstrate that wild-type let-7 microRNA binds in vitro to RNA from the lin-41 3'UTR. This interaction is dependent on two co...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.1165404

    authors： Vella MC,Choi EY,Lin SY,Reinert K,Slack FJ

    更新日期：2004-01-15 00:00:00

  • Genome integrity and disease prevention in the nervous system.

    abstract：:Multiple DNA repair pathways maintain genome stability and ensure that DNA remains essentially unchanged over the life of a cell. Various human diseases occur if DNA repair is compromised, and most of these impact the nervous system, in some cases exclusively. However, it is often unclear what specific endogenous dama...

    journal_title：Genes & development

    pub_type： 杂志文章,评审

    doi：10.1101/gad.301325.117

    authors： McKinnon PJ

    更新日期：2017-06-15 00:00:00

  • Mutations in the Drosophila gene extradenticle affect the way specific homeo domain proteins regulate segmental identity.

    abstract：:We characterized a gene, extradenticle, which seems to interact with a specific subset of Drosophila homeo domain proteins, possibly affecting their target specificity. This interpretation is based on an examination of the zygotic and maternal effect phenotypes of extradenticle mutations. In embryos with reduced level...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.4.7.1209

    authors： Peifer M,Wieschaus E

    更新日期：1990-07-01 00:00:00

  • Brg1 promotes both tumor-suppressive and oncogenic activities at distinct stages of pancreatic cancer formation.

    abstract：:Pancreatic ductal adenocarcinoma (PDA) develops predominantly through pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasm (IPMN) precursor lesions. Pancreatic acinar cells are reprogrammed to a "ductal-like" state during PanIN-PDA formation. Here, we demonstrate a parallel mechanis...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.256628.114

    authors： Roy N,Malik S,Villanueva KE,Urano A,Lu X,Von Figura G,Seeley ES,Dawson DW,Collisson EA,Hebrok M

    更新日期：2015-03-15 00:00:00

  • Caudal, a key developmental regulator, is a DPE-specific transcriptional factor.

    abstract：:The regulation of gene transcription is critical for the proper development and growth of an organism. The transcription of protein-coding genes initiates at the RNA polymerase II core promoter, which is a diverse module that can be controlled by many different elements such as the TATA box and downstream core promote...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.1698108

    authors： Juven-Gershon T,Hsu JY,Kadonaga JT

    更新日期：2008-10-15 00:00:00

  • Genomic instability and endoreduplication triggered by RAD17 deletion.

    abstract：:Cell cycle checkpoints are critical for genomic stability. Rad17, a component of the checkpoint clamp loader complex (Rad17/Rfc2-5), is required for the response to DNA damage and replication stress. To explore the role of Rad17 in the maintenance of genomic integrity, we established somatic conditional alleles of RAD...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.1065103

    authors： Wang X,Zou L,Zheng H,Wei Q,Elledge SJ,Li L

    更新日期：2003-04-15 00:00:00

  • The function of Xenopus Bloom's syndrome protein homolog (xBLM) in DNA replication.

    abstract：:The Bloom's syndrome gene (BLM) plays a pivotal role in the maintenance of genomic stability in somatic cells. It encodes a DNA helicase (BLM) of the RecQ family, but the exact function of BLM remains elusive. To study this question, we have cloned the BLM homolog of the frog Xenopus laevis (xBLM) and have raised anti...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.822400

    authors： Liao S,Graham J,Yan H

    更新日期：2000-10-15 00:00:00

  • Codon usage affects the structure and function of the Drosophila circadian clock protein PERIOD.

    abstract：:Codon usage bias is a universal feature of all genomes, but its in vivo biological functions in animal systems are not clear. To investigate the in vivo role of codon usage in animals, we took advantage of the sensitivity and robustness of the Drosophila circadian system. By codon-optimizing parts of Drosophila period...

    journal_title：Genes & development

    pub_type： 杂志文章

    doi：10.1101/gad.281030.116

    authors： Fu J,Murphy KA,Zhou M,Li YH,Lam VH,Tabuloc CA,Chiu JC,Liu Y

    更新日期：2016-08-01 00:00:00