biniou (FoxF), a central component in a regulatory network controlling visceral mesoderm development and midgut morphogenesis in Drosophila.

abstract：:The RecQ protein family is a highly conserved group of DNA helicases that play roles in maintaining genomic stability. In this study, we present biochemical and genetic evidence that Escherichia coli RecQ processes stalled replication forks and participates in SOS signaling. Cells that carry dnaE486, a mutation in the...

journal_title：Genes & development

authors： Hishida T,Han YW,Shibata T,Kubota Y,Ishino Y,Iwasaki H,Shinagawa H

更新日期：2004-08-01 00:00:00

abstract：:Genome instability is a recurring feature of tumorigenesis. Mutation in MLL2, encoding a histone methyltransferase, is a driver in numerous different cancer types, but the mechanism is unclear. Here, we present evidence that MLL2 mutation results in genome instability. Mouse cells in which MLL2 gene deletion can be in...

journal_title：Genes & development

authors： Kantidakis T,Saponaro M,Mitter R,Horswell S,Kranz A,Boeing S,Aygün O,Kelly GP,Matthews N,Stewart A,Stewart AF,Svejstrup JQ

更新日期：2016-02-15 00:00:00

abstract：:To investigate the relationship between splicing and polyadenylation during the production of vertebrate mRNAs, we examined the effect of mutation of a poly(A) site on splicing of upstream introns. Mutation of the AAUAAA polyadenylation consensus sequence inhibited in vitro splicing of an upstream intron. The magnitud...

journal_title：Genes & development

authors： Niwa M,Berget SM

更新日期：1991-11-01 00:00:00

abstract：:The choice of self-renewal versus differentiation is a fundamental issue in stem cell and cancer biology. Neural progenitors of the Drosophila post-embryonic brain, larval neuroblasts (NBs), divide asymmetrically in a stem cell-like fashion to generate a self-renewing NB and a Ganglion Mother Cell (GMC), which divides...

journal_title：Genes & development

authors： Wang H,Somers GW,Bashirullah A,Heberlein U,Yu F,Chia W

更新日期：2006-12-15 00:00:00

abstract：:Extensive DNA elimination via a DNA breakage and rejoining process occurs during macronuclear development in the hypotrich ciliate Euplotes crassus. The excision process involves the removal of short, unique segments of DNA (internal eliminated sequences; IESs) and at least two highly repetitive families of transposon...

journal_title：Genes & development

authors： Klobutcher LA,Turner LR,LaPlante J

更新日期：1993-01-01 00:00:00

abstract：:Tuberous sclerosis (TSC) is an autosomal dominant disease characterized by hamartoma formation in various organs and is caused by mutations targeting either the TSC1 or TSC2 genes. TSC1 and TSC2 proteins form a functionally interdependent dimeric complex. Phosphorylation of either TSC subunit by different kinases regu...

journal_title：Genes & development

authors： Hu J,Zacharek S,He YJ,Lee H,Shumway S,Duronio RJ,Xiong Y

更新日期：2008-04-01 00:00:00

abstract：:The HOP2 and MND1 genes are indispensable for meiotic recombination. The products of these genes associate to form a stable heterodimeric complex that binds DNA and stimulates the recombinase activity of Rad51 and Dmc1. Here we conduct molecular studies to delineate the action mechanism of the Hop2-Mnd1 complex. We pr...

journal_title：Genes & development

authors： Chi P,San Filippo J,Sehorn MG,Petukhova GV,Sung P

更新日期：2007-07-15 00:00:00

abstract：:A conditional allele of type 1 protein phosphatase (glc7-129) in Saccharomyces cerevisiae causes first cycle arrest in G2/M, characterized by cells with a short spindle and high H1 kinase activity. Point-of-execution experiments indicate Glc7p function is required in G2/M just before anaphase for the completion of mit...

journal_title：Genes & development

authors： Bloecher A,Tatchell K

更新日期：1999-03-01 00:00:00

abstract：:How muscle diversity is generated in the vertebrate body is poorly understood. In the limb, dorsal and ventral muscle masses constitute the first myogenic diversification, as each gives rise to distinct muscles. Myogenesis initiates after muscle precursor cells (MPCs) have migrated from the somites to the limb bud and...

journal_title：Genes & development

authors： Anderson C,Williams VC,Moyon B,Daubas P,Tajbakhsh S,Buckingham ME,Shiroishi T,Hughes SM,Borycki AG

更新日期：2012-09-15 00:00:00

abstract：:C-factor, the product of the csgA gene, is a cell-surface associated short-range intercellular signaling protein in Myxococcus xanthus. C-factor is required for at least four responses during starvation-induced fruiting body morphogenesis: rippling, aggregation, sporulation, and full expression of the csgA gene, all o...

journal_title：Genes & development

authors： Søgaard-Andersen L,Slack FJ,Kimsey H,Kaiser D

更新日期：1996-03-15 00:00:00

abstract：:The td, nrdB, and sunY introns of bacteriophage T4 each contain a long open reading frame (ORF). These ORFs are preceded by functional T4 late promoters and, in the case of the nrdB intron ORF, a functional middle promoter. Expression of phage-encoded intron ORF-lacZ fusions indicates that these T4 genes are highly re...

journal_title：Genes & development

authors： Gott JM,Zeeh A,Bell-Pedersen D,Ehrenman K,Belfort M,Shub DA

更新日期：1988-12-01 00:00:00

abstract：:Classical embryology has provided a clear view of the timing and hormonal cues that govern sexual differentiation. Molecular biology has added important details to this picture. The cloning of SRY, MIS, and INSL3 provide insight into the molecular signals that provide important cues at the cellular level. Continued un...

journal_title：Genes & development

authors： Nef S,Parada LF

更新日期：2000-12-15 00:00:00

abstract：:Cellular senescence is a potent tumor suppressor mechanism but also contributes to aging and aging-related diseases. Senescence is characterized by a stable cell cycle arrest and a complex proinflammatory secretome, termed the senescence-associated secretory phenotype (SASP). We recently discovered that cytoplasmic ch...

journal_title：Genes & development

authors： Vizioli MG,Liu T,Miller KN,Robertson NA,Gilroy K,Lagnado AB,Perez-Garcia A,Kiourtis C,Dasgupta N,Lei X,Kruger PJ,Nixon C,Clark W,Jurk D,Bird TG,Passos JF,Berger SL,Dou Z,Adams PD

更新日期：2020-03-01 00:00:00

abstract：:IkappaB kinases (IKKs) IKK1 and IKK2 are two putative IkappaBalpha kinases involved in NF-kappaB activation. To examine the in vivo functions of IKK1, we generated IKK1-deficient mice. The mutant mice are perinatally lethal and exhibit a wide range of developmental defects. Newborn mutant mice have shiny, taut, and st...

journal_title：Genes & development

authors： Li Q,Lu Q,Hwang JY,Büscher D,Lee KF,Izpisua-Belmonte JC,Verma IM

更新日期：1999-05-15 00:00:00

abstract：:Repression of a-cell specific gene expression in yeast alpha cells requires MAT alpha 2 and MCM1, as well as two global repressors, SSN6 and TUP1. Previous studies demonstrated that nucleosomes positioned adjacent to the alpha 2/MCM1 operator in alpha cells directly contribute to repression. To investigate the possibi...

journal_title：Genes & development

authors： Cooper JP,Roth SY,Simpson RT

更新日期：1994-06-15 00:00:00

abstract：:To understand the organization of the transcriptional networks that govern cell differentiation, we have investigated the transcriptional circuitry controlling pseudohyphal development in Saccharomyces cerevisiae. The binding targets of Ste12, Tec1, Sok2, Phd1, Mga1, and Flo8 were globally mapped across the yeast geno...

journal_title：Genes & development

authors： Borneman AR,Leigh-Bell JA,Yu H,Bertone P,Gerstein M,Snyder M

更新日期：2006-02-15 00:00:00

abstract：:Cyclin B3 has been conserved during higher eukaryote evolution as evidenced by its identification in chicken, nematodes, and insects. We demonstrate that Cyclin B3 is present in addition to Cyclins A and B in mitotically proliferating cells and not detectable in endoreduplicating tissues of Drosophila embryos. Cyclin ...

journal_title：Genes & development

authors： Jacobs HW,Knoblich JA,Lehner CF

更新日期：1998-12-01 00:00:00

abstract：:Bistability in developmental pathways refers to the generation of binary outputs from graded or noisy inputs. Signaling thresholds are critical for bistability. Specification of the left/right (LR) axis in vertebrate embryos involves bistable expression of transforming growth factor beta (TGFbeta) member NODAL in the ...

journal_title：Genes & development

authors： Furtado MB,Solloway MJ,Jones VJ,Costa MW,Biben C,Wolstein O,Preis JI,Sparrow DB,Saga Y,Dunwoodie SL,Robertson EJ,Tam PP,Harvey RP

更新日期：2008-11-01 00:00:00

abstract：:The p53 inhibitor murine double-minute gene 2 (Mdm2) is a target for potential cancer therapies, however increased p53 function can be lethal. To directly address whether reduced Mdm2 function can inhibit tumorigenesis without causing detrimental side effects, we exploited a hypomorphic murine allele of mdm2 to compar...

journal_title：Genes & development

authors： Mendrysa SM,O'Leary KA,McElwee MK,Michalowski J,Eisenman RN,Powell DA,Perry ME

更新日期：2006-01-01 00:00:00

abstract：:Far1p is a bifunctional protein that is required to arrest the cell cycle and to establish cell polarity during yeast mating. Far1p is localized predominantly in the nucleus but accumulates in the cytoplasm in cells exposed to pheromones. Here we show that Far1p functions in both subcellular compartments: nuclear Far1...

journal_title：Genes & development

authors： Blondel M,Alepuz PM,Huang LS,Shaham S,Ammerer G,Peter M

更新日期：1999-09-01 00:00:00

abstract：:The WD40 domain-containing protein WRAP53β (WD40 encoding RNA antisense to p53; also referred to as WDR79/TCAB1) controls trafficking of splicing factors and the telomerase enzyme to Cajal bodies, and its functional loss has been linked to carcinogenesis, premature aging, and neurodegeneration. Here, we identify WRAP5...

journal_title：Genes & development

authors： Henriksson S,Rassoolzadeh H,Hedström E,Coucoravas C,Julner A,Goldstein M,Imreh G,Zhivotovsky B,Kastan MB,Helleday T,Farnebo M

更新日期：2014-12-15 00:00:00

abstract：:While microRNAs (miRNAs) regulate the vast majority of protein-encoding transcripts, little is known about how miRNAs themselves are degraded. We recently described Tudor-staphylococcal/micrococcal-like nuclease (TSN)-mediated miRNA decay (TumiD) as a cellular pathway in which the nuclease TSN promotes the decay of mi...

journal_title：Genes & development

authors： Elbarbary RA,Miyoshi K,Hedaya O,Myers JR,Maquat LE

更新日期：2017-07-15 00:00:00

abstract：:The p53 tumor suppressor is often disrupted in human cancers by the acquisition of missense mutations. We generated mice with a missense mutation at codon 172 that mimics the p53R175H hot spot mutation in human cancer. p53 homozygous mutant mice have unstable mutant p53 in normal cells and stabilize mutant p53 in some...

journal_title：Genes & development

authors： Terzian T,Suh YA,Iwakuma T,Post SM,Neumann M,Lang GA,Van Pelt CS,Lozano G

更新日期：2008-05-15 00:00:00

abstract：:We report a new role for Wnt signaling in the vertebrate embryo: the induction of neural tissue from ectoderm. Early expression of mouse wnt8, Xwnt8, beta-catenin, or dominant-negative GSK3 induces the expression of neural-specific markers and inhibits the expression of Bmp4 in Xenopus ectoderm. We show that Wnt8, but...

journal_title：Genes & development

authors： Baker JC,Beddington RS,Harland RM

更新日期：1999-12-01 00:00:00

abstract：:GRF2, an abundant yeast protein of Mr approximately 127,000, binds to the GAL upstream activating sequence (UASG) and creates a nucleosome-free region of approximately 230 bp. Purified GRF2 binds to sequences found in many other UASs, in the 35S rRNA enhancer, at centromeres, and at telomeres. Although GRF2 stimulates...

journal_title：Genes & development

authors： Chasman DI,Lue NF,Buchman AR,LaPointe JW,Lorch Y,Kornberg RD

更新日期：1990-04-01 00:00:00

abstract：:Cohesin is a chromosome-associated multisubunit protein complex that is highly conserved in eukaryotes and has close homologs in bacteria. Cohesin mediates cohesion between replicated sister chromatids and is therefore essential for chromosome segregation in dividing cells. Cohesin is also required for efficient repai...

journal_title：Genes & development

authors： Peters JM,Tedeschi A,Schmitz J

更新日期：2008-11-15 00:00:00

abstract：:In many species, a dosage compensation complex (DCC) is targeted to X chromosomes of one sex to equalize levels of X-gene products between males (1X) and females (2X). Here we identify cis-acting regulatory elements that target the Caenorhabditis elegans X chromosome for repression by the DCC. The DCC binds to discret...

journal_title：Genes & development

authors： Jans J,Gladden JM,Ralston EJ,Pickle CS,Michel AH,Pferdehirt RR,Eisen MB,Meyer BJ

更新日期：2009-03-01 00:00:00

abstract：:Mammalian histone gene transcription is increased approximately fivefold during the transition from the G1 phase to the S phase of the cell cycle. In this study, we present a detailed in vivo analysis of the human histone H2b promoter, which establishes that transcriptional regulation of this gene is mediated by a sub...

journal_title：Genes & development

authors： LaBella F,Sive HL,Roeder RG,Heintz N

更新日期：1988-01-01 00:00:00

abstract：:Regions on the surface of human TATA-box binding protein (TBP) required for activated transcription in vivo were defined by construction of a library of 89 surface residue mutants with radical substitutions that were assayed for their ability to support activated transcription in vivo, basal transcription in vitro, an...

journal_title：Genes & development

authors： Bryant GO,Martel LS,Burley SK,Berk AJ

更新日期：1996-10-01 00:00:00

abstract：:A major class of bacterial small RNAs (sRNAs), along with RNA-binding protein Hfq and endoribonuclease RNase E, acts on target mRNAs through base-pairing, leading to translational repression and rapid degradation of the mRNAs. In this issue of Genes & Development, Prévost and colleagues (pp. 385-396) demonstrate by us...

journal_title：Genes & development

authors： Morita T,Aiba H

更新日期：2011-02-15 00:00:00