Genes within genes: independent expression of phage T4 intron open reading frames and the genes in which they reside.

abstract：:We have studied the sequence requirements for 3'-end formation of rDNA transcripts in a cell-free system and show that the generation of correct ends of mouse pre-rRNA is brought about by a two-step process that involves a bona fide termination reaction, followed by a specific trimming of the primary transcript by 10 ...

journal_title：Genes & development

authors： Kuhn A,Grummt I

更新日期：1989-02-01 00:00:00

abstract：:The progressive bone marrow failure syndrome dyskeratosis congenita (DC) is often caused by mutations in telomerase or the factors involved in telomerase biogenesis and trafficking. However, a subset of DC patients is heterozygous for mutations in the shelterin component TIN2. To determine how the TIN2-DC mutations af...

journal_title：Genes & development

authors： Frescas D,de Lange T

更新日期：2014-01-15 00:00:00

abstract：:Activation of p53-mediated transcription is a critical cellular response to DNA damage. p53 stability and site-specific DNA-binding activity and, therefore, transcriptional activity, are modulated by post-translational modifications including phosphorylation and acetylation. Here we show that p53 is acetylated in vitr...

journal_title：Genes & development

authors： Sakaguchi K,Herrera JE,Saito S,Miki T,Bustin M,Vassilev A,Anderson CW,Appella E

更新日期：1998-09-15 00:00:00

abstract：:Mu DNA transposition proceeds through a series of higher-order nucleoprotein complexes called transpososomes. The structural core of the transpososome is a tetramer of the transposase, Mu A, bound to the two transposon ends. High-resolution structural analysis of the intact transposase and the transpososome has not be...

journal_title：Genes & development

authors： Yuan JF,Beniac DR,Chaconas G,Ottensmeyer FP

更新日期：2005-04-01 00:00:00

abstract：:Expression of both N-myc and c-myc is induced rapidly and dramatically in normal pre-B cells after stimulation with interleukin-7 (IL-7), a pre-B cell-specific growth factor. These IL-7-induced increases in N-myc and c-myc expression are mediated at the transcriptional level; for N-myc, a major portion of the inductio...

journal_title：Genes & development

authors： Morrow MA,Lee G,Gillis S,Yancopoulos GD,Alt FW

更新日期：1992-01-01 00:00:00

abstract：:The epidemic of obesity and diabetes is causing an increased incidence of dyslipidemia-related heart failure. While the primary etiology of lipotoxic cardiomyopathy is an elevation of lipid levels resulting from an imbalance in energy availability and expenditure, increasing evidence suggests a relationship between dy...

journal_title：Genes & development

authors： Lim HY,Wang W,Wessells RJ,Ocorr K,Bodmer R

更新日期：2011-01-15 00:00:00

abstract：:The circadian rhythm of pineal melatonin requires the nocturnal increment of serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase [AANAT]) protein. To date, only limited information is available in the critical issue of how AANAT protein expression is up-regulated exclusively at night regardless of its sp...

journal_title：Genes & development

authors： Kim TD,Woo KC,Cho S,Ha DC,Jang SK,Kim KT

更新日期：2007-04-01 00:00:00

abstract：:RUNX1/AML1 is required for the development of definitive hematopoiesis, and its activity is altered by mutations, deletions, and chromosome translocations in human acute leukemia. RUNX1 function can be regulated by post-translational modifications and protein-protein interactions. We show that RUNX1 is arginine-methyl...

journal_title：Genes & development

authors： Zhao X,Jankovic V,Gural A,Huang G,Pardanani A,Menendez S,Zhang J,Dunne R,Xiao A,Erdjument-Bromage H,Allis CD,Tempst P,Nimer SD

更新日期：2008-03-01 00:00:00

abstract：:Treatment with retinoic acid (RA) is known to produce complex teratogenic effects in vertebrates, and its presence in the developing embryo as an endogenous substance has led to the suggestion that RA might be a natural morphogenetic agent. Although our understanding of the molecular mechanism of RA action has improve...

journal_title：Genes & development

authors： Rossant J,Zirngibl R,Cado D,Shago M,Giguère V

更新日期：1991-08-01 00:00:00

abstract：:We have investigated the role of erythroid Kruppel-like factor (EKLF) in expression of the human beta-globin genes in compound EKLF knockout/human beta-locus transgenic mice. EKLF affects only the adult mouse beta-globin genes in homozygous knockout mice; heterozygous mice are unaffected. Here we show that EKLF knocko...

journal_title：Genes & development

authors： Wijgerde M,Gribnau J,Trimborn T,Nuez B,Philipsen S,Grosveld F,Fraser P

更新日期：1996-11-15 00:00:00

abstract：:Reactive oxygen species (ROS) participate in numerous cell responses, including proliferation, DNA damage, and cell death. Based on these disparate activities, both promotion and inhibition of ROS have been proposed for cancer therapy. However, how the ROS response is determined is not clear. We examined the activitie...

journal_title：Genes & development

authors： Cheung EC,Lee P,Ceteci F,Nixon C,Blyth K,Sansom OJ,Vousden KH

更新日期：2016-01-01 00:00:00

abstract：:The identification of telomerase-negative HAATI (heterochromatin amplification-mediated and telomerase-independent) cells, in which telomeres are superseded by nontelomeric heterochromatin tracts, challenged the idea that canonical telomeres are essential for chromosome linearity and raised crucial questions as to how...

journal_title：Genes & development

authors： Begnis M,Apte MS,Masuda H,Jain D,Wheeler DL,Cooper JP

更新日期：2018-04-01 00:00:00

abstract：:The bHLH-PAS transcription factor SIM1 is expressed during the development of the hypothalamic-pituitary axis in three hypothalamic nuclei: the paraventricular nucleus (PVN), the anterior periventricular nucleus (aPV), and the supraoptic nucleus (SON). To investigate Sim1 function in the hypothalamus, we produced mice...

journal_title：Genes & development

authors： Michaud JL,Rosenquist T,May NR,Fan CM

更新日期：1998-10-15 00:00:00

abstract：:Most eukaryotic mRNAs are translated using a cap-dependent mechanism of translation. However, approximately 10% of mammalian mRNAs initiate translation using a cap-independent mechanism that is not well understood. These mRNAs contain an internal ribosome entry site (IRES) located in the 5' untranslated region. The cr...

journal_title：Genes & development

authors： Landry DM,Hertz MI,Thompson SR

更新日期：2009-12-01 00:00:00

abstract：:The contact site A glycoprotein is a developmentally regulated cell-surface component expressed during the aggregation stage of Dictyostelium discoideum. This protein has been implicated in the EDTA-stable (Ca2(+)-independent) type of cell adhesion of aggregating cells. The gene coding for the contact site A protein w...

journal_title：Genes & development

authors： Harloff C,Gerisch G,Noegel AA

更新日期：1989-12-01 00:00:00

abstract：:Genome-wide association studies (GWASs) have identified a genetic variant of moderate effect size at 6p21.1 associated with erythrocyte traits in humans. We show that this variant affects an erythroid-specific enhancer of CCND3. A Ccnd3 knockout mouse phenocopies these erythroid phenotypes, with a dramatic increase in...

journal_title：Genes & development

authors： Sankaran VG,Ludwig LS,Sicinska E,Xu J,Bauer DE,Eng JC,Patterson HC,Metcalf RA,Natkunam Y,Orkin SH,Sicinski P,Lander ES,Lodish HF

更新日期：2012-09-15 00:00:00

abstract：:The regulation of gene transcription is critical for the proper development and growth of an organism. The transcription of protein-coding genes initiates at the RNA polymerase II core promoter, which is a diverse module that can be controlled by many different elements such as the TATA box and downstream core promote...

journal_title：Genes & development

authors： Juven-Gershon T,Hsu JY,Kadonaga JT

更新日期：2008-10-15 00:00:00

abstract：:Eukaryotic chromosomes reach their stable rod-shaped appearance in mitosis in a reaction dependent on the evolutionarily conserved condensin complex. Little is known about how and where condensin associates with chromosomes. Here, we analyze condensin binding to budding yeast chromosomes using high-resolution oligonuc...

journal_title：Genes & development

authors： D'Ambrosio C,Schmidt CK,Katou Y,Kelly G,Itoh T,Shirahige K,Uhlmann F

更新日期：2008-08-15 00:00:00

abstract：:The allosteric and torpedo models have been used for 30 yr to explain how transcription terminates on protein-coding genes. The former invokes termination via conformational changes in the transcription complex and the latter proposes that degradation of the downstream product of poly(A) signal (PAS) processing is imp...

journal_title：Genes & development

authors： Eaton JD,Francis L,Davidson L,West S

更新日期：2020-01-01 00:00:00

abstract：:Protein kinases are key regulators of cellular processes. In spite of considerable effort, a full understanding of the pathways they participate in remains elusive. We globally investigated the proteins that interact with the majority of yeast protein kinases using protein microarrays. Eighty-five kinases were purifie...

journal_title：Genes & development

authors： Fasolo J,Sboner A,Sun MG,Yu H,Chen R,Sharon D,Kim PM,Gerstein M,Snyder M

更新日期：2011-04-01 00:00:00

abstract：:The Hox gene products are transcription factors involved in specifying regional identity along the anteroposterior body axis. In the mouse, several single mutants for Hox genes show variably penetrant, partial homeotic transformations of vertebrae at their anterior limits of expression, suggesting that compound Hox mu...

journal_title：Genes & development

authors： Horan GS,Ramírez-Solis R,Featherstone MS,Wolgemuth DJ,Bradley A,Behringer RR

更新日期：1995-07-01 00:00:00

abstract：:The WD40 domain-containing protein WRAP53β (WD40 encoding RNA antisense to p53; also referred to as WDR79/TCAB1) controls trafficking of splicing factors and the telomerase enzyme to Cajal bodies, and its functional loss has been linked to carcinogenesis, premature aging, and neurodegeneration. Here, we identify WRAP5...

journal_title：Genes & development

authors： Henriksson S,Rassoolzadeh H,Hedström E,Coucoravas C,Julner A,Goldstein M,Imreh G,Zhivotovsky B,Kastan MB,Helleday T,Farnebo M

更新日期：2014-12-15 00:00:00

abstract：:In enteric bacteria, the transcription factor σ(E) maintains membrane homeostasis by inducing synthesis of proteins involved in membrane repair and two small regulatory RNAs (sRNAs) that down-regulate synthesis of abundant membrane porins. Here, we describe the discovery of a third σ(E)-dependent sRNA, MicL (mRNA-inte...

journal_title：Genes & development

authors： Guo MS,Updegrove TB,Gogol EB,Shabalina SA,Gross CA,Storz G

更新日期：2014-07-15 00:00:00

abstract：:The eukaryotic ribosomal RNA (rRNA) is associated cotranscriptionally with numerous factors into an enormous 90S preribosomal particle that conducts early processing of small ribosomal subunits. The assembly pathway and structure of the 90S particle is poorly understood. Here, we affinity-purified and analyzed the con...

journal_title：Genes & development

authors： Zhang L,Wu C,Cai G,Chen S,Ye K

更新日期：2016-03-15 00:00:00

abstract：:Calcineurin, a conserved Ca(2+)/calmodulin-regulated protein phosphatase, plays a crucial role in Ca(2+) signaling in a wide variety of cell types. In Saccharomyces cerevisiae, calcineurin positively regulates transcription in response to stress by dephosphorylating the transcription factor Crz1p/Tcn1p. Dephosphorylat...

journal_title：Genes & development

authors： Boustany LM,Cyert MS

更新日期：2002-03-01 00:00:00

abstract：:In many eukaryotes, siRNAs bound to Argonaute proteins guide chromatin-modifying enzymes to complementary loci, resulting in transcriptional gene silencing. Multiple lines of evidence indicate that siRNAs base-pair with longer RNAs produced at target loci, but the possibility that siRNAs base-pair directly with DNA re...

journal_title：Genes & development

authors： Wendte JM,Pikaard CS

更新日期：2016-12-15 00:00:00

abstract：:The ATR (ATM and Rad3-related) kinase and its regulatory partner ATRIP (ATR-interacting protein) coordinate checkpoint responses to DNA damage and replication stress. TopBP1 functions as a general activator of ATR. However, the mechanism by which TopBP1 activates ATR is unknown. Here, we show that ATRIP contains a Top...

journal_title：Genes & development

authors： Mordes DA,Glick GG,Zhao R,Cortez D

更新日期：2008-06-01 00:00:00

abstract：:We isolated a novel bHLH protein gene Mesp2 (for mesoderm posterior 2) that cross-hybridizes with Mesp1 expressed in the early mouse mesoderm. Mesp2 is expressed in the rostral presomitic mesoderm, but down-regulated immediately after the formation of the segmented somites. To determine the function of MesP2 protein (...

journal_title：Genes & development

authors： Saga Y,Hata N,Koseki H,Taketo MM

更新日期：1997-07-15 00:00:00

abstract：:Adenocarcinoma of the lung is the most common form of lung cancer, but the cell of origin and the stages of progression of this tumor type are not well understood. We have developed a new model of lung adenocarcinoma in mice harboring a conditionally activatable allele of oncogenic K-ras. Here we show that the use of ...

journal_title：Genes & development

authors： Jackson EL,Willis N,Mercer K,Bronson RT,Crowley D,Montoya R,Jacks T,Tuveson DA

更新日期：2001-12-15 00:00:00

abstract：:DNA methylation is a key regulator of embryonic stem cell (ESC) biology, dynamically changing between naïve, primed, and differentiated states. The p53 tumor suppressor is a pivotal guardian of genomic stability, but its contributions to epigenetic regulation and stem cell biology are less explored. We report that, in...

journal_title：Genes & development

authors： Tovy A,Spiro A,McCarthy R,Shipony Z,Aylon Y,Allton K,Ainbinder E,Furth N,Tanay A,Barton M,Oren M

更新日期：2017-05-15 00:00:00