Abstract：
:In many eukaryotes, siRNAs bound to Argonaute proteins guide chromatin-modifying enzymes to complementary loci, resulting in transcriptional gene silencing. Multiple lines of evidence indicate that siRNAs base-pair with longer RNAs produced at target loci, but the possibility that siRNAs base-pair directly with DNA remains an attractive hypothesis. In a recent study, Shimada et al. (pp. 2571-2580) conducted experiments that address these alternative hypotheses, yielding additional evidence that fission yeast siRNA-Argonaute silencing complexes are recruited to target loci exclusively via interactions with nascent transcripts.
journal_name
Genes Devjournal_title
Genes & developmentauthors
Wendte JM,Pikaard CSdoi
10.1101/gad.294900.116subject
Has Abstractpub_date
2016-12-15 00:00:00pages
2649-2650issue
24eissn
0890-9369issn
1549-5477pii
30/24/2649journal_volume
30pub_type
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journal_title：Genes & development
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