Human intron-encoded Alu RNAs are processed and packaged into Wdr79-associated nucleoplasmic box H/ACA RNPs.

abstract：:Epithelial-mesenchymal transition (EMT) is thought to be an important, possibly essential, component of the process of tumor dissemination and metastasis. About 20%-30% of Hras mutant mouse skin carcinomas induced by chemical initiation/promotion protocols have undergone EMT. Reduced exposure to TPA-induced chronic in...

journal_title：Genes & development

authors： Wong CE,Yu JS,Quigley DA,To MD,Jen KY,Huang PY,Del Rosario R,Balmain A

更新日期：2013-03-15 00:00:00

abstract：:Myxococcus xanthus fruiting body development is induced by amino acid limitation. The decision to grow or develop is established by the RelA-dependent stringent response and A-signaling. We identified two new members of this regulatory hierarchy, socE and the C-signaling gene csgA. SocE depletion arrests growth and in...

journal_title：Genes & development

authors： Crawford EW Jr,Shimkets LJ

更新日期：2000-02-15 00:00:00

abstract：:The Tat protein of human immunodeficiency virus type 1 (HIV-1) activates transcription following binding to nascent trans-activation response (TAR) RNA downstream of the transcription start site. Because Tat functions when bound to RNA, and in a position-dependent manner, it has been proposed that Tat works by a novel...

journal_title：Genes & development

authors： Southgate CD,Green MR

更新日期：1991-12-01 00:00:00

abstract：:Post-translational modifications of conserved N-terminal tail residues in histones regulate many aspects of chromosome activity. Thr 3 of histone H3 is highly conserved, but the significance of its phosphorylation is unclear, and the identity of the corresponding kinase unknown. Immunostaining with phospho-specific an...

journal_title：Genes & development

authors： Dai J,Sultan S,Taylor SS,Higgins JM

更新日期：2005-02-15 00:00:00

abstract：:It is now well appreciated that the apoptosome, which governs caspase-dependent cell death, also drives nonapoptotic caspase activation to remodel cells. However, the determinants that specify whether the apoptosome acts to kill or remodel have yet to be identified. Here we report that Tango7 collaborates with the Dro...

journal_title：Genes & development

authors： D'Brot A,Chen P,Vaishnav M,Yuan S,Akey CW,Abrams JM

更新日期：2013-08-01 00:00:00

abstract：:The abundance of retinoic acid (RA) is determined by the balance between its synthesis by retinaldehyde dehydrogenase (RALDH) and its degradation by CYP26. In particular, the dynamic expression of three CYP26 genes controls the regional level of RA within the body. Pregastrulation mouse embryos express CYP26 but not R...

journal_title：Genes & development

authors： Uehara M,Yashiro K,Takaoka K,Yamamoto M,Hamada H

更新日期：2009-07-15 00:00:00

abstract：:Activating JAK2 point mutations are implicated in the pathogenesis of myeloid and lymphoid malignancies, including high-risk B-cell acute lymphoblastic leukemia (B-ALL). In preclinical studies, treatment of JAK2 mutant leukemias with type I JAK2 inhibitors (e.g., Food and Drug Administration [FDA]-approved ruxolitinib...

journal_title：Genes & development

authors： Kim SK,Knight DA,Jones LR,Vervoort S,Ng AP,Seymour JF,Bradner JE,Waibel M,Kats L,Johnstone RW

更新日期：2018-06-01 00:00:00

abstract：:Treatment with retinoic acid (RA) is known to produce complex teratogenic effects in vertebrates, and its presence in the developing embryo as an endogenous substance has led to the suggestion that RA might be a natural morphogenetic agent. Although our understanding of the molecular mechanism of RA action has improve...

journal_title：Genes & development

authors： Rossant J,Zirngibl R,Cado D,Shago M,Giguère V

更新日期：1991-08-01 00:00:00

abstract：:Homeotic genes are expressed in spatially precise patterns during Drosophila development to control segmental differentiation. The Sex combs reduced (Scr) gene of the Antennapedia gene complex is involved in the determination of the labial and prothoracic segments of the embryo. To study both the wild-type pattern of ...

journal_title：Genes & development

authors： Riley PD,Carroll SB,Scott MP

更新日期：1987-09-01 00:00:00

abstract：:In budding yeast, a switch between the mutually exclusive pathways of cell cycle progression and conjugation is controlled at Start in late G1 phase. Mating pheromones promote conjugation by arresting cells in G1 phase before Start. Pheromone-induced cell cycle arrest requires a functional FAR1 gene. We have found tha...

journal_title：Genes & development

authors： McKinney JD,Chang F,Heintz N,Cross FR

更新日期：1993-05-01 00:00:00

abstract：:Gastrulation in mice is associated with the start of extreme proliferation and differentiation. The potential cost to the embryo of a very rapid proliferation rate is a high production of damaged cells. We demonstrate a novel surveillance mechanism for the elimination of cells damaged by ionizing radiation during mous...

journal_title：Genes & development

authors： Heyer BS,MacAuley A,Behrendtsen O,Werb Z

更新日期：2000-08-15 00:00:00

abstract：:In the July 15, 2010, issue of Genes & Development, Yoon and colleagues (pp. 1507-1518) report that, in a siRNA knockdown survey of 6363 genes in mouse C2C12 cells, they discovered 150 genes that regulated mitochondrial biogenesis and bioenergetics. Many of these genes have been studied previously for their importance...

journal_title：Genes & development

authors： Wallace DC

更新日期：2010-08-01 00:00:00

abstract：:Chromatin structure is believed to be important for a number of cellular processes, including transcription. However, the role of nucleosomes in transcription is not well understood. We have identified the yeast histone locus HTB1-HTB1, encoding histones H2A and H2B, as a suppressor of solo delta insertion mutations t...

journal_title：Genes & development

authors： Clark-Adams CD,Norris D,Osley MA,Fassler JS,Winston F

更新日期：1988-02-01 00:00:00

abstract：:Transcription factor IIA has been shown to interact with the TATA-binding protein and to act early during preinitiation complex formation. The human factor is composed of three subunits (alpha, beta, gamma). A human cDNA clone encoding the largest subunit of TFIIA (alpha) was isolated. The recombinant alpha polypeptid...

journal_title：Genes & development

authors： Ma D,Watanabe H,Mermelstein F,Admon A,Oguri K,Sun X,Wada T,Imai T,Shiroya T,Reinberg D

更新日期：1993-11-01 00:00:00

abstract：:The embryonic ectoderm in Drosophila displays a highly organized arrangement of specific structures along the dorsal-ventral axis. To establish this characteristic design, cells must receive instructive cues regarding their position. We present evidence that during stages 8-9 of embryonic development, the Drosophila E...

journal_title：Genes & development

authors： Raz E,Shilo BZ

更新日期：1993-10-01 00:00:00

abstract：:Mammalian cells mostly rely on extracellular molecules to transfer signals to other cells. However, in stress conditions, more robust mechanisms might be necessary to facilitate cell-cell communications. Cellular senescence, a stress response associated with permanent exit from the cell cycle and the development of an...

journal_title：Genes & development

authors： Biran A,Perelmutter M,Gal H,Burton DG,Ovadya Y,Vadai E,Geiger T,Krizhanovsky V

更新日期：2015-04-15 00:00:00

abstract：:Translation of encephalomyocarditis virus (EMCV) mRNA occurs by ribosomal internal entry into the 5'-nontranslated region (5' NTR) rather than by ribosomal scanning. The internal ribosomal entry site (IRES) in the EMCV 5' NTR was determined by in vitro translation with RNAs that were generated by in vitro transcriptio...

journal_title：Genes & development

authors： Jang SK,Wimmer E

更新日期：1990-09-01 00:00:00

abstract：:For a number of human genes that encode transcripts containing inverted repeat Alu elements (IRAlus) within their 3' untranslated region (UTR), product mRNA is efficiently exported to the cytoplasm when the IRAlus, which mediate nuclear retention, are removed by alternative polyadenylation. Here we report a new mechan...

journal_title：Genes & development

authors： Elbarbary RA,Li W,Tian B,Maquat LE

更新日期：2013-07-01 00:00:00

abstract：:Human TFIIA activity is composed of three subunits (alpha, beta, gamma). Here we report the isolation of a human cDNA clone encoding the gamma-subunit and the reconstitution of TFIIA activity from recombinant polypeptides (holo-TFIIA). Protein-protein interaction analysis established that the beta and gamma subunits o...

journal_title：Genes & development

authors： Sun X,Ma D,Sheldon M,Yeung K,Reinberg D

更新日期：1994-10-01 00:00:00

abstract：:A core promoter element called an initiator (Inr) overlaps the transcription start site of numerous mammalian protein-coding genes. In promoters that lack a TATA box, the Inr is functionally analogous to TATA, in that it is capable of directing basal transcription by RNA polymerase II and of determining the precise si...

journal_title：Genes & development

authors： Kaufmann J,Smale ST

更新日期：1994-04-01 00:00:00

abstract：:MCM1 is an essential yeast DNA-binding protein that affects both minichromosome maintenance, in a manner suggesting that it has DNA replication initiation function, and gene expression. It activates alpha-specific genes together with MAT alpha 1, and represses a-specific genes together with MAT alpha 2. Alone, MCM1 ca...

journal_title：Genes & development

authors： Christ C,Tye BK

更新日期：1991-05-01 00:00:00

abstract：:Activated transcription by RNA polymerase II (Pol II) requires coactivators, one of which is the SRB/mediator. Whereas Srb4, an essential subunit of the SRB/mediator, is broadly required for Pol II transcription in yeast, we have shown that it is dispensable for the transcriptional activation of some genes. Here, we s...

journal_title：Genes & development

authors： Lee DK,Kim S,Lis JT

更新日期：1999-11-15 00:00:00

abstract：:A conditional allele of type 1 protein phosphatase (glc7-129) in Saccharomyces cerevisiae causes first cycle arrest in G2/M, characterized by cells with a short spindle and high H1 kinase activity. Point-of-execution experiments indicate Glc7p function is required in G2/M just before anaphase for the completion of mit...

journal_title：Genes & development

authors： Bloecher A,Tatchell K

更新日期：1999-03-01 00:00:00

abstract：:Inspired by a zebrafish mutation, two recent studies by Creanga and colleagues (pp. 1312-1325) and Tukachinsky and colleagues have shed new light on the way in which lipidated Hedgehog proteins are secreted and released from expressing cells, suggesting a model for the sequential action of the Disp and Scube2 proteins...

journal_title：Genes & development

authors： Ingham PW

更新日期：2012-11-15 00:00:00

abstract：:Kinetochores play an essential role in chromosome segregation by forming dynamic connections with spindle microtubules. Here, we identify a set of 10 copurifying kinetochore proteins from Caenorhabditis elegans, seven of which were previously uncharacterized. Using in vivo assays to monitor chromosome segregation, kin...

journal_title：Genes & development

authors： Cheeseman IM,Niessen S,Anderson S,Hyndman F,Yates JR 3rd,Oegema K,Desai A

更新日期：2004-09-15 00:00:00

abstract：:A conditional block to transcriptional elongation is an important mechanism for regulating c-myc gene expression. This elongation block within the first c-myc exon was defined originally in mammalian cells by nuclear run-on transcription analyses. Subsequent oocyte injection and in vitro transcription analyses suggest...

journal_title：Genes & development

authors： Krumm A,Meulia T,Brunvand M,Groudine M

更新日期：1992-11-01 00:00:00

abstract：:A major class of bacterial small RNAs (sRNAs), along with RNA-binding protein Hfq and endoribonuclease RNase E, acts on target mRNAs through base-pairing, leading to translational repression and rapid degradation of the mRNAs. In this issue of Genes & Development, Prévost and colleagues (pp. 385-396) demonstrate by us...

journal_title：Genes & development

authors： Morita T,Aiba H

更新日期：2011-02-15 00:00:00

abstract：:The regulation of gene transcription is critical for the proper development and growth of an organism. The transcription of protein-coding genes initiates at the RNA polymerase II core promoter, which is a diverse module that can be controlled by many different elements such as the TATA box and downstream core promote...

journal_title：Genes & development

authors： Juven-Gershon T,Hsu JY,Kadonaga JT

更新日期：2008-10-15 00:00:00

abstract：:The activity of the SCF(skp2) E3 ligase is required for the proteolytic turnover of several proteins involved in cell cycle control and transcriptional regulation. Loss of skp2 in the mouse leads to a complex phenotype including changes in cell size and DNA content as well as severe proliferation defects. Here we show...

journal_title：Genes & development

authors： Kossatz U,Dietrich N,Zender L,Buer J,Manns MP,Malek NP

更新日期：2004-11-01 00:00:00

abstract：:Translation initiation factor 2 (eIF2) bound to GTP transfers the initiator methionyl tRNA to the 40S ribosomal subunit. The eIF5 stimulates GTP hydrolysis by the eIF2/GTP/Met-tRNA(i)(Met) ternary complex on base-pairing between Met-tRNA(i)(Met) and the start codon. The eIF2, eIF5, and eIF1 all have been implicated in...

journal_title：Genes & development

authors： Asano K,Clayton J,Shalev A,Hinnebusch AG

更新日期：2000-10-01 00:00:00