Time to move the fat.

Abstract:

:In this issue of Genes & Development, Dowen and colleagues (pp. 1515-1528) elegantly unify two previously unconnected aspects of physiology. The investigators provide significant genetic evidence to support a critical link between developmental timing decisions and the regulation of lipid mobilization at the transition to adulthood in Caenorhabditis elegans This novel connection involves cross-tissue signaling from the hypodermis (epidermis) to the intestine to promote reproductive success in the germline.

journal_name

Genes Dev

journal_title

Genes & development

authors

Weaver BP,Sewell AK,Han M

doi

10.1101/gad.285460.116

subject

Has Abstract

pub_date

2016-07-01 00:00:00

pages

1481-2

issue

13

eissn

0890-9369

issn

1549-5477

pii

30/13/1481

journal_volume

30

pub_type

评论,杂志文章
  • Neuroectoderm in Drosophila embryos is dependent on the mesoderm for positioning but not for formation.

    abstract::By studying neuroectoderm formation in the absence of mesoderm and mesectoderm in mutants of the zygotic genes snail and twist, we have found that the number of neuroblasts is not reduced in these mutants, suggesting that mesoderm and mesectoderm are not essential for the initiation of neural development. The position...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.5.9.1577

    authors: Rao Y,Vaessin H,Jan LY,Jan YN

    更新日期:1991-09-01 00:00:00

  • Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor.

    abstract::The bcl-6 proto-oncogene encodes a POZ/zinc finger transcriptional repressor expressed in germinal center (GC) B and T cells and required for GC formation and antibody affinity maturation. Deregulation of bcl-6 expression by chromosomal rearrangements and point mutations of the bcl-6 promoter region are implicated in ...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.12.13.1953

    authors: Niu H,Ye BH,Dalla-Favera R

    更新日期:1998-07-01 00:00:00

  • Localization of RecA-like recombination proteins on chromosomes of the lily at various meiotic stages.

    abstract::The Rad51 and Lim15 proteins of lily, which are homologs of the bacterial RecA protein, were found on chromosomes in various stages of meiotic prophase 1. The presence of both Rad51 and Lim15 proteins as discrete foci on leptotene and zygotene chromosomes and their colocalization suggest that meiotic recombination beg...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.9.8.925

    authors: Terasawa M,Shinohara A,Hotta Y,Ogawa H,Ogawa T

    更新日期:1995-04-15 00:00:00

  • VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases.

    abstract::The ECS (Elongin B/C-Cul2/Cul5-SOCS-box protein) complex is a member of a family of ubiquitin ligases that share a Cullin-Rbx module. SOCS-box proteins recruit substrates to the ECS complex and are linked to Cullin-Rbx via Elongin B/C. VHL has been implicated as a SOCS-box protein, but lacks a C-terminal sequence (dow...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.1252404

    authors: Kamura T,Maenaka K,Kotoshiba S,Matsumoto M,Kohda D,Conaway RC,Conaway JW,Nakayama KI

    更新日期:2004-12-15 00:00:00

  • Isolation of a cDNA encoding the largest subunit of TFIIA reveals functions important for activated transcription.

    abstract::Transcription factor IIA has been shown to interact with the TATA-binding protein and to act early during preinitiation complex formation. The human factor is composed of three subunits (alpha, beta, gamma). A human cDNA clone encoding the largest subunit of TFIIA (alpha) was isolated. The recombinant alpha polypeptid...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.7.11.2246

    authors: Ma D,Watanabe H,Mermelstein F,Admon A,Oguri K,Sun X,Wada T,Imai T,Shiroya T,Reinberg D

    更新日期:1993-11-01 00:00:00

  • A tetramer of the Flp recombinase silences the trimers within it during resolution of a Holliday junction substrate.

    abstract::Recombination catalyzed by the Flp site-specific recombinase involves breakage and joining of four DNA strands between two target substrates. The reaction is carried out in two steps of pairwise strand exchanges by a DNA-protein assembly in which four Flp monomers act cooperatively to execute strand cleavage and joini...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.11.18.2438

    authors: Lee J,Jayaram M

    更新日期:1997-09-15 00:00:00

  • Brg1 promotes both tumor-suppressive and oncogenic activities at distinct stages of pancreatic cancer formation.

    abstract::Pancreatic ductal adenocarcinoma (PDA) develops predominantly through pancreatic intraepithelial neoplasia (PanIN) and intraductal papillary mucinous neoplasm (IPMN) precursor lesions. Pancreatic acinar cells are reprogrammed to a "ductal-like" state during PanIN-PDA formation. Here, we demonstrate a parallel mechanis...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.256628.114

    authors: Roy N,Malik S,Villanueva KE,Urano A,Lu X,Von Figura G,Seeley ES,Dawson DW,Collisson EA,Hebrok M

    更新日期:2015-03-15 00:00:00

  • mRNA 5'-leader trans-splicing in the chordates.

    abstract::We report the discovery of mRNA 5'-leader trans-splicing (SL trans-splicing) in the chordates. In the ascidian protochordate Ciona intestinalis, the mRNAs of at least seven genes undergo trans-splicing of a 16-nucleotide 5'-leader apparently derived from a 46-nucleotide RNA that shares features with previously charact...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.865401

    authors: Vandenberghe AE,Meedel TH,Hastings KE

    更新日期:2001-02-01 00:00:00

  • The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair.

    abstract::The WD40 domain-containing protein WRAP53β (WD40 encoding RNA antisense to p53; also referred to as WDR79/TCAB1) controls trafficking of splicing factors and the telomerase enzyme to Cajal bodies, and its functional loss has been linked to carcinogenesis, premature aging, and neurodegeneration. Here, we identify WRAP5...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.246546.114

    authors: Henriksson S,Rassoolzadeh H,Hedström E,Coucoravas C,Julner A,Goldstein M,Imreh G,Zhivotovsky B,Kastan MB,Helleday T,Farnebo M

    更新日期:2014-12-15 00:00:00

  • SCAMP4 enhances the senescent cell secretome.

    abstract::The senescence-associated secretory phenotype (SASP) is a major trait of senescent cells, but the molecular regulators of SASP factor secretion are poorly understood. Mass spectrometry analysis revealed that secretory carrier membrane protein 4 (SCAMP4) levels were strikingly elevated on the surface of senescent cells...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.313270.118

    authors: Kim KM,Noh JH,Bodogai M,Martindale JL,Pandey PR,Yang X,Biragyn A,Abdelmohsen K,Gorospe M

    更新日期:2018-07-01 00:00:00

  • Coregulation of anterior and posterior mesendodermal development by a hairy-related transcriptional repressor.

    abstract::During embryonic development in vertebrates, the endoderm becomes patterned along the anteroposterior axis to produce distinct derivatives. How this regulation is controlled is not well understood. We report that the zebrafish hairy/enhancer of split [E(spl)]-related gene her5 plays a critical role in this process. At...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:

    authors: Bally-Cuif L,Goutel C,Wassef M,Wurst W,Rosa F

    更新日期:2000-07-01 00:00:00

  • Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes.

    abstract::Alteration of nucleosomes by ATP-dependent remodeling complexes represents a critical step in the regulation of transcription. The human SWI/SNF (hSWI/SNF) family is composed of complexes that contain either Brg1 or hBrm as the central ATPase; however, these separate complexes have not been compared functionally. Here...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.872801

    authors: Sif S,Saurin AJ,Imbalzano AN,Kingston RE

    更新日期:2001-03-01 00:00:00

  • Tandem AP-1-binding sites within the human beta-globin dominant control region function as an inducible enhancer in erythroid cells.

    abstract::A powerful enhancer has been mapped to an 18-bp DNA segment located 11 kb 5' to the human epsilon-globin gene within the dominant control or locus-activating region. This enhancer is inducible in K562 human erythroleukemia cells, increasing linked gamma-globin promoter/luciferase gene expression to 170-fold over an en...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.4.6.993

    authors: Ney PA,Sorrentino BP,McDonagh KT,Nienhuis AW

    更新日期:1990-06-01 00:00:00

  • RAG-1 mutations that affect the target specificity of V(D)j recombination: a possible direct role of RAG-1 in site recognition.

    abstract::The RAG-1 protein plays an essential role in V(D)j recombination, but its exact function has not yet been defined. Here we report that a particular mutation in RAG-1 affects recombination by altering the specificity of target sequence usage. Recombination mediated by wild-type RAG-1 is tolerant of a wide range of codi...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.9.17.2193

    authors: Sadofsky MJ,Hesse JE,van Gent DC,Gellert M

    更新日期:1995-09-01 00:00:00

  • Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras.

    abstract::Adenocarcinoma of the lung is the most common form of lung cancer, but the cell of origin and the stages of progression of this tumor type are not well understood. We have developed a new model of lung adenocarcinoma in mice harboring a conditionally activatable allele of oncogenic K-ras. Here we show that the use of ...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.943001

    authors: Jackson EL,Willis N,Mercer K,Bronson RT,Crowley D,Montoya R,Jacks T,Tuveson DA

    更新日期:2001-12-15 00:00:00

  • Maternal Eed knockout causes loss of H3K27me3 imprinting and random X inactivation in the extraembryonic cells.

    abstract::Genomic imprinting is essential for mammalian development. Recent studies have revealed that maternal histone H3 Lys27 trimethylation (H3K27me3) can mediate DNA methylation-independent genomic imprinting. However, the regulatory mechanisms and functions of this new imprinting mechanism are largely unknown. Here we dem...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.318675.118

    authors: Inoue A,Chen Z,Yin Q,Zhang Y

    更新日期:2018-12-01 00:00:00

  • Loss of l(3)mbt leads to acquisition of the ping-pong cycle in Drosophila ovarian somatic cells.

    abstract::In Drosophila germ cells, PIWI-interacting RNAs (piRNAs) are amplified through a PIWI slicer-dependent feed-forward loop termed the ping-pong cycle, yielding secondary piRNAs. However, the detailed mechanism remains poorly understood, largely because an ex vivo model system amenable to biochemical analyses has not bee...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.283929.116

    authors: Sumiyoshi T,Sato K,Yamamoto H,Iwasaki YW,Siomi H,Siomi MC

    更新日期:2016-07-15 00:00:00

  • The C. elegans microRNA let-7 binds to imperfect let-7 complementary sites from the lin-41 3'UTR.

    abstract::Caenorhabditis elegans let-7, a founding member of the microRNA family, is predicted to bind to six sites in the 3'UTR of the mRNA of its target gene, lin-41, to down-regulate LIN-41. Here, we demonstrate that wild-type let-7 microRNA binds in vitro to RNA from the lin-41 3'UTR. This interaction is dependent on two co...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.1165404

    authors: Vella MC,Choi EY,Lin SY,Reinert K,Slack FJ

    更新日期:2004-01-15 00:00:00

  • Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit.

    abstract::The mitotic kinase Aurora A (Aur-A) is required for formation of a bipolar mitotic spindle and accurate chromosome segregation. In somatic cells, Aur-A protein and kinase activity levels peak during mitosis, and Aur-A is degraded during mitotic exit. Here, we investigated how Aur-A protein and kinase activity levels a...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.1007302

    authors: Littlepage LE,Ruderman JV

    更新日期:2002-09-01 00:00:00

  • Development of neuroendocrine lineages requires the bHLH-PAS transcription factor SIM1.

    abstract::The bHLH-PAS transcription factor SIM1 is expressed during the development of the hypothalamic-pituitary axis in three hypothalamic nuclei: the paraventricular nucleus (PVN), the anterior periventricular nucleus (aPV), and the supraoptic nucleus (SON). To investigate Sim1 function in the hypothalamus, we produced mice...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.12.20.3264

    authors: Michaud JL,Rosenquist T,May NR,Fan CM

    更新日期:1998-10-15 00:00:00

  • Developmentally regulated fetal thymic and extrathymic T-cell receptor gamma delta gene expression.

    abstract::The gamma delta T-cell receptor (TCR) is the first TCR to be expressed in ontogeny in all vertebrates in which it has been examined thoroughly. Murine gamma delta cell-surface protein is detected by the fourteenth day of gestation. In this work, the activation of gamma delta RNA has been studied. Data indicate that th...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.4.8.1304

    authors: Carding SR,Kyes S,Jenkinson EJ,Kingston R,Bottomly K,Owen JJ,Hayday AC

    更新日期:1990-08-01 00:00:00

  • Biological functions of the ISWI chromatin remodeling complex NURF.

    abstract::The nucleosome remodeling factor (NURF) is one of several ISWI-containing protein complexes that catalyze ATP-dependent nucleosome sliding and facilitate transcription of chromatin in vitro. To establish the physiological requirements of NURF, and to distinguish NURF genetically from other ISWI-containing complexes, w...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.1032202

    authors: Badenhorst P,Voas M,Rebay I,Wu C

    更新日期:2002-12-15 00:00:00

  • Core promoter elements can regulate transcription on a separate chromosome in trans.

    abstract::Transvection can cause the expression of a gene to be sensitive to the proximity of a homolog. It can account for many cases of intragenic complementation at the Drosophila yellow gene, where one mode of transvection involves the action of enhancers in trans on a promoter present on a separate chromosome. Our goal was...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.13.3.253

    authors: Morris JR,Geyer PK,Wu CT

    更新日期:1999-02-01 00:00:00

  • Drosophila Jun kinase regulates expression of decapentaplegic via the ETS-domain protein Aop and the AP-1 transcription factor DJun during dorsal closure.

    abstract::During Drosophila embryogenesis, ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally. This process, dorsal closure, requires two signaling pathways: the Drosophila Jun-amino-terminal kinase (DJNK) pathway and the Dpp pathway. We...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.11.13.1717

    authors: Riesgo-Escovar JR,Hafen E

    更新日期:1997-07-01 00:00:00

  • Cadherins in development: cell adhesion, sorting, and tissue morphogenesis.

    abstract::Tissue morphogenesis during development is dependent on activities of the cadherin family of cell-cell adhesion proteins that includes classical cadherins, protocadherins, and atypical cadherins (Fat, Dachsous, and Flamingo). The extracellular domain of cadherins contains characteristic repeats that regulate homophili...

    journal_title:Genes & development

    pub_type: 杂志文章,评审

    doi:10.1101/gad.1486806

    authors: Halbleib JM,Nelson WJ

    更新日期:2006-12-01 00:00:00

  • TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres.

    abstract::Mammalian telomeres are coated by the sequence-specific, DNA-binding protein, TRF1, a negative regulator of telomere length. Previous results showed that ADP-ribosylation of TRF1 by tankyrase 1 released TRF1 from telomeres and promoted telomere elongation. We now show that loss of TRF1 from telomeres results in ubiqui...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.1077103

    authors: Chang W,Dynek JN,Smith S

    更新日期:2003-06-01 00:00:00

  • Transcript levels and translational control of hsp70 synthesis in Xenopus oocytes.

    abstract::Until recently it was believed that Xenopus oocytes respond to heat shock by synthesizing the 70-kD heat shock protein hsp70 and that, uniquely amongst animal cell types, this response is mediated entirely at the translational level. This view has now been challenged and we present data that reevaluate the involvement...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.1.5.433

    authors: Horrell A,Shuttleworth J,Colman A

    更新日期:1987-07-01 00:00:00

  • Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine.

    abstract::Reactive oxygen species (ROS) participate in numerous cell responses, including proliferation, DNA damage, and cell death. Based on these disparate activities, both promotion and inhibition of ROS have been proposed for cancer therapy. However, how the ROS response is determined is not clear. We examined the activitie...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.271130.115

    authors: Cheung EC,Lee P,Ceteci F,Nixon C,Blyth K,Sansom OJ,Vousden KH

    更新日期:2016-01-01 00:00:00

  • Infrequently transcribed long genes depend on the Set2/Rpd3S pathway for accurate transcription.

    abstract::The presence of Set2-mediated methylation of H3K36 (K36me) correlates with transcription frequency throughout the yeast genome. K36me targets the Rpd3S complex to deacetylate transcribed regions and suppress cryptic transcription initiation at certain genes. Here, using a genome-wide approach, we report that the Set2-...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.1539307

    authors: Li B,Gogol M,Carey M,Pattenden SG,Seidel C,Workman JL

    更新日期:2007-06-01 00:00:00

  • Mismatch repair-dependent processing of methylation damage gives rise to persistent single-stranded gaps in newly replicated DNA.

    abstract::O(6)-Methylguanine ((Me)G) is a highly cytotoxic DNA modification generated by S(N)1-type methylating agents. Despite numerous studies implicating DNA replication, mismatch repair (MMR), and homologous recombination (HR) in (Me)G toxicity, its mode of action has remained elusive. We studied the molecular transactions ...

    journal_title:Genes & development

    pub_type: 杂志文章

    doi:10.1101/gad.455407

    authors: Mojas N,Lopes M,Jiricny J

    更新日期:2007-12-15 00:00:00