A novel class of small RNAs in mouse spermatogenic cells.

Abstract:

:Small noncoding RNAs, including small interfering RNAs (siRNAs) and micro RNAs (miRNAs) of approximately 21 nucleotides (nt) in length, have emerged as potent regulators of gene expression at both transcriptional and post-transcriptional levels in diverse organisms. Here we report the identification of a novel class of small RNAs in the mouse male germline termed piwi-interacting RNAs (piRNAs). piRNAs are approximately 30 nt in length. They are expressed during spermatogenesis, mostly in spermatids. piRNAs are associated with MIWI, a spermatogenesis-specific PIWI subfamily member of the Argonaute protein family, and depend on MIWI for their biogenesis and/or stability. Furthermore, a subpopulation of piRNAs are associated with polysomes, suggesting their potential role in translational regulation.

journal_name

Genes Dev

journal_title

Genes & development

authors

Grivna ST,Beyret E,Wang Z,Lin H

doi

10.1101/gad.1434406

subject

Has Abstract

pub_date

2006-07-01 00:00:00

pages

1709-14

issue

13

eissn

0890-9369

issn

1549-5477

pii

gad.1434406

journal_volume

20

pub_type

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