Abstract:
:Mice mutant for the bHLH gene Hes1, which is known to keep cells in a proliferative state, mostly lack thymus. Transfer of Hes1-null fetal liver cells into RAG2-null host mice normally reconstitutes B cells but fails to generate mature T cells in the thymus. In the reconstituted thymus, T cell differentiation is arrested at the CD4(-)CD8(-) double negative (DN) stage. Both the initial T cell receptor (TCR)-independent and the subsequent TCR-dependent selective expansion during the DN stage are severely affected. Thus, Hes1 is essential for the earliest thymocyte expansion in a cell-autonomous manner.
journal_name
Genes Devjournal_title
Genes & developmentauthors
Tomita K,Hattori M,Nakamura E,Nakanishi S,Minato N,Kageyama Rdoi
10.1101/gad.13.9.1203subject
Has Abstractpub_date
1999-05-01 00:00:00pages
1203-10issue
9eissn
0890-9369issn
1549-5477journal_volume
13pub_type
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journal_title:Genes & development
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1101/gad.13.6.643
更新日期:1999-03-15 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
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更新日期:2013-05-15 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
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更新日期:2006-10-01 00:00:00
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journal_title:Genes & development
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