Mutations in the Drosophila gene extradenticle affect the way specific homeo domain proteins regulate segmental identity.

abstract：:The Komeda miniature rat Ishikawa (KMI) is a naturally occurring mutant caused by an autosomal recessive mutation mri, which exhibits longitudinal growth retardation. Here we identified the mri mutation as a deletion in the rat gene encoding cGMP-dependent protein kinase type II (cGKII). KMIs showed an expanded growth...

journal_title：Genes & development

authors： Chikuda H,Kugimiya F,Hoshi K,Ikeda T,Ogasawara T,Shimoaka T,Kawano H,Kamekura S,Tsuchida A,Yokoi N,Nakamura K,Komeda K,Chung UI,Kawaguchi H

更新日期：2004-10-01 00:00:00

abstract：:Nonsense-mediated mRNA decay (NMD) is a quality control mechanism that detects and degrades mRNAs containing premature stop codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Degradation of PTC-containing mRNAs requires the endonucleolytic activity of SMG...

journal_title：Genes & development

authors： Kashima I,Jonas S,Jayachandran U,Buchwald G,Conti E,Lupas AN,Izaurralde E

更新日期：2010-11-01 00:00:00

abstract：:Placental development is profoundly influenced by oxygen (O(2)) tension. Human cytotrophoblasts proliferate in vitro under low O(2) conditions but differentiate at higher O(2) levels, mimicking the developmental transition they undergo as they invade the placental bed to establish the maternal-fetal circulation in viv...

journal_title：Genes & development

authors： Adelman DM,Gertsenstein M,Nagy A,Simon MC,Maltepe E

更新日期：2000-12-15 00:00:00

abstract：:The NF-kappa B transcription factor complex is comprised of two subunits, p50 and p65, that share significant homology to the rel oncogene. We have isolated a cDNA encoding a novel 66-kD rel-related protein, designated I-Rel. Unlike other rel-related proteins, I-Rel does not interact with DNA. I-Rel forms heterodimers...

journal_title：Genes & development

authors： Ruben SM,Klement JF,Coleman TA,Maher M,Chen CH,Rosen CA

更新日期：1992-05-01 00:00:00

abstract：:Our understanding of eukaryotic transcriptional activation mechanisms has been hampered by an inability to identify the direct in vivo targets of activator proteins, primarily because of lack of appropriate experimental methods. To circumvent this problem, we have developed a fluorescence resonance energy transfer (FR...

journal_title：Genes & development

authors： Bhaumik SR,Raha T,Aiello DP,Green MR

更新日期：2004-02-01 00:00:00

abstract：:Two retrovirus promoter trap vectors (U3His and U3Neo) have been used to disrupt genes expressed in totipotent murine embryonal stem (ES) cells. Selection in L-histidinol or G418 produced clones in which the coding sequences for histidinol-dehydrogenase or neomycin-phosphotransferase were fused to sequences in or near...

journal_title：Genes & development

authors： von Melchner H,DeGregori JV,Rayburn H,Reddy S,Friedel C,Ruley HE

更新日期：1992-06-01 00:00:00

abstract：:Class Ia phosphatidylinositol 3 kinase (PI3K) is required for oncogenic receptor-mediated transformation; however, the individual roles of the two commonly expressed class Ia PI3K isoforms in oncogenic receptor signaling have not been elucidated in vivo. Here, we show that genetic ablation of p110α blocks tumor format...

journal_title：Genes & development

authors： Utermark T,Rao T,Cheng H,Wang Q,Lee SH,Wang ZC,Iglehart JD,Roberts TM,Muller WJ,Zhao JJ

更新日期：2012-07-15 00:00:00

abstract：:In Saccharomyces cerevisiae, gene silencing at the HMR and HML loci is normally dependent on Sir2p, Sir3p, and Sir4p, which are structural components of silenced chromatin. Sir2p is a NAD+-dependent histone deacetylase required for silencing. Silencing can be restored in cells lacking Sir proteins by a dominant mutati...

journal_title：Genes & development

authors： Rusché LN,Rine J

更新日期：2001-04-15 00:00:00

abstract：:The p53 tumor suppressor is often disrupted in human cancers by the acquisition of missense mutations. We generated mice with a missense mutation at codon 172 that mimics the p53R175H hot spot mutation in human cancer. p53 homozygous mutant mice have unstable mutant p53 in normal cells and stabilize mutant p53 in some...

journal_title：Genes & development

authors： Terzian T,Suh YA,Iwakuma T,Post SM,Neumann M,Lang GA,Van Pelt CS,Lozano G

更新日期：2008-05-15 00:00:00

abstract：:Cdc42p, a Rho-related GTP-binding protein, regulates cytoskeletal polarization and rearrangements in eukaryotic cells, but the effectors mediating this control remain unknown. Through the use of the complete yeast genomic sequence, we have identified two novel Cdc42p targets, Gic1p and Gic2p, which contain consensus C...

journal_title：Genes & development

authors： Brown JL,Jaquenoud M,Gulli MP,Chant J,Peter M

更新日期：1997-11-15 00:00:00

abstract：:The histone variants H3.3 and H2A.Z have recently emerged as two of the most important features in transcriptional regulation, the molecular mechanism of which still remains poorly understood. In this study, we investigated the regulation of H3.3 and H2A.Z on chromatin dynamics during transcriptional activation. Our i...

journal_title：Genes & development

authors： Chen P,Zhao J,Wang Y,Wang M,Long H,Liang D,Huang L,Wen Z,Li W,Li X,Feng H,Zhao H,Zhu P,Li M,Wang QF,Li G

更新日期：2013-10-01 00:00:00

abstract：:DBP (albumin D-site-binding protein), HLF (hepatic leukemia factor), and TEF (thyrotroph embryonic factor) are the three members of the PAR bZip (proline and acidic amino acid-rich basic leucine zipper) transcription factor family. All three of these transcriptional regulatory proteins accumulate with robust circadian...

journal_title：Genes & development

authors： Gachon F,Fonjallaz P,Damiola F,Gos P,Kodama T,Zakany J,Duboule D,Petit B,Tafti M,Schibler U

更新日期：2004-06-15 00:00:00

abstract：:U4 and U6 small nuclear RNAs are associated by an extensive base-pairing interaction that must be disrupted and reformed with each round of splicing. U4 mutations within the U4/U6 interaction domain destabilize the complex in vitro and cause a cold-sensitive phenotype in vivo. Restabilization of the U4/U6 helix by dom...

journal_title：Genes & development

authors： Shannon KW,Guthrie C

更新日期：1991-05-01 00:00:00

abstract：:In petunia flowers, the loci an1, an2, and an11 control the pigmentation of the flower by stimulating the transcription of anthocyanin biosynthetic genes. The an1 and an2 locus were recently cloned and encode a basic helix-loop-helix (bHLH) and MYB-domain transcriptional activator, respectively. Here, we report the is...

journal_title：Genes & development

authors： de Vetten N,Quattrocchio F,Mol J,Koes R

更新日期：1997-06-01 00:00:00

abstract：:Viable aristaless (al) mutations of Drosophila affect pattern elements at both ends of the proximodistal axis in a subset of adult appendages. The al gene has been cloned and identified by P-element-mediated germ-line transformation with a genomic DNA fragment, which rescues a lethal mutation of al as well as aspects ...

journal_title：Genes & development

authors： Schneitz K,Spielmann P,Noll M

更新日期：1993-01-01 00:00:00

abstract：:Although progesterone has been recognized as essential for the establishment and maintenance of pregnancy, this steroid hormone has been recently implicated to have a functional role in a number of other reproductive events. The physiological effects of progesterone are mediated by the progesterone receptor (PR), a me...

journal_title：Genes & development

authors： Lydon JP,DeMayo FJ,Funk CR,Mani SK,Hughes AR,Montgomery CA Jr,Shyamala G,Conneely OM,O'Malley BW

更新日期：1995-09-15 00:00:00

abstract：:Expression of both N-myc and c-myc is induced rapidly and dramatically in normal pre-B cells after stimulation with interleukin-7 (IL-7), a pre-B cell-specific growth factor. These IL-7-induced increases in N-myc and c-myc expression are mediated at the transcriptional level; for N-myc, a major portion of the inductio...

journal_title：Genes & development

authors： Morrow MA,Lee G,Gillis S,Yancopoulos GD,Alt FW

更新日期：1992-01-01 00:00:00

abstract：:Abcission, the natural shedding of leaves, flowers and fruits, is a fundamental component of plant development. Abscission is a highly regulated process that occurs at distinct zones of cells that undergo enlargement and subsequent separation. Although some components of abscission, including accumulation of the hormo...

journal_title：Genes & development

authors： Jinn TL,Stone JM,Walker JC

更新日期：2000-01-01 00:00:00

abstract：:We have investigated the DNA-binding, oligomerization, and trans-activation functions of isolated segments of murine p53. We find that p53 has two autonomous DNA-binding regions. One domain, from amino acid 280 to 390, forms stable tetramers and binds DNA nonspecifically. The biological significance, if any, of this D...

journal_title：Genes & development

authors： Wang Y,Reed M,Wang P,Stenger JE,Mayr G,Anderson ME,Schwedes JF,Tegtmeyer P

更新日期：1993-12-01 00:00:00

abstract：:The LIM motif defines a double zinc finger structure found in proteins involved in cell fate determination and growth control. LIM proteins, which include LIM homeo domain, LIM kinase, focal adhesion, and LIM-only proteins, usually contain two or more LIM motifs clustered at their amino- or carboxy-terminal end. At pr...

journal_title：Genes & development

authors： Arber S,Caroni P

更新日期：1996-02-01 00:00:00

abstract：:We have identified protein kinase C-zeta (PKC-zeta) as a novel suppressor of neoplastic transformation caused by the v-raf oncogene. PKC-zeta overexpression drastically retards proliferation, abolishes anchorage-independent growth, and reverts the morphological transformation of v-raf-transformed NIH-3T3 cells. The mo...

journal_title：Genes & development

authors： Kieser A,Seitz T,Adler HS,Coffer P,Kremmer E,Crespo P,Gutkind JS,Henderson DW,Mushinski JF,Kolch W,Mischak H

更新日期：1996-06-15 00:00:00

abstract：:Mice carrying a germ-line null mutation of the prolactin receptor gene have been produced by gene targeting in embryonic stem cells. Heterozygous females showed almost complete failure of lactation attributable to greatly reduced mammary gland development after their first, but not subsequent, pregnancies. Homozygous ...

journal_title：Genes & development

authors： Ormandy CJ,Camus A,Barra J,Damotte D,Lucas B,Buteau H,Edery M,Brousse N,Babinet C,Binart N,Kelly PA

更新日期：1997-01-15 00:00:00

abstract：:Ecsit is a cytosolic adaptor protein essential for inflammatory response and embryonic development via the Toll-like and BMP (bone morphogenetic protein) signal transduction pathways, respectively. Here, we demonstrate a mitochondrial function for Ecsit (an evolutionary conserved signaling intermediate in Toll pathway...

journal_title：Genes & development

authors： Vogel RO,Janssen RJ,van den Brand MA,Dieteren CE,Verkaart S,Koopman WJ,Willems PH,Pluk W,van den Heuvel LP,Smeitink JA,Nijtmans LG

更新日期：2007-03-01 00:00:00

abstract：:Faithful inheritance of genetic information requires that DNA be copied only once each cell cycle. Initiation of DNA replication involves the establishment of a prereplication complex (pre-RC) and subsequent activation by CDK/cyclins, converting the pre-RC to a post-RC. The origin recognition complex (ORC), Cdc6p, and...

journal_title：Genes & development

authors： Liang C,Stillman B

更新日期：1997-12-15 00:00:00

abstract：:The physiological functions of many vital tissues and organs continue to mature after birth, but the genetic mechanisms governing this postnatal maturation remain an unsolved mystery. Human pancreatic β cells produce and secrete insulin in response to physiological cues like glucose, and these hallmark functions impro...

journal_title：Genes & development

authors： Bevacqua RJ,Lam JY,Peiris H,Whitener RL,Kim S,Gu X,Friedlander MSH,Kim SK

更新日期：2021-01-14 00:00:00

abstract：:Telomerase is a ribonucleoprotein enzyme that adds telomeric repeats to chromosomes, maintaining telomere length and stabilizing chromosome ends. In vitro, telomerase from the ciliate Tetrahymena elongates single-stranded, guanosine-rich DNA primers by adding repeats of the Tetrahymena telomeric sequence, dT2G4. We ha...

journal_title：Genes & development

authors： Collins K,Greider CW

更新日期：1993-07-01 00:00:00

abstract：:A core promoter element called an initiator (Inr) overlaps the transcription start site of numerous mammalian protein-coding genes. In promoters that lack a TATA box, the Inr is functionally analogous to TATA, in that it is capable of directing basal transcription by RNA polymerase II and of determining the precise si...

journal_title：Genes & development

authors： Kaufmann J,Smale ST

更新日期：1994-04-01 00:00:00

abstract：:Plant water homeostasis is maintained by the phytohormone abscisic acid (ABA), which triggers stomatal pore closure in response to drought stress. We identified the Arabidopsis small guanosine triphosphatase (GTPase) protein AtRac1 as a central component in the ABA-mediated stomatal closure process. ABA treatment indu...

journal_title：Genes & development

authors： Lemichez E,Wu Y,Sanchez JP,Mettouchi A,Mathur J,Chua NH

更新日期：2001-07-15 00:00:00

abstract：:Lipids play crucial roles in many aspects of glial cell biology, affecting processes ranging from myelin membrane biosynthesis to axo-glial interactions. In order to study the role of lipid metabolism in myelinating glial cells, we specifically deleted in Schwann cells the Lpin1 gene, which encodes the Mg2+-dependent ...

journal_title：Genes & development

authors： Nadra K,de Preux Charles AS,Médard JJ,Hendriks WT,Han GS,Grès S,Carman GM,Saulnier-Blache JS,Verheijen MH,Chrast R

更新日期：2008-06-15 00:00:00

abstract：:Historically, biomedical research has been based on two paradigms. First, measurements of biological behaviors have been based on bulk assays that average over large populations. Second, these behaviors have then been crudely perturbed by systemic administration of therapeutic treatments. Nanotechnology has the potent...

journal_title：Genes & development

authors： Wong IY,Bhatia SN,Toner M

更新日期：2013-11-15 00:00:00