Abstract：
:Nuclear pore complexes (NPCs) emerged as nuclear transport channels in eukaryotic cells ∼1.5 billion years ago. While the primary role of NPCs is to regulate nucleo-cytoplasmic transport, recent research suggests that certain NPC proteins have additionally acquired the role of affecting gene expression at the nuclear periphery and in the nucleoplasm in metazoans. Here we identify a widely expressed variant of the transmembrane nucleoporin (Nup) Pom121 (named sPom121, for "soluble Pom121") that arose by genomic rearrangement before the divergence of hominoids. sPom121 lacks the nuclear membrane-anchoring domain and thus does not localize to the NPC. Instead, sPom121 colocalizes and interacts with nucleoplasmic Nup98, a previously identified transcriptional regulator, at gene promoters to control transcription of its target genes in human cells. Interestingly, sPom121 transcripts appear independently in several mammalian species, suggesting convergent innovation of Nup-mediated transcription regulation during mammalian evolution. Our findings implicate alternate transcription initiation as a mechanism to increase the functional diversity of NPC components.
journal_name
Genes Devjournal_title
Genes & developmentauthors
Franks TM,Benner C,Narvaiza I,Marchetto MC,Young JM,Malik HS,Gage FH,Hetzer MWdoi
10.1101/gad.280941.116subject
Has Abstractpub_date
2016-05-15 00:00:00pages
1155-71issue
10eissn
0890-9369issn
1549-5477pii
gad.280941.116journal_volume
30pub_type
杂志文章abstract：:Chromatin structure is believed to be important for a number of cellular processes, including transcription. However, the role of nucleosomes in transcription is not well understood. We have identified the yeast histone locus HTB1-HTB1, encoding histones H2A and H2B, as a suppressor of solo delta insertion mutations t...
journal_title：Genes & development
pub_type： 杂志文章
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abstract：:Histone post-translational modifications regulate chromatin structure and function largely through interactions with effector proteins that often contain multiple histone-binding domains. While significant progress has been made characterizing individual effector domains, the role of paired domains and how they functi...
journal_title：Genes & development
pub_type： 杂志文章
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journal_title：Genes & development
pub_type： 杂志文章
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更新日期：2003-12-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
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更新日期：2011-04-01 00:00:00
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journal_title：Genes & development
pub_type： 评论,杂志文章,评审
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更新日期：2009-12-15 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
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journal_title：Genes & development
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journal_title：Genes & development
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journal_title：Genes & development
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更新日期：1997-10-01 00:00:00
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journal_title：Genes & development
pub_type： 评论,杂志文章,评审
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更新日期：2017-05-15 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1666208
更新日期：2008-06-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.11.23.3182
更新日期：1997-12-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.220962.113
更新日期：2013-07-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章,评审
doi：10.1101/gad.1717808
更新日期：2008-11-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.8.16.1962
更新日期：1994-08-15 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.903101
更新日期：2001-10-01 00:00:00
abstract：:De novo chromatin assembly into regularly spaced nucleosomal arrays is essential for eukaryotic genome maintenance and inheritance. The Anti-Silencing Function 1 protein (ASF1) has been shown to be a histone chaperone, participating in DNA-replication-coupled nucleosome assembly. We show that mutations in the Drosophi...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.231202
更新日期：2002-10-15 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.2.5.567
更新日期：1988-05-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.377106
更新日期：2006-06-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.844900
更新日期：2000-11-15 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1643308
更新日期：2008-05-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.256628.114
更新日期：2015-03-15 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.6.7.1241
更新日期：1992-07-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
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更新日期：1999-04-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.862101
更新日期：2001-04-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.331272.119
更新日期：2020-03-01 00:00:00
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journal_title：Genes & development
pub_type： 杂志文章
doi：
更新日期：2000-05-01 00:00:00
abstract：:Restricted expression of a mouse Vasa homolog gene (Mvh) expression is first detected in primordial germ cells (PGCs) after colonization of the genital ridges. Subsequently, Mvh is maintained until postmeiotic germ cells are formed. Here, we demonstrate that male mice homozygous for a targeted mutation of Mvh exhibit ...
journal_title：Genes & development
pub_type： 杂志文章
doi：
更新日期：2000-04-01 00:00:00
abstract：:DNA loops that juxtapose the promoter and terminator regions of RNA polymerase II-transcribed genes have been identified in yeast and mammalian cells. Loop formation is transcription-dependent and requires components of the pre-mRNA 3'-end processing machinery. Here we report that looping at the yeast GAL10 gene persi...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1823609
更新日期：2009-11-15 00:00:00
