Noncoding RNA control of the making and breaking of sugars.


:Noncoding RNA regulators have been implicated in almost all imaginable cellular processes. Here we review how regulatory small RNAs such as Spot42, SgrS, GlmY, and GlmZ and a cis-encoded ribozyme in glmS mRNA control sugar metabolism. Besides discussing the physiological implications, we show how the study of these molecules contributed to our understanding of the mechanisms and of general principles of RNA-based regulation. These include the post-transcriptional repression or activation of gene expression within polycistronic mRNAs; novel ribonucleoprotein complexes composed of small RNA, Hfq, and/or RNase E; and the hierarchical action of regulatory RNAs.


Genes Dev


Genes & development


Görke B,Vogel J




Has Abstract


2008-11-01 00:00:00














  • Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway.

    abstract::The Wnt pathway controls numerous developmental processes via the beta-catenin-TCF/LEF transcription complex. Deregulation of the pathway results in the aberrant accumulation of beta-catenin in the nucleus, often leading to cancer. Normally, cytoplasmic beta-catenin associates with APC and axin and is continuously pho...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Amit S,Hatzubai A,Birman Y,Andersen JS,Ben-Shushan E,Mann M,Ben-Neriah Y,Alkalay I

    更新日期:2002-05-01 00:00:00

  • Interleukin-7 induces N-myc and c-myc expression in normal precursor B lymphocytes.

    abstract::Expression of both N-myc and c-myc is induced rapidly and dramatically in normal pre-B cells after stimulation with interleukin-7 (IL-7), a pre-B cell-specific growth factor. These IL-7-induced increases in N-myc and c-myc expression are mediated at the transcriptional level; for N-myc, a major portion of the inductio...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Morrow MA,Lee G,Gillis S,Yancopoulos GD,Alt FW

    更新日期:1992-01-01 00:00:00

  • The efficiency of RNA 3'-end formation is determined by the distance between the cap site and the poly(A) site in spleen necrosis virus.

    abstract::The efficiency of RNA 3'-end formation of spleen necrosis virus (SNV) is determined by the distance between the cap site and the poly(A) site. When the distance between the cap site and the poly(A) site was shorter than 500 bases, only 3-9% of the RNA was polyadenylated at the SNV poly(A) site. However, when the dista...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Iwasaki K,Temin HM

    更新日期:1990-12-01 00:00:00

  • Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities.

    abstract::Although progesterone has been recognized as essential for the establishment and maintenance of pregnancy, this steroid hormone has been recently implicated to have a functional role in a number of other reproductive events. The physiological effects of progesterone are mediated by the progesterone receptor (PR), a me...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Lydon JP,DeMayo FJ,Funk CR,Mani SK,Hughes AR,Montgomery CA Jr,Shyamala G,Conneely OM,O'Malley BW

    更新日期:1995-09-15 00:00:00

  • Myc family oncoproteins function through a common pathway to transform normal cells in culture: cross-interference by Max and trans-acting dominant mutants.

    abstract::The myc family of cellular oncogenes encodes three highly related nuclear phosphoproteins (c-Myc, N-Myc, and L-Myc) that are believed to function as sequence-specific transcription factors capable of regulating genes important in cellular growth and differentiation. Current evidence indicates that Myc family proteins ...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Mukherjee B,Morgenbesser SD,DePinho RA

    更新日期:1992-08-01 00:00:00

  • Specific regulation of Xenopus chromosomal 5S rRNA gene transcription in vivo by histone H1.

    abstract::The incorporation of histone H1 into chromatin during embryogenesis directs the specific repression of the Xenopus oocyte 5S rRNA genes. An increase in histone H1 content specifically restricts TFIIIA-activated transcription, and a decrease in histone H1 within chromatin facilitates the activation of the oocyte 5S rRN...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Bouvet P,Dimitrov S,Wolffe AP

    更新日期:1994-05-15 00:00:00

  • Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for the epigenetic inheritance of DNA methylation.

    abstract::Histone post-translational modifications regulate chromatin structure and function largely through interactions with effector proteins that often contain multiple histone-binding domains. While significant progress has been made characterizing individual effector domains, the role of paired domains and how they functi...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Rothbart SB,Dickson BM,Ong MS,Krajewski K,Houliston S,Kireev DB,Arrowsmith CH,Strahl BD

    更新日期:2013-06-01 00:00:00

  • Cooperating oncogenes converge to regulate cyclin/cdk complexes.

    abstract::The cooperation of oncogenes in the transformation of primary rat Schwann cells is a strikingly synergistic process. We have explored the molecular mechanisms involved. Activation of an inducible Raf kinase results in morphologically transformed cells that are arrested in G1 via the induction of p21(CiP1) and subseque...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Lloyd AC,Obermüller F,Staddon S,Barth CF,McMahon M,Land H

    更新日期:1997-03-01 00:00:00

  • Localized surface activity of torso, a receptor tyrosine kinase, specifies terminal body pattern in Drosophila.

    abstract::The subdivision of the Drosophila body into distinct terminal and central domains depends on the torso (tor) protein, a putative receptor tyrosine kinase that is active at both ends of the early embryo. We show that the tor protein is uniformly expressed along the surface membrane of early embryos despite its localize...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Casanova J,Struhl G

    更新日期:1989-12-01 00:00:00

  • Compound mutants for the paralogous hoxa-4, hoxb-4, and hoxd-4 genes show more complete homeotic transformations and a dose-dependent increase in the number of vertebrae transformed.

    abstract::The Hox gene products are transcription factors involved in specifying regional identity along the anteroposterior body axis. In the mouse, several single mutants for Hox genes show variably penetrant, partial homeotic transformations of vertebrae at their anterior limits of expression, suggesting that compound Hox mu...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Horan GS,Ramírez-Solis R,Featherstone MS,Wolgemuth DJ,Bradley A,Behringer RR

    更新日期:1995-07-01 00:00:00

  • Role of DNA damage-induced replication checkpoint in promoting lesion bypass by translesion synthesis in yeast.

    abstract::Unrepaired DNA lesions in the template strand block the replication fork. In yeast, Mec1 protein kinase-mediated replication checkpoint prevents the breakdown of replication forks and maintains viability in DNA-damaged cells going through the S phase. By ensuring that the replisome does not dissociate from the fork st...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Pagès V,Santa Maria SR,Prakash L,Prakash S

    更新日期:2009-06-15 00:00:00

  • Kinetochores accelerate or delay APC/C activation by directing Cdc20 to opposing fates.

    abstract::Mitotic duration is determined by activation of the anaphase-promoting complex/cyclosome (APC/C) bound to its coactivator, Cdc20. Kinetochores, the microtubule-interacting machines on chromosomes, restrain mitotic exit when not attached to spindle microtubules by generating a Cdc20-containing complex that inhibits the...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Kim T,Lara-Gonzalez P,Prevo B,Meitinger F,Cheerambathur DK,Oegema K,Desai A

    更新日期:2017-06-01 00:00:00

  • Reconstitution of human TFIIA activity from recombinant polypeptides: a role in TFIID-mediated transcription.

    abstract::Human TFIIA activity is composed of three subunits (alpha, beta, gamma). Here we report the isolation of a human cDNA clone encoding the gamma-subunit and the reconstitution of TFIIA activity from recombinant polypeptides (holo-TFIIA). Protein-protein interaction analysis established that the beta and gamma subunits o...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Sun X,Ma D,Sheldon M,Yeung K,Reinberg D

    更新日期:1994-10-01 00:00:00

  • Xenopus Sprouty2 inhibits FGF-mediated gastrulation movements but does not affect mesoderm induction and patterning.

    abstract::Signal transduction through the FGF receptor is essential for the specification of the vertebrate body plan. Blocking the FGF pathway in early Xenopus embryos inhibits mesoderm induction and results in truncation of the anterior-posterior axis. The Drosophila gene sprouty encodes an antagonist of FGF signaling, which ...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Nutt SL,Dingwell KS,Holt CE,Amaya E

    更新日期:2001-05-01 00:00:00

  • PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family.

    abstract::The p53 tumor suppressor activates either cell cycle arrest or apoptosis in response to cellular stress. Mouse embryo fibroblasts (MEFs) provide a powerful primary cell system to study both p53-dependent pathways. Specifically, in response to DNA damage, MEFs undergo p53-dependent G(1) arrest, whereas MEFs expressing ...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Attardi LD,Reczek EE,Cosmas C,Demicco EG,McCurrach ME,Lowe SW,Jacks T

    更新日期:2000-03-15 00:00:00

  • Heartless, a Drosophila FGF receptor homolog, is essential for cell migration and establishment of several mesodermal lineages.

    abstract::A Drosophila FGF receptor homolog (DFGF-R2/DFRI) termed Heartless (Htl) is expressed in the embryonic mesoderm. The phenotypes of null mutant embryos demonstrated that Htl is a central player that is required for the development of several mesodermal lineages. No abnormalities in the primary specification of the mesod...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Beiman M,Shilo BZ,Volk T

    更新日期:1996-12-01 00:00:00

  • A bZIP protein, sisterless-a, collaborates with bHLH transcription factors early in Drosophila development to determine sex.

    abstract::Sexual identity in Drosophila is determined by zygotic X-chromosome dose. Two potent indicators of X-chromosome dose are sisterless-a (sis-a) and sisterless-b (sis-b). Genetic analysis has shown that a diplo-X dose of these genes activates their regulatory target, the feminizing switch gene Sex-lethal (Sxl), whereas a...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Erickson JW,Cline TW

    更新日期:1993-09-01 00:00:00

  • Codon usage affects the structure and function of the Drosophila circadian clock protein PERIOD.

    abstract::Codon usage bias is a universal feature of all genomes, but its in vivo biological functions in animal systems are not clear. To investigate the in vivo role of codon usage in animals, we took advantage of the sensitivity and robustness of the Drosophila circadian system. By codon-optimizing parts of Drosophila period...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Fu J,Murphy KA,Zhou M,Li YH,Lam VH,Tabuloc CA,Chiu JC,Liu Y

    更新日期:2016-08-01 00:00:00

  • Functional domains of the yeast transcription/replication factor MCM1.

    abstract::MCM1 is an essential yeast DNA-binding protein that affects both minichromosome maintenance, in a manner suggesting that it has DNA replication initiation function, and gene expression. It activates alpha-specific genes together with MAT alpha 1, and represses a-specific genes together with MAT alpha 2. Alone, MCM1 ca...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Christ C,Tye BK

    更新日期:1991-05-01 00:00:00

  • Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly.

    abstract::In cytoplasm, the survival of motor neuron (SMN) complex delivers pre-small nuclear RNAs (pre-snRNAs) to the heptameric Sm ring for the assembly of the ring complex on pre-snRNAs at the conserved Sm site [A(U)4-6G]. Gemin5, a WD40 protein component of the SMN complex, is responsible for recognizing pre-snRNAs. In addi...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Xu C,Ishikawa H,Izumikawa K,Li L,He H,Nobe Y,Yamauchi Y,Shahjee HM,Wu XH,Yu YT,Isobe T,Takahashi N,Min J

    更新日期:2016-11-01 00:00:00

  • ELAV tumor antigen, Hel-N1, increases translation of neurofilament M mRNA and induces formation of neurites in human teratocarcinoma cells.

    abstract::Human ELAV proteins are implicated in cell growth and differentiation via regulation of mRNA expression in the cytoplasm. In human embryonic teratocarcinoma (hNT2) cells transfected with the human neuronal ELAV-like protein, Hel-N1, neurites formed, yet cells were not terminally differentiated. Cells in which neurite ...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Antic D,Lu N,Keene JD

    更新日期:1999-02-15 00:00:00

  • Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development.

    abstract::Myocardial infarction and ischemic heart disease are the leading cause of death in the industrial world. Therapies employed for treating these diseases are aimed at promoting increased blood flow to cardiac tissue. Pharmacological induction of new coronary growth has recently been explored, however, clinical trials wi...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Lavine KJ,White AC,Park C,Smith CS,Choi K,Long F,Hui CC,Ornitz DM

    更新日期:2006-06-15 00:00:00

  • SAS-mediated acetylation of histone H4 Lys 16 is required for H2A.Z incorporation at subtelomeric regions in Saccharomyces cerevisiae.

    abstract::The yeast SAS (Something About Silencing) complex and the histone variant H2A.Z have both previously been linked to an antisilencing function at the subtelomeric regions. SAS is an H4 Lys 16-specific histone acetyltransferase complex. Here we demonstrate that the H4 Lys 16 acetylation by SAS is required for efficient ...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Shia WJ,Li B,Workman JL

    更新日期:2006-09-15 00:00:00

  • Transcription factor Ebf1 regulates differentiation stage-specific signaling, proliferation, and survival of B cells.

    abstract::The transcription factor Ebf1 is an important determinant of early B lymphopoiesis. To gain insight into the functions of Ebf1 at distinct stages of differentiation, we conditionally inactivated Ebf1. We found that Ebf1 is required for the proliferation, survival, and signaling of pro-B cells and peripheral B-cell sub...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Györy I,Boller S,Nechanitzky R,Mandel E,Pott S,Liu E,Grosschedl R

    更新日期:2012-04-01 00:00:00

  • Analysis of the lethal interaction between the prune and Killer of prune mutations of Drosophila.

    abstract::The third-chromosome mutation Killer of prune (K-pn) causes no phenotype by itself, but causes lethality in individuals homozygous for the nonlethal X-chromosome mutation prune (pn). We have recovered 12 gamma-ray-induced revertants of Killer of prune. All of the revertants fail to complement a recessive cell lethal m...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Biggs J,Tripoulas N,Hersperger E,Dearolf C,Shearn A

    更新日期:1988-10-01 00:00:00

  • Precommitment low-level Neurog3 expression defines a long-lived mitotic endocrine-biased progenitor pool that drives production of endocrine-committed cells.

    abstract::The current model for endocrine cell specification in the pancreas invokes high-level production of the transcription factor Neurogenin 3 (Neurog3) in Sox9(+) bipotent epithelial cells as the trigger for endocrine commitment, cell cycle exit, and rapid delamination toward proto-islet clusters. This model posits a tran...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Bechard ME,Bankaitis ED,Hipkens SB,Ustione A,Piston DW,Yang YP,Magnuson MA,Wright CV

    更新日期:2016-08-15 00:00:00

  • Mismatch repair-dependent processing of methylation damage gives rise to persistent single-stranded gaps in newly replicated DNA.

    abstract::O(6)-Methylguanine ((Me)G) is a highly cytotoxic DNA modification generated by S(N)1-type methylating agents. Despite numerous studies implicating DNA replication, mismatch repair (MMR), and homologous recombination (HR) in (Me)G toxicity, its mode of action has remained elusive. We studied the molecular transactions ...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Mojas N,Lopes M,Jiricny J

    更新日期:2007-12-15 00:00:00

  • Selective disruption of genes expressed in totipotent embryonal stem cells.

    abstract::Two retrovirus promoter trap vectors (U3His and U3Neo) have been used to disrupt genes expressed in totipotent murine embryonal stem (ES) cells. Selection in L-histidinol or G418 produced clones in which the coding sequences for histidinol-dehydrogenase or neomycin-phosphotransferase were fused to sequences in or near...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: von Melchner H,DeGregori JV,Rayburn H,Reddy S,Friedel C,Ruley HE

    更新日期:1992-06-01 00:00:00

  • Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein.

    abstract::How dividing mammalian cells overcome blocks to DNA replication by DNA damage, depleted nucleotide pools, or template-bound proteins is unclear. Here, we show that the response to blocked replication requires BRCA2, a suppressor of human breast cancer. By using two-dimensional gel electrophoresis, we demonstrate that ...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Lomonosov M,Anand S,Sangrithi M,Davies R,Venkitaraman AR

    更新日期:2003-12-15 00:00:00

  • The p110α and p110β isoforms of PI3K play divergent roles in mammary gland development and tumorigenesis.

    abstract::Class Ia phosphatidylinositol 3 kinase (PI3K) is required for oncogenic receptor-mediated transformation; however, the individual roles of the two commonly expressed class Ia PI3K isoforms in oncogenic receptor signaling have not been elucidated in vivo. Here, we show that genetic ablation of p110α blocks tumor format...

    journal_title:Genes & development

    pub_type: 杂志文章


    authors: Utermark T,Rao T,Cheng H,Wang Q,Lee SH,Wang ZC,Iglehart JD,Roberts TM,Muller WJ,Zhao JJ

    更新日期:2012-07-15 00:00:00