Abstract:
:Early during Dictyostelium development a fundamental cell-fate decision establishes the anteroposterior (prestalk/prespore) axis. Signaling via the 7-transmembrane cAMP receptor CAR4 is essential for creating and maintaining a normal pattern; car4-null alleles have decreased levels of prestalk-specific mRNAs but enhanced expression of prespore genes. car4- cells produce all of the signals required for prestalk differentiation but lack an extracellular factor necessary for prespore differentiation of wild-type cells. This secreted factor decreases the sensitivity of prespore cells to inhibition by the prestalk morphogen DIF-1. At the cell autonomous level, CAR4 is linked to intracellular circuits that activate prestalk but inhibit prespore differentiation. The autonomous action of CAR4 is antagonistic to the positive intracellular signals mediated by another cAMP receptor, CAR1 and/or CAR3. Additional data indicate that these CAR-mediated pathways converge at the serine/threonine protein kinase GSK3, suggesting that the anterior (prestalk)/posterior (prespore) axis of Dictyostelium is regulated by an ancient mechanism that is shared by the Wnt/Fz circuits for dorsoventral patterning during early Xenopus development and establishing Drosophila segment polarity.
journal_name
Genes Devjournal_title
Genes & developmentauthors
Ginsburg GT,Kimmel ARdoi
10.1101/gad.11.16.2112subject
Has Abstractpub_date
1997-08-15 00:00:00pages
2112-23issue
16eissn
0890-9369issn
1549-5477journal_volume
11pub_type
杂志文章abstract::The discovery of transcription factors (TFs) controlling pathways in health and disease is of paramount interest. We designed a widely applicable method, dubbed barcorded synthetic tandem repeat promoter screening (BC-STAR-PROM), to identify signal-activated TFs without any a priori knowledge about their properties. T...
journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.284828.116
更新日期:2016-08-15 00:00:00
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journal_title:Genes & development
pub_type: 评论,杂志文章
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journal_title:Genes & development
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.12.21.3331
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journal_title:Genes & development
pub_type: 杂志文章
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journal_title:Genes & development
pub_type: 杂志文章
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journal_title:Genes & development
pub_type: 杂志文章
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更新日期:1993-06-01 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.295404
更新日期:2004-04-01 00:00:00
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journal_title:Genes & development
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journal_title:Genes & development
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更新日期:2010-06-01 00:00:00
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journal_title:Genes & development
pub_type: 评论,杂志文章
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更新日期:2011-06-01 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
doi:
更新日期:2000-01-15 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.220962.113
更新日期:2013-07-01 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.3.9.1462
更新日期:1989-09-01 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.1079403
更新日期:2003-05-15 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.417607
更新日期:2007-03-15 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.4.11.1835
更新日期:1990-11-01 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.1010302
更新日期:2002-11-15 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章,评审
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更新日期:2006-12-01 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
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更新日期:2011-07-15 00:00:00
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journal_title:Genes & development
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journal_title:Genes & development
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更新日期:2009-10-01 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
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更新日期:2007-02-15 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
doi:10.1101/gad.9.2.139
更新日期:1995-01-15 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
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更新日期:1994-06-01 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章,评审
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更新日期:2006-11-15 00:00:00
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journal_title:Genes & development
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journal_title:Genes & development
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更新日期:2002-04-01 00:00:00
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更新日期:1988-12-01 00:00:00
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journal_title:Genes & development
pub_type: 杂志文章
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更新日期:1997-11-15 00:00:00