Expression patterns of the homeo box-containing genes En-1 and En-2 and the proto-oncogene int-1 diverge during mouse development.

abstract：:The liver regenerates upon partial hepatectomy (PH) as terminally differentiated hepatocytes undergo a tremendous proliferative process. CREM gene expression is powerfully induced during liver regeneration. We show that cell proliferation is significantly reduced upon PH in CREM-/- mice. There is a reduction in DNA sy...

journal_title：Genes & development

authors： Servillo G,Della Fazia MA,Sassone-Corsi P

更新日期：1998-12-01 00:00:00

abstract：:The presence of Set2-mediated methylation of H3K36 (K36me) correlates with transcription frequency throughout the yeast genome. K36me targets the Rpd3S complex to deacetylate transcribed regions and suppress cryptic transcription initiation at certain genes. Here, using a genome-wide approach, we report that the Set2-...

journal_title：Genes & development

authors： Li B,Gogol M,Carey M,Pattenden SG,Seidel C,Workman JL

更新日期：2007-06-01 00:00:00

abstract：:Treatment with retinoic acid (RA) is known to produce complex teratogenic effects in vertebrates, and its presence in the developing embryo as an endogenous substance has led to the suggestion that RA might be a natural morphogenetic agent. Although our understanding of the molecular mechanism of RA action has improve...

journal_title：Genes & development

authors： Rossant J,Zirngibl R,Cado D,Shago M,Giguère V

更新日期：1991-08-01 00:00:00

abstract：:During embryonic development in vertebrates, the endoderm becomes patterned along the anteroposterior axis to produce distinct derivatives. How this regulation is controlled is not well understood. We report that the zebrafish hairy/enhancer of split [E(spl)]-related gene her5 plays a critical role in this process. At...

journal_title：Genes & development

authors： Bally-Cuif L,Goutel C,Wassef M,Wurst W,Rosa F

更新日期：2000-07-01 00:00:00

abstract：:A major class of bacterial small RNAs (sRNAs), along with RNA-binding protein Hfq and endoribonuclease RNase E, acts on target mRNAs through base-pairing, leading to translational repression and rapid degradation of the mRNAs. In this issue of Genes & Development, Prévost and colleagues (pp. 385-396) demonstrate by us...

journal_title：Genes & development

authors： Morita T,Aiba H

更新日期：2011-02-15 00:00:00

abstract：:Export to the cytoplasm of U3 RNA transcribed from a rat U3 gene injected into the nucleus of Xenopus oocytes indicates that the biogenesis of U3 RNA, like that of the previously studied Sm-precipitable nucleoplasmic snRNAs (U1, U2, U4, and U5), includes a cytoplasmic phase. The regulation of import of the U3 snRNA in...

journal_title：Genes & development

authors： Baserga SJ,Gilmore-Hebert M,Yang XW

更新日期：1992-06-01 00:00:00

abstract：:The number of known long noncoding RNA (lncRNA) functions is rapidly growing, but how those functions are encoded in their sequence and structure remains poorly understood. NORAD (noncoding RNA activated by DNA damage) is a recently characterized, abundant, and highly conserved lncRNA that is required for proper mitot...

journal_title：Genes & development

authors： Tichon A,Perry RB,Stojic L,Ulitsky I

更新日期：2018-01-01 00:00:00

abstract：:The Hox-2 locus on chromosome 11 represents one of the major clusters of homeo-box-containing genes in the mouse. We have identified two new members (Hox-2.6 and Hox-2.7), which form part of this cluster of seven linked genes, and it appears that the Hox-2 locus is related by duplication and divergence to at least one...

journal_title：Genes & development

authors： Graham A,Papalopulu N,Lorimer J,McVey JH,Tuddenham EG,Krumlauf R

更新日期：1988-11-01 00:00:00

abstract：:The recombination site dif is the target on the Escherichia coli chromosome of the site-specific recombinases XerC and XerD. The dif/XerC-D system plays a role during the cell cycle, probably by favoring sister chromosome monomerization or separation. A phenomenon of regional control over dif activity, also analyzed i...

journal_title：Genes & development

authors： Cornet F,Louarn J,Patte J,Louarn JM

更新日期：1996-05-01 00:00:00

abstract：:The Rbfox proteins (Rbfox1, Rbfox2, and Rbfox3) regulate the alternative splicing of many important neuronal transcripts and have been implicated in a variety of neurological disorders. However, their roles in brain development and function are not well understood, in part due to redundancy in their activities. Here w...

journal_title：Genes & development

authors： Gehman LT,Meera P,Stoilov P,Shiue L,O'Brien JE,Meisler MH,Ares M Jr,Otis TS,Black DL

更新日期：2012-03-01 00:00:00

abstract：:The neurofibromatosis type II (NF2) tumor suppressor encodes a putative cytoskeletal associated protein, the loss of which leads to the development of Schwann cell tumors associated with NF2 in humans. The NF2 protein merlin belongs to the band 4.1 family of proteins that link membrane proteins to the cytoskeleton and...

journal_title：Genes & development

authors： McClatchey AI,Saotome I,Ramesh V,Gusella JF,Jacks T

更新日期：1997-05-15 00:00:00

abstract：:Placental development is profoundly influenced by oxygen (O(2)) tension. Human cytotrophoblasts proliferate in vitro under low O(2) conditions but differentiate at higher O(2) levels, mimicking the developmental transition they undergo as they invade the placental bed to establish the maternal-fetal circulation in viv...

journal_title：Genes & development

authors： Adelman DM,Gertsenstein M,Nagy A,Simon MC,Maltepe E

更新日期：2000-12-15 00:00:00

abstract：:Dorsal mesoderm induction in arthropods and ventral mesoderm induction in vertebrates are closely related processes that involve signals of the BMP family. In Drosophila, induction of visceral mesoderm, dorsal muscles, and the heart by Dpp is, at least in part, effected through the transcriptional activation and funct...

journal_title：Genes & development

authors： Xu X,Yin Z,Hudson JB,Ferguson EL,Frasch M

更新日期：1998-08-01 00:00:00

abstract：:Most eukaryotic mRNAs are translated using a cap-dependent mechanism of translation. However, approximately 10% of mammalian mRNAs initiate translation using a cap-independent mechanism that is not well understood. These mRNAs contain an internal ribosome entry site (IRES) located in the 5' untranslated region. The cr...

journal_title：Genes & development

authors： Landry DM,Hertz MI,Thompson SR

更新日期：2009-12-01 00:00:00

abstract：:Atypical teratoid rhabdoid tumors (ATRTs) are challenging pediatric brain cancers that are predominantly associated with inactivation of the gene SMARCB1, a conserved subunit of the chromatin remodeling BAF complex, which has known contributions to developmental processes. To identify potential interactions between SM...

journal_title：Genes & development

authors： Parisian AD,Koga T,Miki S,Johann PD,Kool M,Crawford JR,Furnari FB

更新日期：2020-10-01 00:00:00

abstract：:Multiple DNA repair pathways maintain genome stability and ensure that DNA remains essentially unchanged over the life of a cell. Various human diseases occur if DNA repair is compromised, and most of these impact the nervous system, in some cases exclusively. However, it is often unclear what specific endogenous dama...

journal_title：Genes & development

authors： McKinnon PJ

更新日期：2017-06-15 00:00:00

abstract：:Telomeres are specialized nucleoprotein structures that protect chromosome ends from DNA damage response (DDR) and DNA rearrangements. The telomeric shelterin protein TRF2 suppresses the DDR, and this function has been attributed to its abilities to trigger t-loop formation or prevent massive decompaction and loss of ...

journal_title：Genes & development

authors： Vancevska A,Douglass KM,Pfeiffer V,Manley S,Lingner J

更新日期：2017-03-15 00:00:00

abstract：:For a number of human genes that encode transcripts containing inverted repeat Alu elements (IRAlus) within their 3' untranslated region (UTR), product mRNA is efficiently exported to the cytoplasm when the IRAlus, which mediate nuclear retention, are removed by alternative polyadenylation. Here we report a new mechan...

journal_title：Genes & development

authors： Elbarbary RA,Li W,Tian B,Maquat LE

更新日期：2013-07-01 00:00:00

abstract：:We have purified and cloned a new splicing factor, KSRP. KSRP is a component of a multiprotein complex that binds specifically to an intronic splicing enhancer element downstream of the neuron-specific c-src N1 exon. This 75-kD protein induces the assembly of five other proteins, including the heterogeneous nuclear ri...

journal_title：Genes & development

authors： Min H,Turck CW,Nikolic JM,Black DL

更新日期：1997-04-15 00:00:00

abstract：:The Rad51 and Lim15 proteins of lily, which are homologs of the bacterial RecA protein, were found on chromosomes in various stages of meiotic prophase 1. The presence of both Rad51 and Lim15 proteins as discrete foci on leptotene and zygotene chromosomes and their colocalization suggest that meiotic recombination beg...

journal_title：Genes & development

authors： Terasawa M,Shinohara A,Hotta Y,Ogawa H,Ogawa T

更新日期：1995-04-15 00:00:00

abstract：:Estrogen receptor α (ER) is the major driver of ∼75% of breast cancers, and multiple ER targeting drugs are routinely used clinically to treat patients with ER+ breast cancer. However, many patients relapse on these targeted therapies and ultimately develop metastatic and incurable disease, and understanding the mecha...

journal_title：Genes & development

authors： Siersbæk R,Kumar S,Carroll JS

更新日期：2018-09-01 00:00:00

abstract：:SET8 (also known as PR-SET7) is a histone H4-Lys-20-specific methyltransferase that is implicated in cell-cycle-dependent transcriptional silencing and mitotic regulation in metazoans. Herein we report the crystal structure of human SET8 (hSET8) bound to a histone H4 peptide bearing Lys-20 and the product cofactor S-a...

journal_title：Genes & development

authors： Couture JF,Collazo E,Brunzelle JS,Trievel RC

更新日期：2005-06-15 00:00:00

abstract：:The Bloom's syndrome gene (BLM) plays a pivotal role in the maintenance of genomic stability in somatic cells. It encodes a DNA helicase (BLM) of the RecQ family, but the exact function of BLM remains elusive. To study this question, we have cloned the BLM homolog of the frog Xenopus laevis (xBLM) and have raised anti...

journal_title：Genes & development

authors： Liao S,Graham J,Yan H

更新日期：2000-10-15 00:00:00

abstract：:Metastasis accounts for the vast majority of cancer-related deaths, yet the molecular mechanisms that drive metastatic spread remain poorly understood. Here we report that Tks5, which has been linked to the formation of proteolytic cellular protrusions known as invadopodia, undergoes an isoform switch during metastati...

journal_title：Genes & development

authors： Li CM,Chen G,Dayton TL,Kim-Kiselak C,Hoersch S,Whittaker CA,Bronson RT,Beer DG,Winslow MM,Jacks T

更新日期：2013-07-15 00:00:00

abstract：:Transcriptional repressors play a key role in establishing localized patterns of gene expression in the early Drosophila embryo. Several different modes of repression have been implicated in previous studies, including competition and direct interference with the transcription complex. Here, we present evidence for "q...

journal_title：Genes & development

authors： Gray S,Szymanski P,Levine M

更新日期：1994-08-01 00:00:00

abstract：:In the yeast Saccharomyces cerevisiae, sequence-specific DNA binding by the origin recognition complex (ORC) is responsible for selecting origins of DNA replication. In metazoans, origin selection is poorly understood and it is unknown whether specific DNA binding by metazoan ORC controls replication. To address this ...

journal_title：Genes & development

authors： Austin RJ,Orr-Weaver TL,Bell SP

更新日期：1999-10-15 00:00:00

abstract：:VASA is an evolutionarily conserved RNA helicase essential for germ cell development. The mouse PIWI family proteins MILI and MIWI2 are involved in production of Piwi-interacting RNAs (piRNAs) in fetal male germ cells through a ping-pong amplification cycle. Expression of retrotransposons is elevated in MILI- and MIWI...

journal_title：Genes & development

authors： Kuramochi-Miyagawa S,Watanabe T,Gotoh K,Takamatsu K,Chuma S,Kojima-Kita K,Shiromoto Y,Asada N,Toyoda A,Fujiyama A,Totoki Y,Shibata T,Kimura T,Nakatsuji N,Noce T,Sasaki H,Nakano T

更新日期：2010-05-01 00:00:00

abstract：:MicF, one of the first chromosomally encoded regulatory small RNAs (sRNAs) to be discovered, was found to modulate the expression of OmpF, an abundant outer membrane protein. Several recent papers have now shown that this is not an isolated case. At least five other sRNAs also regulate the synthesis of outer membrane ...

journal_title：Genes & development

authors： Guillier M,Gottesman S,Storz G

更新日期：2006-09-01 00:00:00

abstract：:The RAG-1 protein plays an essential role in V(D)j recombination, but its exact function has not yet been defined. Here we report that a particular mutation in RAG-1 affects recombination by altering the specificity of target sequence usage. Recombination mediated by wild-type RAG-1 is tolerant of a wide range of codi...

journal_title：Genes & development

authors： Sadofsky MJ,Hesse JE,van Gent DC,Gellert M

更新日期：1995-09-01 00:00:00

abstract：:Pre-mRNA splicing is essential for generating mature mRNA and is also important for subsequent mRNA export and quality control. The splicing history is imprinted on spliced mRNA through the deposition of a splicing-dependent multiprotein complex, the exon junction complex (EJC), at approximately 20 nucleotides upstrea...

journal_title：Genes & development

authors： Shi H,Xu RM

更新日期：2003-04-15 00:00:00