Abstract：
:Genomic imprinting is an epigenetic mechanism by which genes are expressed in a parental origin-dependent manner. We recently discovered that, like DNA methylation, oocyte-inherited H3K27me3 can also serve as an imprinting mark in mouse preimplantation embryos. In this study, we found H3K27me3 is strongly biased toward the maternal allele with some associated with DNA methylation-independent paternally expressed genes (PEGs) in human morulae. The H3K27me3 domains largely overlap with DNA partially methylated domains (PMDs) and occupy developmental gene promoters. Thus, our study not only reveals the H3K27me3 landscape but also establishes a correlation between maternal-biased H3K27me3 and PEGs in human morulae.
journal_name
Genes Devjournal_title
Genes & developmentauthors
Zhang W,Chen Z,Yin Q,Zhang D,Racowsky C,Zhang Ydoi
10.1101/gad.323105.118subject
Has Abstractpub_date
2019-04-01 00:00:00pages
382-387issue
7-8eissn
0890-9369issn
1549-5477pii
gad.323105.118journal_volume
33pub_type
杂志文章abstract：:Transgenic mice expressing wild-type murine p53 under the control of the mouse mammary tumor virus long terminal repeat (MMTV LTR) undergo progressive renal failure due to abnormal kidney development. Similar phenotypes are observed in two transgenic lines that express wild-type p53 within the ureteric bud but not in ...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.10.7.836
更新日期：1996-04-01 00:00:00
abstract：:Faithful inheritance of genetic information requires that DNA be copied only once each cell cycle. Initiation of DNA replication involves the establishment of a prereplication complex (pre-RC) and subsequent activation by CDK/cyclins, converting the pre-RC to a post-RC. The origin recognition complex (ORC), Cdc6p, and...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.11.24.3375
更新日期：1997-12-15 00:00:00
abstract：:DOCK180 is involved in integrin signaling through CrkII-p130(Cas) complexes. We have studied the involvement of DOCK180 in Rac1 signaling cascades. DOCK180 activated JNK in a manner dependent on Rac1, Cdc42Hs, and SEK, and overexpression of DOCK180 increased the amount of GTP-bound Rac1 in 293T cells. Coexpression of ...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.12.21.3331
更新日期：1998-11-01 00:00:00
abstract：:Expression of the gene encoding atrial natriuretic factor (ANF) during mouse cardiac embryogenesis was studied using in situ hybridization to histologic sections. ANF mRNA was first detected in a subpopulation of myocardial cells at day 8 of embryogenesis. During day 9, abundant hybridization of the ANF probe to the a...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1.7.693
更新日期：1987-09-01 00:00:00
abstract：:During vasculogenesis and angiogenesis, endothelial cell responses to growth factors are modulated by the compositional and mechanical properties of a surrounding three-dimensional (3D) extracellular matrix (ECM) that is dominated by either cross-linked fibrin or type I collagen. While 3D-embedded endothelial cells es...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1643308
更新日期：2008-05-01 00:00:00
abstract：:An RNA-binding protein gene (rbp1) from Drosophila melanogaster, encoding an RNA recognition motif and an Arg-Ser rich (RS) domain, has been characterized. The predicted amino acid sequence of rbp1 is similar to those of the human splicing factor ASF/SF2, the Drosophila nuclear phosphoprotein SRp55, and the Drosophila...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.6.12b.2569
更新日期：1992-12-01 00:00:00
abstract：:During gastrulation of Xenopus embryos the prospective mesoderm is induced initially with domains of dorsal and ventral fate, then further patterned to generate somitic mesoderm by signals from the gastrula organizer. Although Xwnt-8 is expressed in future ventrolateral mesoderm and induces prospective epidermis to di...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.10.21.2805
更新日期：1996-11-01 00:00:00
abstract：:The serine/threonine kinase Akt/PKB is a major downstream effector of growth factor-mediated cell survival. Activated Akt, like Bcl-2 and Bcl-xL, prevents closure of a PT pore component, the voltage-dependent anion channel (VDAC); intracellular acidification; mitochondrial hyperpolarization; and the decline in oxidati...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.889901
更新日期：2001-06-01 00:00:00
abstract：:The female mammary gland is a very dynamic organ that undergoes continuous tissue remodeling during adulthood. Although it is well established that the number of menstrual cycles and pregnancy (in this case transiently) increase the risk of breast cancer, the reasons are unclear. Growing clinical and experimental evid...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.292318.116
更新日期：2017-03-15 00:00:00
abstract：:Two broad gene classes are distinguished within multicellular organisms: cell type-specific genes, which confer particular cellular properties, and ubiquitous genes that support general cellular functions. However, certain so-called ubiquitous genes show functionally relevant cell type-specific repression. How such re...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.287904.116
更新日期：2016-09-15 00:00:00
abstract：:The ECS (Elongin B/C-Cul2/Cul5-SOCS-box protein) complex is a member of a family of ubiquitin ligases that share a Cullin-Rbx module. SOCS-box proteins recruit substrates to the ECS complex and are linked to Cullin-Rbx via Elongin B/C. VHL has been implicated as a SOCS-box protein, but lacks a C-terminal sequence (dow...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1252404
更新日期：2004-12-15 00:00:00
abstract：:Cell fates in the optic neuroepithelium are determined by the combinational action of homeotic transcription factors. One of these is Vax2, a homeodomain protein that ventralizes the vertebrate eye field by repressing transcription of the Pax6 gene. We find that Vax2 shuttles between the nucleus and cytoplasm as a fun...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1462706
更新日期：2006-10-15 00:00:00
abstract：:Activated transcription by RNA polymerase II (Pol II) requires coactivators, one of which is the SRB/mediator. Whereas Srb4, an essential subunit of the SRB/mediator, is broadly required for Pol II transcription in yeast, we have shown that it is dispensable for the transcriptional activation of some genes. Here, we s...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.13.22.2934
更新日期：1999-11-15 00:00:00
abstract：:Sexual identity in Drosophila is determined by zygotic X-chromosome dose. Two potent indicators of X-chromosome dose are sisterless-a (sis-a) and sisterless-b (sis-b). Genetic analysis has shown that a diplo-X dose of these genes activates their regulatory target, the feminizing switch gene Sex-lethal (Sxl), whereas a...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.7.9.1688
更新日期：1993-09-01 00:00:00
abstract：:Alternative splicing factor/splicing factor 2 (ASF/SF2) is the prototype of a family of nuclear proteins highly conserved throughout metazoa, the SR (serine/arginine) proteins. Based largely on in vitro studies, SR proteins have been suggested to play important roles in constitutive and alternative splicing of pre-mRN...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.10.20.2588
更新日期：1996-10-15 00:00:00
abstract：:Lethal yellow (Ay) is a mutation at the mouse agouti (a) locus that is associated with an all-yellow coat color, obesity, diabetes, tumors in heterozygotes, and preimplantation embryonic lethality in homozygotes. Previously, we cloned and characterized the wild-type agouti gene and demonstrated that it expresses a 0.8...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.7.7a.1203
更新日期：1993-07-01 00:00:00
abstract：:Genome integrity is constantly monitored by sophisticated cellular networks, collectively termed the DNA damage response (DDR). A common feature of DDR proteins is their mobilization in response to genotoxic stress. Here, we outline how the development of various complementary methodologies has provided valuable insig...
journal_title：Genes & development
pub_type： 杂志文章,评审
doi：10.1101/gad.2021311
更新日期：2011-03-01 00:00:00
abstract：:Extensive DNA elimination via a DNA breakage and rejoining process occurs during macronuclear development in the hypotrich ciliate Euplotes crassus. The excision process involves the removal of short, unique segments of DNA (internal eliminated sequences; IESs) and at least two highly repetitive families of transposon...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.7.1.84
更新日期：1993-01-01 00:00:00
abstract：:Cell cycle transitions are often accompanied by the degradation of regulatory molecules. Targeting proteins to the proteasome for degradation is accomplished by the covalent addition of ubiquitin chains. The specificity of this pathway is largely dictated by a set of enzymes called ubiquitin ligases (or E3s). The anap...
journal_title：Genes & development
pub_type： 杂志文章,评审
doi：10.1101/gad.1478306
更新日期：2006-11-15 00:00:00
abstract：:The yeast HO gene is transcribed transiently during G1 as cells undergo START. START-specific HO activation requires two proteins, SWI4 and SWI6, which act via a motif (CACGA4) repeated up to 10 times within the URS2 region of the HO promoter. We identified a DNA-binding activity containing SWI4 and SWI6 that recogniz...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.5.11.2000
更新日期：1991-11-01 00:00:00
abstract：:The crucifer Arabidopsis thaliana has been used widely as a model organism for the study of plant development. We describe here the development of an efficient insertional mutagenesis system in Arabidopsis that permits identification of genes by their patterns of expression during development. Transposable elements of...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.9.14.1797
更新日期：1995-07-15 00:00:00
abstract：:The spectrum of tumors associated with oncogenic Ras in humans often differs from those in mice either treated with carcinogens or engineered to sporadically express oncogenic Ras, suggesting that the mechanism of Ras transformation may be different in humans. Ras stimulates primarily three main classes of effector pr...
journal_title：Genes & development
pub_type： 杂志文章,评审
doi：10.1101/gad.993902
更新日期：2002-08-15 00:00:00
abstract：:Changes in the pattern of gene expression play an important role in allowing cancer cells to acquire their hallmark characteristics, while genomic instability enables cells to acquire genetic alterations that promote oncogenesis. Chromatin plays central roles in both transcriptional regulation and the maintenance of g...
journal_title：Genes & development
pub_type： 杂志文章,评审
doi：10.1101/gad.255182.114
更新日期：2015-02-01 00:00:00
abstract：:The repression of the maternally inherited Igf2 allele has been proposed to depend on a methylation-sensitive chromatin insulator organized by the 11 zinc finger protein CTCF at the H19 imprinting control region (ICR). Here we document that point mutations of the nucleotides in physical contact with CTCF within the en...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.254903
更新日期：2003-03-01 00:00:00
abstract：:Chromatin structure is believed to be important for a number of cellular processes, including transcription. However, the role of nucleosomes in transcription is not well understood. We have identified the yeast histone locus HTB1-HTB1, encoding histones H2A and H2B, as a suppressor of solo delta insertion mutations t...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.2.2.150
更新日期：1988-02-01 00:00:00
abstract：:We show the intracellular localization of the Escherichia coli replication origin (oriC) and chromosome terminus during the cell division cycle by FISH. In newborn cells, oriC is localized at the old-pole-proximal nucleoid border and the terminus at the new-pole-proximal nucleoid border. One copy of replicated oriC mi...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.12.7.1036
更新日期：1998-04-01 00:00:00
abstract：:The Drosophila brain tumor (brat) gene encodes a member of the conserved NHL family of proteins, which appear to regulate differentiation and growth in a variety of organisms. One of the founding family members, Caenorhabditis elegans LIN-41, is thought to control posttranscriptional gene expression. However, the mech...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.870801
更新日期：2001-03-15 00:00:00
abstract：:Transcription factors represent one of the largest groups of proteins regulated by SUMO (small ubiquitin-like modifier) modification, and their sumoylation is usually associated with transcriptional repression. To investigate whether sumoylation plays a general role in regulating transcription in yeast, we determined ...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.1917910
更新日期：2010-06-15 00:00:00
abstract：:Cap-dependent translation is mediated by eIF4F, a protein complex composed of three subunits as follows: eIF4E, which recognizes the mRNA 5' cap structure; eIF4A, an RNA-helicase; and eIF4G, a scaffolding protein that binds eIF4E, eIF4A, and the eIF4E-kinase Mnk1 simultaneously. eIF4E is hypophosphorylated and cap-dep...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.889201
更新日期：2001-08-15 00:00:00
abstract：:The neurofibromatosis type II (NF2) tumor suppressor encodes a putative cytoskeletal associated protein, the loss of which leads to the development of Schwann cell tumors associated with NF2 in humans. The NF2 protein merlin belongs to the band 4.1 family of proteins that link membrane proteins to the cytoskeleton and...
journal_title：Genes & development
pub_type： 杂志文章
doi：10.1101/gad.11.10.1253
更新日期：1997-05-15 00:00:00
