Abstract:
:Motor axons make synaptic connections with specific muscles, and this specificity unfolds during development as motoneuron growth cones make specific pathway choices and ultimately recognize and synapse on their specific muscle targets. The Drosophila clueless mutation was identified previously in a genetic screen for mutations that disrupt motoneuron guidance and connectivity. We show here that clueless is allelic to abrupt. The abrupt gene is required for the embryonic formation of specific synaptic connections between a subset of motoneurons and a subset of muscles. Mutations in abrupt also reveal its role in establishing and maintaining muscle attachments, adult sensory cell formation, and morphogenesis of adult appendages. The abrupt gene encodes a zinc finger protein with a conserved BTB domain. Abrupt is expressed in muscle nuclei but not motoneurons, suggesting that abrupt controls the muscle expression of molecules required for correct motoneuron targeting, as well as molecules required for correct muscle attachments.
journal_name
Genes Devjournal_title
Genes & developmentauthors
Hu S,Fambrough D,Atashi JR,Goodman CS,Crews STdoi
10.1101/gad.9.23.2936subject
Has Abstractpub_date
1995-12-01 00:00:00pages
2936-48issue
23eissn
0890-9369issn
1549-5477journal_volume
9pub_type
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