The silencing complex SAS-I links histone acetylation to the assembly of repressed chromatin by CAF-I and Asf1 in Saccharomyces cerevisiae.

abstract：:Autophagy is crucial for cellular homeostasis and plays important roles in tumorigenesis. FIP200 (FAK family-interacting protein of 200 kDa) is an essential autophagy gene required for autophagy induction, functioning in the ULK1-ATG13-FIP200 complex. Our previous studies showed that conditional knockout of FIP200 sig...

journal_title：Genes & development

authors： Wei H,Wang C,Croce CM,Guan JL

更新日期：2014-06-01 00:00:00

abstract：:DOCK180 is involved in integrin signaling through CrkII-p130(Cas) complexes. We have studied the involvement of DOCK180 in Rac1 signaling cascades. DOCK180 activated JNK in a manner dependent on Rac1, Cdc42Hs, and SEK, and overexpression of DOCK180 increased the amount of GTP-bound Rac1 in 293T cells. Coexpression of ...

journal_title：Genes & development

authors： Kiyokawa E,Hashimoto Y,Kobayashi S,Sugimura H,Kurata T,Matsuda M

更新日期：1998-11-01 00:00:00

abstract：:Irradiation in the G1 phase of the cell cycle delays the onset of DNA synthesis and transiently inhibits the activation of replication origins in mammalian cells. It has been suggested that this inhibition is the result of the loss of torsional tension in the DNA after it has been damaged. Because irradiation causes D...

journal_title：Genes & development

authors： Raghuraman MK,Brewer BJ,Fangman WL

更新日期：1994-03-01 00:00:00

abstract：:Glucocorticoid (GC) receptor (GR) has been shown recently to bind a subset of mRNAs and elicit rapid mRNA degradation. However, the molecular details of GR-mediated mRNA decay (GMD) remain unclear. Here, we demonstrate that GMD triggers rapid degradation of target mRNAs in a translation-independent and exon junction c...

journal_title：Genes & development

authors： Park OH,Park J,Yu M,An HT,Ko J,Kim YK

更新日期：2016-09-15 00:00:00

abstract：:Estrogen receptor α (ER) is the major driver of ∼75% of breast cancers, and multiple ER targeting drugs are routinely used clinically to treat patients with ER+ breast cancer. However, many patients relapse on these targeted therapies and ultimately develop metastatic and incurable disease, and understanding the mecha...

journal_title：Genes & development

authors： Siersbæk R,Kumar S,Carroll JS

更新日期：2018-09-01 00:00:00

abstract：:Two broad gene classes are distinguished within multicellular organisms: cell type-specific genes, which confer particular cellular properties, and ubiquitous genes that support general cellular functions. However, certain so-called ubiquitous genes show functionally relevant cell type-specific repression. How such re...

journal_title：Genes & development

authors： Drexel T,Mahofsky K,Latham R,Zimmer M,Cochella L

更新日期：2016-09-15 00:00:00

abstract：:TGF-β receptors phosphorylate SMAD2 and SMAD3 transcription factors, which then form heterotrimeric complexes with SMAD4 and cooperate with context-specific transcription factors to activate target genes. Here we provide biochemical and structural evidence showing that binding of SMAD2 to DNA depends on the conformati...

journal_title：Genes & development

authors： Aragón E,Wang Q,Zou Y,Morgani SM,Ruiz L,Kaczmarska Z,Su J,Torner C,Tian L,Hu J,Shu W,Agrawal S,Gomes T,Márquez JA,Hadjantonakis AK,Macias MJ,Massagué J

更新日期：2019-11-01 00:00:00

abstract：:Natural scrapie has been viewed both as a recessive trait and as a contagious disease modulated by a host locus. To address this conundrum, we determined the structure of the sheep prion protein (PrP) gene, which contains three exons and extends over 20 kb of DNA. In the United States 86.4% of scrapie cases occur in S...

journal_title：Genes & development

authors： Westaway D,Zuliani V,Cooper CM,Da Costa M,Neuman S,Jenny AL,Detwiler L,Prusiner SB

更新日期：1994-04-15 00:00:00

abstract：:Cell differentiation is essential for the development of multicellular organisms. In flowering plants, the haploid male gametophytes (pollen grains) are generated in the anther from reproductive cells called microsporocytes. Several types of somatic cells ensure successful pollen development, and thus reproduction. Ho...

journal_title：Genes & development

authors： Zhao DZ,Wang GF,Speal B,Ma H

更新日期：2002-08-01 00:00:00

abstract：:Class Ia phosphatidylinositol 3 kinase (PI3K) is required for oncogenic receptor-mediated transformation; however, the individual roles of the two commonly expressed class Ia PI3K isoforms in oncogenic receptor signaling have not been elucidated in vivo. Here, we show that genetic ablation of p110α blocks tumor format...

journal_title：Genes & development

authors： Utermark T,Rao T,Cheng H,Wang Q,Lee SH,Wang ZC,Iglehart JD,Roberts TM,Muller WJ,Zhao JJ

更新日期：2012-07-15 00:00:00

abstract：:A conditional allele of type 1 protein phosphatase (glc7-129) in Saccharomyces cerevisiae causes first cycle arrest in G2/M, characterized by cells with a short spindle and high H1 kinase activity. Point-of-execution experiments indicate Glc7p function is required in G2/M just before anaphase for the completion of mit...

journal_title：Genes & development

authors： Bloecher A,Tatchell K

更新日期：1999-03-01 00:00:00

abstract：:This year is the centenary of Edward G. Conklin's signal findings in embryology: the elucidation of complete cell lineages and the discovery of localized maternal determinants. Conklin used ascidian embryos to elucidate universal principles in embryology. A century later, ascidians, or sea squirts, have not only enter...

journal_title：Genes & development

authors： Satoh N,Levine M

更新日期：2005-10-15 00:00:00

abstract：:The contact site A glycoprotein is a developmentally regulated cell-surface component expressed during the aggregation stage of Dictyostelium discoideum. This protein has been implicated in the EDTA-stable (Ca2(+)-independent) type of cell adhesion of aggregating cells. The gene coding for the contact site A protein w...

journal_title：Genes & development

authors： Harloff C,Gerisch G,Noegel AA

更新日期：1989-12-01 00:00:00

abstract：:Eukaryotic morphogenesis is seeded with the establishment and subsequent amplification of polarity cues at key times during the cell cycle, often using (cyclic) nucleotide signals. We discovered that flagellum de- and repolarization in the model prokaryote Caulobacter crescentus is precisely orchestrated through at le...

journal_title：Genes & development

authors： Davis NJ,Cohen Y,Sanselicio S,Fumeaux C,Ozaki S,Luciano J,Guerrero-Ferreira RC,Wright ER,Jenal U,Viollier PH

更新日期：2013-09-15 00:00:00

abstract：:Pre-mRNA splicing is essential for generating mature mRNA and is also important for subsequent mRNA export and quality control. The splicing history is imprinted on spliced mRNA through the deposition of a splicing-dependent multiprotein complex, the exon junction complex (EJC), at approximately 20 nucleotides upstrea...

journal_title：Genes & development

authors： Shi H,Xu RM

更新日期：2003-04-15 00:00:00

abstract：:The Purkinje cell protein 2 (Pcp-2) is expressed in cerebellar Purkinje cells and retinal bipolar neurons. To illuminate how Pcp-2 expression is restricted to only two neuronal types and to derive tools to express heterologous genes in these neuronal subpopulations, genomic sequences of the mouse Pcp-2 gene have been ...

journal_title：Genes & development

authors： Vandaele S,Nordquist DT,Feddersen RM,Tretjakoff I,Peterson AC,Orr HT

更新日期：1991-07-01 00:00:00

abstract：:The eukaryotic ribosomal RNA (rRNA) is associated cotranscriptionally with numerous factors into an enormous 90S preribosomal particle that conducts early processing of small ribosomal subunits. The assembly pathway and structure of the 90S particle is poorly understood. Here, we affinity-purified and analyzed the con...

journal_title：Genes & development

authors： Zhang L,Wu C,Cai G,Chen S,Ye K

更新日期：2016-03-15 00:00:00

abstract：:Cell fates in the optic neuroepithelium are determined by the combinational action of homeotic transcription factors. One of these is Vax2, a homeodomain protein that ventralizes the vertebrate eye field by repressing transcription of the Pax6 gene. We find that Vax2 shuttles between the nucleus and cytoplasm as a fun...

journal_title：Genes & development

authors： Kim JW,Lemke G

更新日期：2006-10-15 00:00:00

abstract：:Gene dosage alterations caused by aneuploidy are a common feature of most cancers yet pose severe proteotoxic challenges. Therefore, cells have evolved various dosage compensation mechanisms to limit the damage caused by the ensuing protein level imbalances. For instance, for heteromeric protein complexes, excess nons...

journal_title：Genes & development

authors： Samant RS,Masto VB,Frydman J

更新日期：2019-08-01 00:00:00

abstract：:In vivo experiments have demonstrated that the ribosomal protein L32 of Saccharomyces cerevisiae brings about the inhibition of splicing of the transcript of its own gene through an RNA structure comprised largely of the first exon. We now show that L32, itself, binds specifically to this RNA. Splicing of the RPL32 tr...

journal_title：Genes & development

authors： Vilardell J,Warner JR

更新日期：1994-01-01 00:00:00

abstract：:TDP-43 is a critical RNA-binding factor associated with pre-mRNA splicing in mammals. Its expression is tightly autoregulated, with loss of this regulation implicated in human neuropathology. We demonstrate that TDP-43 overexpression in humans and mice activates a 3' untranslated region (UTR) intron, resulting in exci...

journal_title：Genes & development

authors： Avendaño-Vázquez SE,Dhir A,Bembich S,Buratti E,Proudfoot N,Baralle FE

更新日期：2012-08-01 00:00:00

abstract：:The LIM motif defines a double zinc finger structure found in proteins involved in cell fate determination and growth control. LIM proteins, which include LIM homeo domain, LIM kinase, focal adhesion, and LIM-only proteins, usually contain two or more LIM motifs clustered at their amino- or carboxy-terminal end. At pr...

journal_title：Genes & development

authors： Arber S,Caroni P

更新日期：1996-02-01 00:00:00

abstract：:The RAG-1 protein plays an essential role in V(D)j recombination, but its exact function has not yet been defined. Here we report that a particular mutation in RAG-1 affects recombination by altering the specificity of target sequence usage. Recombination mediated by wild-type RAG-1 is tolerant of a wide range of codi...

journal_title：Genes & development

authors： Sadofsky MJ,Hesse JE,van Gent DC,Gellert M

更新日期：1995-09-01 00:00:00

abstract：:In enteric bacteria, the transcription factor σ(E) maintains membrane homeostasis by inducing synthesis of proteins involved in membrane repair and two small regulatory RNAs (sRNAs) that down-regulate synthesis of abundant membrane porins. Here, we describe the discovery of a third σ(E)-dependent sRNA, MicL (mRNA-inte...

journal_title：Genes & development

authors： Guo MS,Updegrove TB,Gogol EB,Shabalina SA,Gross CA,Storz G

更新日期：2014-07-15 00:00:00

abstract：:Persistent DNA double-strand breaks and telomeres represent genomic hazards, as they can instigate inappropriate repair reactions. Two recent papers by Oza and colleagues (pp. 912-917) and Schober and colleagues (pp. 928-938) show that both types of DNA ends are sequestered from bulk DNA by Mps3, a SUN domain protein ...

journal_title：Genes & development

authors： Gartenberg MR

更新日期：2009-05-01 00:00:00

abstract：:DNA repair associated with DNA replication is important for the conservation of genomic sequence information, whereas reconstitution of chromatin after replication sustains epigenetic information. We have isolated and characterized mutations in the BRU1 gene of Arabidopsis that suggest a novel link between these under...

journal_title：Genes & development

authors： Takeda S,Tadele Z,Hofmann I,Probst AV,Angelis KJ,Kaya H,Araki T,Mengiste T,Mittelsten Scheid O,Shibahara K,Scheel D,Paszkowski J

更新日期：2004-04-01 00:00:00

abstract：:RNA polymerase II (Pol II) transcribes all protein-coding genes and many noncoding RNAs in eukaryotic genomes. Although Pol II is a complex, 12-subunit enzyme, it lacks the ability to initiate transcription and cannot consistently transcribe through long DNA sequences. To execute these essential functions, an array of...

journal_title：Genes & development

authors： Schier AC,Taatjes DJ

更新日期：2020-04-01 00:00:00

abstract：:Translation initiation factor 2 (eIF2) bound to GTP transfers the initiator methionyl tRNA to the 40S ribosomal subunit. The eIF5 stimulates GTP hydrolysis by the eIF2/GTP/Met-tRNA(i)(Met) ternary complex on base-pairing between Met-tRNA(i)(Met) and the start codon. The eIF2, eIF5, and eIF1 all have been implicated in...

journal_title：Genes & development

authors： Asano K,Clayton J,Shalev A,Hinnebusch AG

更新日期：2000-10-01 00:00:00

abstract：:In many species, a dosage compensation complex (DCC) is targeted to X chromosomes of one sex to equalize levels of X-gene products between males (1X) and females (2X). Here we identify cis-acting regulatory elements that target the Caenorhabditis elegans X chromosome for repression by the DCC. The DCC binds to discret...

journal_title：Genes & development

authors： Jans J,Gladden JM,Ralston EJ,Pickle CS,Michel AH,Pferdehirt RR,Eisen MB,Meyer BJ

更新日期：2009-03-01 00:00:00

abstract：:MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due t...

journal_title：Genes & development

authors： Lipchina I,Elkabetz Y,Hafner M,Sheridan R,Mihailovic A,Tuschl T,Sander C,Studer L,Betel D

更新日期：2011-10-15 00:00:00