Nutrient-dependent control of RNA polymerase II elongation rate regulates specific gene expression programs by alternative polyadenylation.

abstract：:Expression of the Arabidopsis CGS1 gene that codes for cystathionine gamma-synthase is feedback regulated at the step of mRNA stability in response to S-adenosyl-L-methionine (AdoMet). A short stretch of amino acid sequence, called the MTO1 region, encoded by the first exon of CGS1 itself is involved in this regulatio...

journal_title：Genes & development

authors： Onouchi H,Nagami Y,Haraguchi Y,Nakamoto M,Nishimura Y,Sakurai R,Nagao N,Kawasaki D,Kadokura Y,Naito S

更新日期：2005-08-01 00:00:00

abstract：:The PWI motif is a highly conserved domain of unknown function in the SRm160 splicing and 3'-end cleavage-stimulatory factor, as well as in several other known or putative pre-mRNA processing components. We show here that the PWI motif is a new type of RNA/DNA-binding domain that has an equal preference for single- an...

journal_title：Genes & development

authors： Szymczyna BR,Bowman J,McCracken S,Pineda-Lucena A,Lu Y,Cox B,Lambermon M,Graveley BR,Arrowsmith CH,Blencowe BJ

更新日期：2003-02-15 00:00:00

abstract：:The catalytic RNA subunit (M1 RNA) of RNase P from Escherichia coli has been converted to an endoribonuclease that specifically cleaves the mRNA that encodes thymidine kinase (TK) of herpes simplex virus 1 (HSV-1). Covalent attachment to the 3' end of M1 RNA of a sequence complementary to TK mRNA results in very effic...

journal_title：Genes & development

authors： Liu F,Altman S

更新日期：1995-02-15 00:00:00

abstract：:The chromo domain was identified as a homologous protein motif between Polycomb (Pc)--a member of the Pc-group genes encoding transcriptional repressors of the homeotic genes--and HP1--a heterochromatin-associated protein encoded by the suppressor of position effect variegation gene Su(var)205. Together with previous ...

journal_title：Genes & development

authors： Messmer S,Franke A,Paro R

更新日期：1992-07-01 00:00:00

abstract：:In Drosophila germ cells, PIWI-interacting RNAs (piRNAs) are amplified through a PIWI slicer-dependent feed-forward loop termed the ping-pong cycle, yielding secondary piRNAs. However, the detailed mechanism remains poorly understood, largely because an ex vivo model system amenable to biochemical analyses has not bee...

journal_title：Genes & development

authors： Sumiyoshi T,Sato K,Yamamoto H,Iwasaki YW,Siomi H,Siomi MC

更新日期：2016-07-15 00:00:00

abstract：:Dorsal mesoderm induction in arthropods and ventral mesoderm induction in vertebrates are closely related processes that involve signals of the BMP family. In Drosophila, induction of visceral mesoderm, dorsal muscles, and the heart by Dpp is, at least in part, effected through the transcriptional activation and funct...

journal_title：Genes & development

authors： Xu X,Yin Z,Hudson JB,Ferguson EL,Frasch M

更新日期：1998-08-01 00:00:00

abstract：:Plant water homeostasis is maintained by the phytohormone abscisic acid (ABA), which triggers stomatal pore closure in response to drought stress. We identified the Arabidopsis small guanosine triphosphatase (GTPase) protein AtRac1 as a central component in the ABA-mediated stomatal closure process. ABA treatment indu...

journal_title：Genes & development

authors： Lemichez E,Wu Y,Sanchez JP,Mettouchi A,Mathur J,Chua NH

更新日期：2001-07-15 00:00:00

abstract：:Maternal imprinting at the Xist gene is essential to achieve paternal allele-specific imprinted X-chromosome inactivation (XCI) in female mammals. However, the mechanism underlying Xist imprinting is unclear. Here we show that the Xist locus is coated with a broad H3K27me3 domain that is established during oocyte grow...

journal_title：Genes & development

authors： Inoue A,Jiang L,Lu F,Zhang Y

更新日期：2017-10-01 00:00:00

abstract：:An insulin receptor-like signaling pathway regulates Caenorhabditis elegans metabolism, development, and longevity. Inactivation of the insulin receptor homolog DAF-2, the AGE-1 PI3K, or the AKT-1 and AKT-2 kinases causes a developmental arrest at the dauer stage. A null mutation in the daf-16 Fork head transcription ...

journal_title：Genes & development

authors： Paradis S,Ailion M,Toker A,Thomas JH,Ruvkun G

更新日期：1999-06-01 00:00:00

abstract：:The Rad51 and Lim15 proteins of lily, which are homologs of the bacterial RecA protein, were found on chromosomes in various stages of meiotic prophase 1. The presence of both Rad51 and Lim15 proteins as discrete foci on leptotene and zygotene chromosomes and their colocalization suggest that meiotic recombination beg...

journal_title：Genes & development

authors： Terasawa M,Shinohara A,Hotta Y,Ogawa H,Ogawa T

更新日期：1995-04-15 00:00:00

abstract：:We have developed a new technique, called 'toeprinting,' which has allowed a study of the tRNA-binding properties of Escherichia coli translation initiation complexes. In response to natural mRNAs, the initiator tRNA and a variety of elongator tRNAs bind to the same tRNA-binding site on the 30S ribosomal subunit as lo...

journal_title：Genes & development

authors： Hartz D,McPheeters DS,Gold L

更新日期：1989-12-01 00:00:00

abstract：:The nonsense-mediated mRNA decay (NMD) pathway selectively degrades mRNAs harboring premature termination codons (PTCs). Seven genes (smg-1-7, for suppressor with morphological effect on genitalia) that are essential for NMD were originally identified in the nematode Caenorhabditis elegans, and orthologs of these gene...

journal_title：Genes & development

authors： Longman D,Plasterk RH,Johnstone IL,Cáceres JF

更新日期：2007-05-01 00:00:00

abstract：:We showed previously that the MAP kinase ERK2 is essential for aggregation. erk2 null cells lack cAMP stimulation of adenylyl cyclase and thus cannot relay the cAMP chemotactic signal, although the cells chemotax to cAMP (Segall et al. 1995). In this paper we have examined the role of ERK2 in controlling developmental...

journal_title：Genes & development

authors： Gaskins C,Clark AM,Aubry L,Segall JE,Firtel RA

更新日期：1996-01-01 00:00:00

abstract：:Cyclin B3 has been conserved during higher eukaryote evolution as evidenced by its identification in chicken, nematodes, and insects. We demonstrate that Cyclin B3 is present in addition to Cyclins A and B in mitotically proliferating cells and not detectable in endoreduplicating tissues of Drosophila embryos. Cyclin ...

journal_title：Genes & development

authors： Jacobs HW,Knoblich JA,Lehner CF

更新日期：1998-12-01 00:00:00

abstract：:The structurally related POU homeo domain proteins Pit-1 and Oct-2 activate pituitary- and lymphoid-specific transcription, respectively, by binding to similar AT-rich motifs in their target genes. In this study we identify bases critical for recognition and activation by Pit-1 and examine how small differences in Pit...

journal_title：Genes & development

authors： Elsholtz HP,Albert VR,Treacy MN,Rosenfeld MG

更新日期：1990-01-01 00:00:00

abstract：:The product of the nuclear MRS2 gene, Mrs2p, is the only candidate splicing factor essential for all group II introns in mitochondria of the yeast Saccharomyces cerevisiae. It has been shown to be an integral protein of the inner mitochondrial membrane, structurally and functionally related to the bacterial CorA Mg(2+...

journal_title：Genes & development

authors： Gregan J,Kolisek M,Schweyen RJ

更新日期：2001-09-01 00:00:00

abstract：:The agouti gene regulates the differential production of eumelanin (black or brown) and phaeomelanin (yellow) pigment granules by melanocytes in the hair follicles of mice. The original nonagouti (a) allele, which confers a predominantly black coat color, has been shown to revert to two other more dominant agouti alle...

journal_title：Genes & development

authors： Bultman SJ,Klebig ML,Michaud EJ,Sweet HO,Davisson MT,Woychik RP

更新日期：1994-02-15 00:00:00

abstract：:Sox2 is expressed in basal epithelial cells of the tongue, with high levels in taste bud placodes, fungiform papillae, and mature taste cells, and low levels in filiform papillae. High Sox2 expression appears to lie downstream from canonical Wnt signaling. In hypomorphic Sox2(EGFP/LP) embryos, placodes form but no mat...

journal_title：Genes & development

authors： Okubo T,Pevny LH,Hogan BL

更新日期：2006-10-01 00:00:00

abstract：:Evidence is presented that the activation of the RNA polymerase sigma factor sigma(W) in Bacillus subtilis by regulated intramembrane proteolysis is governed by a novel, membrane-embedded protease. The sigma(W) factor is activated by proteolytic destruction of the membrane-bound anti-sigma(W) factor RsiW in response t...

journal_title：Genes & development

authors： Ellermeier CD,Losick R

更新日期：2006-07-15 00:00:00

abstract：:Growth of numerous cancer types is believed to be driven by a subpopulation of poorly differentiated cells, often referred to as cancer stem cells (CSCs), that have the capacity for self-renewal, tumor initiation, and generation of nontumorigenic progeny. Despite their potentially key role in tumor establishment and m...

journal_title：Genes & development

authors： Janiszewska M,Suvà ML,Riggi N,Houtkooper RH,Auwerx J,Clément-Schatlo V,Radovanovic I,Rheinbay E,Provero P,Stamenkovic I

更新日期：2012-09-01 00:00:00

abstract：:The contact site A glycoprotein is a developmentally regulated cell-surface component expressed during the aggregation stage of Dictyostelium discoideum. This protein has been implicated in the EDTA-stable (Ca2(+)-independent) type of cell adhesion of aggregating cells. The gene coding for the contact site A protein w...

journal_title：Genes & development

authors： Harloff C,Gerisch G,Noegel AA

更新日期：1989-12-01 00:00:00

abstract：:Asymmetric localization of cell fate determinants is a crucial step in neuroblast asymmetric divisions. Whereas several protein kinases have been shown to mediate this process, no protein phosphatase has so far been implicated. In a clonal screen of larval neuroblasts we identified the evolutionarily conserved Protein...

journal_title：Genes & development

authors： Sousa-Nunes R,Chia W,Somers WG

更新日期：2009-02-01 00:00:00

abstract：:Deregulated expression of the c-myc proto-oncogene can lead to apoptosis under certain physiological conditions. By introducing a conditionally active Myc allele into primary embryo fibroblasts null for p53, and into fibroblasts without endogenous p53 expression but ectopically expressing a temperature-sensitive p53 a...

journal_title：Genes & development

authors： Wagner AJ,Kokontis JM,Hay N

更新日期：1994-12-01 00:00:00

abstract：:We have studied the effect of exogenous expression of the basal transcription factor TFIID on the activities of several different TATA-containing and TATA-lacking promoters. Overexpression of TFIID from a transfected plasmid in Drosophila Schneider cells resulted in substantial concentration-dependent increases in exp...

journal_title：Genes & development

authors： Colgan J,Manley JL

更新日期：1992-02-01 00:00:00

abstract：:The distal appendages (DAPs) of centrioles have been proposed to anchor cilia to the plasma membrane, but their molecular composition, assembly, and exact function in ciliogenesis remain poorly understood. Using quantitative centrosome proteomics and superresolution microscopy, we identified five DAP components, inclu...

journal_title：Genes & development

authors： Tanos BE,Yang HJ,Soni R,Wang WJ,Macaluso FP,Asara JM,Tsou MF

更新日期：2013-01-15 00:00:00

abstract：:The Rbfox proteins (Rbfox1, Rbfox2, and Rbfox3) regulate the alternative splicing of many important neuronal transcripts and have been implicated in a variety of neurological disorders. However, their roles in brain development and function are not well understood, in part due to redundancy in their activities. Here w...

journal_title：Genes & development

authors： Gehman LT,Meera P,Stoilov P,Shiue L,O'Brien JE,Meisler MH,Ares M Jr,Otis TS,Black DL

更新日期：2012-03-01 00:00:00

abstract：:To determine whether 9-cis retinoic acid receptors (RXRs) regulate the biological activity of all-trans retinoic acid (tRA) and its receptors (RARs) in skin, we have targeted a dominant-negative RXR alpha (dnRXR alpha) lacking transactivation function AF-2 to differentiated suprabasal keratinocytes in the epidermis of...

journal_title：Genes & development

authors： Feng X,Peng ZH,Di W,Li XY,Rochette-Egly C,Chambon P,Voorhees JJ,Xiao JH

更新日期：1997-01-01 00:00:00

abstract：:Alu repetitive sequences are the most abundant short interspersed DNA elements in the human genome. Full-length Alu elements are composed of two tandem sequence monomers, the left and right Alu arms, both derived from the 7SL signal recognition particle RNA. Since Alu elements are common in protein-coding genes, they ...

journal_title：Genes & development

authors： Jády BE,Ketele A,Kiss T

更新日期：2012-09-01 00:00:00

abstract：:In this issue of Genes & Development, Abruzzi et al. (pp. 2374-2386) use chromatin immunoprecipitation (ChIP) tiling array assays (ChIP-chip) to show that physical interactions between circadian (≅24-h) clock machineries and genomes are more widespread than previously thought and provide novel insights into how clocks...

journal_title：Genes & development

authors： Edery I

更新日期：2011-11-15 00:00:00

abstract：:Activated transcription by RNA polymerase II (Pol II) requires coactivators, one of which is the SRB/mediator. Whereas Srb4, an essential subunit of the SRB/mediator, is broadly required for Pol II transcription in yeast, we have shown that it is dispensable for the transcriptional activation of some genes. Here, we s...

journal_title：Genes & development

authors： Lee DK,Kim S,Lis JT

更新日期：1999-11-15 00:00:00