Isolation, structure, and expression of labial, a homeotic gene of the Antennapedia Complex involved in Drosophila head development.

abstract：:Expression of both N-myc and c-myc is induced rapidly and dramatically in normal pre-B cells after stimulation with interleukin-7 (IL-7), a pre-B cell-specific growth factor. These IL-7-induced increases in N-myc and c-myc expression are mediated at the transcriptional level; for N-myc, a major portion of the inductio...

journal_title：Genes & development

authors： Morrow MA,Lee G,Gillis S,Yancopoulos GD,Alt FW

更新日期：1992-01-01 00:00:00

abstract：:The reelin (reln) and disabled 1 (dab1) genes both ensure correct neuronal positioning during brain development. We have found that the intracellular Dab1 protein receives a tyrosine phosphorylation signal from extracellular Reln protein. Genetic analysis shows that reln function depends on dab1, and vice versa, as ex...

journal_title：Genes & development

authors： Howell BW,Herrick TM,Cooper JA

更新日期：1999-03-15 00:00:00

abstract：:Histone methylation plays an important role in regulating gene expression. One such methylation occurs at Lys 79 of histone H3 (H3K79) and is catalyzed by the yeast DOT1 (disruptor of telomeric silencing) and its mammalian homolog, DOT1L. Previous studies have demonstrated that germline disruption of Dot1L in mice res...

journal_title：Genes & development

authors： Nguyen AT,Xiao B,Neppl RL,Kallin EM,Li J,Chen T,Wang DZ,Xiao X,Zhang Y

更新日期：2011-02-01 00:00:00

abstract：:The C-terminal domain of the Escherichia coli RNA polymerase (RNAP) alpha subunit (alphaCTD) stimulates transcription initiation by interacting with upstream (UP) element DNA and a variety of transcription activators. Here we identify specific substitutions in region 4.2 of sigma 70 (sigma(70)) and in alphaCTD that de...

journal_title：Genes & development

authors： Ross W,Schneider DA,Paul BJ,Mertens A,Gourse RL

更新日期：2003-05-15 00:00:00

abstract：:Cytosolic RNA/DNA sensing elicits primary defense against viral pathogens. Interferon regulatory factor 3 (IRF3), a key signal mediator/transcriptional factor of the antiviral-sensing pathway, is indispensible for interferon production and antiviral defense. However, how the status of IRF3 activation is controlled rem...

journal_title：Genes & development

authors： Meng F,Zhou R,Wu S,Zhang Q,Jin Q,Zhou Y,Plouffe SW,Liu S,Song H,Xia Z,Zhao B,Ye S,Feng XH,Guan KL,Zou J,Xu P

更新日期：2016-05-01 00:00:00

abstract：:Human TFIIA activity is composed of three subunits (alpha, beta, gamma). Here we report the isolation of a human cDNA clone encoding the gamma-subunit and the reconstitution of TFIIA activity from recombinant polypeptides (holo-TFIIA). Protein-protein interaction analysis established that the beta and gamma subunits o...

journal_title：Genes & development

authors： Sun X,Ma D,Sheldon M,Yeung K,Reinberg D

更新日期：1994-10-01 00:00:00

abstract：:Start sites of DNA replication are marked by the origin recognition complex (ORC), which coordinates Mcm2-7 helicase loading to form the prereplicative complex (pre-RC). Although pre-RC assembly is well characterized in vitro, the process is poorly understood within the local chromatin environment surrounding replicat...

journal_title：Genes & development

authors： Belsky JA,MacAlpine HK,Lubelsky Y,Hartemink AJ,MacAlpine DM

更新日期：2015-01-15 00:00:00

abstract：:Treatment of early Xenopus embryos with retinoic acid (RA) produces a concentration-dependent series of defects in anterior axial structures that range from small deletions to embryos lacking heads. The graded series of axial defects obtained after RA administration to early embryos appears to result, in part, from ac...

journal_title：Genes & development

authors： Ruiz i Altaba A,Jessell T

更新日期：1991-02-01 00:00:00

abstract：:The product of the nuclear MRS2 gene, Mrs2p, is the only candidate splicing factor essential for all group II introns in mitochondria of the yeast Saccharomyces cerevisiae. It has been shown to be an integral protein of the inner mitochondrial membrane, structurally and functionally related to the bacterial CorA Mg(2+...

journal_title：Genes & development

authors： Gregan J,Kolisek M,Schweyen RJ

更新日期：2001-09-01 00:00:00

abstract：:The mechanisms that control energy homeostasis and tissue growth during development are closely linked through the insulin signal transduction pathway. Changes in the level of insulin and other hormones reflect the nutritional status of the animal to control circulating sugar levels and fat metabolism. Systemic defect...

journal_title：Genes & development

authors： Teleman AA,Maitra S,Cohen SM

更新日期：2006-02-15 00:00:00

abstract：:We identify the "M region" of the muscle-specific Xenopus cardiac actin gene promoter from -282 to -348 as necessary for the embryonic expression of a cardiac actin-beta-globin reporter gene injected into fertilized eggs. Four DNA-binding activities in embryo extracts, embryonic M-region factors 1-4 (EMF1-4), are desc...

journal_title：Genes & development

authors： Taylor MV,Gurdon JB,Hopwood ND,Towers N,Mohun TJ

更新日期：1991-07-01 00:00:00

abstract：:The circadian rhythm of pineal melatonin requires the nocturnal increment of serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase [AANAT]) protein. To date, only limited information is available in the critical issue of how AANAT protein expression is up-regulated exclusively at night regardless of its sp...

journal_title：Genes & development

authors： Kim TD,Woo KC,Cho S,Ha DC,Jang SK,Kim KT

更新日期：2007-04-01 00:00:00

abstract：:Estrogen receptor α (ER) is the major driver of ∼75% of breast cancers, and multiple ER targeting drugs are routinely used clinically to treat patients with ER+ breast cancer. However, many patients relapse on these targeted therapies and ultimately develop metastatic and incurable disease, and understanding the mecha...

journal_title：Genes & development

authors： Siersbæk R,Kumar S,Carroll JS

更新日期：2018-09-01 00:00:00

abstract：:The SNF1 protein kinase is broadly conserved in eukaryotes and has been implicated in responses to environmental and nutritional stress. In yeast, the SNF1 kinase has a central role in the response to glucose starvation. SNF1 is associated with its activating subunit, SNF4, and other proteins in complexes. Using the t...

journal_title：Genes & development

authors： Jiang R,Carlson M

更新日期：1996-12-15 00:00:00

abstract：:We report a systematic mutational analysis of the helix-turn-helix motif (HTH) of the fushi tarazu (ftz) homeo domain (HD) of Drosophila. We started out by testing the function of chimeric ftz proteins containing either a part of the Sex combs reduced (Scr) or the muscle segment homeobox (msh) HDs. By complementation ...

journal_title：Genes & development

authors： Furukubo-Tokunaga K,Müller M,Affolter M,Pick L,Kloter U,Gehring WJ

更新日期：1992-06-01 00:00:00

abstract：:Dosage compensation in Drosophila occurs by a twofold increase in transcription per copy of X-linked genes in males (XY) compared with females (XX). msl-1 is one of four genes that are essential for dosage compensation in males, and MSL-1 protein is associated specifically with the male X chromosome. To explore the ba...

journal_title：Genes & development

authors： Palmer MJ,Richman R,Richter L,Kuroda MI

更新日期：1994-03-15 00:00:00

abstract：:Although Apc is well characterized as a tumor-suppressor gene in the intestine, the precise mechanism of this suppression remains to be defined. Using a novel inducible Ahcre transgenic line in conjunction with a loxP-flanked Apc allele we, show that loss of Apc acutely activates Wnt signaling through the nuclear accu...

journal_title：Genes & development

authors： Sansom OJ,Reed KR,Hayes AJ,Ireland H,Brinkmann H,Newton IP,Batlle E,Simon-Assmann P,Clevers H,Nathke IS,Clarke AR,Winton DJ

更新日期：2004-06-15 00:00:00

abstract：:The hair follicle undergoes a lifelong developmental cycle that depends on the integration between activating and inhibitory signals acting to regulate and guide the proliferation and differentiation of pluripotent epithelial stem cells. The effectors and mechanisms responsible for re-entry of quiescent telogen hair f...

journal_title：Genes & development

authors： Coulombe PA,Caterina MJ

更新日期：2013-06-15 00:00:00

abstract：:Codon usage bias is a universal feature of all genomes, but its in vivo biological functions in animal systems are not clear. To investigate the in vivo role of codon usage in animals, we took advantage of the sensitivity and robustness of the Drosophila circadian system. By codon-optimizing parts of Drosophila period...

journal_title：Genes & development

authors： Fu J,Murphy KA,Zhou M,Li YH,Lam VH,Tabuloc CA,Chiu JC,Liu Y

更新日期：2016-08-01 00:00:00

abstract：:The eukaryotic ribosomal RNA (rRNA) is associated cotranscriptionally with numerous factors into an enormous 90S preribosomal particle that conducts early processing of small ribosomal subunits. The assembly pathway and structure of the 90S particle is poorly understood. Here, we affinity-purified and analyzed the con...

journal_title：Genes & development

authors： Zhang L,Wu C,Cai G,Chen S,Ye K

更新日期：2016-03-15 00:00:00

abstract：:Cellular senescence limits proliferation of potentially detrimental cells, preventing tumorigenesis and restricting tissue damage. However, the function of senescence in nonpathological conditions is unknown. We found that the human placental syncytiotrophoblast exhibited the phenotype and expressed molecular markers ...

journal_title：Genes & development

authors： Chuprin A,Gal H,Biron-Shental T,Biran A,Amiel A,Rozenblatt S,Krizhanovsky V

更新日期：2013-11-01 00:00:00

abstract：:We describe here a new murine homeo box gene, denoted Hlx, which is expressed within specific hematopoietic lineages. The cDNA sequence indicates that Hlx differs markedly from known vertebrate homeo box genes, and linkage analysis of an interspecific murine backcross showed that it resides at a novel homeo box locus ...

journal_title：Genes & development

authors： Allen JD,Lints T,Jenkins NA,Copeland NG,Strasser A,Harvey RP,Adams JM

更新日期：1991-04-01 00:00:00

abstract：:Lipids play crucial roles in many aspects of glial cell biology, affecting processes ranging from myelin membrane biosynthesis to axo-glial interactions. In order to study the role of lipid metabolism in myelinating glial cells, we specifically deleted in Schwann cells the Lpin1 gene, which encodes the Mg2+-dependent ...

journal_title：Genes & development

authors： Nadra K,de Preux Charles AS,Médard JJ,Hendriks WT,Han GS,Grès S,Carman GM,Saulnier-Blache JS,Verheijen MH,Chrast R

更新日期：2008-06-15 00:00:00

abstract：:In eubacteria, the ClpS adaptor has been proposed to be essential for degradation of N-end rule substrates by the AAA(+) protease ClpAP. To test this model, we assayed degradation of substrates bearing N-end rule sequences isolated in a genetic screen for efficient degradation tags. ClpS was not vital for degradation ...

journal_title：Genes & development

authors： Wang KH,Sauer RT,Baker TA

更新日期：2007-02-15 00:00:00

abstract：:Multiple congenital disorders often present complex phenotypes, but how the mutation of individual genetic factors can lead to multiple defects remains poorly understood. In the present study, we used human neuroepithelial (NE) cells and CHARGE patient-derived cells as an in vitro model system to identify the function...

journal_title：Genes & development

authors： Chai M,Sanosaka T,Okuno H,Zhou Z,Koya I,Banno S,Andoh-Noda T,Tabata Y,Shimamura R,Hayashi T,Ebisawa M,Sasagawa Y,Nikaido I,Okano H,Kohyama J

更新日期：2018-01-15 00:00:00

abstract：:The association of proteins with the branch site region during pre-mRNA splicing was probed using a novel methodology to site-specifically modify the pre-mRNA with the photo-reagent benzophenone. Three sets of proteins were distinguished by the kinetics of their associations with pre-mRNAs, by their association with d...

journal_title：Genes & development

authors： MacMillan AM,Query CC,Allerson CR,Chen S,Verdine GL,Sharp PA

更新日期：1994-12-15 00:00:00

abstract：:Although the human U2 and U6 snRNA genes are transcribed by different RNA polymerases (i.e., RNA polymerases II and III, respectively), their promoters are very similar in structure. Both contain a proximal sequence element (PSE) and an octamer motif-containing enhancer, and these elements are interchangeable between ...

journal_title：Genes & development

authors： Lobo SM,Lister J,Sullivan ML,Hernandez N

更新日期：1991-08-01 00:00:00

abstract：:Genomic imprinting is essential for mammalian development. Recent studies have revealed that maternal histone H3 Lys27 trimethylation (H3K27me3) can mediate DNA methylation-independent genomic imprinting. However, the regulatory mechanisms and functions of this new imprinting mechanism are largely unknown. Here we dem...

journal_title：Genes & development

authors： Inoue A,Chen Z,Yin Q,Zhang Y

更新日期：2018-12-01 00:00:00

abstract：:The mitotic kinase Aurora A (Aur-A) is required for formation of a bipolar mitotic spindle and accurate chromosome segregation. In somatic cells, Aur-A protein and kinase activity levels peak during mitosis, and Aur-A is degraded during mitotic exit. Here, we investigated how Aur-A protein and kinase activity levels a...

journal_title：Genes & development

authors： Littlepage LE,Ruderman JV

更新日期：2002-09-01 00:00:00

abstract：:During embryonic development in vertebrates, the endoderm becomes patterned along the anteroposterior axis to produce distinct derivatives. How this regulation is controlled is not well understood. We report that the zebrafish hairy/enhancer of split [E(spl)]-related gene her5 plays a critical role in this process. At...

journal_title：Genes & development

authors： Bally-Cuif L,Goutel C,Wassef M,Wurst W,Rosa F

更新日期：2000-07-01 00:00:00