Anticonvulsant drug-induced osteomalacia: alterations in mineral metabolism and response to vitamin D3 administration.

abstract：:Little is known about hypoxia-induced modification of the canal network in the cortical bone despite its involvement in intracortical vascularity and bone blood supply. In this study, we examined the effect of chronic hypoxia on the canal network in postnatal bone. Tibiae were harvested from 4- and 8-week-old rats (hy...

journal_title：Calcified tissue international

authors： Matsumoto T,Ando N,Tomii T,Uesugi K

更新日期：2011-01-01 00:00:00

abstract：:Toxicological studies have demonstrated that intermittent PTH1-34 treatment is associated with an increased incidence of osteosarcoma in Fischer 344 rats. Comet and micronucleus (MN) tests, standard methods to evaluate genotoxic potential of drugs, were used to detect DNA and chromosome breaks, respectively, after PTH...

journal_title：Calcified tissue international

authors： Alves de Oliveira EC,Szejnfeld VL,Pereira da Silva N,Coelho Andrade LE,Heldan de Moura Castro C

更新日期：2010-11-01 00:00:00

abstract：:This cross-sectional, observational study was designed to identify clinical risk factors of osteoporosis and fractures in Korean women to validate the probability of osteoporosis and subsequent fractures. A total of 1541 Korean women were recruited nationally. Fracture history of any site, risk factors of osteoporosis...

journal_title：Calcified tissue international

authors： Kim YM,Hyun NR,Shon HS,Kim HS,Park SY,Park IH,Chung YS,Jung HG,Kim DH,Lim SK

更新日期：2008-12-01 00:00:00

abstract：:Proline biosynthetic and degradative enzymes are unevenly distributed in differentiated mammalian tissues. Activities of the synthetic enzymes are relatively high in collagenous tissues, whereas activities of the degradative enzymes are high in noncollagenous tissues. In order to further characterize tissue-specific p...

journal_title：Calcified tissue international

authors： Smith RJ,Reddi AH,Phang JM

更新日期：1979-07-03 00:00:00

abstract：:The aim of this study was to analyze the efficacy of using rhBMP-2 (recombinant human morphogenetic protein-2) in the treatment of patients with cleft lip and palate defects (CLPD). Seven databases were screened: PubMed (Medline), Lilacs, Ibecs, Web of Science, BBO, Scopus, and The Cochrane Library. Clinical trials th...

journal_title：Calcified tissue international

authors： da Rosa WLO,da Silva TM,Galarça AD,Piva E,da Silva AF

更新日期：2019-02-01 00:00:00

abstract：:The current study is based on our earlier investigation carried out in 1999, where bone mineral density (BMD) of 35 neurofibromatosis type 1 (NF1) patients was measured and osteoporosis was shown to be common in NF1. The findings have been confirmed by a number of later publications. The purpose of the current longitu...

journal_title：Calcified tissue international

authors： Heervä E,Leinonen P,Kuorilehto T,Peltonen S,Pöyhönen M,Väänänen K,Peltonen J

更新日期：2013-01-01 00:00:00

abstract：:Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA levels are commonly used as an internal control to normalize gene expression data based on the belief that this gene is constitutively expressed. However, GAPDH mRNA levels increased by more than 2.5-fold in tibiae of hindlimb unloaded female rats compared to L32 m...

journal_title：Calcified tissue international

authors： Maran A,Hefferan TE,Zhang M,Turner RT

更新日期：2004-02-01 00:00:00

abstract：:In humans, gastric surgery results in in osteopenia via mechanisms that are insufficiently understood; surgery-induced changes in the hormonal axes involving the stomach, thyroid, and the parathyroids may play a role. To study this in more detail, we evaluated calcium (Ca), magnesium (Mg), and phosphorus (P) metabolis...

journal_title：Calcified tissue international

authors： Rümenapf G,Schwille PO,Erben RG,Schreiber M,Bergé B,Fries W,Schmiedl A,Koroma S,Hohenberger W

更新日期：1998-11-01 00:00:00

abstract：:A 69-year-old man became hypocalcemic under medical observation. The hypocalcemia occurred in the presence of circulating immunoreactive parathyroid hormone (PTH). Common causes of secondary hyperparathyroidism were excluded, as was PTH resistance using PTH infusions. The immunoreactive PTH was examined in detail. PTH...

journal_title：Calcified tissue international

authors： McElduff A,Lackmann M,Wilkinson M

更新日期：1992-08-01 00:00:00

abstract：:The effect of teriparatide treatment on microdamage accumulation has yet to be examined in animal studies. The purpose of this study was to investigate the effect of once-weekly teriparatide treatment on bone microdamage accumulation and the relationship between microdamage parameters and bone mass, architecture, turn...

journal_title：Calcified tissue international

authors： Yoshitake S,Mashiba T,Saito M,Fujihara R,Iwata K,Takao-Kawabata R,Yamamoto T

更新日期：2019-04-01 00:00:00

abstract：:We compared the cytotoxic effects of alendronate (ALN) and incadronate (YM175) on isolated rabbit osteoclasts in vitro and on rats in vivo. In the in vitro experiment, each bisphosphonate was added to the culture of isolated osteoclasts at the final concentration of 3 x 10(-5), 3 x 10(-4), or 3 x 10(-3) M, and the amo...

journal_title：Calcified tissue international

authors： Ito M,Chokki M,Ogino Y,Satomi Y,Azuma Y,Ohta T,Kiyoki M

更新日期：1998-08-01 00:00:00

abstract：:Syndesmophyte occurrence and axial bone loss were investigated in the heterozygous Tg187 tumor necrosis factor (TNF) transgenic mouse model (Tg-huTNF) of arthritis. Female and male Tg-huTNF mice were compared to wild-type mice (WT) at 2, 4, 6, 8, and 10 weeks. Syndesmophytes, intervertebral disc space, osteoclasts, os...

journal_title：Calcified tissue international

authors： Courbon G,Flammier S,Laroche N,Vico L,Marotte H,Coury F

更新日期：2017-06-01 00:00:00

abstract：:Mononuclear phagocytes have been implicated as important cellular elements in the process of bone resorption. We have postulated that the recruitment and migration of mononuclear phagocytes to bone occurs via a mechanism(s) in which bone-derived chemotactic factors (BDCF) are released from foci undergoing resorption. ...

journal_title：Calcified tissue international

authors： Minkin C,Bannon DJ Jr,Pokress S

更新日期：1985-01-01 00:00:00

abstract：:Human osteoblasts were obtained by migration and proliferation of cells from embryonic membranous bone on glass fragments. Light and electron microscopy analyses revealed a typical osteoblast-like appearance with high protein synthesis activity. The cells showed high alkaline phosphatase activity that was associated w...

journal_title：Calcified tissue international

authors： Oliva A,Marrone G,Della Ragione F,Riccio V,Palumbo R,Rossano F,Zappia V

更新日期：1992-11-01 00:00:00

abstract：:The goals of internal fixation are an accurate reduction and stable fixation in the presence of adequate bony vascularity. This can be achieved by a variety of means including plate fixation. A certain amount of periosteal stripping is necessary for proper open reduction of a fracture and for proper plate application....

journal_title：Calcified tissue international

authors： Kowalski MJ,Schemitsch EH,Kregor PJ,Senft D,Swiontkowski MF

更新日期：1996-07-01 00:00:00

abstract：:Extracellular ATP, and to a lesser extent adenosine, an ATP metabolite, stimulated cell proliferation in osteoblast-like cells (MC3T3-E1). ATP increased cytosolic Ca2+ due to Ca2+ mobilization from intracellular storage in the same concentration range of the nucleotide as that effective for DNA synthesis, suggesting t...

journal_title：Calcified tissue international

authors： Shimegi S

更新日期：1996-02-01 00:00:00

abstract：:Diets with a high saturated fat content can produce deleterious effects on the absorption of dietary calcium and consequently an adverse effect on bone mineralization in growing animals. Hence dietary fat may have long-term consequences for skeletal health and skeletal pathologies such as osteoporosis. Whether a diet ...

journal_title：Calcified tissue international

authors： Wohl GR,Loehrke L,Watkins BA,Zernicke RF

更新日期：1998-07-01 00:00:00

abstract：:Pleiotrophin (PTN) was found to have potent effects on regulation of osteoblast recruitment, proliferation and differentiation. The present study examined the long-term effects of targeted PTN over-expression on bone development and repair in a transgenic mouse model. Femurs and tibiae from the PTN transgenic mice and...

journal_title：Calcified tissue international

authors： Li G,Bunn JR,Mushipe MT,He Q,Chen X

更新日期：2005-04-01 00:00:00

abstract：:Noncarious cervical lesions have a multifactorial etiology. Mechanical stress has been identified as one of the factors, but little evidence exists for its cause-effect relationship. This study was conducted at three different pH levels to observe the surface loss on dentin beams under tension and compression. Bovine ...

journal_title：Calcified tissue international

authors： Mishra P,Palamara JE,Tyas MJ,Burrow MF

更新日期：2006-12-01 00:00:00

abstract：:The gut microbiota (GM) is the whole of commensal, symbiotic, and pathogenic microorganisms living in our intestine. The GM-host interactions contribute to the maturation of the host immune system, modulating its systemic response. It is well documented that GM can interact with non-enteral cells such as immune cells,...

journal_title：Calcified tissue international

authors： D'Amelio P,Sassi F

更新日期：2018-04-01 00:00:00

abstract：:X-linked hypophosphatemia (XLH) is a rare, inheritable disorder manifesting as rickets in children and osteomalacia in adults. While conventional medical treatment with oral phosphate and alfacalcidol is recommended in childhood, it is undecided whether adults should continue therapy. The aim of this 6-year prospectiv...

journal_title：Calcified tissue international

authors： Shanbhogue VV,Hansen S,Jørgensen NR,Beck-Nielsen SS

更新日期：2018-03-01 00:00:00

abstract：:Calcium deficiency is a major etiological determinant of rickets in Nigerian children and is accompanied by undermineralization of the developing bone matrix which is composed largely of type I collagen. We have assessed types I and III collagen metabolism by measuring the circulating concentrations of teh N- and C-te...

journal_title：Calcified tissue international

authors： Sharp CA,Oginni LM,Worsfold M,Oyelami OA,Risteli L,Risteli J,Davie MW

更新日期：1997-08-01 00:00:00

abstract：:A strategy based on high pressure liquid chromatography (HPLC) techniques for the isolation or a principal amelogenin molecule from a single human dentition is described. A partial sequence (33 residues) for this 24 kDa amelogenin is presented and related to earlier studies of human 5 kDa tyrosine-rich amelogenin poly...

journal_title：Calcified tissue international

authors： Fincham AG,Hu YY,Lau E,Pavlova Z,Slavkin HC,Snead ML

更新日期：1990-08-01 00:00:00

abstract：:Thyroparathyroidectomized rats fed a diet containing 1.2% calcium, 0.55% phosphorus maintain normal serum levels of these ions. Treatment of such rats with parathyroid extract (PTE; 20 U/100 g twice daily; 10 days) has no statistically significant effect on rates of bone formation, matrix apposition, or osteoid matura...

journal_title：Calcified tissue international

authors： Rader JI,Howard GA,Feist E,Turner RT,Baylink DJ

更新日期：1979-11-01 00:00:00

abstract：:Normal rat bone maturation has been studied using biochemical methods and hydrazine separation of matrix and mineral for X-ray diffraction. In the bone, the amount of mineral increases between 4 and 22 weeks of age, while in the matrix, the ratio of noncollagenous protein to collagen progressively decreases. In minera...

journal_title：Calcified tissue international

authors： Burnell JM,Teubner EJ,Miller AG

更新日期：1980-01-01 00:00:00

abstract：:The definition of osteoporosis was based for several years on bone mineral density values, which were used by most guidelines for defining treatment thresholds. The availability of tools for the estimation of fracture risk, such as FRAX™ or its adapted Italian version, DeFRA, is providing a way to grade osteoporosis s...

journal_title：Calcified tissue international

authors： Adami S,Bertoldo F,Gatti D,Minisola G,Rossini M,Sinigaglia L,Varenna M

更新日期：2013-09-01 00:00:00

abstract：:Vitamin D supplements are often recommended to restore sufficiency, although the adherence to treatment is low. This study assessed vitamin D status at different time intervals following the cessation of treatment. The database of Clalit-Health-Services (CHS), a not-for-profit HMO covering more than half of the Israel...

journal_title：Calcified tissue international

authors： Saliba W,Barnett O,Rennert HS,Lavi I,Rennert G

更新日期：2011-11-01 00:00:00

abstract：:The evidence now strongly supports a central role for oestrogen in the maintenance of the normal female skeleton. Loss of endogenous oestrogen leads to a period of accelerated bone loss which can be prevented with appropriate oestrogen replacement. The route of administration is not important provided adequate dosages...

journal_title：Calcified tissue international

authors： Hillard TC,Stevenson JC

更新日期：1991-01-01 00:00:00

abstract：:Identifying persons with a high risk of osteoporotic fractures remains a challenge. DXA uptake in women with elevated risk of osteoporosis seems to be depending on distance to scanning facilities. This study aimed to investigate the ability of a small portable scanner in identifying women with reduced bone mineral den...

journal_title：Calcified tissue international

authors： Holmberg T,Bech M,Gram J,Hermann AP,Rubin KH,Brixen K

更新日期：2016-03-01 00:00:00

abstract：:The bone mineral density (BMD) of the spine was measured in the posteroanterior (PA) and lateral projections as well as the total body BMD in 447 black and white women. The lateral projection is comprised predominantly of cancellous bone whereas the total body BMD is predominantly cortical bone, and the PA spine is in...

journal_title：Calcified tissue international

authors： Aloia JF,Vaswani A,Mikhail M,Badshah M,Flaster E

更新日期：1999-07-01 00:00:00