Abstract：
:Identifying persons with a high risk of osteoporotic fractures remains a challenge. DXA uptake in women with elevated risk of osteoporosis seems to be depending on distance to scanning facilities. This study aimed to investigate the ability of a small portable scanner in identifying women with reduced bone mineral density (BMD), and to define triage thresholds for pre-selection. Total hip and lumbar spine BMD was measured by dual-energy X-ray absorptiometry and phalangeal BMD by radiographic absorptiometry in 121 Danish women with intermediate or high 10-year fracture probability (aged 61-81 years). Correlation between the two methods was estimated using correlation coefficient (r) and Bland-Altman plots. A moderate correlation between phalangeal BMD versus total hip (r = 0.47) and lumbar spine (r = 0.51), and an AUC on 0.80 was found. The mean difference between phalangeal T score and total hip T score/lumbar spine T score was low, and ranged from -0.26 SD to -0.31 SD depending on site and reference database used for calculation of T scores, but, large variation was seen at an individual level. When applying a triage approach approx. one-third of all DXA scan could be avoided and only 6 % of women in the low-risk group would be false negatives.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Holmberg T,Bech M,Gram J,Hermann AP,Rubin KH,Brixen Kdoi
10.1007/s00223-015-0084-4subject
Has Abstractpub_date
2016-03-01 00:00:00pages
244-52issue
3eissn
0171-967Xissn
1432-0827pii
10.1007/s00223-015-0084-4journal_volume
98pub_type
杂志文章,随机对照试验abstract：:The perilacunar areas of low mineral density in microradiographs from cortical bone of patients with hypophosphatemic (vitamin D-resistant) rickets are not evenly distributed throughout the bone tissue. Their frequency and distribution were determined in bone from 9 patients with this disease. It was found that the le...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02441169
更新日期：1979-04-17 00:00:00
abstract：:Age-related loss of skeletal muscle is associated with increased risk of functional limitation and cardiovascular (CV) mortality. In the elderly abdominal aortic calcification (AAC) can increase CV risk by altering aortic properties which may raise blood pressure and increase cardiac workload. This study investigated ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-016-0157-z
更新日期：2016-10-01 00:00:00
abstract：:Our objective was to assess the effects of HIV infection and antiretroviral therapy on trabecular and cortical microarchitecture in postmenopausal minority women. A subgroup of 106 (46 HIV-infected, 60 uninfected) postmenopausal Hispanic and African American women from an established cohort had areal bone mineral dens...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-013-9716-8
更新日期：2013-06-01 00:00:00
abstract：:The aim of this study was to investigate the effect of transplanted chondrocytes on endochondral bone formation in cartilage repair tissue. In the knee joint of miniature pigs, cartilage lesions were treated by microfracturing and were then either left empty, covered with a collagen membrane, or treated by matrix-asso...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-009-9288-9
更新日期：2009-11-01 00:00:00
abstract：:Primary cilia are responsible for sensing mechanical loading in osteocytes. However, the underlying working mechanism of cilia remains elusive. An osteocyte model is necessary to reveal the role of cilia. Furthermore, the osteocyte model should be with upregulated or downregulated primary cilium expression. Herein, we...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-020-00756-6
更新日期：2020-12-01 00:00:00
abstract：:Although hypogonadism is a risk factor for bone loss and fractures, the different etiopathophysiology and hormonal profile of classical and obesity-induced hypogonadism may lead to differences in musculoskeletal profile. This is a cross-sectional study of hypogonadal men between 40 and 74 years old. Our outcomes inclu...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-017-0316-x
更新日期：2017-12-01 00:00:00
abstract：:Icariin, the main constituent of Herba Epimedii, appears to be a promising alternative to classic drugs used to treat osteoporosis. However, the detailed molecular mechanisms of its action and the role of icariin in the cross-talk between osteoblasts and adipocytes remain unclear. The present study was designed to inv...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-016-0138-2
更新日期：2016-08-01 00:00:00
abstract：:The aim of our study was to compare the results provided by the measurement of vertebral and femoral bone mineral density (BMD) for assessing the individual risk of osteoporosis as defined by either low BMD and/or rapid bone loss. Vertebral and femoral BMD were measured twice at a mean interval of 21 months in 85 norm...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00310196
更新日期：1993-05-01 00:00:00
abstract：:The primary aim of the project was to determine the combined effect of whole-body electromyostimulation (WB-EMS) and protein supplements on local and overall muscle/fat distribution in older man with sarcopenic obesity (SO). Community-dwelling (cdw) men ≥ 70 years with SO were randomly allocated to a WB-EMS and protei...
journal_title：Calcified tissue international
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00223-018-0424-2
更新日期：2018-09-01 00:00:00
abstract：:Vit-D-Dependent calcium binding protein and parvalbumin have both been detected in ameloblasts and calcified cartilage by immunohistochemical techniques. These two Ca2+ binding proteins may play a crucial role in the local accumulation of Ca2+ ions during the process of mineralization. The mechanisms underlying the de...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02405306
更新日期：1984-01-01 00:00:00
abstract：:Pleiotrophin (PTN) was found to have potent effects on regulation of osteoblast recruitment, proliferation and differentiation. The present study examined the long-term effects of targeted PTN over-expression on bone development and repair in a transgenic mouse model. Femurs and tibiae from the PTN transgenic mice and...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-004-0145-6
更新日期：2005-04-01 00:00:00
abstract：:Thyroparathyroidectomized rats fed a diet containing 1.2% calcium, 0.55% phosphorus maintain normal serum levels of these ions. Treatment of such rats with parathyroid extract (PTE; 20 U/100 g twice daily; 10 days) has no statistically significant effect on rates of bone formation, matrix apposition, or osteoid matura...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02408051
更新日期：1979-11-01 00:00:00
abstract：:In adult human bone, fluoride uptake is accompanied by an increase in apatite crystal size. This increase, however, is not isotropic but is restricted primarily to growth in width and/or thickness, with no measurable change in length. In the present study, seeded growth experiments were conducted in vitro to determine...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900522
更新日期：1998-09-01 00:00:00
abstract：:Seventy-two eugonadal women, mean age 39 +/- 4 years, with a z score for total body bone mineral content (BMC) of less than -1.5 (mean -1.80 +/- 0.12) were selected from a previous screening study of normal values of total body and regional BMC in women using dual-energy X-ray absorptiometry. The women were distribute...
journal_title：Calcified tissue international
pub_type： 临床试验,杂志文章
doi：10.1007/BF00334327
更新日期：1994-06-01 00:00:00
abstract：:The primary objective of the present study was to evaluate the impact of physical activity and muscle strength on bone mineral density (BMD) of the tuberositas tibiae in adolescent boys. Two groups with different exercise levels were compared. The high activity group consisted of 20 subjects (age 15.9 +/- 0.3) from a ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02509438
更新日期：1996-06-01 00:00:00
abstract：:ATP is as effective as inorganic pyrophosphate in retarding the rate of dissolution of calcium hydroxyapatite at pH 7, ADP is less effective, and AMP is without effect. The inhibition is due to the adsorption of ATP and ADP units on the crystal surface. ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02405386
更新日期：1984-12-01 00:00:00
abstract：:GNAS is one of the most complex gene loci in the human genome and encodes multiple gene products including Gsα, XLαs, NESP55, A/B, and AS transcripts. XLαs, the extra-large G protein ɑ-subunit, is paternally expressed. XLɑs and Gsɑ share the common 2-13 exons with different promoters and first exons. Therefore, XLɑs c...
journal_title：Calcified tissue international
pub_type： 杂志文章,评审
doi：10.1007/s00223-020-00714-2
更新日期：2020-09-01 00:00:00
abstract：:To assess the usefulness of the measurement of the os calcis by ultrasound, a method that probably reflects bone quality as well as density, we have studied 54 women with hip fracture of the proximal femur and a control group. Ultrasound evaluation of the os calcis [broadband ultrasound attenuation (BUA), speed of the...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00310252
更新日期：1995-09-01 00:00:00
abstract：:The calcium ion binding properties of a high molecular weight bovine phosphophoryn preparation have been studied at high ionic strength (0.5 M KCl as supporting electrolyte). Surprisingly, even under these conditions at which intermolecular ionic interactions are effectively screened, phosphophoryn was capable of bind...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555712
更新日期：1987-02-01 00:00:00
abstract：:This randomized, double-blind study assessed the antifracture efficacy and safety of intermittent intravenous (IV) ibandronate versus oral daily risedronate in Japanese patients with primary osteoporosis. Ambulatory patients aged ≥60 years were randomized to receive 0.5 or 1 mg/month IV ibandronate plus oral daily pla...
journal_title：Calcified tissue international
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00223-013-9734-6
更新日期：2013-08-01 00:00:00
abstract：:Dual photon absorptiometry (DPA) is currently the most widely used method for noninvasive bone mineral density (BMD) measurement of the axial skeleton. Dual energy X-ray absorptiometry (DEXA) is a recently developed technique that uses an X-ray tube as a photon source; it has demonstrated several significant advantage...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02556250
更新日期：1991-11-01 00:00:00
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journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00369209
更新日期：1996-12-01 00:00:00
abstract：:SUMMARY. The high variation often observed in the ex vivo fibroblastic-colony forming unit (CFU-f) assay is likely to be due to both biological and experimental variation. To determine whether we could improve experimental methods we developed an alternative method of bone marrow cell (BMC) isolation employing a centr...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900723
更新日期：1999-11-01 00:00:00
abstract：:Osteocalcin, the gamma-carboxyglutamic acid-containing protein, which is the most abundant noncollagenous protein of bone and dentin, is considered to play roles in bone formation and remodeling. It is unclear how the gamma-carboxyglutamic acid side-chains in osteocalcin coordinate to Ca2+, since the X-ray structure o...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002230010042
更新日期：2001-12-01 00:00:00
abstract：:Radioimmunoassay of the carboxyterminal propeptide of human type I procollagen has been recently introduced to measure in vitro synthesis of type I collagen by osteoblasts and fibroblasts. However, it has not been assessed whether the equivalent results are obtained with this new assay and with tritiated proline incor...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900607
更新日期：1999-03-01 00:00:00
abstract：:It has been suggested that oxidative stress is associated with the pathogenesis of osteoporosis. The objective of this study was to explore the association between a marker of oxidative stress and either bone turnover markers or bone mineral density (BMD) in postmenopausal women. In addition, the effects of oxidative ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-010-9393-9
更新日期：2010-09-01 00:00:00
abstract：:Discarded tissues, like human amniotic membranes and adipose tissue, were investigated for the application of Decellularized Human Amniotic Membrane (DAM) as a viable scaffold for transplantation of Adipose-derived stromal cells (ASCs) in bone regeneration of non-healing calvarial defects in rats. Amniotic membrane wa...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-020-00793-1
更新日期：2021-01-09 00:00:00
abstract：:Polymorphisms in the region of the gene for the vitamin D receptor (VDR) (chromosome 12q12-14) have been associated with differences in bone mineral density (BMD) in some studies but not in others. Because linkage analysis assesses allele sharing identical-by-descent among relatives instead of the association of a par...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002230001175
更新日期：2000-12-01 00:00:00
abstract：:The solubilization of alkaline phosphatase (AP) from osteoblastic cell membranes obtained from human primary bone cell cultures was studied according to the age and sex of the donors (17 females, 11 males; age range: 2-77 years). Cell membranes were treated by non-ionic (n-octyl beta-D-glucopyranoside, OG), ionic or z...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002230050006
更新日期：2000-01-01 00:00:00
abstract：:The effect of SrCl(2) treatment on bone nanostructure in a rat ovariectomy model was studied using scanning small-angle X-ray scattering (sSAXS). Twelve 6-month-old female Wistar rats were used. Six animals were ovariectomized (+ovx) and six were left intact after sham surgery (-ovx). Six animals, three +ovx and three...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-010-9341-8
更新日期：2010-04-01 00:00:00
