Abstract：
:The aim of this study was to analyze the efficacy of using rhBMP-2 (recombinant human morphogenetic protein-2) in the treatment of patients with cleft lip and palate defects (CLPD). Seven databases were screened: PubMed (Medline), Lilacs, Ibecs, Web of Science, BBO, Scopus, and The Cochrane Library. Clinical trials that evaluated the use of bioactive treatment with rhBMP-2 in the treatment of patients with CLPD were included. Statistical analyses were performed by comparing the standardized mean difference of bone formation volume and bone filling percentage (p = 0.05). Ten studies compared the use of rhBMP-2 and iliac crest bone graft (ICBG). The global analysis for bone formation volume and bone filling percentage showed that bioactive materials were similar to ICBG with a standardized mean difference of respectively 0.07 (95% CI - 0.41 to 0.56) and 0.24 (95% CI - 0.32 to 0.80). The available literature suggested that use of rhBMP-2 presented similar bone formation results to those of ICBG in secondary alveolar bone grafting for patients with CLPD.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
da Rosa WLO,da Silva TM,Galarça AD,Piva E,da Silva AFdoi
10.1007/s00223-018-0486-1subject
Has Abstractpub_date
2019-02-01 00:00:00pages
115-129issue
2eissn
0171-967Xissn
1432-0827pii
10.1007/s00223-018-0486-1journal_volume
104pub_type
杂志文章,meta分析abstract：:The purpose of this study was to investigate the mineral induction capacity in vitro of polyanionic proteins covalently bound to a surface. Rat dentin gamma-carboxyglutamate-containing protein of the osteocalcin type (Gla-protein), proteoglycan (PG), and phosphoprotein (PP-H), as well as phosvitin (PhV) and bovine ser...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02553763
更新日期：1989-04-01 00:00:00
abstract：:Acute spinal cord injury is associated with rapid bone loss and an increased risk of fracture. In this double-blind, randomized, placebo-controlled trial, 17 patients were followed for 1 year after administration of either 4 or 5 mg of zoledronic acid or placebo. Bone mineral density (BMD) and structural analyses of t...
journal_title：Calcified tissue international
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00223-007-9012-6
更新日期：2007-05-01 00:00:00
abstract：:The effect of ascorbic acid deficiency on bone metabolism was evaluated using the ascorbate-requiring Osteogenic Disorder Shionogi (ODS) rat model. Ascorbic acid (Asc)-deficient rats gained body weight in a manner similar to Asc-supplemented rats (control) during 3 weeks, but began to lose weight during the 4th week o...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-002-2040-3
更新日期：2003-08-01 00:00:00
abstract：:Humanin (HN), a mitochondrial derived peptide, plays cyto-protective role under various stress. In this study, we aimed to investigate the effects of HNGF6A, an analogue of HN, on osteoblast apoptosis and differentiation and the underlying mechanisms. Cell proliferation of murine osteoblastic cell line MC3TC-E1 was ex...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-020-00660-z
更新日期：2020-05-01 00:00:00
abstract：:Osteoporosis is characterized by low bone mass and a deterioration of bone architecture and likely is influenced by genetic factors. The ovariectomized (OVX) mouse is well suited for osteoporosis research, as shown to date by cross-sectional studies. Here, we investigate longitudinal changes by in vivo micro-computed ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-008-9150-5
更新日期：2008-07-01 00:00:00
abstract：:The calcium ion binding properties of a high molecular weight bovine phosphophoryn preparation have been studied at high ionic strength (0.5 M KCl as supporting electrolyte). Surprisingly, even under these conditions at which intermolecular ionic interactions are effectively screened, phosphophoryn was capable of bind...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555712
更新日期：1987-02-01 00:00:00
abstract：:Two rheumatic syndromes associated with deposition of calcium phosphate crystals in soft tissues of the shoulder have prompted us to study the cellular mechanisms of calcium phosphate crystal solubilization. Synthetic 45Ca labeled calcium phosphate crystal aggregates were solubilized by cultured human fibroblasts or m...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02405384
更新日期：1984-12-01 00:00:00
abstract：:Our objective was to assess the effects of HIV infection and antiretroviral therapy on trabecular and cortical microarchitecture in postmenopausal minority women. A subgroup of 106 (46 HIV-infected, 60 uninfected) postmenopausal Hispanic and African American women from an established cohort had areal bone mineral dens...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-013-9716-8
更新日期：2013-06-01 00:00:00
abstract：:The binding of prostaglandin E2 (PGE2) to bone cells was studied to provide direct evidence for the existence of specific receptors in bone. Bone cells were isolated by collagenase digestion of fetal and newborn rat calvaria. Isolated cells were incubated with 3H-PGE2 and collected on Millipore filters. Specific bindi...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02405038
更新日期：1983-01-01 00:00:00
abstract：:Although treatment with intranasal salmon calcitonin (sCT) has been shown to effectively inhibit postmenopausal bone loss, there is still controversy over both timing and the duration of its application. In an open prospective study, we therefore assessed the effect of shortterm intranasal sCT on postmenopausal bone t...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02508638
更新日期：1996-04-01 00:00:00
abstract：:The effects of long-term running were studied in 20 beagle dogs. Ten dogs ran from the age of 15 weeks to the age of 70 weeks in a progressive program for up to 40 km/day. Ten sister dogs spent the same time in individual cages. At the age of 70 weeks the spines of the dogs were studied with regard to mineral density ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555099
更新日期：1991-01-01 00:00:00
abstract：:The acute-phase response (APR) is a frequent occurrence after infusion of zoledronic acid and is caused by activation of γδ T cells. Vitamin D receptor is expressed in immune cells, and vitamin D has immunomodulatory properties. The aim of this prospective study was to test the effect of vitamin D (cholecalciferol) on...
journal_title：Calcified tissue international
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00223-012-9577-6
更新日期：2012-04-01 00:00:00
abstract：:The effects of a series of novel phosphonates on the kinetics of mineral development in an ionophore-primed 7:2:1 phosphatidylcholine (PC): dicetylphosphate (DCP): cholesterol (Chol) liposomal model system are reported. When present at 2.5 micromol/liter or 25 micromol/liter concentrations in the solution surrounding ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02509384
更新日期：1996-05-01 00:00:00
abstract：:Connective tissue diseases, including osteogenesis imperfecta (OI) and Ehlers-Danlos syndrome (EDS), exhibit a high degree of clinical and genetic heterogeneity. We report two sisters with blue sclerae, joint hypermobility and hearing loss. Whole-exome sequencing identified two compound heterozygous ZNF469 loss-of-fun...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-020-00721-3
更新日期：2020-09-01 00:00:00
abstract：:Several studies have demonstrated that bone has the power of regeneration and repair. BMPs (bone morphogenetic proteins) are involved in the determination of osteoblast phenotype and bone turnover, therefore genes coding for these proteins, like BMP-4, could be considered potential candidate genes for osteoporosis. We...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223001103
更新日期：2000-07-01 00:00:00
abstract：:The influence of the macroscale material properties of bone on its mechanical competence has been extensively investigated, but less is known about possible contributions from bone's nanoscale material properties. These nanoscale properties, particularly the collagen network and the size and shape of hydroxyapatite mi...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-014-9913-0
更新日期：2014-11-01 00:00:00
abstract：:This cross-sectional, observational study was designed to identify clinical risk factors of osteoporosis and fractures in Korean women to validate the probability of osteoporosis and subsequent fractures. A total of 1541 Korean women were recruited nationally. Fracture history of any site, risk factors of osteoporosis...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-008-9182-x
更新日期：2008-12-01 00:00:00
abstract：:The extractions of 85Sr2+, 18F-, sucrose-14C, EDTA-51Cr, and antipyrine-14C in bone were determined by the multiple indicator-dilution method. Fluoride and strontium extractions were 18 to 70% during a single transcapillary passage, and those of EDTA and sucrose were from 11 to 59%, whereas extraction of antipyrine wa...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02407178
更新日期：1980-01-01 00:00:00
abstract：:ATP is as effective as inorganic pyrophosphate in retarding the rate of dissolution of calcium hydroxyapatite at pH 7, ADP is less effective, and AMP is without effect. The inhibition is due to the adsorption of ATP and ADP units on the crystal surface. ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02405386
更新日期：1984-12-01 00:00:00
abstract：:Interleukin (IL)-6 is a bone-resorbing cytokine that acts primarily on osteoclast progenitors to stimulate both proliferation and differentiation. Glucocorticoids (GC) down-regulate IL-6 synthesis in different cell types, including osteoblasts. Given the fact that bone remodeling is a tightly controlled process, it is...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-001-2024-8
更新日期：2001-11-01 00:00:00
abstract：:We have previously shown that cyclosporin A (CsA) produces high bone remodeling with resorption exceeding formation and loss of bone volume in the rat. This may have important clinical implications where CsA is widely used in organ transplantation. 1,25 dihydroxyvitamin D3 (1,25(OH)2D3) is a bone mineralizing hormone ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555980
更新日期：1990-09-01 00:00:00
abstract：:Quantitative trait locus analysis can be used to identify genes critically involved in biological processes. No such analysis has been applied to identifying genes that control bone fracture healing. To determine the feasibility of such an approach, healing of femur fractures was measured between C57BL/6, DBA/2, and C...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-008-9144-3
更新日期：2008-06-01 00:00:00
abstract：:The present study was undertaken to determine the fluoride distribution profile in the rat femur. Male Wistar rats were divided into four groups and given water containing 0, 25, 50, and 100 ppm of fluoride, respectively, for 10 weeks. The fluoride distribution from the periosteum to the endosteum was determined in ea...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555045
更新日期：1990-03-01 00:00:00
abstract：:Sarcopenia and osteoporosis are two sides of the same coin. They represent different aspects of the same age-related process of musculoskeletal atrophy and together culminate in falls, fractures, deconditioning, and increased mortality in older individuals. However, the current therapeutic approach to the prevention o...
journal_title：Calcified tissue international
pub_type： 杂志文章,评审
doi：10.1007/s00223-015-9956-x
更新日期：2015-03-01 00:00:00
abstract：:The small proteoglycan decorin had been localized previously at the d-band in the gap zone of collagen fibrils in nonmineralizing tissues. In bone matrix this zone is proteoglycan free and is at least in some species the place where mineralization along collagen fibrils starts. To study the metabolism of the small pro...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900279
更新日期：1997-06-01 00:00:00
abstract：:The histologic heterogeneity of osteoporosis relative to normal controls has attracted great interest. There has been controversy as to whether patients with high turnover osteoporosis may convert to a normal or low turnover form, and vice versa. We have studied 44 patients over 12 years by dynamic histomorphometry an...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00675620
更新日期：1993-01-01 00:00:00
abstract：:Icariin, the main constituent of Herba Epimedii, appears to be a promising alternative to classic drugs used to treat osteoporosis. However, the detailed molecular mechanisms of its action and the role of icariin in the cross-talk between osteoblasts and adipocytes remain unclear. The present study was designed to inv...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-016-0138-2
更新日期：2016-08-01 00:00:00
abstract：:Enhanced osteoclast formation and function is a fundamental cause of alterations to bone structure and plays an important role in several diseases impairing bone quality. Recent work revealed that TRP calcium channels 3 and 6 might play a special role in this context. By analyzing the bone phenotype of TRPC6-deficient...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-020-00673-8
更新日期：2020-06-01 00:00:00
abstract：:The effect of the degree of carboxylation of osteocalcin (OC) on the properties of bone is unclear. The aim of this study was to relate serum concentrations of total OC (tOC) and undercarboxylated OC (ucOC), measured with a two-site immunoassay, to bone mineral density (BMD) at the femoral neck and ultrasonic transmit...
journal_title：Calcified tissue international
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s002239900432
更新日期：1998-04-01 00:00:00
abstract：:Ipriflavone (i.p.) positively affects bone density in postmenopausal osteoporosis, primarily by inhibiting bone resorption. Using in vitro models of human osteoblast differentiation, we have observed that i.p. and some of its metabolites stimulate the expression of bone sialoprotein, decorin, and type I collagen, and ...
journal_title：Calcified tissue international
pub_type： 杂志文章,评审
doi：10.1007/s002239900378
更新日期：1997-01-01 00:00:00
