Abstract：
:The present study was undertaken to determine the fluoride distribution profile in the rat femur. Male Wistar rats were divided into four groups and given water containing 0, 25, 50, and 100 ppm of fluoride, respectively, for 10 weeks. The fluoride distribution from the periosteum to the endosteum was determined in each specimen after sampling using the abrasive microsampling technique. In the outer circumferential lamellae, the concentration of fluoride was relatively high in the periosteal layer and then decreased gradually towards its interior. In the haversian and interstitial lamellae, it was lower and roughly constant through the tissue. In the inner circumferential lamellae, it rose again to reach the highest level towards the endosteal surface. Fluoride concentration throughout the cortex increased significantly with increasing intake of fluoride. These increases were especially marked at periosteal and endosteal surfaces.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Narita N,Kato K,Nakagaki H,Ohno N,Kameyama Y,Weatherell JAdoi
10.1007/BF02555045subject
Has Abstractpub_date
1990-03-01 00:00:00pages
200-4issue
3eissn
0171-967Xissn
1432-0827journal_volume
46pub_type
杂志文章abstract：:To investigate the effect of low doses of intranasal salmon calcitonin on plasma cyclic AMP (cAMP) and serum ionized calcium, 40 healthy postmenopausal women were randomized to receive a single dose of either placebo or 50, 100, or 200 IU of salmon calcitonin as a nasal spray. Blood samples were collected throughout a...
journal_title：Calcified tissue international
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF02555817
更新日期：1990-01-01 00:00:00
abstract：:The present report compares the effects of different membrane phospholipid (PL)-cholesterol compositions on the kinetics of liposome-mediated formation of calcium phosphates from metastable solutions (2.25 mM CaCl2; 1.5 mM KH2PO4) at 22 degrees C, pH 7.4 and 240 mOsm. In most experiments, the liposomes were composed o...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00296290
更新日期：1992-03-01 00:00:00
abstract：:Magnetic resonance imaging (MRI) is commonly used in the assessment of the musculoskeletal system and associated pathology. The ability of MRI to measure the signals from water and lipid protons enables quantitative measurements of bone porosity. The goal of this investigation was to demonstrate that the density and c...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002230050015
更新日期：2000-01-01 00:00:00
abstract：:Thyroparathyroidectomized rats fed a diet containing 1.2% calcium, 0.55% phosphorus maintain normal serum levels of these ions. Treatment of such rats with parathyroid extract (PTE; 20 U/100 g twice daily; 10 days) has no statistically significant effect on rates of bone formation, matrix apposition, or osteoid matura...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02408051
更新日期：1979-11-01 00:00:00
abstract：:Seventy-two eugonadal women, mean age 39 +/- 4 years, with a z score for total body bone mineral content (BMC) of less than -1.5 (mean -1.80 +/- 0.12) were selected from a previous screening study of normal values of total body and regional BMC in women using dual-energy X-ray absorptiometry. The women were distribute...
journal_title：Calcified tissue international
pub_type： 临床试验,杂志文章
doi：10.1007/BF00334327
更新日期：1994-06-01 00:00:00
abstract：:Several phosphoprotein preparations (phosvitin, rat incisor and fetal calf molar dentin phosphoproteins) all inhibit apatite growth/replication from pre-existing crystal seeds in metastable solutions. Two stages of the crystal growth process were inhibited by these phosphoproteins. First an initial lag period was indu...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02407188
更新日期：1980-01-01 00:00:00
abstract：:Targeted disruption of the c-src gene leads to a severe form of osteopetrosis in mice [2]. As the c-src gene is expressed in all tissues and cells tested, we have analyzed fibroblasts from three individuals with malignant, congenital osteopetrosis for the expression of c-src at the protein level. No differences could ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF01352018
更新日期：1993-07-01 00:00:00
abstract：:The purpose of the present work was to investigate the appearance of ossification centers in human femur by Dual-energy X-ray Absorptiometry (DXA), comparing densitometric data with morphogenetic events. Posteroanterior scans were performed on 31 dried femora (from 11.5 weeks of conceptual age to 1 year of postnatal l...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/pl00005841
更新日期：2000-04-01 00:00:00
abstract：:The relationship between bisphosphonate-induced bone mineral density (BMD) gains and antifracture efficacy remains to be fully elucidated. Data from two antifracture studies were analyzed. Postmenopausal osteoporotic women received oral (2.5 mg daily, 20 mg intermittent) or intravenous (0.5 mg, 1 mg quarterly) ibandro...
journal_title：Calcified tissue international
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00223-010-9403-y
更新日期：2010-10-01 00:00:00
abstract：:Mandibular first molars of 17-day-old mouse embryos were cultured in vitro to examine the histological effects of various concentrations of parathyroid hormone (PTH) on odontogenesis of the molars. PTH did not affect the cytodifferentiation of mesenchymal cells into preodontoblasts but inhibited that of preodontoblast...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555728
更新日期：1987-01-01 00:00:00
abstract：:Osteoporosis is commonly associated with estrogen deficiency. However, the mechanisms by which the lack of this hormone causes bone loss are poorly understood. The bone structure of the oral cavity seems to be affected by estrogen deficiency, since a delayed healing process after tooth extraction has been observed aft...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-004-0013-4
更新日期：2005-02-01 00:00:00
abstract：:In this study, we demonstrated that type I collagen matrix induced the expression of osteoblastic phenotypes of bone marrow cells, and that antibone sialoprotein (BSP) monoclonal antibody suppressed the expression of these phenotypes. On the other hand, BSP accelerated the expression of osteoblastic phenotypes of bone...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002230010078
更新日期：2000-05-01 00:00:00
abstract：:Acute spinal cord injury is associated with rapid bone loss and an increased risk of fracture. In this double-blind, randomized, placebo-controlled trial, 17 patients were followed for 1 year after administration of either 4 or 5 mg of zoledronic acid or placebo. Bone mineral density (BMD) and structural analyses of t...
journal_title：Calcified tissue international
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00223-007-9012-6
更新日期：2007-05-01 00:00:00
abstract：:Our objective was to assess the effects of HIV infection and antiretroviral therapy on trabecular and cortical microarchitecture in postmenopausal minority women. A subgroup of 106 (46 HIV-infected, 60 uninfected) postmenopausal Hispanic and African American women from an established cohort had areal bone mineral dens...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-013-9716-8
更新日期：2013-06-01 00:00:00
abstract：:Tumor tissue from a patient with squamous cell carcinoma of the lung and hypercalcemia has been serially implanted into athymic mice. Tumor-bearing mice develop cachexia, hypercalcemia without bone metastases, hypophosphatemia, increased urinary cyclic adenosine monophosphate (cAMP) to creatinine ratio, and undetectab...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02405367
更新日期：1984-09-01 00:00:00
abstract：:Abnormal PTH secretion and cell growth in hyperparathyroid tissues are accompanied with reduced expression of Ca2+-sensing receptor (CaR) which plays a key role in Ca-regulated PTH release. In this study, we examined the receptor expression in parathyroid adenomas using specific anti-CaR antibody and investigated rela...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900617
更新日期：1999-03-01 00:00:00
abstract：:Recommendations from the FNIH Sarcopenia Project are that appendicular lean mass (ALM, kg) adjusted for body mass index (BMI, kg/m2) be used for identifying low lean mass, with ALM/BMI cutpoints of < 0.789 m2 for men and < 0.512 m2 for women. We report normative ALM/BMI values for Australian adults, and compare the pe...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-018-0506-1
更新日期：2019-04-01 00:00:00
abstract：:As tobacco smoking has been identified as a risk factor in the development of osteoporosis, possible deleterious effects of nicotine inhalation on bone mineral density (BMD) and mechanical properties of the femur in female rats were studied. Female Sprague Dawley rats were exposed to nicotine vapour 20 hours a day 5 d...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900692
更新日期：1999-09-01 00:00:00
abstract：:The purpose of this study was to investigate the mineral induction capacity in vitro of polyanionic proteins covalently bound to a surface. Rat dentin gamma-carboxyglutamate-containing protein of the osteocalcin type (Gla-protein), proteoglycan (PG), and phosphoprotein (PP-H), as well as phosvitin (PhV) and bovine ser...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02553763
更新日期：1989-04-01 00:00:00
abstract：:Normative bone mineral density (BMD) and bone mineral content (BMC) values for the total body (TB), proximal femur (PF), and antero-posterior lumbar spine (LS) were obtained from a large cross-sectional sample of children and adolescents who were 8-17 years of age. There were 977 scans for the TB, 892 for the PF, and ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900138
更新日期：1996-11-01 00:00:00
abstract：:Genome-wide association studies (GWAS) have demonstrated that genetic variation at the MADS box transcription enhancer factor 2, polypeptide C (MEF2C) locus is robustly associated with bone mineral density, primarily at the femoral neck. MEF2C is a transcription factor known to operate via the Wnt signaling pathway. O...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-013-9824-5
更新日期：2014-04-01 00:00:00
abstract：:The purpose of this study was to determine the efficacy of using bone mineral measurements of the calcaneus to evaluate osteoporosis. Dual energy X-ray absorptiometry (DXA) of the calcaneus was compared with posteroanterior lumbar absorptiometry (DXA) and vertebral quantitative computed tomography (QCT) measurements i...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00298738
更新日期：1995-01-01 00:00:00
abstract：:Sustained exposure to high levels of parathyroid hormone (PTH), as observed in hyperparathyroidism, is catabolic to bone. The increase in the RANKL/OPG ratio in response to continuous PTH, resulting in increased osteoclastogenesis, is well established. However, the effects of prolonged PTH exposure on key regulators o...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-016-0176-9
更新日期：2016-11-01 00:00:00
abstract：:Parameters of mineral metabolism were examined in 6 patients with moderately severe anticonvulsant drug-induced osteomalacia. Compared to 15 matched controls, the patients exhibited significantly reduced serum calcium, inorganic phosphate, and 25-hydroxyvitamin D concentration, elevated serum alkaline phosphatase and ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02441155
更新日期：1979-03-13 00:00:00
abstract：:Ipriflavone (i.p.) positively affects bone density in postmenopausal osteoporosis, primarily by inhibiting bone resorption. Using in vitro models of human osteoblast differentiation, we have observed that i.p. and some of its metabolites stimulate the expression of bone sialoprotein, decorin, and type I collagen, and ...
journal_title：Calcified tissue international
pub_type： 杂志文章,评审
doi：10.1007/s002239900378
更新日期：1997-01-01 00:00:00
abstract：:Diets with a high saturated fat content can produce deleterious effects on the absorption of dietary calcium and consequently an adverse effect on bone mineralization in growing animals. Hence dietary fat may have long-term consequences for skeletal health and skeletal pathologies such as osteoporosis. Whether a diet ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900492
更新日期：1998-07-01 00:00:00
abstract：:Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA levels are commonly used as an internal control to normalize gene expression data based on the belief that this gene is constitutively expressed. However, GAPDH mRNA levels increased by more than 2.5-fold in tibiae of hindlimb unloaded female rats compared to L32 m...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-002-1098-2
更新日期：2004-02-01 00:00:00
abstract：:Using a histochemical method for demonstrating acid phosphatase activity, we have studied osteoclasts residing at two different bone sites in rat incisor alveolar bone, one at the endosteum and the other at the tooth socket, and compared the response of these osteoclasts to systemic changes. After 12 days of calcium (...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02405315
更新日期：1984-03-01 00:00:00
abstract：:Correlated studies were performed with light and electron microscopy, and backscattered electron image in conjunction with X-ray microanalysis, of lanthanum-incubated epiphyseal cartilage of the young rat. The hall-mark of this procedure is the appearance of LaP electron-dense deposits (not present in control sections...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02508648
更新日期：1996-04-01 00:00:00
abstract：:Osteoclasts are large, multinucleated, terminally differentiated cells formed by the fusion of mononuclear hemopoietic precursors. Their function is the resorption of bone, which is an essential part of the growth, modeling and remodeling of the skeleton. Though some osteoclast differentiation factors have recently be...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-002-2098-y
更新日期：2003-10-01 00:00:00
