Bone sialoprotein (BSP) is a crucial factor for the expression of osteoblastic phenotypes of bone marrow cells cultured on type I collagen matrix.

abstract：:The effects of the trace metals zinc (Zn), manganese (Mn), and cadmium (Cd) on the metabolism of growth plate chondrocytes was examined using a mineralizing culture system. Supplementation of serum-free primary cultures of growth plate chondrocytes with 10-100 mu m Zn resulted in an increase in cell protein and greatl...

journal_title：Calcified tissue international

authors： Litchfield TM,Ishikawa Y,Wu LN,Wuthier RE,Sauer GR

更新日期：1998-04-01 00:00:00

abstract：:Amelogenins, the major protein components of the enamel extracellular matrix, are postulated to be involved in controlling the elongated and oriented growth of enamel carbonated apatite crystals. In order to clarify the functional role of amelogenin during the early stage of enamel biomineralization, octacalcium phosp...

journal_title：Calcified tissue international

authors： Iijima M,Moradian-Oldak J

更新日期：2004-06-01 00:00:00

abstract：:Sclerostin and parathyroid hormones are strong negative and positive regulators of bone formation, respectively. The anabolic response induced by intermittent (iPTH) treatment is sclerostin status-dependent. However, the interaction between sclerostin and iPTH at the matrix level is unknown. The goal of the current st...

journal_title：Calcified tissue international

authors： Ross RD,Mashiatulla M,Robling AG,Miller LM,Sumner DR

更新日期：2016-02-01 00:00:00

abstract：:The effect of parathormone (PTH), lipopolysaccharide (LPS), or interleukin-1 (IL-1) on calcium release and collagen degradation in bone was examined in vitro using labeled neonatal calvaria of normal mice and also of osteopetrotic microphthalmic (mi/mi) mice that have defective osteoclasts. All three agents stimulated...

journal_title：Calcified tissue international

authors： Jilka RL,Hamilton JW

更新日期：1985-05-01 00:00:00

abstract：:Impact activity is an important contributor to bone accrual. Children engaging in such activity have been shown to have greater bone mineral density (BMD) than their peers. This cross-sectional study was designed to quantify the association between BMD and impact activity in pre-pubescent girls, specifically examining...

journal_title：Calcified tissue international

authors： Scerpella TA,Davenport M,Morganti CM,Kanaley JA,Johnson LM

更新日期：2003-01-01 00:00:00

abstract：:Treatment of large bone defects (LBDs) is technically demanding. Tissue engineering is an option. A bioactive graft may be produced by combining tissue scaffolds and healing promotive factors in order to accelerate bone repair. We investigated the role of Simvastatin (Sim)-embedded porous Gelapin (Gel) scaffold on exp...

journal_title：Calcified tissue international

authors： Moshiri A,Shahrezaee M,Shekarchi B,Oryan A,Azma K

更新日期：2015-06-01 00:00:00

abstract：:Syndesmophyte occurrence and axial bone loss were investigated in the heterozygous Tg187 tumor necrosis factor (TNF) transgenic mouse model (Tg-huTNF) of arthritis. Female and male Tg-huTNF mice were compared to wild-type mice (WT) at 2, 4, 6, 8, and 10 weeks. Syndesmophytes, intervertebral disc space, osteoclasts, os...

journal_title：Calcified tissue international

authors： Courbon G,Flammier S,Laroche N,Vico L,Marotte H,Coury F

更新日期：2017-06-01 00:00:00

abstract：:It is our hypothesis that interstitial fluid flow plays a role in the bone remodeling response to mechanical loading. The fluid flow-induced expression of three proteins (collagen, osteopontin, and alkaline phosphatase) involved in bone remodeling was investigated. Rat calvarial osteoblasts subjected to pulsatile flui...

journal_title：Calcified tissue international

authors： Hillsley MV,Frangos JA

更新日期：1997-01-01 00:00:00

abstract：:Acute spinal cord injury is associated with rapid bone loss and an increased risk of fracture. In this double-blind, randomized, placebo-controlled trial, 17 patients were followed for 1 year after administration of either 4 or 5 mg of zoledronic acid or placebo. Bone mineral density (BMD) and structural analyses of t...

journal_title：Calcified tissue international

authors： Shapiro J,Smith B,Beck T,Ballard P,Dapthary M,BrintzenhofeSzoc K,Caminis J

更新日期：2007-05-01 00:00:00

abstract：:Using a combination of gel filtration and DEAE-cellulose chromatography, together with small-scale preparative polyacrylamide gel electrophoresis, we isolated five proteins (amelogenins) from demineralized bovine fetal dental enamel matrix. These purified proteins were characterized by amino acid analysis and gel elec...

journal_title：Calcified tissue international

authors： Fincham AG

更新日期：1979-03-13 00:00:00

abstract：:Osteoporosis is characterized by low bone mass and a deterioration of bone architecture and likely is influenced by genetic factors. The ovariectomized (OVX) mouse is well suited for osteoporosis research, as shown to date by cross-sectional studies. Here, we investigate longitudinal changes by in vivo micro-computed ...

journal_title：Calcified tissue international

authors： Klinck J,Boyd SK

更新日期：2008-07-01 00:00:00

abstract：:The aim of this study was to determine whether forearm bone mineral density (BMD) measurements are affected by clinical risk factors for osteoporosis to the same extent as spine and hip BMD. The study population consisted of 1,009 female patients and volunteers, of whom 238 were premenopausal. Women were placed into s...

journal_title：Calcified tissue international

authors： Patel R,Blake GM,Fogelman I

更新日期：2007-02-01 00:00:00

abstract：:Whether the decrease of zinc content in the femoral-metaphyseal tissues of rats with skeletal unloading is involved in the alteration of bone metabolism was investigated. Skeletal unloading was designed using the model of hindlimb suspension in rats. Animals were fed for 4 days with the unloading. The metaphyseal zinc...

journal_title：Calcified tissue international

authors： Yamaguchi M,Ehara Y

更新日期：1995-09-01 00:00:00

abstract：:The ultimate hope of researchers and patients is a pathway to development of treatments for osteoarthritis to modify the disease process in addition to the symptoms. However, development of disease modifying drugs requires objective endpoints such as measures of joint structure, joint tissue homeostasis and/or joint s...

journal_title：Calcified tissue international

authors： Kraus VB,Karsdal MA

更新日期：2020-05-04 00:00:00

abstract：:Seventy-two postmenopausal osteoporotic women having more than one nontraumatic vertebral crush fracture were studied. Thirty-six of them, aged 68.8 +/- 1.2 years (18 +/- 4 YSM-years since menopause), were treated with 100 IU/day of salmon calcitonin i.m. plus 500 mg of elemental calcium for 10 days each month. The re...

journal_title：Calcified tissue international

authors： Rico H,Revilla M,Hernández ER,Villa LF,Alvarez de Buergo M

更新日期：1995-03-01 00:00:00

abstract：:We separated osteoclasts from bone and observed the effect of several known and potential mediators of the control of bone resorption on their cytoplasmic motility. We already found that calcitonin (CT), a hormone that inhibits bone resorption, regularly causes complete inhibition of cytoplasmic motility, specific for...

journal_title：Calcified tissue international

authors： Chambers TJ,Dunn CJ

更新日期：1983-07-01 00:00:00

abstract：:The relationship between oral indicators and bone mineral density (BMD) has been studied by many investigators, with mixed and complex results. The purpose of the present cross-sectional study was to evaluate the associations of periodontal conditions and tooth loss with metacarpal BMD (m-BMD) in a community-based coh...

journal_title：Calcified tissue international

authors： Inagaki K,Kurosu Y,Yoshinari N,Noguchi T,Krall EA,Garcia RI

更新日期：2005-07-01 00:00:00

abstract：:The pharmacokinetics and bioavailability of pamidronate were assessed in patients with breast cancer, 6 subjects received the drug intravenously and 7 orally. The initial plasma half-life of pamidronate was short (42 +/- 27 min) and the apparent total plasma clearance was high (471 +/- 298 ml/min). The renal clearance...

journal_title：Calcified tissue international

authors： Daley-Yates PT,Dodwell DJ,Pongchaidecha M,Coleman RE,Howell A

更新日期：1991-12-01 00:00:00

abstract：:MicroRNAs (miRNAs/miRs) are important biomarkers for the progression of intervertebral disc degeneration (IDD). We investigated the role of miR-30d in IDD progression through its interactions with forkhead box O3 (FOXO3) and C-X-C motif ligand 10 (CXCL10). We first measured the expression of miR-30d, FOXO3, and CXCL10...

journal_title：Calcified tissue international

authors： Xia P,Gao X,Li F,Shao L,Sun Y

更新日期：2021-02-01 00:00:00

abstract：:Macroporous biphasic calcium phosphate (MBCP) blocks were implanted into rabbit trabecular bone and muscle, recovered 18 weeks later, and then observed and analyzed by transmission electron microscopy (TEM), electron diffraction, and electron microprobes. The results showed that (1) apatitic microcrystals appeared by ...

journal_title：Calcified tissue international

authors： Rohanizadeh R,Trécant-Viana M,Daculsi G

更新日期：1999-05-01 00:00:00

abstract：:Several rare inherited disorders have been described that show phenotypic overlap with Paget's disease of bone (PDB) and in which PDB is a component of a multisystem disorder affecting muscle and the central nervous system. These conditions are the subject of this review article. Insertion mutations within exon 1 of t...

journal_title：Calcified tissue international

authors： Ralston SH,Taylor JP

更新日期：2019-05-01 00:00:00

abstract：:Osteoporosis is a common disease among patients undergoing transplantation. Its prevalence and complications have been well described in solid organ recipients, especially kidney, liver, and heart. However, studies in bone marrow transplantation (BMT) are scarce. Among the mechanisms invoked in the pathogenesis of BMT...

journal_title：Calcified tissue international

authors： Castañeda S,Carmona L,Carvajal I,Arranz R,Díaz A,García-Vadillo A

更新日期：1997-04-01 00:00:00

abstract：:ATP is as effective as inorganic pyrophosphate in retarding the rate of dissolution of calcium hydroxyapatite at pH 7, ADP is less effective, and AMP is without effect. The inhibition is due to the adsorption of ATP and ADP units on the crystal surface. ...

journal_title：Calcified tissue international

authors： Christoffersen MR,Christoffersen J

更新日期：1984-12-01 00:00:00

abstract：:Five years ago we reported results from a cross-sectional study of the effect of nutritional factors on calcium-regulating hormones and bone loss in perimenopausal women. We found an inverse correlation between serum 25-hydroxyvitamin D (25OHD) and immunoreactive parathyroid hormone (PTH), and we postulated that over ...

journal_title：Calcified tissue international

authors： Lukert B,Higgins J,Stoskopf M

更新日期：1992-09-01 00:00:00

abstract：:Little is known about hypoxia-induced modification of the canal network in the cortical bone despite its involvement in intracortical vascularity and bone blood supply. In this study, we examined the effect of chronic hypoxia on the canal network in postnatal bone. Tibiae were harvested from 4- and 8-week-old rats (hy...

journal_title：Calcified tissue international

authors： Matsumoto T,Ando N,Tomii T,Uesugi K

更新日期：2011-01-01 00:00:00

abstract：:Patients put at bedrest for medical reasons lose 1-2% of spinal bone mineral per week. Losses of this magnitude during even short-term space flights of a few months would pose a serious limitation and require countermeasures. The spinal bone mineral (L2-L4) was determined in 6 healthy males (precision = 2%) before and...

journal_title：Calcified tissue international

authors： LeBlanc A,Schneider V,Krebs J,Evans H,Jhingran S,Johnson P

更新日期：1987-11-01 00:00:00

abstract：:High serum levels of IGFBP-1 are related both to low body mass index (BMI) and to low insulin-like growth factor 1 (IGF-I), which both in turn are related to low bone mineral density (BMD) and to increased fracture risk. However, we have found no previous prospective studies on IGFBP-1 and fracture risk. Despite its n...

journal_title：Calcified tissue international

authors： Lundin H,Sääf M,Strender LE,Nyren S,Johansson SE,Salminen H

更新日期：2016-10-01 00:00:00

abstract：:In general, physical exercise appears to have favorable effects on the skeleton. However, a few recent reports have described negative effects, including reduced bone density (BMD) and high bone turnover in runners. The aim of our study was to compare endurance runners to controls with respect to BMD at different site...

journal_title：Calcified tissue international

authors： Brahm H,Ström H,Piehl-Aulin K,Mallmin H,Ljunghall S

更新日期：1997-12-01 00:00:00

abstract：:Men and women (n = 518) receiving moderate-to-high doses of corticosteroids were enrolled in two studies with similar protocols and randomly assigned to receive either placebo or risedronate (2.5 or 5 mg) for 1 year. All patients received daily calcium supplementation (500-1000 mg), and most also received supplemental...

journal_title：Calcified tissue international

authors： Wallach S,Cohen S,Reid DM,Hughes RA,Hosking DJ,Laan RF,Doherty SM,Maricic M,Rosen C,Brown J,Barton I,Chines AA

更新日期：2000-10-01 00:00:00

abstract：:Noncarious cervical lesions have a multifactorial etiology. Mechanical stress has been identified as one of the factors, but little evidence exists for its cause-effect relationship. This study was conducted at three different pH levels to observe the surface loss on dentin beams under tension and compression. Bovine ...

journal_title：Calcified tissue international

authors： Mishra P,Palamara JE,Tyas MJ,Burrow MF

更新日期：2006-12-01 00:00:00