Menopausal bone loss is partially regulated by dietary intake of vitamin D.


:Five years ago we reported results from a cross-sectional study of the effect of nutritional factors on calcium-regulating hormones and bone loss in perimenopausal women. We found an inverse correlation between serum 25-hydroxyvitamin D (25OHD) and immunoreactive parathyroid hormone (PTH), and we postulated that over time, women with lower 25OHD would lose more bone because of increased bone remodeling induced by secondary hyperparathyroidism. We have followed 38 of these women for 5 years. Twenty-two have gone through menopause and we are reporting observations on these 22 subjects. Bone mineral analysis was performed twice a year at the distal and mid-radius using single-photon absorptiometry. The slope of the bone mineral content curve was calculated by least squares. Bone loss increased within 6 months of the rise in serum follicle stimulating hormone (FSH) to greater than 40 mIU/ml. We continued to see a negative correlation between 25OHD and PTH (r = -0.450, P = 0.03). Premenopause, PTH was negatively correlated with the proximal bone mineral content (PBMC) slope (-0.604, P = 0.002). The distal bone mineral content (DBMC) 5-year slope was correlated with dietary vitamin D (r = 0.509, P = 0.02), the higher the intake, the less negative the slope. The 5-year PBMC slope was negatively correlated with serum osteocalcin (OC) levels (r = -0.382, P = 0.08). Before menopause, the change in PBMC was positively correlated with OC (r = 0.450, P = 0.03). Postmenopause, the correlation with DBMC slope was negative (r = -0.506, P = 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)


Calcif Tissue Int


Lukert B,Higgins J,Stoskopf M




Has Abstract


1992-09-01 00:00:00












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    journal_title:Calcified tissue international

    pub_type: 杂志文章


    authors: Augat P,Merk J,Genant HK,Claes L

    更新日期:1997-02-01 00:00:00

  • Comparison of the effects of vitamin D metabolites on collagen synthesis and resportion of fetal rat bone in organ culture.

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    journal_title:Calcified tissue international

    pub_type: 杂志文章


    authors: Raisz LG,Kream BE,Smith MD,Simmons HA

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  • A resolution-enhanced Fourier transform infrared spectroscopic study of the environment of the CO3(2-) ion in the mineral phase of enamel during its formation and maturation.

    abstract::A resolution-enhanced Fourier Transform Infrared (FTIR) Spectroscopic study of the CO3(2-) ion in pig enamel of increasing age and maturity has demonstrated the existence of four different, main carbonate locations. The major CO3(2-) site arises as a result of the substitution of CO3(2-) ions in the positions occupied...

    journal_title:Calcified tissue international

    pub_type: 杂志文章


    authors: Rey C,Renugopalakrishnan V,Shimizu M,Collins B,Glimcher MJ

    更新日期:1991-10-01 00:00:00

  • Increased Risk of Hip Fracture in Patients with Lymphoma, a Swedish Population Study of 37,236 Lymphoma Patients.

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    journal_title:Calcified tissue international

    pub_type: 杂志文章


    authors: Johansson P,Lind Kristjansdottir H,Johansson H,Jakir A,Mellström D,Lewerin C

    更新日期:2020-06-01 00:00:00

  • Parathyroid hormone as a calcium ionophore in bone cells: tests of specificity.

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    journal_title:Calcified tissue international

    pub_type: 杂志文章


    authors: Marcus R,Orner FB

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    authors: Baker SM,Sugars RV,Wendel M,Smith AJ,Waddington RJ,Cooper PR,Sloan AJ

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    abstract::The definition of osteoporosis was based for several years on bone mineral density values, which were used by most guidelines for defining treatment thresholds. The availability of tools for the estimation of fracture risk, such as FRAX™ or its adapted Italian version, DeFRA, is providing a way to grade osteoporosis s...

    journal_title:Calcified tissue international

    pub_type: 社论


    authors: Adami S,Bertoldo F,Gatti D,Minisola G,Rossini M,Sinigaglia L,Varenna M

    更新日期:2013-09-01 00:00:00

  • Cancellous bone of the spine is greater in black women.

    abstract::The bone mineral density (BMD) of the spine was measured in the posteroanterior (PA) and lateral projections as well as the total body BMD in 447 black and white women. The lateral projection is comprised predominantly of cancellous bone whereas the total body BMD is predominantly cortical bone, and the PA spine is in...

    journal_title:Calcified tissue international

    pub_type: 杂志文章


    authors: Aloia JF,Vaswani A,Mikhail M,Badshah M,Flaster E

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  • Effect of physical activity during teenage years, based on type of sport and duration of exercise, on bone mineral density of young, premenopausal Japanese women.

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    journal_title:Calcified tissue international

    pub_type: 杂志文章


    authors: Hara S,Yanagi H,Amagai H,Endoh K,Tsuchiya S,Tomura S

    更新日期:2001-01-01 00:00:00

  • Mechanical stimulation promotes osteogenic differentiation of human bone marrow stromal cells on 3-D partially demineralized bone scaffolds in vitro.

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    journal_title:Calcified tissue international

    pub_type: 杂志文章


    authors: Mauney JR,Sjostorm S,Blumberg J,Horan R,O'Leary JP,Vunjak-Novakovic G,Volloch V,Kaplan DL

    更新日期:2004-05-01 00:00:00

  • Sulfated glycoconjugates in rat incisor secretory ameloblasts and developing enamel matrix.

    abstract::We investigated the ultrastructural distribution and histochemical properties of sulfated glycoconjugates, which could be preserved by glutaraldehyde fixation, in secretory ameloblasts and developing enamel matrix, by use of the high iron diamine thiocarbohydrazide silver proteinate (HID-TCH-SP) staining and enzymatic...

    journal_title:Calcified tissue international

    pub_type: 杂志文章


    authors: Kogaya Y,Furuhashi K

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  • Demonstration of calmodulin-sensitive calcium translocation by isolated osteoclast plasma membrane vesicles.

    abstract::Plasma membrane vesicles were prepared from chicken osteoclasts, and active calcium transport was demonstrated in a spectrofluorimetric assay using the fluorescent calcium concentration indicator, fura-2. Transport activity was inhibited by quercetin (10 microM), sodium vanadate (10 microM), and the anticalmodulin age...

    journal_title:Calcified tissue international

    pub_type: 杂志文章


    authors: Bekker PJ,Gay CV

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  • Spine and femur densitometry at the menopause: are both sites necessary in the assessment of the risk of osteoporosis?

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    journal_title:Calcified tissue international

    pub_type: 杂志文章


    authors: Pouilles JM,Tremollieres F,Ribot C

    更新日期:1993-05-01 00:00:00

  • Comparison of cytotoxic effects of bisphosphonates in vitro and in vivo.

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    journal_title:Calcified tissue international

    pub_type: 杂志文章


    authors: Ito M,Chokki M,Ogino Y,Satomi Y,Azuma Y,Ohta T,Kiyoki M

    更新日期:1998-08-01 00:00:00

  • Treatment of Paget's disease of bone with a combination of intranasal salmon calcitonin and oral calcium and thiazide.

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    journal_title:Calcified tissue international

    pub_type: 临床试验,杂志文章


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    journal_title:Calcified tissue international

    pub_type: 杂志文章


    authors: Oshima O,Leboy PS,McDonald SA,Tuan RS,Shapiro IM

    更新日期:1989-09-01 00:00:00

  • Osteoporosis Changes Collagen/Apatite Orientation and Young's Modulus in Vertebral Cortical Bone of Rat.

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    journal_title:Calcified tissue international

    pub_type: 杂志文章


    authors: Ozasa R,Ishimoto T,Miyabe S,Hashimoto J,Hirao M,Yoshikawa H,Nakano T

    更新日期:2019-04-01 00:00:00

  • Intestinal lactase activity and calcium absorption in the aging female with osteoporosis.

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    journal_title:Calcified tissue international

    pub_type: 杂志文章


    authors: Pacifici R,Droke D,Avioli LV

    更新日期:1985-01-01 00:00:00

  • Changes in heated and in laser-irradiated human tooth enamel and their probable effects on solubility.

    abstract::Enamel of intact human teeth laser irradiated in vitro under certain conditions is known to have less subsurface demineralization than unirradiated enamel on exposure to acid; consequently, the potential use of laser irradiance to reduce caries is apparent. The laser-induced physical and/or chemical changes that cause...

    journal_title:Calcified tissue international

    pub_type: 杂志文章,评审


    authors: Fowler BO,Kuroda S

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  • Purification and immunochemistry of a soluble matrix protein of the chicken eggshell (ovocleidin 17).

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    journal_title:Calcified tissue international

    pub_type: 杂志文章


    authors: Hincke MT,Tsang CP,Courtney M,Hill V,Narbaitz R

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  • Prevention of bone loss by phloridzin, an apple polyphenol, in ovariectomized rats under inflammation conditions.

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    journal_title:Calcified tissue international

    pub_type: 杂志文章


    authors: Puel C,Quintin A,Mathey J,Obled C,Davicco MJ,Lebecque P,Kati-Coulibaly S,Horcajada MN,Coxam V

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    journal_title:Calcified tissue international

    pub_type: 杂志文章


    authors: Semprini S,Mango R,Brancati F,Dallapiccola B,Becherini L,Novelli G,De Lorenzo A,Brandi ML,Gennari L

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  • The long bone deformity of osteogenesis imperfecta III: analysis of structural changes carried out with scanning electron microscopic morphometry.

    abstract::The wedges of the mid-diaphyseal osteotomies carried out to correct the femoral and/or tibial native deformity in type III osteogenesis imperfecta (OI III) were used to study the remodeling patterns and lamellar organization at the level of the major deformity. Histology and scanning electron microscopy (SEM) morpholo...

    journal_title:Calcified tissue international

    pub_type: 杂志文章


    authors: Pazzaglia UE,Congiu T,Brunelli PC,Magnano L,Benetti A

    更新日期:2013-11-01 00:00:00

  • Blockade of the pore-forming P2X7 receptor inhibits formation of multinucleated human osteoclasts in vitro.

    abstract::Osteoclasts are large, multinucleated, terminally differentiated cells formed by the fusion of mononuclear hemopoietic precursors. Their function is the resorption of bone, which is an essential part of the growth, modeling and remodeling of the skeleton. Though some osteoclast differentiation factors have recently be...

    journal_title:Calcified tissue international

    pub_type: 杂志文章


    authors: Gartland A,Buckley KA,Bowler WB,Gallagher JA

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  • Combined Biomaterials: Amniotic Membrane and Adipose Tissue to Restore Injured Bone as Promoter of Calcification in Bone Regeneration: Preclinical Model.

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    journal_title:Calcified tissue international

    pub_type: 杂志文章


    authors: Dziedzic DSM,Francisco JC,Mogharbel BF,Irioda AC,Stricker PEF,Floriano J,de Noronha L,Abdelwahid E,Franco CRC,de Carvalho KAT

    更新日期:2021-01-09 00:00:00

  • Bone turnover and the response to alendronate treatment in postmenopausal osteoporosis.

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    journal_title:Calcified tissue international

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Gonnelli S,Cepollaro C,Pondrelli C,Martini S,Montagnani A,Monaco R,Gennari C

    更新日期:1999-11-01 00:00:00

  • Ultrastructural changes accompanying the mechanical deformation of bone tissue: a Raman imaging study.

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    journal_title:Calcified tissue international

    pub_type: 杂志文章


    authors: Carden A,Rajachar RM,Morris MD,Kohn DH

    更新日期:2003-02-01 00:00:00

  • Osteonecrosis in a chemically induced rat model of human hemolytic disorders associated with thrombosis--a new model for avascular necrosis of bone.

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    journal_title:Calcified tissue international

    pub_type: 杂志文章


    authors: Shabat S,Nyska A,Long PH,Goelman G,Abramovitch R,Ezov N,Levin-Harrus T,Peddada S,Redlich M,Yedgar S,Nyska M

    更新日期:2004-03-01 00:00:00

  • Cancer Treatment and Bone Health.

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    journal_title:Calcified tissue international

    pub_type: 杂志文章,评审


    authors: Handforth C,D'Oronzo S,Coleman R,Brown J

    更新日期:2018-02-01 00:00:00

  • Involvement of insulin-like growth factor I in development of ossification of the posterior longitudinal ligament of the spine.

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    journal_title:Calcified tissue international

    pub_type: 杂志文章


    authors: Goto K,Yamazaki M,Tagawa M,Goto S,Kon T,Moriya H,Fujimura S

    更新日期:1998-02-01 00:00:00