Menopausal bone loss is partially regulated by dietary intake of vitamin D.

Abstract:

:Five years ago we reported results from a cross-sectional study of the effect of nutritional factors on calcium-regulating hormones and bone loss in perimenopausal women. We found an inverse correlation between serum 25-hydroxyvitamin D (25OHD) and immunoreactive parathyroid hormone (PTH), and we postulated that over time, women with lower 25OHD would lose more bone because of increased bone remodeling induced by secondary hyperparathyroidism. We have followed 38 of these women for 5 years. Twenty-two have gone through menopause and we are reporting observations on these 22 subjects. Bone mineral analysis was performed twice a year at the distal and mid-radius using single-photon absorptiometry. The slope of the bone mineral content curve was calculated by least squares. Bone loss increased within 6 months of the rise in serum follicle stimulating hormone (FSH) to greater than 40 mIU/ml. We continued to see a negative correlation between 25OHD and PTH (r = -0.450, P = 0.03). Premenopause, PTH was negatively correlated with the proximal bone mineral content (PBMC) slope (-0.604, P = 0.002). The distal bone mineral content (DBMC) 5-year slope was correlated with dietary vitamin D (r = 0.509, P = 0.02), the higher the intake, the less negative the slope. The 5-year PBMC slope was negatively correlated with serum osteocalcin (OC) levels (r = -0.382, P = 0.08). Before menopause, the change in PBMC was positively correlated with OC (r = 0.450, P = 0.03). Postmenopause, the correlation with DBMC slope was negative (r = -0.506, P = 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Calcif Tissue Int

authors

Lukert B,Higgins J,Stoskopf M

doi

10.1007/BF00334543

subject

Has Abstract

pub_date

1992-09-01 00:00:00

pages

173-9

issue

3

eissn

0171-967X

issn

1432-0827

journal_volume

51

pub_type

临床试验,杂志文章
  • Effects of high-fat diet on mature bone mineral content, structure, and mechanical properties.

    abstract::Diets with a high saturated fat content can produce deleterious effects on the absorption of dietary calcium and consequently an adverse effect on bone mineralization in growing animals. Hence dietary fat may have long-term consequences for skeletal health and skeletal pathologies such as osteoporosis. Whether a diet ...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s002239900492

    authors: Wohl GR,Loehrke L,Watkins BA,Zernicke RF

    更新日期:1998-07-01 00:00:00

  • Recombinant Human Bone Morphogenetic Protein 7 Exerts Osteo-Catabolic Effects on Bone Grafts That Outweigh Its Osteo-Anabolic Capacity.

    abstract::This study aimed to investigate the effects of recombinant human bone morphogenetic protein (rhBMP-7) on human cancellous bone grafts (BGs) while differentiating between anabolic and catabolic events. Human BGs alone or supplemented with rhBMP-7 were harvested 14 weeks after subcutaneous implantation into NOD/Scid mic...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s00223-019-00574-5

    authors: Lahr CA,Wagner F,Shafiee A,Rudert M,Hutmacher DW,Holzapfel BM

    更新日期:2019-09-01 00:00:00

  • The Predictive Value of Sarcopenia and Falls for 2-Year Major Osteoporotic Fractures in Community-Dwelling Older Adults.

    abstract::To evaluate the associations of sarcopenia and previous falls with 2-year major osteoporotic fractures (MOFs) in community-dwelling older adults. Four thousand Chinese men and women ≥ 65 years recruited from Hong Kong communities were prospectively followed up. Measures of muscle mass, grip strength, gait speed and fa...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s00223-020-00709-z

    authors: Su Y,Lam FMH,Leung J,Cheung WH,Ho SC,Kwok T

    更新日期:2020-08-01 00:00:00

  • Influence of magnesium supplementation on bone turnover in the normal young mouse.

    abstract::The effect of magnesium (Mg) supplementation on bone metabolism has been studied in the normal young mouse. Weanling male mice were given Mg-supplemented drinking water (5 mM or 32 mM Mg) for 4 weeks. Mineral and skeletal changes were assessed by biochemical methods and by histomorphometric analysis of endosteal bone ...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF02405119

    authors: Marie PJ,Travers R,Delvin EE

    更新日期:1983-09-01 00:00:00

  • Cancer Treatment and Bone Health.

    abstract::Considerable advances in oncology over recent decades have led to improved survival, while raising concerns about long-term consequences of anticancer treatments. In patients with breast or prostate malignancies, bone health is a major issue due to the high risk of bone metastases and the frequent prolonged use of hor...

    journal_title:Calcified tissue international

    pub_type: 杂志文章,评审

    doi:10.1007/s00223-017-0369-x

    authors: Handforth C,D'Oronzo S,Coleman R,Brown J

    更新日期:2018-02-01 00:00:00

  • A histochemical method for the demonstration of calcifying cartilage.

    abstract::The demonstration of histochemical characteristics in calcifying cartilage is fraught with methodological difficulties including the distinction of mineralized from unmineralized cartilage and the demonstration of cell detail in relatively hard tissue. This study uses the decalcified bone matrix-induced enchondral (en...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF02555141

    authors: Aaron RK,Jolly G,Ciombor DM,Barrach HJ

    更新日期:1988-10-01 00:00:00

  • Relationship of calcification of atherosclerotic plaque and arterial stiffness to bone mineral density and osteoprotegerin in postmenopausal women referred for osteoporosis screening.

    abstract::Arterial calcification leading to increased arterial stiffness, a powerful risk factor for cardiovascular disease, may underlie the association of osteoporosis with cardiovascular disease in postmenopausal women. Osteoprotegerin (OPG), an indirect inhibitor of osteoclastogenesis, may be involved in arterial calcificat...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s00223-008-9153-2

    authors: Frost ML,Grella R,Millasseau SC,Jiang BY,Hampson G,Fogelman I,Chowienczyk PJ

    更新日期:2008-08-01 00:00:00

  • Regulation of C-myc protooncogene expression in osteoblastic cells by arachidonic acid metabolites: relationship to proliferation.

    abstract::Prostaglandin E2 and leukotriene B4 are metabolites of arachidonic acid with well-characterized effects on osteoblastic cells. Prostaglandin E2 has been shown to be a potent bone-resorbing agent and to stimulate as well as inhibit osteoblastic cell proliferation. Leukotriene B4 has also been demonstrated to stimulate ...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF00301636

    authors: Ren W,Kinniburgh AJ,Dziak R

    更新日期:1992-04-01 00:00:00

  • Genetically Predicted Sex Hormone-Binding Globulin and Bone Mineral Density: A Mendelian Randomization Study.

    abstract::Previous observational studies have identified various risk factors associated with the development of osteoporosis, including sex hormone-binding globulin (SHBG). The aim of this study was to determine the potential causal effects of circulating SHBG concentrations on bone mineral density (BMD). Two-sample Mendelian ...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s00223-020-00770-8

    authors: Qu Z,Jiang J,Yang F,Huang J,Zhao J,Yan S

    更新日期:2020-10-17 00:00:00

  • Familial hypocalciuric hypercalcemia in Israel: a preliminary report.

    abstract::Familial hypocalciuric hypercalcemia (FHH) is often considered in the differential diagnosis of hyperparathyroidism, but is rarely diagnosed. So far, FHH has not been documented in Israel. This report presents preliminary evidence for the occurrence of FHH in Israel. ...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s002239900290

    authors: Liel Y,Arie R,Vered I

    更新日期:1997-07-01 00:00:00

  • Ultrasound velocity through the phalanges in normal and osteoporotic patients.

    abstract::Quantitative ultrasound (US) measurements have been shown to be a new technique assessing bone status. This study aimed to assess a new US instrument, the DBM Sonic 1200(R) (IGEA) which permits the measurement of the speed of sound in the proximal phalanges (SOSp) of the hand. The results obtained were compared with D...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s002239900574

    authors: Blanckaert F,Cortet B,Coquerelle P,Flipo RM,Duquesnoy B,Delcambre B

    更新日期:1999-01-01 00:00:00

  • Sulfated glycoconjugates in rat incisor secretory ameloblasts and developing enamel matrix.

    abstract::We investigated the ultrastructural distribution and histochemical properties of sulfated glycoconjugates, which could be preserved by glutaraldehyde fixation, in secretory ameloblasts and developing enamel matrix, by use of the high iron diamine thiocarbohydrazide silver proteinate (HID-TCH-SP) staining and enzymatic...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF02556641

    authors: Kogaya Y,Furuhashi K

    更新日期:1988-11-01 00:00:00

  • Developing antler, a model for endocrine regulation of bone growth. Concentration gradient of T3, T4, and alkaline phosphatase in the antler, jugular, and the saphenous veins.

    abstract::Thyroxine (T4), triiodothyronine (T3), and alkaline phosphatase (AP) were assayed monthly in white-tailed deer plasma obtained from the antler (A), jugular (J), and the saphenous (S) veins during the period of antler growth and the period of mineralization. The concentrations of T3, T4, and AP in the J and S were not ...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF02555129

    authors: Bubenik GA,Sempere AJ,Hamr J

    更新日期:1987-07-01 00:00:00

  • A critical review of bone mass and the risk of fractures in osteoporosis.

    abstract::The usefulness of various bone mineral measurement techniques is a subject of current controversy. In order to explore whether disparate conclusions may have arisen from differences in analytic methodology, data from published reports of bone mass and nonviolent fractures have been reanalyzed in terms of fracture risk...

    journal_title:Calcified tissue international

    pub_type: 杂志文章,meta分析

    doi:10.1007/BF02555036

    authors: Ross PD,Davis JW,Vogel JM,Wasnich RD

    更新日期:1990-03-01 00:00:00

  • The magnitude and rate of bone loss in ovariectomized mice differs among inbred strains as determined by longitudinal in vivo micro-computed tomography.

    abstract::Osteoporosis is characterized by low bone mass and a deterioration of bone architecture and likely is influenced by genetic factors. The ovariectomized (OVX) mouse is well suited for osteoporosis research, as shown to date by cross-sectional studies. Here, we investigate longitudinal changes by in vivo micro-computed ...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s00223-008-9150-5

    authors: Klinck J,Boyd SK

    更新日期:2008-07-01 00:00:00

  • Bone-derived macrophage chemotactic factors: methods of extraction and further characterization.

    abstract::Mononuclear phagocytes have been implicated as important cellular elements in the process of bone resorption. We have postulated that the recruitment and migration of mononuclear phagocytes to bone occurs via a mechanism(s) in which bone-derived chemotactic factors (BDCF) are released from foci undergoing resorption. ...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF02557681

    authors: Minkin C,Bannon DJ Jr,Pokress S

    更新日期:1985-01-01 00:00:00

  • Long-Term Intake of Green Tea Extract Causes Mal-Conformation of Trabecular Bone Microarchitecture in Growing Rats.

    abstract::The purpose of this study was to examine the effects of green tea extract (GTE) intake on bone structural and physiological properties, such as bone mass, trabecular bone microarchitecture, cortical bone geometry, and bone mechanical strength, in growing rats. Four-week-old male Wistar rats were divided into the follo...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s00223-017-0358-0

    authors: Minematsu A,Nishii Y,Imagita H,Sakata S

    更新日期:2018-03-01 00:00:00

  • Subregional DXA-derived vertebral bone mineral measures are stronger predictors of failure load in specimens with lower areal bone mineral density, compared to those with higher areal bone mineral density.

    abstract::Measurement of areal bone mineral density (aBMD) in intravertebral subregions may increase the diagnostic sensitivity of dual-energy X-ray absorptiometry (DXA)-derived parameters for vertebral fragility. This study investigated whether DXA-derived bone parameters in vertebral subregions were better predictors of verte...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s00223-014-9866-3

    authors: Briggs AM,Perilli E,Codrington J,Reynolds KJ,Parkinson IH,Wark JD

    更新日期:2014-08-01 00:00:00

  • Validation of a food-frequency questionnaire for the assessment of calcium intake in schoolchildren aged 9-10 years.

    abstract::Bone mass increases steadily until age 20-30 years, when peak bone mass (PBM) is acquired. Nutrition plays a critical role in achievement of the optimal genetically programmed PBM, with reduction in the risk of osteoporosis later in life. Intake of nutrients can be estimated through the use of various tools; typically...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s00223-013-9721-y

    authors: Pampaloni B,Bartolini E,Barbieri M,Piscitelli P,Di Tanna GL,Giolli L,Brandi ML

    更新日期:2013-07-01 00:00:00

  • Treatment thresholds for osteoporosis and reimbursability criteria: perspectives associated with fracture risk-assessment tools.

    abstract::The definition of osteoporosis was based for several years on bone mineral density values, which were used by most guidelines for defining treatment thresholds. The availability of tools for the estimation of fracture risk, such as FRAX™ or its adapted Italian version, DeFRA, is providing a way to grade osteoporosis s...

    journal_title:Calcified tissue international

    pub_type: 社论

    doi:10.1007/s00223-013-9748-0

    authors: Adami S,Bertoldo F,Gatti D,Minisola G,Rossini M,Sinigaglia L,Varenna M

    更新日期:2013-09-01 00:00:00

  • Hip fracture in nursing homes: an Italian study on prevalence, latency, risk factors, and impact on mobility.

    abstract::Hip fracture may cause and/or complicate institutionalization. We undertook this study to define its overall prevalence among the residents of four nursing homes in Central Italy as well as its latency and impact on mobility when it occurred within institutions. We also performed a case control analysis with the aim o...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s002230001212

    authors: Maggio D,Ubaldi E,Simonelli G,Cenci S,Pedone C,Cherubini A

    更新日期:2001-06-01 00:00:00

  • Development and application of a serum C-telopeptide and osteocalcin assay to measure bone turnover in an ovariectomized rat model.

    abstract::Biochemical markers applicable to the ovariectomized rat model can provide important tools for studying the bone remodeling process in this animal model of postmenopausal osteoporosis. We describe the development and application of two biochemical markers, a C-telopeptide (of type-I collagen) enzyme-linked immunosorbe...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s002230010088

    authors: Srivastava AK,Bhattacharyya S,Castillo G,Wergedal J,Mohan S,Baylink DJ

    更新日期:2000-06-01 00:00:00

  • A resolution-enhanced Fourier transform infrared spectroscopic study of the environment of the CO3(2-) ion in the mineral phase of enamel during its formation and maturation.

    abstract::A resolution-enhanced Fourier Transform Infrared (FTIR) Spectroscopic study of the CO3(2-) ion in pig enamel of increasing age and maturity has demonstrated the existence of four different, main carbonate locations. The major CO3(2-) site arises as a result of the substitution of CO3(2-) ions in the positions occupied...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF02556215

    authors: Rey C,Renugopalakrishnan V,Shimizu M,Collins B,Glimcher MJ

    更新日期:1991-10-01 00:00:00

  • Comparison of fracture healing among different inbred mouse strains.

    abstract::Quantitative trait locus analysis can be used to identify genes critically involved in biological processes. No such analysis has been applied to identifying genes that control bone fracture healing. To determine the feasibility of such an approach, healing of femur fractures was measured between C57BL/6, DBA/2, and C...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s00223-008-9144-3

    authors: Manigrasso MB,O'Connor JP

    更新日期:2008-06-01 00:00:00

  • Impact of spinal degenerative changes on the evaluation of bone mineral density with dual energy X-ray absorptiometry (DXA).

    abstract::The purpose of this study is to evaluate degenerative factors in a postmenopausal patient group and differentiate the influence on bone mineral density (BMD) measurements by dual-energy X-ray absorptiometry (DXA). The patients and methods included an investigation of 144 postmenopausal women (mean 63.3 years) with PA-...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s002239900258

    authors: Rand T,Seidl G,Kainberger F,Resch A,Hittmair K,Schneider B,Glüer CC,Imhof H

    更新日期:1997-05-01 00:00:00

  • HNGF6A Inhibits Oxidative Stress-Induced MC3T3-E1 Cell Apoptosis and Osteoblast Phenotype Inhibition by Targeting Circ_0001843/miR-214 Pathway.

    abstract::Humanin (HN), a mitochondrial derived peptide, plays cyto-protective role under various stress. In this study, we aimed to investigate the effects of HNGF6A, an analogue of HN, on osteoblast apoptosis and differentiation and the underlying mechanisms. Cell proliferation of murine osteoblastic cell line MC3TC-E1 was ex...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s00223-020-00660-z

    authors: Zhu X,Zhao Z,Zeng C,Chen B,Huang H,Chen Y,Zhou Q,Yang L,Lv J,Zhang J,Pan D,Shen J,Duque G,Cai D

    更新日期:2020-05-01 00:00:00

  • Cancellous bone of the spine is greater in black women.

    abstract::The bone mineral density (BMD) of the spine was measured in the posteroanterior (PA) and lateral projections as well as the total body BMD in 447 black and white women. The lateral projection is comprised predominantly of cancellous bone whereas the total body BMD is predominantly cortical bone, and the PA spine is in...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s002239900653

    authors: Aloia JF,Vaswani A,Mikhail M,Badshah M,Flaster E

    更新日期:1999-07-01 00:00:00

  • Regulation of osteoclasts by calcitonin and amphiphilic calcitonin conjugates: role of cytosolic calcium.

    abstract::The peptide hormone calcitonin is a potent inhibitor of osteoclastic resorption, but it is unstable and poorly absorbed following oral administration. Conjugates of salmon calcitonin covalently linked to low-molecular-weight amphiphilic polymers show improved stability and absorption. The purpose of this study was to ...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s00223-002-1051-4

    authors: Komarova SV,Shum JB,Paige LA,Sims SM,Dixon SJ

    更新日期:2003-09-01 00:00:00

  • Densitometric study of developing femur.

    abstract::The purpose of this work was to extend to long bones the study on the ossification of human fetal skeleton in relation to conceptual age by a quantitative methodological approach. Postero-anterior scans were performed on 29 dried fetal femora (from 11.5 weeks of conceptual age to term) by a Hologic QDR 1000 X-ray dens...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/s002239900591

    authors: Panattoni GL,D'Amelio P,Di Stefano M,Sciolla A,Isaia GC

    更新日期:1999-02-01 00:00:00

  • Prostaglandin E2 binding and cyclic AMP production in isolated bone cells.

    abstract::The binding of prostaglandin E2 (PGE2) to bone cells was studied to provide direct evidence for the existence of specific receptors in bone. Bone cells were isolated by collagenase digestion of fetal and newborn rat calvaria. Isolated cells were incubated with 3H-PGE2 and collected on Millipore filters. Specific bindi...

    journal_title:Calcified tissue international

    pub_type: 杂志文章

    doi:10.1007/BF02405038

    authors: Dziak RM,Hurd D,Miyasaki KT,Brown M,Weinfeld N,Hausmann E

    更新日期:1983-01-01 00:00:00