Abstract:
:Quantitative ultrasound (US) measurements have been shown to be a new technique assessing bone status. This study aimed to assess a new US instrument, the DBM Sonic 1200(R) (IGEA) which permits the measurement of the speed of sound in the proximal phalanges (SOSp) of the hand. The results obtained were compared with DXA (SOPHOS) and US measurements at the calcaneus (Achilles(R) LUNAR). The in vivo precision expressed by coefficient of variation was 0.91%. Ultrasound measurements of phalanges were significantly correlated with BMD in the entire group of 90 subjects: osteoporotic patients (n = 47) and controls (n = 43) (r = 0.44, femoral neck and 0.45, lumbar spine, P < 0.01). A significant correlation was also found in the control group (r = 0.33, lumbar spine and 0.38, femoral neck, P < 0.05) but not in the osteoporotic group (r = 0.3, lumbar spine and 0.17, femoral neck, P > 0.05). Mean values for 31 postmenopausal, osteoporotic women and age-matched controls showed a significant decrease in US measurements at the phalanges (P < 0.05) and the calcaneus (P < 0.01) as well as bone mineral density (BMD) at the spine and femoral neck (P < 0.01) in the osteoporotic group. A decision threshold for a sensitivity of 80% for osteoporotic fractures resulted in a specificity value of only 37% for SOSp, between 53 to 65% for calcaneus US measurements and 45 to 56% for BMD. The Z score, the odds ratio, the ROC curves, and areas under the curves plotted for the subgroup of 31 fractures and their healthy controls showed poorer values for SOSp than BMD and calcaneus US measurements. In conclusion, US measurements of phalanges seem to be less efficient than calcaneus US and BMD measurements to distinguish osteoporotic from healthy women. Other studies and also prospective studies are required to assess the interest in fracture risk assessment.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Blanckaert F,Cortet B,Coquerelle P,Flipo RM,Duquesnoy B,Delcambre Bdoi
10.1007/s002239900574subject
Has Abstractpub_date
1999-01-01 00:00:00pages
28-33issue
1eissn
0171-967Xissn
1432-0827journal_volume
64pub_type
杂志文章abstract::The present study reports on the separation of fluid from soft, "cheeselike" enamel of porcine permanent teeth in the secretory stage, and the determination of its chemical composition. The enamel tissues were dissected from mandibles of 5 to 6-month-old piglets and pooled under mineral oil in centrifuge tubes, and th...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555250
更新日期:1987-08-01 00:00:00
abstract::The P2X7 nucleotide receptor (P2X7R) is an ATP-gated ion channel expressed in bone cells. Homozygous null P2X7R (P2X7R(-/-)) mice have reduced bone formation, so we hypothesized that P2X7R(-/-) mice have impaired fracture healing compared to P2X7R(+/+) control mice. To test the hypothesis, adult P2X7R(-/-) mice and P2...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-009-9237-7
更新日期:2009-05-01 00:00:00
abstract::Abnormal PTH secretion and cell growth in hyperparathyroid tissues are accompanied with reduced expression of Ca2+-sensing receptor (CaR) which plays a key role in Ca-regulated PTH release. In this study, we examined the receptor expression in parathyroid adenomas using specific anti-CaR antibody and investigated rela...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900617
更新日期:1999-03-01 00:00:00
abstract::We have recently reported that soy isoflavones particularly when provided in the context of soy protein are capable of preventing loss of bone mineral density due to orchidectomy in F344 rats. We hypothesize, that soy isoflavones also exert beneficial effects on bone microstructural properties, in part, by enhancing b...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-005-0069-9
更新日期:2006-06-01 00:00:00
abstract::Results from previous quasi-static mechanical tests indicate that femurs from elderly subjects fail in vitro at forces 50% below those available in a fall from standing height. However, bone is a rate-dependent material, and it is not known whether this imbalance is present at rates of loading which occur in a fall. B...
journal_title:Calcified tissue international
pub_type: 临床试验,杂志文章
doi:10.1007/BF00310169
更新日期:1994-07-01 00:00:00
abstract::A continuous flow organ culture system (CFCS) was used to determine the effect of ascorbic acid on the synthesis of collagen and noncollagenous protein by bone of the alveolar process and periodontal ligament in organ cultures of adult mouse periodontium. For the last 24 h of 2 day cultures, 5 microCi/ml 3H-proline wa...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02411276
更新日期:1982-07-01 00:00:00
abstract::The discriminating ability and relevance of clinical risk factors, quantitative ultrasound (QUS) variables, X-ray-based bone mineral density (BMD) and hip axis length (HAL) measurements to evaluate the risk of osteoporotic fracture in elderly Brazilian women were examined in this study. QUS at the calcaneus (Achilles ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-002-1096-4
更新日期:2003-12-01 00:00:00
abstract::This study sought to develop a noninvasive, reliable, clinically relevant, and easy-to-implement mouse model that can be used for investigation of the pathophysiology of PTOA and for preclinical testing of new therapies of PTOA. Accordingly, we have established a closed intraarticular tibial plateau compression loadin...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-019-00614-0
更新日期:2020-02-01 00:00:00
abstract::We have compared two components of bacterial cell walls, muramyl dipeptide (MDP) and lipopolysaccharide (LPS), for their effects on bone resorption as measured by the release of previously incorporated 45Ca. MDP is the smallest active component of peptidoglycan, whereas LPS is the active component of endotoxin. Fetal ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02411269
更新日期:1982-07-01 00:00:00
abstract::The present study was designed to characterize dentin formed in transplanted rat molars by investigating calcium (Ca), phosphorus (P), and magnesium (Mg) concentrations using electron probe microanalysis (EPMA) as well as examining the rate of dentin matrix formation by vital staining. The unerupted immature lower rig...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-005-0134-4
更新日期:2006-03-01 00:00:00
abstract::Amelogenins are the most abundant secreted proteins in developing dental enamel. These evolutionarily-conserved proteins have important roles in enamel mineral formation, as mutations within the amelogenin gene coding region lead to defects in enamel thickness or mineral structure. Because of extensive alternative spl...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-002-0036-7
更新日期:2003-11-01 00:00:00
abstract::High impact loading is known to prevent some of the age-related bone loss but its effects on the density distribution of cortical bone are relatively unknown. This study examined the effects of age and habitual sprinting on tibial and fibular mid-shaft bone traits (structural, cortical radial and polar bone mineral de...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-014-9881-4
更新日期:2014-08-01 00:00:00
abstract::Limited information is available on the effect of bisphosphonates in men receiving corticosteroid therapy. We studied 184 men among the patients enrolled in two, double-blind, placebo-controlled, 1-year studies with similar protocols. The studies evaluated the effects of risedronate in patients beginning corticosteroi...
journal_title:Calcified tissue international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s00223-001-1060-8
更新日期:2001-10-01 00:00:00
abstract::The small proteoglycan decorin had been localized previously at the d-band in the gap zone of collagen fibrils in nonmineralizing tissues. In bone matrix this zone is proteoglycan free and is at least in some species the place where mineralization along collagen fibrils starts. To study the metabolism of the small pro...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900279
更新日期:1997-06-01 00:00:00
abstract::The purpose of this study was to examine the effects of green tea extract (GTE) intake on bone structural and physiological properties, such as bone mass, trabecular bone microarchitecture, cortical bone geometry, and bone mechanical strength, in growing rats. Four-week-old male Wistar rats were divided into the follo...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-017-0358-0
更新日期:2018-03-01 00:00:00
abstract::To investigate the possible role of calmodulin in the calcium sensitivity of parathyroid adenylate cyclase (AC), the effect of the calmodulin inhibitor trifluoperazine hydrochloride (TFP) on the calcium sensitivity of forskolin-stimulated AC activity was investigated in membranes prepared from normal porcine parathyro...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02556606
更新日期:1986-05-01 00:00:00
abstract::The purpose of the present study was to determine if the type of dietary fat can modify the fatty acid composition and arachidonic acid levels in the alveolar bone phospholipids. Three groups of rats were fed nutritionally adequate semipurified diets containing different lipids: 10% corn oil (control, group I, rich in...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF01351838
更新日期:1993-11-01 00:00:00
abstract::Matrix extracellular phosphoglycoprotein (MEPE) is an inhibitor of mineralization in situ and in cell cultures where altered expression is associated with oncogenic osteomalacia and hypophosphatemic rickets. The purpose of this study was to determine whether the intact protein or the peptide(s) originating from this p...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-009-9313-z
更新日期:2010-01-01 00:00:00
abstract::The fossil record shows that bone remodeling has existed since the earliest large vertebrates became weight-bearing on land, but the functions of remodeling have long been debated. The principal protagonists in this debate have been those favoring a mechanical function and those asserting that remodeling serves to mov...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/s00223-002-1059-9
更新日期:2003-08-01 00:00:00
abstract::Raman spectroscopy has been used to demonstrate, for the first time, that calcium mineralization in the core of the major lateral teeth of the chiton Acanthopleura echinata takes place as an ordered process, with crystalline carbonated apatite being the first mineral deposited. Deposition begins at the top of the toot...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002230001156
更新日期:2000-11-01 00:00:00
abstract::Dickkopf-1 (DKK1) and sclerostin are antagonists of the Wnt/β-catenin pathway and decreased expression of either results in increased bone formation and mass. As both affect the same signaling pathway, we aimed to elucidate the redundancy and/or compensation of sclerostin and DKK1. Weekly sclerostin antibody (Scl-Ab) ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-018-0420-6
更新日期:2018-09-01 00:00:00
abstract::In the rat, prolonged administration of the luteinizing, hormone-releasing hormone agonist buserelin (25 micrograms/kg body wt/day s.c.) lowers blood estradiol, raises bone resorption, and induces osteopenia. The present study was undertaken to determine whether withdrawal of buserelin normalizes blood estradiol, slow...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555819
更新日期:1990-01-01 00:00:00
abstract::Vit-D-Dependent calcium binding protein and parvalbumin have both been detected in ameloblasts and calcified cartilage by immunohistochemical techniques. These two Ca2+ binding proteins may play a crucial role in the local accumulation of Ca2+ ions during the process of mineralization. The mechanisms underlying the de...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02405306
更新日期:1984-01-01 00:00:00
abstract::Familial hypocalciuric hypercalcemia (FHH) is often considered in the differential diagnosis of hyperparathyroidism, but is rarely diagnosed. So far, FHH has not been documented in Israel. This report presents preliminary evidence for the occurrence of FHH in Israel. ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900290
更新日期:1997-07-01 00:00:00
abstract::Quantitative ultrasound measurement (QUS) and bone mineral density (BMD) have each been shown to predict fracture risk in women. The present study examined whether a combination of QUS and BMD could improve the predictive accuracy of fracture risk. This is a population-based prospective study which involved 454 women ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-011-9556-3
更新日期:2012-02-01 00:00:00
abstract::Mature dental enamel is the most mineralized of all mammalian tissues and considered to be free of collagen. Hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP) are two nonreducible cross-links of mature collagen. Hydroxyproline (Hyp) is an amino acid that is believed to be indicative of the presence of collagen....
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-004-0122-0
更新日期:2005-02-01 00:00:00
abstract::To clarify the mechanisms underlying shockwave-induced osteogenesis, we applied shockwave to rat femoral shafts from the ventral side. We assessed bone mineral content (BMC) and bone mineral density (BMD), and analyzed the spatial and temporal gene expression for pro-alpha1 (I) collagen (COL1A1), pro-alpha1 (II) colla...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-003-0043-3
更新日期:2004-02-01 00:00:00
abstract::The effect of parathormone (PTH), lipopolysaccharide (LPS), or interleukin-1 (IL-1) on calcium release and collagen degradation in bone was examined in vitro using labeled neonatal calvaria of normal mice and also of osteopetrotic microphthalmic (mi/mi) mice that have defective osteoclasts. All three agents stimulated...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02554878
更新日期:1985-05-01 00:00:00
abstract::In general, physical exercise appears to have favorable effects on the skeleton. However, a few recent reports have described negative effects, including reduced bone density (BMD) and high bone turnover in runners. The aim of our study was to compare endurance runners to controls with respect to BMD at different site...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900366
更新日期:1997-12-01 00:00:00
abstract::The values of in vivo T1 relaxation time (T1) of phosphorus atoms of wrist bone have been measured by phosphorus-31 magnetic resonance spectroscopy (MRS) in 65 menopausal women separated into three groups: (1) age-matched women without any paraclinical or clinical osteoporosis; (2) patients with paraclinical osteoporo...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00298583
更新日期:1995-06-01 00:00:00