Abstract：
:Quantitative ultrasound measurement (QUS) and bone mineral density (BMD) have each been shown to predict fracture risk in women. The present study examined whether a combination of QUS and BMD could improve the predictive accuracy of fracture risk. This is a population-based prospective study which involved 454 women and 445 men aged 62-89 years. Femoral neck BMD (FNBMD) was measured by DXA and calcaneal QUS was measured as broadband ultrasound attenuation (BUA) by a CUBA sonometer. Fragility fracture was ascertained by X-ray reports during the follow-up period, which took place between mid-1989 and 2009. During the follow-up period (median 13 years, range 11-15), 75 men and 154 women sustained a fragility fracture. In women, the model with FNBMD and BUA had a higher AUC compared to that without BUA (0.73 vs. 0.71 for any fracture, 0.81 vs. 0.77 for hip fracture, and 0.72 vs. 0.70 for vertebral fracture). Reclassification analysis yielded a total net reclassification improvement of 7.3%, 11.1%, and 5.2% for any, hip, and vertebral fractures, respectively. For men, the addition of BUA to FNBMD did not improve the predictive power for any, hip, or vertebral fracture. These results suggest that calcaneal QUS is an independent predictor of fracture risk and that a combination of QUS and BMD measurement could improve the predictive accuracy of fracture risk in elderly women.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Chan MY,Nguyen ND,Center JR,Eisman JA,Nguyen TVdoi
10.1007/s00223-011-9556-3subject
Has Abstractpub_date
2012-02-01 00:00:00pages
128-36issue
2eissn
0171-967Xissn
1432-0827journal_volume
90pub_type
杂志文章abstract：:The purpose of this study is to evaluate degenerative factors in a postmenopausal patient group and differentiate the influence on bone mineral density (BMD) measurements by dual-energy X-ray absorptiometry (DXA). The patients and methods included an investigation of 144 postmenopausal women (mean 63.3 years) with PA-...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900258
更新日期：1997-05-01 00:00:00
abstract：:In order to assess similarities and differences in women that suffer surgical versus natural menopause, a series of bone, clinical, and biochemical parameters was assayed in a clinical sample of 35 women with surgical menopause and 112 women with natural menopause. Biochemical parameters included hormones [parathyroid...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-003-0054-0
更新日期：2004-02-01 00:00:00
abstract：:Radioimmunoassay of the carboxyterminal propeptide of human type I procollagen has been recently introduced to measure in vitro synthesis of type I collagen by osteoblasts and fibroblasts. However, it has not been assessed whether the equivalent results are obtained with this new assay and with tritiated proline incor...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900607
更新日期：1999-03-01 00:00:00
abstract：:Mice deficient in the chloride channel ClC-7, which is likely involved in acidification of the resorption lacuna, display severe osteopetrosis. To fully characterize the osteopetrotic phenotype, the phenotypes of osteoclasts and osteoblasts were evaluated. ClC-7(-/-) mice and their corresponding wild-type littermates ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-008-9185-7
更新日期：2008-12-01 00:00:00
abstract：:The P2X7 nucleotide receptor (P2X7R) is an ATP-gated ion channel expressed in bone cells. Homozygous null P2X7R (P2X7R(-/-)) mice have reduced bone formation, so we hypothesized that P2X7R(-/-) mice have impaired fracture healing compared to P2X7R(+/+) control mice. To test the hypothesis, adult P2X7R(-/-) mice and P2...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-009-9237-7
更新日期：2009-05-01 00:00:00
abstract：:Energy-dispersive X-ray microanalysis was used to determine calcium/phosphorous (Ca/P) ratios in undecalcified teeth, and the sulfur (S) content of dentin of decalcified teeth from normal patients and patients with familial hypophosphatemia, in an attempt to determine the effect of phosphorus deficiency. The results s...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555886
更新日期：1990-12-01 00:00:00
abstract：:Prosected vertebrae and phalanges from 32 cadavera were examined using noninvasive methods commonly used for assessment of osteoporosis. Bone measures were then compared with a strength variable obtained by mechanically crushing or breaking the bones. All of the phalangeal density assessment techniques were found to b...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555150
更新日期：1988-08-01 00:00:00
abstract：:The usefulness of various bone mineral measurement techniques is a subject of current controversy. In order to explore whether disparate conclusions may have arisen from differences in analytic methodology, data from published reports of bone mass and nonviolent fractures have been reanalyzed in terms of fracture risk...
journal_title：Calcified tissue international
pub_type： 杂志文章,meta分析
doi：10.1007/BF02555036
更新日期：1990-03-01 00:00:00
abstract：:The recent advancement of high resolution magnetic resonance imaging has opened up new avenues for the determination of structural characteristics of the trabecular network, which may significantly improve the diagnosis of osteoporosis. An analysis of the calcaneus in healthy women has shown similar age-related change...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002230001168
更新日期：2001-03-01 00:00:00
abstract：:Tumor cells with high skeletal homing affinity express numerous cell surface receptors that bind ligands produced in bone. Upon arrival, these cells survive in the host environment, encompassed in close proximity to bone marrow cells. Interactions between tumor cells and cells of the host microenvironment are essentia...
journal_title：Calcified tissue international
pub_type： 杂志文章,评审
doi：10.1007/s00223-013-9794-7
更新日期：2014-01-01 00:00:00
abstract：:We compared indices of three-dimensional microstructure of iliac trabecular bone between 26 patients with vertebral compression fractures due to postmenopausal osteoporosis and 24 control subjects without vertebral fracture, who were matched for age, sex, race, menopausal status, and several densitometric and histolog...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02554913
更新日期：1985-12-01 00:00:00
abstract：:Several rare inherited disorders have been described that show phenotypic overlap with Paget's disease of bone (PDB) and in which PDB is a component of a multisystem disorder affecting muscle and the central nervous system. These conditions are the subject of this review article. Insertion mutations within exon 1 of t...
journal_title：Calcified tissue international
pub_type： 杂志文章,评审
doi：10.1007/s00223-019-00520-5
更新日期：2019-05-01 00:00:00
abstract：:Bone loss occurs as early as the third decade and its cumulative effect throughout adulthood may impact risk for osteoporosis in later life, however, the genes and environmental factors influencing early bone loss are largely unknown. We investigated the role of genes in the change in bone mineral density (BMD) in par...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-008-9197-3
更新日期：2009-02-01 00:00:00
abstract：:Risk factors for increased mortality in hip fracture patients include older age, male sex, fracture type, bone mineral density, and pre-existing co-morbidities. The role of biochemical and other anthropometric parameters on hip fracture mortality remains unclear. The aim of this study was to identify the risk factors ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-015-0070-x
更新日期：2016-01-01 00:00:00
abstract：:Teriparatide (TPTD) is the most widely used anabolic agent in the treatment of patients with osteoporosis although its use is restricted in many countries. A recent randomised trial confirmed that TPTD was superior to risedronate at preventing vertebral fractures over a 2-year period. There is limited information on t...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-019-00563-8
更新日期：2019-08-01 00:00:00
abstract：:The definition of osteoporosis was based for several years on bone mineral density values, which were used by most guidelines for defining treatment thresholds. The availability of tools for the estimation of fracture risk, such as FRAX™ or its adapted Italian version, DeFRA, is providing a way to grade osteoporosis s...
journal_title：Calcified tissue international
pub_type： 社论
doi：10.1007/s00223-013-9748-0
更新日期：2013-09-01 00:00:00
abstract：:Syndesmophyte occurrence and axial bone loss were investigated in the heterozygous Tg187 tumor necrosis factor (TNF) transgenic mouse model (Tg-huTNF) of arthritis. Female and male Tg-huTNF mice were compared to wild-type mice (WT) at 2, 4, 6, 8, and 10 weeks. Syndesmophytes, intervertebral disc space, osteoclasts, os...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-017-0237-8
更新日期：2017-06-01 00:00:00
abstract：:We separated osteoclasts from bone and observed the effect of several known and potential mediators of the control of bone resorption on their cytoplasmic motility. We already found that calcitonin (CT), a hormone that inhibits bone resorption, regularly causes complete inhibition of cytoplasmic motility, specific for...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02405095
更新日期：1983-07-01 00:00:00
abstract：:The purpose of this study was to investigate the mineral induction capacity in vitro of polyanionic proteins covalently bound to a surface. Rat dentin gamma-carboxyglutamate-containing protein of the osteocalcin type (Gla-protein), proteoglycan (PG), and phosphoprotein (PP-H), as well as phosvitin (PhV) and bovine ser...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02553763
更新日期：1989-04-01 00:00:00
abstract：:Bone involvement, mainly osteoporosis but also osteosclerosis, is frequent in patients with indolent systemic mastocytosis (ISM). The recent characterization of the canonical Wnt/β-catenin pathway in the regulation of bone remodeling provided important insights for our understanding of the pathophysiology of a number ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-015-9969-5
更新日期：2015-05-01 00:00:00
abstract：:The present study was designed to characterize dentin formed in transplanted rat molars by investigating calcium (Ca), phosphorus (P), and magnesium (Mg) concentrations using electron probe microanalysis (EPMA) as well as examining the rate of dentin matrix formation by vital staining. The unerupted immature lower rig...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-005-0134-4
更新日期：2006-03-01 00:00:00
abstract：:Raman spectroscopy and imaging are known to be valuable tools for the analysis of bone, the determination of protein secondary structure, and the study of the composition of crystalline materials. We have utilized all of these attributes to examine how mechanical loading and the resulting deformation affects bone ultr...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-002-1039-0
更新日期：2003-02-01 00:00:00
abstract：:Mononuclear phagocytes have been implicated as important cellular elements in the process of bone resorption. We have postulated that the recruitment and migration of mononuclear phagocytes to bone occurs via a mechanism(s) in which bone-derived chemotactic factors (BDCF) are released from foci undergoing resorption. ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02557681
更新日期：1985-01-01 00:00:00
abstract：:Results from previous quasi-static mechanical tests indicate that femurs from elderly subjects fail in vitro at forces 50% below those available in a fall from standing height. However, bone is a rate-dependent material, and it is not known whether this imbalance is present at rates of loading which occur in a fall. B...
journal_title：Calcified tissue international
pub_type： 临床试验,杂志文章
doi：10.1007/BF00310169
更新日期：1994-07-01 00:00:00
abstract：:High impact loading is known to prevent some of the age-related bone loss but its effects on the density distribution of cortical bone are relatively unknown. This study examined the effects of age and habitual sprinting on tibial and fibular mid-shaft bone traits (structural, cortical radial and polar bone mineral de...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-014-9881-4
更新日期：2014-08-01 00:00:00
abstract：:Mandibular first molars from 17-day-old mouse embryos were cultivated in vitro for 10 days using a new organ culture method. This method consisted of using a small glass dish and an agar chamber to slowly float the molars to the gas-medium interface where they were maintained by the surface tension of the medium. The ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555218
更新日期：1986-10-01 00:00:00
abstract：:Currently used diagnostic measures for sarcopenia are based on the evaluation of appendicular skeletal muscle mass (ASMM) divided by height-squared (ASMMI). This study aimed to investigate the associations between different operational definitions of appendicular muscle mass and BMD at different skeletal sites in agin...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-014-9902-3
更新日期：2014-10-01 00:00:00
abstract：:Acute spinal cord injury is associated with rapid bone loss and an increased risk of fracture. In this double-blind, randomized, placebo-controlled trial, 17 patients were followed for 1 year after administration of either 4 or 5 mg of zoledronic acid or placebo. Bone mineral density (BMD) and structural analyses of t...
journal_title：Calcified tissue international
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00223-007-9012-6
更新日期：2007-05-01 00:00:00
abstract：:The calcium ion binding properties of a high molecular weight bovine phosphophoryn preparation have been studied at high ionic strength (0.5 M KCl as supporting electrolyte). Surprisingly, even under these conditions at which intermolecular ionic interactions are effectively screened, phosphophoryn was capable of bind...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555712
更新日期：1987-02-01 00:00:00
abstract：:A positional cloning effort in French Canadian families with Paget's disease of bone (PDB) resulted in the identification of a mutation in the sequestosome1 (SQSTM1) gene in a subset of both familial and sporadic PDB cases. This was confirmed in samples of mainly United Kingdom (UK) origin. In this study, we performed...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-004-0244-4
更新日期：2004-08-01 00:00:00
