Abstract：
:We compared indices of three-dimensional microstructure of iliac trabecular bone between 26 patients with vertebral compression fractures due to postmenopausal osteoporosis and 24 control subjects without vertebral fracture, who were matched for age, sex, race, menopausal status, and several densitometric and histologic indices of both cortical and trabecular bone mass. The patients with fracture had a significantly lower mean value (1.03 +/- 0.15 vs. 1.26 +/- 0.26; P less than 0.005) for indirectly calculated mean trabecular plate density, an index of the number and connectivity of structural elements, and as a necessary corollary, a significantly higher mean value for the mean thickness of structural elements. Plate density was more than one standard deviation below the age-adjusted mean value for normal postmenopausal white females in 19 (73%) of the fracture cases and in only 5 (21%) of the nonfracture cases (P less than 0.001). We conclude that the biomechanical competence of trabecular bone is dependent not only on the absolute amount of bone present but also on the trabecular microstructure.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Kleerekoper M,Villanueva AR,Stanciu J,Rao DS,Parfitt AMdoi
10.1007/BF02554913subject
Has Abstractpub_date
1985-12-01 00:00:00pages
594-7issue
6eissn
0171-967Xissn
1432-0827journal_volume
37pub_type
杂志文章abstract：:Cross-sectional and case-control studies are efficient and inexpensive approaches to the study of osteoporosis; their validity depends primarily on how the subjects are sampled. Retrospective studies of fractures may be biased if measurements change as a result of the fracture. Prospective cohort studies are less pron...
journal_title：Calcified tissue international
pub_type： 杂志文章,评审
doi：10.1007/BF02555081
更新日期：1991-01-01 00:00:00
abstract：:TGF-beta isoforms sequestrated in dentin matrix potentially provide a reservoir of bioactive molecules that may influence cell behavior in the dentin-pulp complex following tissue injury. The association of these growth factors with dentin matrix and the influence of such associations on the bioactivity of growth fact...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-009-9248-4
更新日期：2009-07-01 00:00:00
abstract：:This article reviews the effects of restrictive eating disorders on bone health. The relationship between eating disorders and amenorrhea is discussed in detail. The pathologic impact of malnutrition on bone is explored by examining the results of studies using various available imaging techniques. The multiple hormon...
journal_title：Calcified tissue international
pub_type： 杂志文章,评审
doi：10.1007/s00223-016-0164-0
更新日期：2017-05-01 00:00:00
abstract：:Arterial calcification leading to increased arterial stiffness, a powerful risk factor for cardiovascular disease, may underlie the association of osteoporosis with cardiovascular disease in postmenopausal women. Osteoprotegerin (OPG), an indirect inhibitor of osteoclastogenesis, may be involved in arterial calcificat...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-008-9153-2
更新日期：2008-08-01 00:00:00
abstract：:Duffy antigen receptor for chemokines (DARC) binds to a number of pro-inflammatory chemokines, and since chemokines are known to regulate trafficking of osteoclast (OC) precursors, we predicted that DARC would regulate OC recruitment to sites of inflammation by modulating chemokine activity. To test this hypothesis, w...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-016-0170-2
更新日期：2016-11-01 00:00:00
abstract：:The effects of the trace metals zinc (Zn), manganese (Mn), and cadmium (Cd) on the metabolism of growth plate chondrocytes was examined using a mineralizing culture system. Supplementation of serum-free primary cultures of growth plate chondrocytes with 10-100 mu m Zn resulted in an increase in cell protein and greatl...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900442
更新日期：1998-04-01 00:00:00
abstract：:Prior exposure to PTH markedly decreased the responsiveness of isolated, cultured bone cells to the stimulatory effect of the hormone on cyclic AMP formation. This process of desensitization developed within 30 min, persisted during prolonged incubation of the cells in PTH-free medium, and could not be attributed to e...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02408528
更新日期：1980-01-01 00:00:00
abstract：:The effect of ipriflavone (IP), a synthetic isoflavonoid derivative, on in vivo bone formation was studied in rat perialveolar bone by surgically producing a hole in the mandibular bone. The holes were filled either with powdered IP or with compounds containing no osteoinductive properties such as biostite and Htr (ha...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900533
更新日期：1998-10-01 00:00:00
abstract：:The purpose of this research was to address the following question: How is the solubility of fluoride-pretreated carbonated apatite (CAP) in aqueous acidic media related to the equilibrium solution fluoride and/or the CAP adsorbed fluoride levels? A CAP sample prepared by a precipitation method at 70 degrees C contain...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-001-1069-z
更新日期：2003-03-01 00:00:00
abstract：:The presence of lipids in urinary stones was determined by histochemical and biochemical methods. When crystals of calcium oxalate, made by mixing calcium chloride and potassium oxalate solutions and sections of human calcium oxalate urinary stones, were exposed to osmium vapors, there was no staining of the pure crys...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02556340
更新日期：1988-02-01 00:00:00
abstract：:Bone mineral content (BMC) and bone mineral density (BMD) are common but imperfect surrogate measures of bone strength. The mechanical response tissue analyzer is a device that measures long bone bending stiffness (EI), which strongly predicts bone breaking strength. We hypothesized that isokinetic resistance training...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-009-9247-5
更新日期：2009-06-01 00:00:00
abstract：:Limited information is available on the effect of bisphosphonates in men receiving corticosteroid therapy. We studied 184 men among the patients enrolled in two, double-blind, placebo-controlled, 1-year studies with similar protocols. The studies evaluated the effects of risedronate in patients beginning corticosteroi...
journal_title：Calcified tissue international
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00223-001-1060-8
更新日期：2001-10-01 00:00:00
abstract：:High resolution transmission electron microscopy (Hr TEM) studies on biological and synthetic calcium phosphate have provided information on the dissolution process at the crystal level. The purpose of this study was to investigate the dissolution of ceramic hydroxyapatite (HA) after implantation using Hr TEM. Recover...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02561408
更新日期：1989-08-01 00:00:00
abstract：:Glucocorticoid-induced osteoporosis has been reported to be caused by enhanced bone resorption and suppressed bone formation. To clarify whether administration of vitamin K, which enhances bone formation, prevents prednisolone-induced loss of bone mineral density (BMD), a randomized, prospective, controlled study was ...
journal_title：Calcified tissue international
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/pl00005832
更新日期：2000-02-01 00:00:00
abstract：:We studied the relationship between serum calcium (Ca) and parathyroid hormone (PTH) in patients with idiopathic hypoparathyroidism (IHP) to investigate the diversity of the degree of parathyroid insufficiency and a regulation of PTH secretion by Ca in IHP. Serum intact PTH concentrations ranged from < 1.0 to 10.3 pg/...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
abstract：:Conventional transmission electron microscopy requires an effective dehydration of the tissue specimens under investigation. This dehydration, for which ethanol most often is used, may influence the solubility of the slightly soluble calcium phosphates. To study the behavior of calcium phosphates in ethanol, stable ne...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02554840
更新日期：1985-03-01 00:00:00
abstract：:The crystallinity of bone mineral at different stages of maturation has been measured by quantitative X-ray diffraction methods. Crystallinity measurements were made on tibial mid-diaphyses from 17-day embryonic chicks, newly-formed periosteal bone from embryonic chicks, and density-fractionated bone from post-hatch c...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02405032
更新日期：1983-01-01 00:00:00
abstract：:The ability of 1,25(OH)2D3 and of 24,25(OH)2D3 to prevent or to heal rickets in chicks was evaluated by studies of plasma biochemistry, growth plate histology, bone morphometry and microradiography, and bone mineralization. 1,25(OH)2D3 at a dose of 100 ng/day produced fewest abnormalities compared with vitamin D3-trea...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02405303
更新日期：1984-01-01 00:00:00
abstract：:Synovial fluid basic calcium phosphate (BCP) crystals are associated with severe destructive arthropathy. BCP crystals induce the secretion of matrix-degrading enzymes such as collagenase. No prophylactic or therapeutic agents are recognized to ameliorate the cartilage damage associated with BCP deposits in joints. As...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00571332
更新日期：1993-06-01 00:00:00
abstract：:An experimental fracture model was used to assess bone mineral density at the fracture site by peripheral computed tomography and to compare the model with biomechanical, histological, and radiographic methods for the quantification of the fracture repair process. Transverse osteotomies in the mid-diaphysis of 28 tibi...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900213
更新日期：1997-02-01 00:00:00
abstract：:The relationship between oral indicators and bone mineral density (BMD) has been studied by many investigators, with mixed and complex results. The purpose of the present cross-sectional study was to evaluate the associations of periodontal conditions and tooth loss with metacarpal BMD (m-BMD) in a community-based coh...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-004-0275-x
更新日期：2005-07-01 00:00:00
abstract：:This study examined effects of bone bonding and nonbonding implants on parameters associated with matrix vesicle-mediated primary bone formation, matrix vesicle alkaline phosphatase and phospholipase A2 specific activities, and phosphatidylserine content. Tibia marrow ablation followed by implantation of KG-Cera, Mina...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00296676
更新日期：1992-12-01 00:00:00
abstract：:Sustained exposure to high levels of parathyroid hormone (PTH), as observed in hyperparathyroidism, is catabolic to bone. The increase in the RANKL/OPG ratio in response to continuous PTH, resulting in increased osteoclastogenesis, is well established. However, the effects of prolonged PTH exposure on key regulators o...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-016-0176-9
更新日期：2016-11-01 00:00:00
abstract：:Bone and mineral metabolism has been reported to affect the development of the ossification of the posterior longitudinal ligament (OPLL). The aim of this study was to compare bone mineral densities (BMD) and rate of osteoporosis between cervical OPLL and a matched control group. We also investigated the correlation o...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-012-9662-x
更新日期：2013-01-01 00:00:00
abstract：:KH1060 is a new 20-epi-vitamin D3 analog, which has exerted a considerable immunosuppressive potency in vitro. We have tested in vivo the effect of KH1060 on the suppression of renal allograft rejection in the rat. Allogenic kidney transplantation from DA donor rats to Lewis recipient rats treated intraperitoneally wi...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00296066
更新日期：1994-02-01 00:00:00
abstract：:Human osteoblasts were obtained by migration and proliferation of cells from embryonic membranous bone on glass fragments. Light and electron microscopy analyses revealed a typical osteoblast-like appearance with high protein synthesis activity. The cells showed high alkaline phosphatase activity that was associated w...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00316880
更新日期：1992-11-01 00:00:00
abstract：:Bone is a dynamic tissue that is able to sense and adapt to mechanical stimuli by modulating its mass, geometry, and structure. Bone marrow stromal cells (BMSCs) are known to play an integral part in bone formation by providing an osteoprogenitor cell source capable of differentiating into mature osteoblasts in respon...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-003-0104-7
更新日期：2004-05-01 00:00:00
abstract：:The aim of this study was to evaluate the association among phalangeal morphometric parameters, amplitude-dependent speed of sound (AD-SOS), ultrasound bone profile index (UBPI), and spinal bone mineral density (BMD) and fracture status. One hundred women (controls, mean age 53 +/- 12 years) and 40 osteoporotic women ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-001-1092-0
更新日期：2003-04-01 00:00:00
abstract：:Bone loss occurs as early as the third decade and its cumulative effect throughout adulthood may impact risk for osteoporosis in later life, however, the genes and environmental factors influencing early bone loss are largely unknown. We investigated the role of genes in the change in bone mineral density (BMD) in par...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-008-9197-3
更新日期：2009-02-01 00:00:00
abstract：:Dual photon absorptiometry (DPA) is currently the most widely used method for noninvasive bone mineral density (BMD) measurement of the axial skeleton. Dual energy X-ray absorptiometry (DEXA) is a recently developed technique that uses an X-ray tube as a photon source; it has demonstrated several significant advantage...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02556250
更新日期：1991-11-01 00:00:00
