The in vivo effect of a new, in vitro, extremely potent vitamin D3 analog KH1060 on the suppression of renal allograft rejection in the rat.

abstract：:The small leucine-rich bone proteoglycans, biglycan and decorin, can be purified by chromatography on hydroxyapatite columns, demonstrating their potential affinities for bone apatite. To determine their effects on in vitro apatite formation and growth, a mixture of the chondroitin-sulfate (CS) bone proteoglycans, or ...

journal_title：Calcified tissue international

authors： Boskey AL,Spevak L,Doty SB,Rosenberg L

更新日期：1997-10-01 00:00:00

abstract：:We hypothesized that reactive oxygen species play an important role in avascular/ischemic osteonecrosis. When isolated chick osteocytes were cultured with hydrogen peroxide, annexin V binding, which is the earliest marker of apoptosis, increased in a dose-dependent fashion. Hydrogen peroxide also induced the activatio...

journal_title：Calcified tissue international

authors： Kikuyama A,Fukuda K,Mori S,Okada M,Yamaguchi H,Hamanishi C

更新日期：2002-09-01 00:00:00

abstract：:We separated osteoclasts from bone and observed the effect of several known and potential mediators of the control of bone resorption on their cytoplasmic motility. We already found that calcitonin (CT), a hormone that inhibits bone resorption, regularly causes complete inhibition of cytoplasmic motility, specific for...

journal_title：Calcified tissue international

authors： Chambers TJ,Dunn CJ

更新日期：1983-07-01 00:00:00

abstract：:In 11 postmenopausal women with histologically proven osteoporosis and normal lactose tolerance, a direct correlation between calcium absorption and intestinal lactase activity was observed. The results suggest that varying degrees of relative deficiencies in intestinal lactase might contribute to the graded decrease ...

journal_title：Calcified tissue international

authors： Pacifici R,Droke D,Avioli LV

更新日期：1985-01-01 00:00:00

abstract：:Recommendations from the FNIH Sarcopenia Project are that appendicular lean mass (ALM, kg) adjusted for body mass index (BMI, kg/m2) be used for identifying low lean mass, with ALM/BMI cutpoints of < 0.789 m2 for men and < 0.512 m2 for women. We report normative ALM/BMI values for Australian adults, and compare the pe...

journal_title：Calcified tissue international

authors： Pasco JA,Holloway-Kew KL,Tembo MC,Sui SX,Anderson KB,Rufus-Membere P,Hyde NK,Williams LJ,Kotowicz MA

更新日期：2019-04-01 00:00:00

abstract：:Total fat mass plays a significant role in determining bone mass, but the specific role of central adiposity independent of total fat mass has not been widely studied. Prepubertal (Tanner 1) children (n = 181; 65 boys, 116 girls, 7.8 +/- 1.5 years), including 99 Caucasians and 82 African Americans from Birmingham, Ala...

journal_title：Calcified tissue international

authors： Afghani A,Goran MI

更新日期：2006-12-01 00:00:00

abstract：:Calcium and phosphate were allowed to diffuse into gelatin and Type I collagen gels which were then cut into slices and analyzed for ion concentrations. Solutions of calcium and phosphate were then prepared, with ion concentrations equivalent to the highest levels in the slices, and mixed together, whereupon a rapid a...

journal_title：Calcified tissue international

authors： Blumenthal NC,Cosma V,Gomes E

更新日期：1991-06-01 00:00:00

abstract：:We studied the acute phase response, including specific cytokine production, [interleukin-1 (IL-1), interleukin-6 (IL-6), tumor necrosis factor alpha(TNF alpha)] following a single dose of Aredia (disodium pamidronate) in patients with increased bone turnover and, in vitro, the role played by specific cytokines in the...

journal_title：Calcified tissue international

authors： Thiébaud D,Sauty A,Burckhardt P,Leuenberger P,Sitzler L,Green JR,Kandra A,Zieschang J,Ibarra de Palacios P

更新日期：1997-11-01 00:00:00

abstract：:Osteoporosis is commonly associated with estrogen deficiency. However, the mechanisms by which the lack of this hormone causes bone loss are poorly understood. The bone structure of the oral cavity seems to be affected by estrogen deficiency, since a delayed healing process after tooth extraction has been observed aft...

journal_title：Calcified tissue international

authors： Zecchin KG,Pereira MC,Coletta RD,Graner E,Jorge J

更新日期：2005-02-01 00:00:00

abstract：:Congenital diseases that could result in hyperphosphatemia at an early age include hyperphosphatemic familial tumoral calcinosis (HFTC)/hyperostosis-hyperphosphatemia syndrome (HHS) and congenital hypoparathyroidism/pseudohypoparathyroidism due to the insufficient activity of fibroblast growth factor (FGF) 23 and para...

journal_title：Calcified tissue international

authors： Ito N,Fukumoto S

更新日期：2021-01-01 00:00:00

abstract：:Postmenopausal osteoporosis induced by estrogen deficiency causes inadequate new bone formation and affects millions of women worldwide. Melatonin can improve bone mineral density at the femoral neck in postmenopausal women with osteopenia. This study aimed to investigate the mechanism of melatonin in estrogen deficie...

journal_title：Calcified tissue international

authors： Xu L,Zhang L,Wang Z,Li C,Li S,Li L,Fan Q,Zheng L

更新日期：2018-10-01 00:00:00

abstract：:Even though indirect evidence indicates that PTH exerts an anabolic effect on dentinogenesis, the existence of PTH receptors and any second-messenger response in odontoblasts have not been demonstrated. The aim of this study was to investigate whether rat incisor odontoblasts express PTH receptors, and to identify whi...

journal_title：Calcified tissue international

authors： Lundgren T,Stenport V,Wetter A,Linde A

更新日期：1998-03-01 00:00:00

abstract：:Arterial calcification leading to increased arterial stiffness, a powerful risk factor for cardiovascular disease, may underlie the association of osteoporosis with cardiovascular disease in postmenopausal women. Osteoprotegerin (OPG), an indirect inhibitor of osteoclastogenesis, may be involved in arterial calcificat...

journal_title：Calcified tissue international

authors： Frost ML,Grella R,Millasseau SC,Jiang BY,Hampson G,Fogelman I,Chowienczyk PJ

更新日期：2008-08-01 00:00:00

abstract：:There is considerable interest in determining whether hypergravity can be used as a countermeasure for microgravity-induced bone loss. This study was conducted on 20 immature male rats in order to investigate possible elastic adaptations of cortical bone in rapidly growing rats exposed to chronic hypergravity. Ten rat...

journal_title：Calcified tissue international

authors： Kohles SS,Bowers JR,Vailas AC,Vanderby R Jr

更新日期：1996-09-01 00:00:00

abstract：:Raf-1, the product of proto-oncogene c-raf-1, has key roles in the signal transduction pathways within the cell. The molecular mechanisms of tooth development in the mouse embryo are not known in detail. We examined the expression of Raf-1 during subsequent tooth development by immunohistochemical analysis. In mouse e...

journal_title：Calcified tissue international

authors： Sunohara M,Tanzawa H,Kaneko Y,Fuse A,Sato K

更新日期：1996-01-01 00:00:00

abstract：:Seventy-two eugonadal women, mean age 39 +/- 4 years, with a z score for total body bone mineral content (BMC) of less than -1.5 (mean -1.80 +/- 0.12) were selected from a previous screening study of normal values of total body and regional BMC in women using dual-energy X-ray absorptiometry. The women were distribute...

journal_title：Calcified tissue international

authors： Rico H,Revilla M,Villa LF,Alvarez de Buergo M,Arribas I

更新日期：1994-06-01 00:00:00

abstract：:Men and women (n = 518) receiving moderate-to-high doses of corticosteroids were enrolled in two studies with similar protocols and randomly assigned to receive either placebo or risedronate (2.5 or 5 mg) for 1 year. All patients received daily calcium supplementation (500-1000 mg), and most also received supplemental...

journal_title：Calcified tissue international

authors： Wallach S,Cohen S,Reid DM,Hughes RA,Hosking DJ,Laan RF,Doherty SM,Maricic M,Rosen C,Brown J,Barton I,Chines AA

更新日期：2000-10-01 00:00:00

abstract：:We have recently reported that soy isoflavones particularly when provided in the context of soy protein are capable of preventing loss of bone mineral density due to orchidectomy in F344 rats. We hypothesize, that soy isoflavones also exert beneficial effects on bone microstructural properties, in part, by enhancing b...

journal_title：Calcified tissue international

authors： Soung DY,Devareddy L,Khalil DA,Hooshmand S,Patade A,Lucas EA,Arjmandi BH

更新日期：2006-06-01 00:00:00

abstract：:The extracellular protein matrix of developing enamel includes a major class of proteins, the amelogenins, which are believed to be concerned in regulating enamel biomineralization. Previous studies have shown the amelogenins of the extracellular matrix to be a complex of proline-rich hydrophobic proteins which, it is...

journal_title：Calcified tissue international

authors： Fincham AG,Hu YY,Pavlova Z,Slavkin HC,Snead ML

更新日期：1989-10-01 00:00:00

abstract：:Bone mineralization density distribution (BMDD) is an important determinant of bone mechanical properties. The most available skeletal site for access to the BMDD is the iliac crest. Compared to cancellous bone much less information on BMDD is available for cortical bone. Hence, we analyzed complete transiliac crest b...

journal_title：Calcified tissue international

authors： Misof BM,Dempster DW,Zhou H,Roschger P,Fratzl-Zelman N,Fratzl P,Silverberg SJ,Shane E,Cohen A,Stein E,Nickolas TL,Recker RR,Lappe J,Bilezikian JP,Klaushofer K

更新日期：2014-10-01 00:00:00

abstract：:The dentin-enamel junction (DEJ) plays an important role in preventing crack propagation from enamel into dentin. This function stems from its complex structure and materials properties that are different from either dentin or enamel. The molecular structural differences in both mineral and organic matrix across the D...

journal_title：Calcified tissue international

authors： Xu C,Yao X,Walker MP,Wang Y

更新日期：2009-03-01 00:00:00

abstract：:Discarded tissues, like human amniotic membranes and adipose tissue, were investigated for the application of Decellularized Human Amniotic Membrane (DAM) as a viable scaffold for transplantation of Adipose-derived stromal cells (ASCs) in bone regeneration of non-healing calvarial defects in rats. Amniotic membrane wa...

journal_title：Calcified tissue international

authors： Dziedzic DSM,Francisco JC,Mogharbel BF,Irioda AC,Stricker PEF,Floriano J,de Noronha L,Abdelwahid E,Franco CRC,de Carvalho KAT

更新日期：2021-01-09 00:00:00

abstract：:A strategy based on high pressure liquid chromatography (HPLC) techniques for the isolation or a principal amelogenin molecule from a single human dentition is described. A partial sequence (33 residues) for this 24 kDa amelogenin is presented and related to earlier studies of human 5 kDa tyrosine-rich amelogenin poly...

journal_title：Calcified tissue international

authors： Fincham AG,Hu YY,Lau E,Pavlova Z,Slavkin HC,Snead ML

更新日期：1990-08-01 00:00:00

abstract：:Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA levels are commonly used as an internal control to normalize gene expression data based on the belief that this gene is constitutively expressed. However, GAPDH mRNA levels increased by more than 2.5-fold in tibiae of hindlimb unloaded female rats compared to L32 m...

journal_title：Calcified tissue international

authors： Maran A,Hefferan TE,Zhang M,Turner RT

更新日期：2004-02-01 00:00:00

abstract：:Normative bone mineral density (BMD) and bone mineral content (BMC) values for the total body (TB), proximal femur (PF), and antero-posterior lumbar spine (LS) were obtained from a large cross-sectional sample of children and adolescents who were 8-17 years of age. There were 977 scans for the TB, 892 for the PF, and ...

journal_title：Calcified tissue international

authors： Faulkner RA,Bailey DA,Drinkwater DT,McKay HA,Arnold C,Wilkinson AA

更新日期：1996-11-01 00:00:00

abstract：:Icariin, the main constituent of Herba Epimedii, appears to be a promising alternative to classic drugs used to treat osteoporosis. However, the detailed molecular mechanisms of its action and the role of icariin in the cross-talk between osteoblasts and adipocytes remain unclear. The present study was designed to inv...

journal_title：Calcified tissue international

authors： Zhang D,Fong C,Jia Z,Cui L,Yao X,Yang M

更新日期：2016-08-01 00:00:00

abstract：:Monoclonal antibody against bovine serum alpha 2HS glycoprotein was raised in mice and the localization of this glycoprotein in bovine and human teeth was examined by immunohistochemical techniques on undemineralized ground sections after surface etching with dilute HCl. Positive reactions were found in both bovine an...

journal_title：Calcified tissue international

authors： Takagi Y,Shimokawa H,Suzuki M,Nagai H,Sasaki S

更新日期：1990-07-01 00:00:00

abstract：:Residents of a long-stay geriatric ward at the University Hospital Basel were included in a study to investigate the effects of hypovitaminosis D and immobility. All 91 women (mean age 82.5 years) and 92 men (mean age 78.7 years) were enrolled in the study. Measurements included bone resorption, as measured by urinary...

journal_title：Calcified tissue international

authors： Bischoff H,Stähelin HB,Vogt P,Friderich P,Vonthein R,Tyndall A,Theiler R

更新日期：1999-06-01 00:00:00

abstract：:Urinary pyridinoline (pyr) and deoxypyridinoline (dpyr) are new markers for bone resorption, and serum osteocalcin reportedly indicates osteoblastic activity. Recently, a new ultrasound bone densitometer instrument has been developed that measures ultrasonic properties of the os calcis, namely, the speed of sound (SOS...

journal_title：Calcified tissue international

authors： Kawana K,Kushida K,Takahashi M,Ohishi T,Denda M,Yamazaki K,Inoue T

更新日期：1994-12-01 00:00:00

abstract：:There is increasing evidence that 1,25 dihydroxyvitamin D3 acts directly to differentiate and activate cells of mononuclear phagocyte lineage (MNP). However, it seems possible that in bone marrow this hormone may modulate the differentiation of MNP via the factor elaborated by the stromal cells or the macrophages. We ...

journal_title：Calcified tissue international

authors： Nakamura T,Araki K,Kanda S,Kurisu K

更新日期：1986-01-01 00:00:00