Abstract:
:Urinary pyridinoline (pyr) and deoxypyridinoline (dpyr) are new markers for bone resorption, and serum osteocalcin reportedly indicates osteoblastic activity. Recently, a new ultrasound bone densitometer instrument has been developed that measures ultrasonic properties of the os calcis, namely, the speed of sound (SOS), broadband ultrasound attenuation (BUA), and stiffness index. The effects of menopause on biochemical markers and ultrasound densitometry were investigated in 40 healthy females, 36-39 years, with regular menstruation, and in 117 healthy perimenopausal females, 47-57 years, who were divided into a premenopausal group and a postmenopausal group. Significantly elevated values of pyr, dpyr, and serum osteocalcin were found for the postmenopausal group as a whole compared with the premenopausal group. We examined postmenopausal groups 48-57 years of age stratified into 2-year intervals (within 2 years of the menopause, 2-4 years postmenopause and 4-6 years postmenopause). Elevated values of urinary pyr, dpyr, and serum osteocalcin were evident even in the first 2 years postmenopause compared with the premenopausal group, and these higher values were exhibited until 6 years after menopause. We found a significant decrease in SOS, BUA, and stiffness index of the postmenopausal group as a whole, compared with those of the premenopausal group. SOS, BUA, and stiffness index of the group within 2 years of menopause significantly decreased compared with those of the premenopausal group. The Z-scores of the increase in biochemical markers and the decrease in stiffness index in the postmenopausal group were approximately 0.7-1.3 compared with the premenopausal group.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Kawana K,Kushida K,Takahashi M,Ohishi T,Denda M,Yamazaki K,Inoue Tdoi
10.1007/BF00298555subject
Has Abstractpub_date
1994-12-01 00:00:00pages
420-5issue
6eissn
0171-967Xissn
1432-0827journal_volume
55pub_type
临床试验,杂志文章abstract::The wedges of the mid-diaphyseal osteotomies carried out to correct the femoral and/or tibial native deformity in type III osteogenesis imperfecta (OI III) were used to study the remodeling patterns and lamellar organization at the level of the major deformity. Histology and scanning electron microscopy (SEM) morpholo...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-013-9771-1
更新日期:2013-11-01 00:00:00
abstract::A whole-body counter was used to measure the retention and distribution of radioactivity along the longitudinal axis of the body during 10 days after the intravenous injection of 50 microCi of 47Ca. These data and the simultaneous measurements of the serum specific activity allowed us to calculate, by the Bauer-Carlss...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02405001
更新日期:1983-01-01 00:00:00
abstract::Ribbon-like crystals, from developing enamel of human fetuses, were studied by high resolution electron microscopy. These crystals were classically described as the first organized mineral formed during amelogenesis. They were characterized by a mean width-to-thickness ratio (W.T-1) of 9.5, and 40% were bent. On latti...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00334485
更新日期:1992-10-01 00:00:00
abstract::The mineral of cortical bones has been studied in newborn, growing, and adult rats and in the calf and cow, using X-ray diffraction and infrared spectroscopy during the thermal decomposition of bones and by microassay of carbonate. The mineral of all the bone samples, regardless of species or age, was found to be a ca...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02563793
更新日期:1987-09-01 00:00:00
abstract::Pleiotrophin (PTN) was found to have potent effects on regulation of osteoblast recruitment, proliferation and differentiation. The present study examined the long-term effects of targeted PTN over-expression on bone development and repair in a transgenic mouse model. Femurs and tibiae from the PTN transgenic mice and...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-004-0145-6
更新日期:2005-04-01 00:00:00
abstract::Mononuclear phagocytes have been implicated as important cellular elements in the process of bone resorption. We have postulated that the recruitment and migration of mononuclear phagocytes to bone occurs via a mechanism(s) in which bone-derived chemotactic factors (BDCF) are released from foci undergoing resorption. ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02557681
更新日期:1985-01-01 00:00:00
abstract::Cartilage oligomeric matrix protein (COMP) is a macromolecule of yet unknown function with restricted distribution among tissues. In the present study, the ultrastructural localization of COMP in porcine immature joint cartilage and growth plate cartilage was semiquantitatively delineated. Tissues were fixed in a mixt...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900278
更新日期:1997-06-01 00:00:00
abstract::Energy-dispersive X-ray microanalysis was used to determine calcium/phosphorous (Ca/P) ratios in undecalcified teeth, and the sulfur (S) content of dentin of decalcified teeth from normal patients and patients with familial hypophosphatemia, in an attempt to determine the effect of phosphorus deficiency. The results s...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555886
更新日期:1990-12-01 00:00:00
abstract::Sarcopenia and osteoporosis are two sides of the same coin. They represent different aspects of the same age-related process of musculoskeletal atrophy and together culminate in falls, fractures, deconditioning, and increased mortality in older individuals. However, the current therapeutic approach to the prevention o...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/s00223-015-9956-x
更新日期:2015-03-01 00:00:00
abstract::Increased bone loss has been noted in lymphoma patients; however, the incidence of hip fracture is not known. The aim of our study was to explore the risk for hip fracture in patients with lymphoma compared with the entire Swedish population. The risk of hip fracture was determined in a retrospective population cohort...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-020-00674-7
更新日期:2020-06-01 00:00:00
abstract::The CYP3A7 enzyme metabolizes some steroid hormones, including dehydroepiandrosterone sulfate (DHEAS). The age-related decline of serum DHEAS levels is believed to contribute to osteoporosis. Previously, the CYP3A7*1C polymorphism has been shown to cause a persistent high CYP3A7 enzyme activity, resulting in lower lev...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-006-0227-8
更新日期:2007-03-01 00:00:00
abstract::Non-steroidal anti-inflammatory drugs (NSAID) have been recommended to prevent of heterotopic ossification (HO) after total hip arthroplasty (THA), but debates are still ongoing. The present Bayesian network meta-analysis of randomized clinical trials (RCTs) compared all available pathways of NSAID treatment as prophy...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-020-00763-7
更新日期:2021-02-01 00:00:00
abstract::The accuracy of a radiographic absorptiometry (RA) technique called digital image processing (DIP), discriminative ability of RA for osteoporotic fracture, and the relationship between RA and dual X-ray absorptiometry (DXA) of the spine and forearm were evaluated. We measured 16 cadaver hands, 32 healthy non-black pre...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900400
更新日期:1998-02-01 00:00:00
abstract::Transcriptional regulation of the postnatal skeleton is incompletely understood. Here, we determined the consequence of loss of early growth response gene 1 (EGR-1) on bone properties. Analyses were performed on both the microscopic and molecular levels utilizing micro-computed tomography (micro-CT) and Fourier transf...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-011-9486-0
更新日期:2011-07-01 00:00:00
abstract::Magnetic resonance imaging (MRI) is commonly used in the assessment of the musculoskeletal system and associated pathology. The ability of MRI to measure the signals from water and lipid protons enables quantitative measurements of bone porosity. The goal of this investigation was to demonstrate that the density and c...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002230050015
更新日期:2000-01-01 00:00:00
abstract::Toxicological studies have demonstrated that intermittent PTH1-34 treatment is associated with an increased incidence of osteosarcoma in Fischer 344 rats. Comet and micronucleus (MN) tests, standard methods to evaluate genotoxic potential of drugs, were used to detect DNA and chromosome breaks, respectively, after PTH...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-010-9396-6
更新日期:2010-11-01 00:00:00
abstract::As the correlation of bone mass from childhood to adulthood is unclear, we conducted a long-term prospective observational study to determine if a pediatric bone mass scan could predict adult bone mass. We measured cortical bone mineral content (BMC [g]), bone mineral density (BMD [g/cm(2)]), and bone width (cm) in th...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-013-9802-y
更新日期:2014-02-01 00:00:00
abstract::We studied the influence of age, gender, latitude, season, diet and ethnicity on plasma 25-hydroxyvitamin D 25 OHD, PTH, 1,25-dihydroxyvitamin D, vitamin D-binding protein, bone-specific alkaline phosphatase, and osteocalcin levels in 46 Greenlanders living in Nuuk (64 degrees N) on a traditional fare (group A), 45 Gr...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-003-0110-9
更新日期:2004-03-01 00:00:00
abstract::Impact activity is an important contributor to bone accrual. Children engaging in such activity have been shown to have greater bone mineral density (BMD) than their peers. This cross-sectional study was designed to quantify the association between BMD and impact activity in pre-pubescent girls, specifically examining...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-001-1131-x
更新日期:2003-01-01 00:00:00
abstract::The tumor-suppressor p53 is a transcription factor that regulates a number of genes in the process of cell-cycle inhibition, apoptosis, and DNA damage. Recent studies have revealed a crucial role for p53 in bone remodeling. In our previous studies we have shown that p53 is an important regulator of osteoblast differen...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-011-9533-x
更新日期:2011-11-01 00:00:00
abstract::Data on the association between dietary vitamin K intake and fracture risk are limited among Chinese. This study examined such an association in community-dwelling elderly in Hong Kong. We present data from 2,944 subjects (1,605 men, 1,339 women) who participated in a prospective cohort study. Baseline dietary intakes...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-012-9586-5
更新日期:2012-05-01 00:00:00
abstract::The purpose of this study was to establish the smallest dose of nasally administered salmon calcitonin (SCT) which, if given in conjunction with a previously published calcium/thiazide treatment, would be as effective as parenteral SCT in the treatment of Paget's disease of bone. Forty patients suffering from symptoma...
journal_title:Calcified tissue international
pub_type: 临床试验,杂志文章
doi:10.1007/BF02556111
更新日期:1991-09-01 00:00:00
abstract::The dentin-enamel junction (DEJ) plays an important role in preventing crack propagation from enamel into dentin. This function stems from its complex structure and materials properties that are different from either dentin or enamel. The molecular structural differences in both mineral and organic matrix across the D...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-008-9212-8
更新日期:2009-03-01 00:00:00
abstract::Considerable advances in oncology over recent decades have led to improved survival, while raising concerns about long-term consequences of anticancer treatments. In patients with breast or prostate malignancies, bone health is a major issue due to the high risk of bone metastases and the frequent prolonged use of hor...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/s00223-017-0369-x
更新日期:2018-02-01 00:00:00
abstract::Ipriflavone (i.p.) positively affects bone density in postmenopausal osteoporosis, primarily by inhibiting bone resorption. Using in vitro models of human osteoblast differentiation, we have observed that i.p. and some of its metabolites stimulate the expression of bone sialoprotein, decorin, and type I collagen, and ...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/s002239900378
更新日期:1997-01-01 00:00:00
abstract::Hip fracture may cause and/or complicate institutionalization. We undertook this study to define its overall prevalence among the residents of four nursing homes in Central Italy as well as its latency and impact on mobility when it occurred within institutions. We also performed a case control analysis with the aim o...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002230001212
更新日期:2001-06-01 00:00:00
abstract::The demonstration of histochemical characteristics in calcifying cartilage is fraught with methodological difficulties including the distinction of mineralized from unmineralized cartilage and the demonstration of cell detail in relatively hard tissue. This study uses the decalcified bone matrix-induced enchondral (en...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555141
更新日期:1988-10-01 00:00:00
abstract::Regular exercise and physical activity (PA) are known to be protective factors for maintaining bone mineral density (BMD) and preventing osteoporotic fracture. We investigated the associations between leisure-time PA and BMD in 2,903 premenopausal and 2,267 postmenopausal women in Korea. BMDs of the lumbar spine and f...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-012-9624-3
更新日期:2012-09-01 00:00:00
abstract::Quantitative ultrasound measurement (QUS) and bone mineral density (BMD) have each been shown to predict fracture risk in women. The present study examined whether a combination of QUS and BMD could improve the predictive accuracy of fracture risk. This is a population-based prospective study which involved 454 women ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-011-9556-3
更新日期:2012-02-01 00:00:00
abstract::We studied the effect of raloxifene (RAL) on arthritis and bone mineral density (BMD) in rats with collagen-induced arthritis (CIA). Seven-month-old female Sprague-Dawley rats were divided into five groups: rats without CIA (CNT), CIA rats that underwent ovariectomy (OVX) and were treated with RAL (CIA + OVX + RAL), C...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-010-9432-6
更新日期:2011-02-01 00:00:00