Abstract:
:Magnetic resonance imaging (MRI) is commonly used in the assessment of the musculoskeletal system and associated pathology. The ability of MRI to measure the signals from water and lipid protons enables quantitative measurements of bone porosity. The goal of this investigation was to demonstrate that the density and cross-sectional geometry of whole bones can be noninvasively measured using MRI. Ten trabecular specimens cored from whale vertebrae were used to compare apparent bone density measured directly, and using a quantitative MRI algorithm. Bone density and several cross-sectional geometric properties were also measured using MRI in the distal tibia of 14 volunteers. The MRI measurements were compared with measurements made using quantitative-computed tomography (QCT). A proton density sequence was used for all MRI studies. A porosity phantom was included in the MRI examinations and used to convert the MRI signal intensity to bone volume fraction. Bone density and cross-sectional bone geometry were calculated from the bone volume fractions by assuming constant tissue properties. The apparent density of trabecular bone cores measured directly and using quantitative MRI were linearly related (r(2) = 0.959; P < 0. 01). A strong linear relation also existed between MRI and QCT measurements of ash density (r(2) = 0.923; P < 0.01) and cross-sectional geometric properties (r(2) = 0.976-0.992; P < 0.01). MRI data can be used to measure bone density and cross-sectional geometry of whole bones if a proton density sequence is used to homogenize differences in marrow composition and a porosity phantom is used for slice-specific volume fraction calibration.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Hong J,Hipp JA,Mulkern RV,Jaramillo D,Snyder BDdoi
10.1007/s002230050015subject
Has Abstractpub_date
2000-01-01 00:00:00pages
74-8issue
1eissn
0171-967Xissn
1432-0827pii
CTI-225-98journal_volume
66pub_type
杂志文章abstract::The acute-phase response (APR) is a frequent occurrence after infusion of zoledronic acid and is caused by activation of γδ T cells. Vitamin D receptor is expressed in immune cells, and vitamin D has immunomodulatory properties. The aim of this prospective study was to test the effect of vitamin D (cholecalciferol) on...
journal_title:Calcified tissue international
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00223-012-9577-6
更新日期:2012-04-01 00:00:00
abstract::At 4 and 24 hours after injection of (35S)sulfate, there were 22-67% fewer silver grains on conventionally fixed sections than on sections fixed by cryotechniques. Differences were smaller when (3H) glucosamine was chosen as precursor. The number of silver grains increased between 4 and 24 hours in predentine and in a...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02557834
更新日期:1985-09-01 00:00:00
abstract::We have previously noted that a relatively large load (150 N) is required to induce a strain on the cortex of rat vertebrae similar to that induced on weight-bearing bones by normal mechanical usage. It seems unlikely that the musculature of the tail normally imposes loads of this magnitude, and this suggests that the...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900097
更新日期:1996-08-01 00:00:00
abstract::The low interference with growth expected in child for a cortisol analogue, deflazacort (DFZ), prompted us to verify if DFZ could affect growth less than prednisone (PDN). An interim analysis relative to 27 girls and 38 boys (out of 100 expected) aged 3-12 yrs, after a median period of 14 mo.s is reported. Children wi...
journal_title:Calcified tissue international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02556381
更新日期:1991-04-01 00:00:00
abstract::Bone collagen undergoes a series of enzymatic and nonenzymatic posttranslational modifications with maturation. The aim of this study was to analyze the collagenolytic efficiency of cathepsin K in relation to the extent of bone collagen age. Bone collagen posttranslational maturation was induced in vitro by preincubat...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-012-9604-7
更新日期:2012-07-01 00:00:00
abstract::Doses of 8, 16 (low), 32, 48, 64 (medium), and 150 (high) mg/kg/day of cortisol were administered to groups of 8 growing rats each during 16 days, and their femurs were then submitted to 3-point bending tests at low strain rate. Low doses had no effect. Medium doses, previously shown to improve calcium (Ca) balance an...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00297297
更新日期:1992-01-01 00:00:00
abstract::Irrespective of the method used for noninvasive bone mass determination, data comparison between different centers is a major problem as significant interunit variation may occur. We, therefore, have employed mobile densitometry units to reduce interunit variability in two large epidemiologic studies in Germany. Two c...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00301682
更新日期:1994-03-01 00:00:00
abstract::This manuscript discusses mineral and bone disorders of chronic kidney disease (MBD-CKD) in pediatric patients with special emphasis on the underlying pathophysiology, the causes and clinical profile of growth retardation, the alterations in the growth plate, the strategies to optimize growth and the medical recommend...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/s00223-020-00787-z
更新日期:2021-01-16 00:00:00
abstract::It has long been thought that collagen fibers within the bone matrix are deposited in an aligned pattern that channels mineral growth. If this model of bone structure is correct, both organic and inorganic phases of bone should have similar elastic anisotropy. Using an acoustic microscope, we measured longitudinal and...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00299319
更新日期:1994-11-01 00:00:00
abstract::To study the mechanism of action of thyroid hormones on bone, we examined the effects of immunosuppressive and nonimmunosuppressive cyclosporins, as well as of transforming growth factor beta 1 (TGF beta 1), 17 beta-estradiol (E2), and dihydroxytestosterone (DHT) on thyroxine (T4)- and triiodothyronine (T3)-stimulated...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00298788
更新日期:1992-02-01 00:00:00
abstract::In several studies on patients with rheumatoid arthritis, an association of bone loss with a persistently high disease activity has been found. The aim of our study was to investigate the relation between disease activity and serum levels of vitamin D metabolites, parathyroid hormone (PTH), and parameters of bone turn...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900416
更新日期:1998-03-01 00:00:00
abstract::Periodic fringes corresponding to six different lattice planes have been observed in apatite crystals of human normal alveolar bone by transmission electron microscopy. Three of these sets of fringes have spacings less than 3.5 A corresponding to the Scherzer resolution of the microscope used. The (0002) lattice plane...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02556695
更新日期:1987-06-01 00:00:00
abstract::Forty 5-week-old rats were randomly divided into 1 control group given a normal diet and water low in fluoride (0.026 mM/1) and experimental group receiving the same basic diet and a fluoride supplement of 2.6 mMol/l in the drinking water. After 30 weeks, half of the fluoride-supplemented and half of the nonsupplement...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02405089
更新日期:1983-07-01 00:00:00
abstract::This study aimed to evaluate the association between objectively measured habitual physical activity and calcaneal and forearm bone mineral density (BMD, g/cm(2)), one mechanically more loaded and one less loaded skeletal region, in children aged 6-8 years. BMD was measured in 297 boys and 265 girls by peripheral dual...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-006-0137-9
更新日期:2007-01-01 00:00:00
abstract::The existence of nutritional deficiency rickets among infants in sunny Riyadh was confirmed radiologically. Most of the rachitic infants were breast-fed, some received unsupplemented infant feeding formulae, and all live in an environment that is devoid of sunlight. Their mean age at the time of onset was 10.5 months....
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02405328
更新日期:1984-05-01 00:00:00
abstract::The relationship between bisphosphonate-induced bone mineral density (BMD) gains and antifracture efficacy remains to be fully elucidated. Data from two antifracture studies were analyzed. Postmenopausal osteoporotic women received oral (2.5 mg daily, 20 mg intermittent) or intravenous (0.5 mg, 1 mg quarterly) ibandro...
journal_title:Calcified tissue international
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00223-010-9403-y
更新日期:2010-10-01 00:00:00
abstract::The bone mineral density (BMD) of the spine was measured in the posteroanterior (PA) and lateral projections as well as the total body BMD in 447 black and white women. The lateral projection is comprised predominantly of cancellous bone whereas the total body BMD is predominantly cortical bone, and the PA spine is in...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900653
更新日期:1999-07-01 00:00:00
abstract::Using a histochemical method for demonstrating acid phosphatase activity, we have studied osteoclasts residing at two different bone sites in rat incisor alveolar bone, one at the endosteum and the other at the tooth socket, and compared the response of these osteoclasts to systemic changes. After 12 days of calcium (...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02405315
更新日期:1984-03-01 00:00:00
abstract::Test implant plates surgically retrieved from distal femurs of dogs were studied by Raman spectroscopy in order to characterize the bone-implant interface. The implant surface consisted of phosphate mineral, plasma sprayed on a titanium substrate. On the basis of its spectroscopic signature, the phosphate mineral of b...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02556157
更新日期:1991-05-01 00:00:00
abstract::To compare the ability of the bone mineral density (BMD) at the distal forearm, collagen I alpha 1 (COLIA1) polymorphism, and ultrasound stiffness to identify individuals with increased risk of wrist fracture, we studied 183 postmenopausal Czech women with a wrist fracture and 178 postmenopausal controls, ages 45-70 y...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-004-0134-9
更新日期:2005-02-01 00:00:00
abstract::Urinary pyridinoline (pyr) and deoxypyridinoline (dpyr) are new markers for bone resorption, and serum osteocalcin reportedly indicates osteoblastic activity. Recently, a new ultrasound bone densitometer instrument has been developed that measures ultrasonic properties of the os calcis, namely, the speed of sound (SOS...
journal_title:Calcified tissue international
pub_type: 临床试验,杂志文章
doi:10.1007/BF00298555
更新日期:1994-12-01 00:00:00
abstract::The usefulness of various bone mineral measurement techniques is a subject of current controversy. In order to explore whether disparate conclusions may have arisen from differences in analytic methodology, data from published reports of bone mass and nonviolent fractures have been reanalyzed in terms of fracture risk...
journal_title:Calcified tissue international
pub_type: 杂志文章,meta分析
doi:10.1007/BF02555036
更新日期:1990-03-01 00:00:00
abstract::The evidence now strongly supports a central role for oestrogen in the maintenance of the normal female skeleton. Loss of endogenous oestrogen leads to a period of accelerated bone loss which can be prevented with appropriate oestrogen replacement. The route of administration is not important provided adequate dosages...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/BF02555090
更新日期:1991-01-01 00:00:00
abstract::The effect of ipriflavone (IP), a synthetic isoflavonoid derivative, on in vivo bone formation was studied in rat perialveolar bone by surgically producing a hole in the mandibular bone. The holes were filled either with powdered IP or with compounds containing no osteoinductive properties such as biostite and Htr (ha...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900533
更新日期:1998-10-01 00:00:00
abstract::Bone loss during advancing age in women and men is partly the result of sex steroid deficiency. As the contribution of circulating sex steroids and sex hormone-binding globulin (SHBG) to bone loss remains uncertain, we sought to determine whether levels of sex steroids or SHBG predict change in bone mineral density (B...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-007-9035-z
更新日期:2007-08-01 00:00:00
abstract::Acute spinal cord injury is associated with rapid bone loss and an increased risk of fracture. In this double-blind, randomized, placebo-controlled trial, 17 patients were followed for 1 year after administration of either 4 or 5 mg of zoledronic acid or placebo. Bone mineral density (BMD) and structural analyses of t...
journal_title:Calcified tissue international
pub_type: 杂志文章,随机对照试验
doi:10.1007/s00223-007-9012-6
更新日期:2007-05-01 00:00:00
abstract::The solubilization of alkaline phosphatase (AP) from osteoblastic cell membranes obtained from human primary bone cell cultures was studied according to the age and sex of the donors (17 females, 11 males; age range: 2-77 years). Cell membranes were treated by non-ionic (n-octyl beta-D-glucopyranoside, OG), ionic or z...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002230050006
更新日期:2000-01-01 00:00:00
abstract::Several studies have shown an association between circulating leptin concentration and bone mineral density. but most studies are cross-sectional in design and report findings in women only. We per-formed a population-based longitudinal study relating baseline plasma leptin concentration to bone mass at the lumbar spi...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-002-0017-x
更新日期:2004-05-01 00:00:00
abstract::TGF-beta isoforms sequestrated in dentin matrix potentially provide a reservoir of bioactive molecules that may influence cell behavior in the dentin-pulp complex following tissue injury. The association of these growth factors with dentin matrix and the influence of such associations on the bioactivity of growth fact...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-009-9248-4
更新日期:2009-07-01 00:00:00
abstract::The discriminating ability and relevance of clinical risk factors, quantitative ultrasound (QUS) variables, X-ray-based bone mineral density (BMD) and hip axis length (HAL) measurements to evaluate the risk of osteoporotic fracture in elderly Brazilian women were examined in this study. QUS at the calcaneus (Achilles ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-002-1096-4
更新日期:2003-12-01 00:00:00