Abstract：
:This study aimed to evaluate the association between objectively measured habitual physical activity and calcaneal and forearm bone mineral density (BMD, g/cm(2)), one mechanically more loaded and one less loaded skeletal region, in children aged 6-8 years. BMD was measured in 297 boys and 265 girls by peripheral dual-energy X-ray absorptiometry in the forearm and calcaneus. An accelerometer registered the level of physical activity during 4 days (2 weekdays and the weekend). Weight, height, and skinfold thickness were measured. In order to establish thresholds (count . min(-1)) for bone-stimulating physical activity, we evaluated different definitions of vigorous physical activity. The boys had 3.2% higher distal forearm bone mineral content (BMC, P < 0.001) and 4.5% higher distal forearm BMD (P < 0.001) than the girls. They also carried out 9.7% more daily physical activity and spent 14.6-19.0% more time in vigorous physical activity (all P < 0.05) compared to the girls. In contrast, the girls had 3.8% higher calcaneal BMC (P < 0.01) and 2.5% higher calcaneal BMD (P < 0.05) than the boys. Both calcaneal and forearm BMD were significantly related to total time of daily physical activity as well as with intense physical activity above all the chosen cut-off points (all P < 0.05). The beta value for mean count . min(-1) physical activity was significantly lower than that for all the chosen cut-off points of vigorous activity both for calcaneal and distal forearm BMD. This study suggests that both habitual daily physical activity and amount of vigorous physical activity in children aged 6-8 years are associated with appendicular BMD.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Hasselstrøm H,Karlsson KM,Hansen SE,Grønfeldt V,Froberg K,Andersen LBdoi
10.1007/s00223-006-0137-9subject
Has Abstractpub_date
2007-01-01 00:00:00pages
31-8issue
1eissn
0171-967Xissn
1432-0827journal_volume
80pub_type
杂志文章abstract：:An experimental fracture model was used to assess bone mineral density at the fracture site by peripheral computed tomography and to compare the model with biomechanical, histological, and radiographic methods for the quantification of the fracture repair process. Transverse osteotomies in the mid-diaphysis of 28 tibi...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900213
更新日期：1997-02-01 00:00:00
abstract：:Parathyroid hormone (PTH), hPTH-(1-84), and its hPTH-(1-34), hPTH-(1-31)NH2, and hPTH-(1-30)NH2 fragments reduced the tail artery pressure in anesthetized female Sprague-Dawley rats by 42.4-67.1% within about 1 minute after injection into a femoral vein, but reduced the pressure by only 8.5-36.2% 2-19 minutes after su...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900233
更新日期：1997-03-01 00:00:00
abstract：:1,25(OH)2D3 was found to regulate its own receptor levels via an increase in corresponding mRNA levels in human osteoblast-like osteosarcoma cells (MG-63). In addition, exposure of the cells for 24h to dexamethasone, estradiol, retinoic acid, or triiodothyronine resulted in a dose-dependent accumulation of hVDR mRNA. ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555101
更新日期：1991-01-01 00:00:00
abstract：:The purpose of this study was to establish the smallest dose of nasally administered salmon calcitonin (SCT) which, if given in conjunction with a previously published calcium/thiazide treatment, would be as effective as parenteral SCT in the treatment of Paget's disease of bone. Forty patients suffering from symptoma...
journal_title：Calcified tissue international
pub_type： 临床试验,杂志文章
doi：10.1007/BF02556111
更新日期：1991-09-01 00:00:00
abstract：:In 11 postmenopausal women with histologically proven osteoporosis and normal lactose tolerance, a direct correlation between calcium absorption and intestinal lactase activity was observed. The results suggest that varying degrees of relative deficiencies in intestinal lactase might contribute to the graded decrease ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02557688
更新日期：1985-01-01 00:00:00
abstract：:The European Forsteo Observational Study was designed to examine the effectiveness of teriparatide in postmenopausal women with osteoporosis treated for up to 18 months in normal clinical practice in eight European countries. The incidence of clinical vertebral and nonvertebral fragility fractures, back pain, and heal...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-009-9299-6
更新日期：2009-12-01 00:00:00
abstract：:We compared the cytotoxic effects of alendronate (ALN) and incadronate (YM175) on isolated rabbit osteoclasts in vitro and on rats in vivo. In the in vitro experiment, each bisphosphonate was added to the culture of isolated osteoclasts at the final concentration of 3 x 10(-5), 3 x 10(-4), or 3 x 10(-3) M, and the amo...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900505
更新日期：1998-08-01 00:00:00
abstract：:Effects of a single dose of 200 IU of nasal salmon calcitonin (SCT) on calcium metabolism and biochemical markers of bone turnover were investigated in 12 healthy male volunteers in a randomized, placebo-controlled, cross-over design. The nasal spray was given in the morning, and subsequently blood and urine samples w...
journal_title：Calcified tissue international
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF01320907
更新日期：1993-10-01 00:00:00
abstract：:The current study is based on our earlier investigation carried out in 1999, where bone mineral density (BMD) of 35 neurofibromatosis type 1 (NF1) patients was measured and osteoporosis was shown to be common in NF1. The findings have been confirmed by a number of later publications. The purpose of the current longitu...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-012-9661-y
更新日期：2013-01-01 00:00:00
abstract：:Gnathodiaphyseal dysplasia (GDD; OMIM#166260) is a rare skeletal disorder which is mainly characterized by cemento-osseous lesions in mandibles, bone fragility, bowing and diaphyseal sclerosis of tubular bones. GDD is caused by point mutations in Anoctamin-5 (ANO5); however, the disease mechanisms remain unclear. Here...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-019-00528-x
更新日期：2019-06-01 00:00:00
abstract：:To assess the usefulness of the measurement of the os calcis by ultrasound, a method that probably reflects bone quality as well as density, we have studied 54 women with hip fracture of the proximal femur and a control group. Ultrasound evaluation of the os calcis [broadband ultrasound attenuation (BUA), speed of the...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00310252
更新日期：1995-09-01 00:00:00
abstract：:Proton pump inhibitors are taken by millions of patients for prevention and treatment of gastroesophageal diseases. Case-control studies have suggested that use of omeprazole is associated with an increased risk of hip fractures. The aim of this prospective study was to assess the risk of vertebral fractures in postme...
journal_title：Calcified tissue international
pub_type： 杂志文章,多中心研究
doi：10.1007/s00223-008-9188-4
更新日期：2009-01-01 00:00:00
abstract：:The purpose of this work was to extend to long bones the study on the ossification of human fetal skeleton in relation to conceptual age by a quantitative methodological approach. Postero-anterior scans were performed on 29 dried fetal femora (from 11.5 weeks of conceptual age to term) by a Hologic QDR 1000 X-ray dens...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900591
更新日期：1999-02-01 00:00:00
abstract：:Vitamin D supplementation is recommended for women with osteoporosis. In the FOCUS-D trial comparing the combination tablet alendronate plus vitamin D3 5,600 IU (ALN/D) with standard care (SC) prescribed by patients' personal physicians, ALN/D was more effective in improving serum 25(OH)D and bone turnover markers by ...
journal_title：Calcified tissue international
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1007/s00223-013-9763-1
更新日期：2014-02-01 00:00:00
abstract：:A guidance on the assessment and treatment of postmenopausal women at risk from fractures due to osteoporosis was recently published in Osteoporosis International as a joint effort of the International Osteoporosis Foundation and European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (Ka...
journal_title：Calcified tissue international
pub_type： 杂志文章,评审
doi：10.1007/s00223-018-00512-x
更新日期：2019-03-01 00:00:00
abstract：:Long chain polyunsaturated fatty acids (LCPUFAs) are involved in the regulation of bone metabolism. Increased dietary consumption of n-3, and possibly some n-6, LCPUFAs may limit postmenopausal bone loss. The aim of this study was to determine the effects on bone of specific fatty acids within the n-3 and n-6 LCPUFA f...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-007-9080-7
更新日期：2007-12-01 00:00:00
abstract：:The drawbacks of estrogen restrict the clinical use of hormone replacement therapy, and it would be most helpful to explore new estrogenic substances that could prevent bone loss and be free from any adverse effects. We synthesized a new compound named bone-seeking estrogen (SE2) by combining 17β-estradiol (E2) with i...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-013-9739-1
更新日期：2013-08-01 00:00:00
abstract：:Mature dental enamel is the most mineralized of all mammalian tissues and considered to be free of collagen. Hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP) are two nonreducible cross-links of mature collagen. Hydroxyproline (Hyp) is an amino acid that is believed to be indicative of the presence of collagen....
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-004-0122-0
更新日期：2005-02-01 00:00:00
abstract：:A liposome-centered endogenous precipitation method was used to investigate the effect of ultrafilterable fragments from the enzymatic digestion of rat chondrosarcoma aggrecan on the formation of insoluble calcium phosphate salts in buffered solutions at pH 7.4 and 22 degrees C. Unlike the intact aggrecan and its majo...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00425872
更新日期：1994-09-01 00:00:00
abstract：:The aim of the investigation was to measure the effect of fluoride on vertebral trabecular bone compressive strength and to correlate this with fluoride-induced changes in bone density. This correlation would express changes in the quality of bone during fluoride treatment. Pigs were used in the experiment because the...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02556693
更新日期：1987-06-01 00:00:00
abstract：:Doses of 8, 16 (low), 32, 48, 64 (medium), and 150 (high) mg/kg/day of cortisol were administered to groups of 8 growing rats each during 16 days, and their femurs were then submitted to 3-point bending tests at low strain rate. Low doses had no effect. Medium doses, previously shown to improve calcium (Ca) balance an...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00297297
更新日期：1992-01-01 00:00:00
abstract：:The extractions of 85Sr2+, 18F-, sucrose-14C, EDTA-51Cr, and antipyrine-14C in bone were determined by the multiple indicator-dilution method. Fluoride and strontium extractions were 18 to 70% during a single transcapillary passage, and those of EDTA and sucrose were from 11 to 59%, whereas extraction of antipyrine wa...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02407178
更新日期：1980-01-01 00:00:00
abstract：:The effects of fluoride on human enamel and selachian enameloid in vitro were visualized in TEM and analyzed with electron diffraction. It is demonstrated that under precise pH conditions, inducing concentration balance between F-ions and apatite, calcium fluoride is no longer formed, and crystalline changes occur ins...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02409406
更新日期：1981-01-01 00:00:00
abstract：:The binding of prostaglandin E2 (PGE2) to bone cells was studied to provide direct evidence for the existence of specific receptors in bone. Bone cells were isolated by collagenase digestion of fetal and newborn rat calvaria. Isolated cells were incubated with 3H-PGE2 and collected on Millipore filters. Specific bindi...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02405038
更新日期：1983-01-01 00:00:00
abstract：:Osteoarthritis (OA), the most prevalent chronic joint disease, increases in prevalence with age, and affects majority of individuals over the age of 65 and is a leading musculoskeletal cause of impaired mobility in the elderly. Because the precise molecular mechanisms which are involved in the degradation of cartilage...
journal_title：Calcified tissue international
pub_type： 杂志文章,评审
doi：10.1007/s00223-014-9917-9
更新日期：2014-12-01 00:00:00
abstract：:Alkaptonuria (AKU) is characterised by increased circulating homogentisic acid and deposition of ochronotic pigment in collagen-rich connective tissues (ochronosis), stiffening the tissue. This process over many years leads to a painful and severe osteoarthropathy, particularly affecting the cartilage of the spine and...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-020-00764-6
更新日期：2021-02-01 00:00:00
abstract：:Using a histochemical method for demonstrating acid phosphatase activity, we have studied osteoclasts residing at two different bone sites in rat incisor alveolar bone, one at the endosteum and the other at the tooth socket, and compared the response of these osteoclasts to systemic changes. After 12 days of calcium (...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02405315
更新日期：1984-03-01 00:00:00
abstract：:This article reviews the effects of restrictive eating disorders on bone health. The relationship between eating disorders and amenorrhea is discussed in detail. The pathologic impact of malnutrition on bone is explored by examining the results of studies using various available imaging techniques. The multiple hormon...
journal_title：Calcified tissue international
pub_type： 杂志文章,评审
doi：10.1007/s00223-016-0164-0
更新日期：2017-05-01 00:00:00
abstract：:We carried out a clinical trial of 1 alpha-hydroxycholecalciferol [1 alpha(OH)D3] at a dose of 1.0 microgram a day on 7 patients with psoriasis vulgaris. These patients had been treated by topical applications of corticosteroids before this study without improvement, and during the clinical trial, treatment of topical...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555172
更新日期：1986-12-01 00:00:00
abstract：:Syndesmophyte occurrence and axial bone loss were investigated in the heterozygous Tg187 tumor necrosis factor (TNF) transgenic mouse model (Tg-huTNF) of arthritis. Female and male Tg-huTNF mice were compared to wild-type mice (WT) at 2, 4, 6, 8, and 10 weeks. Syndesmophytes, intervertebral disc space, osteoclasts, os...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-017-0237-8
更新日期：2017-06-01 00:00:00
