Osteoarthritis pathogenesis: a review of molecular mechanisms.

abstract：:Osteoblasts in vitro differentiate from a proliferating to a mineralizing phenotype upon transfer to a medium rich in beta-glycerophosphate and ascorbic acid. The nutritional requirements of the cells at different stages of this differentiation process are not known. In other cell types, nutritional supplementation du...

journal_title：Calcified tissue international

authors： Brown PM,Hutchison JD,Crockett JC

更新日期：2011-12-01 00:00:00

abstract：:Cost-effective intervention thresholds (ITs) based on FRAX(®) were determined for Portugal. Assuming a willingness to pay (WTP) of €32,000 per quality-adjusted life years (QALYs), treatment with generic alendronate is cost effective for men and women aged 50 years or more, with 10-year probabilities for major osteopor...

journal_title：Calcified tissue international

authors： Marques A,Lourenço Ó,Ortsäter G,Borgström F,Kanis JA,da Silva JA

更新日期：2016-08-01 00:00:00

abstract：:Dickkopf-1 (DKK1) and sclerostin are antagonists of the Wnt/β-catenin pathway and decreased expression of either results in increased bone formation and mass. As both affect the same signaling pathway, we aimed to elucidate the redundancy and/or compensation of sclerostin and DKK1. Weekly sclerostin antibody (Scl-Ab) ...

journal_title：Calcified tissue international

authors： Morse A,Cheng TL,Schindeler A,McDonald MM,Mohanty ST,Kneissel M,Kramer I,Little DG

更新日期：2018-09-01 00:00:00

abstract：:This study revealed the distinguished changes of preferential orientation of collagen and apatite and Young's modulus in two different types of osteoporotic bones compared with the normal bone. Little is known about the bone material properties of osteoporotic bones; therefore, we aimed to assess material properties i...

journal_title：Calcified tissue international

authors： Ozasa R,Ishimoto T,Miyabe S,Hashimoto J,Hirao M,Yoshikawa H,Nakano T

更新日期：2019-04-01 00:00:00

abstract：:Previous observational studies have identified various risk factors associated with the development of osteoporosis, including sex hormone-binding globulin (SHBG). The aim of this study was to determine the potential causal effects of circulating SHBG concentrations on bone mineral density (BMD). Two-sample Mendelian ...

journal_title：Calcified tissue international

authors： Qu Z,Jiang J,Yang F,Huang J,Zhao J,Yan S

更新日期：2020-10-17 00:00:00

abstract：:Peritubular dentin (PTD) is a relatively dense mineralized tissue surrounding tooth dentin tubules, whose composition and mode of formation are still unclear. Fourier transform infrared microspectroscopic studies of the organic and mineral components of the highly developed horse PTD indicate that the peritubular matr...

journal_title：Calcified tissue international

authors： Magne D,Guicheux J,Weiss P,Pilet P,Daculsi G

更新日期：2002-08-01 00:00:00

abstract：:Osteoclastic bone resorption can be induced within the auditory bulla of the Mongolian gerbil by minute increases in air pressure. The objective of this study was to determine the rate at which osteoclasts are induced in areas of resorption and to compare the rate of osteoblast recruitment. Stainless steel tubes were ...

journal_title：Calcified tissue international

authors： Chole RA,Chan DE

更新日期：1989-11-01 00:00:00

abstract：:Men and women (n = 518) receiving moderate-to-high doses of corticosteroids were enrolled in two studies with similar protocols and randomly assigned to receive either placebo or risedronate (2.5 or 5 mg) for 1 year. All patients received daily calcium supplementation (500-1000 mg), and most also received supplemental...

journal_title：Calcified tissue international

authors： Wallach S,Cohen S,Reid DM,Hughes RA,Hosking DJ,Laan RF,Doherty SM,Maricic M,Rosen C,Brown J,Barton I,Chines AA

更新日期：2000-10-01 00:00:00

abstract：:Pregnancy and lactation-associated osteoporosis (PAO) is a rare condition with little known pathophysiology. Most cases are diagnosed in the third trimester of pregnancy or in the first weeks postpartum, particularly in first pregnancies. Vertebral fractures are most commonly observed and characterised by prolonged se...

journal_title：Calcified tissue international

authors： Grizzo FM,da Silva Martins J,Pinheiro MM,Jorgetti V,Carvalho MD,Pelloso SM

更新日期：2015-10-01 00:00:00

abstract：:The purpose of this study was to determine whether total serum calcium, parathyroid gland structure, and/or levels of parathyroid hormone, 1,25 and 24,25 DHCC, are altered in pigs with dental and skeletal fluorosis. Eight experimental animals receiving 2 mg F-/kg b.w. per day from age 8-14 months were compared with ei...

journal_title：Calcified tissue international

authors： Andersen L,Richards A,Care AD,Andersen HM,Kragstrup J,Fejerskov O

更新日期：1986-04-01 00:00:00

abstract：:The solubilization of alkaline phosphatase (AP) from osteoblastic cell membranes obtained from human primary bone cell cultures was studied according to the age and sex of the donors (17 females, 11 males; age range: 2-77 years). Cell membranes were treated by non-ionic (n-octyl beta-D-glucopyranoside, OG), ionic or z...

journal_title：Calcified tissue international

authors： Bourrat C,Radisson J,Chavassieux P,Azzar G,Roux B,Meunier PJ

更新日期：2000-01-01 00:00:00

abstract：:ELISAs for measuring the urinary excretion of collagen crosslinks and related peptides appear to show marked differences in sensitivity to anti-resorptive therapy. This presumably reflects variations in specificity of the anylate being detected in these assays, and the way in which they respond to treatment. To clarif...

journal_title：Calcified tissue international

authors： Tobias JH,Laversuch CV,Wilson N,Robins SP

更新日期：1996-11-01 00:00:00

abstract：:Teriparatide (TPTD) is known to increase the cortical thickness and porosity. The purpose of the present study was to determine whether switching from TPTD to ibandronate (IBN) would be useful for improving cortical bone parameters as assessed using high-resolution quantitative computed tomography (HR-QCT) analyses in...

journal_title：Calcified tissue international

authors： Iwamoto J,Seki A,Nango N

更新日期：2016-11-01 00:00:00

abstract：:The bone mineral status of 17 girls with Turner's syndrome was evaluated by single photon absorptiometry. Bone mineral content (BMC) was 25.4% below that predicted by normalization for age, sex, height, weight, and bone width. Only 25% of this demineralization could be attributed to delayed skeletal maturation. Bones ...

journal_title：Calcified tissue international

authors： Shore RM,Chesney RW,Mazess RB,Rose PG,Bargman GJ

更新日期：1982-01-01 00:00:00

abstract：:This manuscript discusses mineral and bone disorders of chronic kidney disease (MBD-CKD) in pediatric patients with special emphasis on the underlying pathophysiology, the causes and clinical profile of growth retardation, the alterations in the growth plate, the strategies to optimize growth and the medical recommend...

journal_title：Calcified tissue international

authors： Santos F,Díaz-Anadón L,Ordóñez FA,Haffner D

更新日期：2021-01-16 00:00:00

abstract：:The purpose of this study is to evaluate degenerative factors in a postmenopausal patient group and differentiate the influence on bone mineral density (BMD) measurements by dual-energy X-ray absorptiometry (DXA). The patients and methods included an investigation of 144 postmenopausal women (mean 63.3 years) with PA-...

journal_title：Calcified tissue international

authors： Rand T,Seidl G,Kainberger F,Resch A,Hittmair K,Schneider B,Glüer CC,Imhof H

更新日期：1997-05-01 00:00:00

abstract：:A morphological and electron microscopic study of bone from patients with osteogenesis imperfecta (OI) has been performed. Bone from OI patients from various anatomical sites has been compared with that from normal, age-, site-, and sex-matched controls. The morphology of OI bone appeared variable among patients and s...

journal_title：Calcified tissue international

authors： Cassella JP,Stamp TC,Ali SY

更新日期：1996-03-01 00:00:00

abstract：:Osteoporosis is a common age-related disease with a strong genetic influence. COLIA1 is one of the most extensively studied candidate genes and has consistently been associated with BMD and fracture. We examined the effects of the polymorphisms -1997G>T, -1663indelT, and +1245G>T and their haplotypes on vertebral frac...

journal_title：Calcified tissue international

authors： Husted LB,Harsløf T,Gonzalez-Bofill N,Schmitz A,Carstens M,Stenkjaer L,Langdahl BL

更新日期：2009-02-01 00:00:00

abstract：:We conducted a case-control study on fracture risk associated with the use of orally administered prednisolone/prednisone, budesonide, methylprednisolone, and hydrocortisone to assess if the various preparations were associated with different fracture patterns. Cases were all subjects with any fracture sustained durin...

journal_title：Calcified tissue international

authors： Vestergaard P,Rejnmark L,Mosekilde L

更新日期：2008-04-01 00:00:00

abstract：:The purpose of this study was to determine the efficacy of using bone mineral measurements of the calcaneus to evaluate osteoporosis. Dual energy X-ray absorptiometry (DXA) of the calcaneus was compared with posteroanterior lumbar absorptiometry (DXA) and vertebral quantitative computed tomography (QCT) measurements i...

journal_title：Calcified tissue international

authors： Laval-Jeantet AM,Bergot C,Williams M,Davidson K,Laval-Jeantet M

更新日期：1995-01-01 00:00:00

abstract：:Measurements of broadband ultrasonic attenuation (BUA) represent an established means of skeletal status assessment in osteoporosis. Today, the skeletal site that is the most widely used clinically is the calcaneus (heel bone). However, we hypothesized that fracture risk predictions could be improved if ultrasound mea...

journal_title：Calcified tissue international

authors： Padilla F,Akrout L,Kolta S,Latremouille C,Roux C,Laugier P

更新日期：2004-11-01 00:00:00

abstract：:The aims of this study were to compare the response to therapy in disease activity in pagetic patients with and without skull involvement and the usefulness of bone markers in the evaluation of these patients. Forty patients with Paget's disease treated with tiludronate and 26 healthy controls were included. Serum tot...

journal_title：Calcified tissue international

authors： Peris P,Alvarez L,Vidal S,Kasper D,Leeming DJ,Monegal A,Angeles Martínez M,Pons F,Guañabens N

更新日期：2006-07-01 00:00:00

abstract：:There are few longitudinal data on change in bone structure and muscle mass, strength and function in later life. We report these, and consider bone-muscle interrelationships in older men and women. We studied 188 men and 166 women from the Hertfordshire Cohort Study, who underwent peripheral quantitative computed tom...

journal_title：Calcified tissue international

authors： Patel A,Edwards MH,Jameson KA,Ward KA,Fuggle N,Cooper C,Dennison EM

更新日期：2018-11-01 00:00:00

abstract：:The usefulness of various bone mineral measurement techniques is a subject of current controversy. In order to explore whether disparate conclusions may have arisen from differences in analytic methodology, data from published reports of bone mass and nonviolent fractures have been reanalyzed in terms of fracture risk...

journal_title：Calcified tissue international

authors： Ross PD,Davis JW,Vogel JM,Wasnich RD

更新日期：1990-03-01 00:00:00

abstract：:Whether the decrease of zinc content in the femoral-metaphyseal tissues of rats with skeletal unloading is involved in the alteration of bone metabolism was investigated. Skeletal unloading was designed using the model of hindlimb suspension in rats. Animals were fed for 4 days with the unloading. The metaphyseal zinc...

journal_title：Calcified tissue international

authors： Yamaguchi M,Ehara Y

更新日期：1995-09-01 00:00:00

abstract：:The effect of parathormone (PTH), lipopolysaccharide (LPS), or interleukin-1 (IL-1) on calcium release and collagen degradation in bone was examined in vitro using labeled neonatal calvaria of normal mice and also of osteopetrotic microphthalmic (mi/mi) mice that have defective osteoclasts. All three agents stimulated...

journal_title：Calcified tissue international

authors： Jilka RL,Hamilton JW

更新日期：1985-05-01 00:00:00

abstract：:Raman spectroscopy has been used to demonstrate, for the first time, that calcium mineralization in the core of the major lateral teeth of the chiton Acanthopleura echinata takes place as an ordered process, with crystalline carbonated apatite being the first mineral deposited. Deposition begins at the top of the toot...

journal_title：Calcified tissue international

authors： Lee AP,Brooker LR,Macey DJ,van Bronswijk W,Webb J

更新日期：2000-11-01 00:00:00

abstract：:Mature dental enamel is the most mineralized of all mammalian tissues and considered to be free of collagen. Hydroxylysylpyridinoline (HP) and lysylpyridinoline (LP) are two nonreducible cross-links of mature collagen. Hydroxyproline (Hyp) is an amino acid that is believed to be indicative of the presence of collagen....

journal_title：Calcified tissue international

authors： Açil Y,Mobasseri AE,Warnke PH,Terheyden H,Wiltfang J,Springer I

更新日期：2005-02-01 00:00:00

abstract：:Several rare inherited disorders have been described that show phenotypic overlap with Paget's disease of bone (PDB) and in which PDB is a component of a multisystem disorder affecting muscle and the central nervous system. These conditions are the subject of this review article. Insertion mutations within exon 1 of t...

journal_title：Calcified tissue international

authors： Ralston SH,Taylor JP

更新日期：2019-05-01 00:00:00

abstract：:We assessed the bone mineral density (BMD) of 16 matched sets of cadaveric proximal femurs and feet using dual-energy x-ray absorptiometry (DXA). We also estimated the femoral neck length from the DXA scans. Quantitative ultrasound densitometry was used to measure the velocity of sound and broadband ultrasound attenua...

journal_title：Calcified tissue international

authors： Bouxsein ML,Courtney AC,Hayes WC

更新日期：1995-02-01 00:00:00