Abstract:
:We assessed the bone mineral density (BMD) of 16 matched sets of cadaveric proximal femurs and feet using dual-energy x-ray absorptiometry (DXA). We also estimated the femoral neck length from the DXA scans. Quantitative ultrasound densitometry was used to measure the velocity of sound and broadband ultrasound attenuation (BUA) in the calcaneus of each foot. The proximal femurs were then tested to failure in a loading configuration designed to simulate a fall with impact to the greater trochanter. Femoral neck BMD and trochanteric BMD were strongly associated with the femoral failure load (r2 = 0.79 and 0.81, respectively; P < 0.001), whereas femoral neck length was modestly correlated with femoral failure load (r2 = 0.27, P = 0.04). Calcaneal BMD (r2 = 0.63, P < 0.001) and BUA (r2 = 0.51, P = 0.002) were also significantly associated with femoral failure load. Given the small sample size, we were unable to detect differences in the strength of the correlations between the independent parameters and femoral failure load. Using linear multiple regression analyses, the strongest predictor of femoral failure load was a combination of femoral neck BMD and femoral neck length (R2 = 0.85, P < 0.001). Thus, it appears that both femoral and calcaneal bone mineral properties may be useful for identifying those persons at greatest risk for hip fracture.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Bouxsein ML,Courtney AC,Hayes WCdoi
10.1007/BF00296338subject
Has Abstractpub_date
1995-02-01 00:00:00pages
99-103issue
2eissn
0171-967Xissn
1432-0827journal_volume
56pub_type
杂志文章abstract::Bone mass increases steadily until age 20-30 years, when peak bone mass (PBM) is acquired. Nutrition plays a critical role in achievement of the optimal genetically programmed PBM, with reduction in the risk of osteoporosis later in life. Intake of nutrients can be estimated through the use of various tools; typically...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-013-9721-y
更新日期:2013-07-01 00:00:00
abstract::The purpose of this study was to determine whether total serum calcium, parathyroid gland structure, and/or levels of parathyroid hormone, 1,25 and 24,25 DHCC, are altered in pigs with dental and skeletal fluorosis. Eight experimental animals receiving 2 mg F-/kg b.w. per day from age 8-14 months were compared with ei...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02556714
更新日期:1986-04-01 00:00:00
abstract::The purpose of this study was to investigate the mineral induction capacity in vitro of polyanionic proteins covalently bound to a surface. Rat dentin gamma-carboxyglutamate-containing protein of the osteocalcin type (Gla-protein), proteoglycan (PG), and phosphoprotein (PP-H), as well as phosvitin (PhV) and bovine ser...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02553763
更新日期:1989-04-01 00:00:00
abstract::The goal of this study was to find out if bone can recover after long-term administration of bisphosphonate. Disodium pamidronate (APD) was given orally by gavage to mature beagle dogs at doses of 0, 2.5, 12.5, and 25 mg/kg/day for 1 year (0.1% concentration) and the animals were allowed to recover for another year. A...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00310408
更新日期:1994-10-01 00:00:00
abstract::Test implant plates surgically retrieved from distal femurs of dogs were studied by Raman spectroscopy in order to characterize the bone-implant interface. The implant surface consisted of phosphate mineral, plasma sprayed on a titanium substrate. On the basis of its spectroscopic signature, the phosphate mineral of b...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02556157
更新日期:1991-05-01 00:00:00
abstract::Doses of 8, 16 (low), 32, 48, 64 (medium), and 150 (high) mg/kg/day of cortisol were administered to groups of 8 growing rats each during 16 days, and their femurs were then submitted to 3-point bending tests at low strain rate. Low doses had no effect. Medium doses, previously shown to improve calcium (Ca) balance an...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00297297
更新日期:1992-01-01 00:00:00
abstract::Enamel of intact human teeth laser irradiated in vitro under certain conditions is known to have less subsurface demineralization than unirradiated enamel on exposure to acid; consequently, the potential use of laser irradiance to reduce caries is apparent. The laser-induced physical and/or chemical changes that cause...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/BF02556711
更新日期:1986-04-01 00:00:00
abstract::Cortical bone can be modeled as a complex hierarchical composite interrelating both structure and material properties on four levels of structural organization: molecular, ultrastructural, microscopic, and macroscopic. In young animals, the microstructural systems are long parallel lamellar units, plexiform bone, whic...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02406131
更新日期:1984-01-01 00:00:00
abstract::Proline biosynthetic and degradative enzymes are unevenly distributed in differentiated mammalian tissues. Activities of the synthetic enzymes are relatively high in collagenous tissues, whereas activities of the degradative enzymes are high in noncollagenous tissues. In order to further characterize tissue-specific p...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02441197
更新日期:1979-07-03 00:00:00
abstract::Whether the decrease of zinc content in the femoral-metaphyseal tissues of rats with skeletal unloading is involved in the alteration of bone metabolism was investigated. Skeletal unloading was designed using the model of hindlimb suspension in rats. Animals were fed for 4 days with the unloading. The metaphyseal zinc...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00310262
更新日期:1995-09-01 00:00:00
abstract::N-acetyl-beta-D-glucosaminidase (NAG) is a lysosomal enzyme predominantly located in renal proximal tubules. In idiopathic hypoparathyroidism (IHP), 100 Units of human PTH (1-34) increased urinary excretion of NAG from 0.029 +/- 0.027 to 0.173 +/- 0.035 U/lGF (p less than 0.05) in two patients before treatment and fro...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02556010
更新日期:1989-12-01 00:00:00
abstract::Non-steroidal anti-inflammatory drugs (NSAID) have been recommended to prevent of heterotopic ossification (HO) after total hip arthroplasty (THA), but debates are still ongoing. The present Bayesian network meta-analysis of randomized clinical trials (RCTs) compared all available pathways of NSAID treatment as prophy...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-020-00763-7
更新日期:2021-02-01 00:00:00
abstract::The usefulness of various bone mineral measurement techniques is a subject of current controversy. In order to explore whether disparate conclusions may have arisen from differences in analytic methodology, data from published reports of bone mass and nonviolent fractures have been reanalyzed in terms of fracture risk...
journal_title:Calcified tissue international
pub_type: 杂志文章,meta分析
doi:10.1007/BF02555036
更新日期:1990-03-01 00:00:00
abstract::Changes in the acidity of osteoclasts were evaluated by direct measurement of the fluorescent intensity of osteoclasts exposed to acridine orange, a fluorescent weak base which becomes concentrated in acid-containing subcellular compartments. Parathyroid hormone (PTH) produced dose-dependent increases in fluorescent i...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02554924
更新日期:1985-12-01 00:00:00
abstract::We compared the cytotoxic effects of alendronate (ALN) and incadronate (YM175) on isolated rabbit osteoclasts in vitro and on rats in vivo. In the in vitro experiment, each bisphosphonate was added to the culture of isolated osteoclasts at the final concentration of 3 x 10(-5), 3 x 10(-4), or 3 x 10(-3) M, and the amo...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900505
更新日期:1998-08-01 00:00:00
abstract::Employing a cytochemical bioassay, we compared parathyroid function in normal and X-linked hypophosphatemic (Hyp) mice. Under basal conditions Hyp mice manifested hypocalcemia and, in accord, had a plasma bioactive parathyroid hormone concentration (3.04 +/- 0.14 pg/ml) significantly greater than that of normals (2.16...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02553712
更新日期:1985-07-01 00:00:00
abstract::As tobacco smoking has been identified as a risk factor in the development of osteoporosis, possible deleterious effects of nicotine inhalation on bone mineral density (BMD) and mechanical properties of the femur in female rats were studied. Female Sprague Dawley rats were exposed to nicotine vapour 20 hours a day 5 d...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900692
更新日期:1999-09-01 00:00:00
abstract::Little is known about hypoxia-induced modification of the canal network in the cortical bone despite its involvement in intracortical vascularity and bone blood supply. In this study, we examined the effect of chronic hypoxia on the canal network in postnatal bone. Tibiae were harvested from 4- and 8-week-old rats (hy...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-010-9415-7
更新日期:2011-01-01 00:00:00
abstract::The effect of zinc on in vitro deoxyribonucleic acid (DNA) synthesis activity in the femoral-diaphyseal and metaphyseal tissues of newborn rats was investigated to determine a role of zinc in bone growth. In vitro DNA synthesis was assayed in a reaction mixture containing the 100 g centrifugation supernatant, which in...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-001-2010-1
更新日期:2001-09-01 00:00:00
abstract::The accuracy of a radiographic absorptiometry (RA) technique called digital image processing (DIP), discriminative ability of RA for osteoporotic fracture, and the relationship between RA and dual X-ray absorptiometry (DXA) of the spine and forearm were evaluated. We measured 16 cadaver hands, 32 healthy non-black pre...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900400
更新日期:1998-02-01 00:00:00
abstract::The present report compares the effects of different membrane phospholipid (PL)-cholesterol compositions on the kinetics of liposome-mediated formation of calcium phosphates from metastable solutions (2.25 mM CaCl2; 1.5 mM KH2PO4) at 22 degrees C, pH 7.4 and 240 mOsm. In most experiments, the liposomes were composed o...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00296290
更新日期:1992-03-01 00:00:00
abstract::Parathyroid hormone (PTH), hPTH-(1-84), and its hPTH-(1-34), hPTH-(1-31)NH2, and hPTH-(1-30)NH2 fragments reduced the tail artery pressure in anesthetized female Sprague-Dawley rats by 42.4-67.1% within about 1 minute after injection into a femoral vein, but reduced the pressure by only 8.5-36.2% 2-19 minutes after su...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900233
更新日期:1997-03-01 00:00:00
abstract::A positional cloning effort in French Canadian families with Paget's disease of bone (PDB) resulted in the identification of a mutation in the sequestosome1 (SQSTM1) gene in a subset of both familial and sporadic PDB cases. This was confirmed in samples of mainly United Kingdom (UK) origin. In this study, we performed...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-004-0244-4
更新日期:2004-08-01 00:00:00
abstract::The effect of SrCl(2) treatment on bone nanostructure in a rat ovariectomy model was studied using scanning small-angle X-ray scattering (sSAXS). Twelve 6-month-old female Wistar rats were used. Six animals were ovariectomized (+ovx) and six were left intact after sham surgery (-ovx). Six animals, three +ovx and three...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-010-9341-8
更新日期:2010-04-01 00:00:00
abstract::We studied the acute phase response, including specific cytokine production, [interleukin-1 (IL-1), interleukin-6 (IL-6), tumor necrosis factor alpha(TNF alpha)] following a single dose of Aredia (disodium pamidronate) in patients with increased bone turnover and, in vitro, the role played by specific cytokines in the...
journal_title:Calcified tissue international
pub_type: 临床试验,杂志文章
doi:10.1007/s002239900353
更新日期:1997-11-01 00:00:00
abstract::The purpose of this research was to address the following question: How is the solubility of fluoride-pretreated carbonated apatite (CAP) in aqueous acidic media related to the equilibrium solution fluoride and/or the CAP adsorbed fluoride levels? A CAP sample prepared by a precipitation method at 70 degrees C contain...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-001-1069-z
更新日期:2003-03-01 00:00:00
abstract::Quantitative trait locus analysis can be used to identify genes critically involved in biological processes. No such analysis has been applied to identifying genes that control bone fracture healing. To determine the feasibility of such an approach, healing of femur fractures was measured between C57BL/6, DBA/2, and C...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-008-9144-3
更新日期:2008-06-01 00:00:00
abstract::The histologic heterogeneity of osteoporosis relative to normal controls has attracted great interest. There has been controversy as to whether patients with high turnover osteoporosis may convert to a normal or low turnover form, and vice versa. We have studied 44 patients over 12 years by dynamic histomorphometry an...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00675620
更新日期:1993-01-01 00:00:00
abstract::GNAS is one of the most complex gene loci in the human genome and encodes multiple gene products including Gsα, XLαs, NESP55, A/B, and AS transcripts. XLαs, the extra-large G protein ɑ-subunit, is paternally expressed. XLɑs and Gsɑ share the common 2-13 exons with different promoters and first exons. Therefore, XLɑs c...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/s00223-020-00714-2
更新日期:2020-09-01 00:00:00
abstract::The purpose of this study is to evaluate degenerative factors in a postmenopausal patient group and differentiate the influence on bone mineral density (BMD) measurements by dual-energy X-ray absorptiometry (DXA). The patients and methods included an investigation of 144 postmenopausal women (mean 63.3 years) with PA-...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900258
更新日期:1997-05-01 00:00:00