当前位置： SCI文献检索 > CALCIFIED TISSUE INTERNATIONAL期刊下所有文献 > Abnormal parathyroid function in the X-linked hypophosphatemic mouse.

Abnormal parathyroid function in the X-linked hypophosphatemic mouse.

Abstract：

:Employing a cytochemical bioassay, we compared parathyroid function in normal and X-linked hypophosphatemic (Hyp) mice. Under basal conditions Hyp mice manifested hypocalcemia and, in accord, had a plasma bioactive parathyroid hormone concentration (3.04 +/- 0.14 pg/ml) significantly greater than that of normals (2.16 +/- 0.14 pg/ml). We confirmed the validity of the bioassay by demonstrating that the plasma collected from both mouse models diluted parallel to the assay standard curve. Moreover, after parathyroidectomy, normal and Hyp mice had plasma bioactive parathyroid hormone levels approximately 90% less than those obtained under basal conditions and indistinguishable from one another. In further studies we observed that dietary calcium and/or vitamin D deprivation in both animal models resulted in a comparable decline of the plasma calcium concentration. However, the concordant increase of the circulating bioactive parathyroid hormone level was greater in the normal mice. Thus, the bioactive parathyroid hormone concentration obtained in response to a low calcium challenge in normals was significantly greater than that in Hyp mice. In contrast, in response to dietary calcium loading, the plasma bioactive parathyroid hormone levels did not decrease significantly from basal values in either animal model. These data illustrate that the bioactive parathyroid hormone concentration in both normal and Hyp mice is inversely correlated with the plasma calcium. However, while the Hyp mice maintain an elevated plasma parathyroid hormone concentration under basal conditions (in response to a decreased plasma calcium), the parathyroid activity of the mutants after a more severe hypocalcemic challenge is attenuated, resulting in a significantly different model of linear correlation. Thus, these data indicate that Hyp mice manifested abnormal regulation of parathyroid function.

journal_name

Calcif Tissue Int

journal_title

Calcified tissue international

authors

Posillico JT,Lobaugh B,Muhlbaier LH,Drezner MK

doi

10.1007/BF02553712

subject

Has Abstract

pub_date

1985-07-01 00:00:00

pages

418-22

issue

eissn

0171-967X

issn

1432-0827

journal_volume

pub_type

杂志文章

在线工具

Abnormal parathyroid function in the X-linked hypophosphatemic mouse.