Abstract：
:Psoriatic arthritis (PsA) is an inflammatory rheumatic disorder that occurs in patients with psoriasis and predominantly affects musculoskeletal structures, skin, and nails. The etiology of PsA is not well understood but evidence supports an interplay of genetic, immunologic, and environmental factors which promote pathological bone remodeling and joint damage in PsA. Localized and systemic bone loss due to increased activity of osteoclasts is well established in PsA based on animal models and translational studies. In contrast, the mechanisms responsible for pathological bone remodeling in PsA remain enigmatic although new candidate molecules and pathways have been identified. Recent reports have revealed novel findings related to bone erosion and pathologic bone formation in PsA. Many associated risk factors and contributing molecular mechanisms have also been identified. In this review, we discuss new developments in the field, point out unresolved questions regarding the pathogenetic origins of the wide array of bone phenotypes in PsA, and discuss new directions for investigation.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Paine A,Ritchlin Cdoi
10.1007/s00223-017-0380-2subject
Has Abstractpub_date
2018-05-01 00:00:00pages
559-574issue
5eissn
0171-967Xissn
1432-0827pii
10.1007/s00223-017-0380-2journal_volume
102pub_type
杂志文章,评审abstract：:Undesirable changes in health-related parameters are thought to occur in retiring female athletes, but this has not been examined in longitudinal studies. The purpose of this study was to examine longitudinal changes in bone mineral density (BMD), body composition, and dietary intake in gymnasts and controls. Nonathle...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-004-0228-4
更新日期：2004-12-01 00:00:00
abstract：:To determine the relationships among nutrients intake, bone mass, and bone turnover in women we have investigated these issues in a population-based, cross-sectional, observational study in one county in central Sweden. A total of 175 women aged 28-74 at entry to the study were included. Dietary assessment was made by...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF00298425
更新日期：1995-08-01 00:00:00
abstract：:It has been well established that bone morphogenetic protein-2 (BMP-2) can induce bone formation bothin vivo andin vitro, although high concentrations (up to milligrams) of BMP-2 have been required to achieve this effectin vivo. Further, clinical applications are usually limited to a single dose at the time of implant...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02678146
更新日期：2001-02-01 00:00:00
abstract：:The effects of a series of novel phosphonates on the kinetics of mineral development in an ionophore-primed 7:2:1 phosphatidylcholine (PC): dicetylphosphate (DCP): cholesterol (Chol) liposomal model system are reported. When present at 2.5 micromol/liter or 25 micromol/liter concentrations in the solution surrounding ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02509384
更新日期：1996-05-01 00:00:00
abstract：:Twenty boys were followed during their puberty for about 2 years with examinations every third month. At each examination we determined serum concentrations of 25OHD3, 1,25(OH)2D3, 24,25(OH)2D3, 25.26(OH)2D3, alkaline phosphatase (AP) and testosterone together with bone mineral content (BMC) at the distal forearm. Hig...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02556871
更新日期：1986-03-01 00:00:00
abstract：:Bone resorption and formation in terms of milligram of calcium deposited into and released from whole humerus of 15-23 weeks old male rats were assessed, via linear least-squares regression analysis of change in calcium content and 3H-tetracycline kinetics of the bone. The rate of resorption was 0.376 mg calcium per d...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555009
更新日期：1990-04-01 00:00:00
abstract：:The evidence now strongly supports a central role for oestrogen in the maintenance of the normal female skeleton. Loss of endogenous oestrogen leads to a period of accelerated bone loss which can be prevented with appropriate oestrogen replacement. The route of administration is not important provided adequate dosages...
journal_title：Calcified tissue international
pub_type： 杂志文章,评审
doi：10.1007/BF02555090
更新日期：1991-01-01 00:00:00
abstract：:Macroporous biphasic calcium phosphate (MBCP) blocks were implanted into rabbit trabecular bone and muscle, recovered 18 weeks later, and then observed and analyzed by transmission electron microscopy (TEM), electron diffraction, and electron microprobes. The results showed that (1) apatitic microcrystals appeared by ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/pl00005825
更新日期：1999-05-01 00:00:00
abstract：:The effects of the trace metals zinc (Zn), manganese (Mn), and cadmium (Cd) on the metabolism of growth plate chondrocytes was examined using a mineralizing culture system. Supplementation of serum-free primary cultures of growth plate chondrocytes with 10-100 mu m Zn resulted in an increase in cell protein and greatl...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900442
更新日期：1998-04-01 00:00:00
abstract：:The effect of magnesium (Mg) supplementation on bone metabolism has been studied in the normal young mouse. Weanling male mice were given Mg-supplemented drinking water (5 mM or 32 mM Mg) for 4 weeks. Mineral and skeletal changes were assessed by biochemical methods and by histomorphometric analysis of endosteal bone ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02405119
更新日期：1983-09-01 00:00:00
abstract：:Parathyroid Hormone (PTH) stimulates calcium entry into bone cells in vitro, and this effect has been proposed to mediate the actions of PTH on bone. Using cells harvested from infant rat calvaria by collagenase digestion, we evaluated the sensitivity and specificity of this phenomenon. Calcium uptake was temperature ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02408543
更新日期：1980-01-01 00:00:00
abstract：:To experimentally examine the participation of amelogenins in controlled mineral-phase maturation of mammalian enamel, the identification of the individual proteins and their corresponding gene(s) is required. For this purpose, cDNAs were constructed from polyadenylated RNA from 2-day postnatal murine teeth, molecular...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02556627
更新日期：1987-04-01 00:00:00
abstract：:It is generally accepted that bone formation is depressed during corticosteroid treatment, but the effects of glucocorticoids on bone resorption are less well characterized. We have investigated the effects of short-term treatment with high-dose oral glucocorticoids on biochemical markers of bone turnover in 20 consec...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900482
更新日期：1998-07-01 00:00:00
abstract：:Osteoporosis is a common disease among patients undergoing transplantation. Its prevalence and complications have been well described in solid organ recipients, especially kidney, liver, and heart. However, studies in bone marrow transplantation (BMT) are scarce. Among the mechanisms invoked in the pathogenesis of BMT...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900240
更新日期：1997-04-01 00:00:00
abstract：:Diets with a high saturated fat content can produce deleterious effects on the absorption of dietary calcium and consequently an adverse effect on bone mineralization in growing animals. Hence dietary fat may have long-term consequences for skeletal health and skeletal pathologies such as osteoporosis. Whether a diet ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900492
更新日期：1998-07-01 00:00:00
abstract：:The ultimate hope of researchers and patients is a pathway to development of treatments for osteoarthritis to modify the disease process in addition to the symptoms. However, development of disease modifying drugs requires objective endpoints such as measures of joint structure, joint tissue homeostasis and/or joint s...
journal_title：Calcified tissue international
pub_type： 杂志文章,评审
doi：10.1007/s00223-020-00701-7
更新日期：2020-05-04 00:00:00
abstract：:We studied the influence of age, gender, latitude, season, diet and ethnicity on plasma 25-hydroxyvitamin D 25 OHD, PTH, 1,25-dihydroxyvitamin D, vitamin D-binding protein, bone-specific alkaline phosphatase, and osteocalcin levels in 46 Greenlanders living in Nuuk (64 degrees N) on a traditional fare (group A), 45 Gr...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-003-0110-9
更新日期：2004-03-01 00:00:00
abstract：:Ultrasonic methods measure properties intrinsic to bone's structure that are not necessarily dependent on bone mass. Therefore, ultrasound may prove to be a useful tool for diagnosing bone fragility and osteoporosis. The goal of this study was to determine the relationship between apparent velocity of ultrasound (AVU)...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02565132
更新日期：1991-08-01 00:00:00
abstract：:Quantitative ultrasound (US) measurements have been shown to be a new technique assessing bone status. This study aimed to assess a new US instrument, the DBM Sonic 1200(R) (IGEA) which permits the measurement of the speed of sound in the proximal phalanges (SOSp) of the hand. The results obtained were compared with D...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900574
更新日期：1999-01-01 00:00:00
abstract：:Plasma osteocalcin (BGP), growth hormone (GH), and somatomedin C(SmC) were measured in 12 patients with acromegaly [7 clinically active (aA), 5 cured (cA)] and 9 control subjects (C). Basal plasma values for the three parameters were higher in aA than in C and in cA. No significant difference was found between cA and ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555167
更新日期：1988-07-01 00:00:00
abstract：:Cytochemical staining of normal human bone cells in monolayer cultures for alkaline phosphatase (ALP) indicated that the cultures contained mixed-cell populations. Time course evaluations of the cytochemical staining revealed, in addition to the ALP-negative cell population, at least two subpopulations of ALP-positive...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555909
更新日期：1990-11-01 00:00:00
abstract：:The feasibility of two noninvasive methods [dual photon absorptiometry (DPA) and dual energy X-ray absorptiometry (DXA)] for prediction in vivo of local variations of trabecular bone strength within the proximal tibia was evaluated in 14 cadaveric knees. Trabecular bone strength was measured using an osteopenetrometer...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900131
更新日期：1996-10-01 00:00:00
abstract：:The increased uptake of bone-seeking radionuclides following a fracture has been stated to be due to an increase in bone blood flow, resulting in an increase in capillary surface area available for exchange. This paper examines the relationship between the maximum instantaneous extraction of 99mTc-MDP and blood flow i...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02405085
更新日期：1983-07-01 00:00:00
abstract：:Hyperthyroidism and thyroid hormone substitutive therapy with serum iT3 in the normal range of values are known to lead to increased bone remodeling and loss of bone mass. We looked for a relationship between serum iT3 and bone metabolic or bone mass parameters in 402 euthyroid women aged 44-60. In a group of 93 preme...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02565128
更新日期：1991-08-01 00:00:00
abstract：:Bone involvement, mainly osteoporosis but also osteosclerosis, is frequent in patients with indolent systemic mastocytosis (ISM). The recent characterization of the canonical Wnt/β-catenin pathway in the regulation of bone remodeling provided important insights for our understanding of the pathophysiology of a number ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-015-9969-5
更新日期：2015-05-01 00:00:00
abstract：:Although radiogenic free radicals are widely used as molecular probes in biological calcified tissues, their nature and their location remain controversial. In the present study we have synthesized and irradiated apatites in which 13CO3(2-) ions substitute hydroxyl or phosphate ions in hydroxyapatite. The 13C-coupling...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:The solubilization of alkaline phosphatase (AP) from osteoblastic cell membranes obtained from human primary bone cell cultures was studied according to the age and sex of the donors (17 females, 11 males; age range: 2-77 years). Cell membranes were treated by non-ionic (n-octyl beta-D-glucopyranoside, OG), ionic or z...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002230050006
更新日期：2000-01-01 00:00:00
abstract：:A 56 year-old man with a 2-year history of transitional-cell carcinoma of the urinary bladder presented with back pain and diffuse radiological osteosclerosis. Laboratory studies revealed borderline-low ionized serum calcium, and markedly elevated serum alkaline phosphatase (ALP) activity and serum osteocalcin. Serum ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900560
更新日期：1998-12-01 00:00:00
abstract：:Limited information is available on the effect of bisphosphonates in men receiving corticosteroid therapy. We studied 184 men among the patients enrolled in two, double-blind, placebo-controlled, 1-year studies with similar protocols. The studies evaluated the effects of risedronate in patients beginning corticosteroi...
journal_title：Calcified tissue international
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00223-001-1060-8
更新日期：2001-10-01 00:00:00
abstract：:Seventy-two postmenopausal osteoporotic women having more than one nontraumatic vertebral crush fracture were studied. Thirty-six of them, aged 68.8 +/- 1.2 years (18 +/- 4 YSM-years since menopause), were treated with 100 IU/day of salmon calcitonin i.m. plus 500 mg of elemental calcium for 10 days each month. The re...
journal_title：Calcified tissue international
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/BF00298606
更新日期：1995-03-01 00:00:00
