Abstract:
:Although radiogenic free radicals are widely used as molecular probes in biological calcified tissues, their nature and their location remain controversial. In the present study we have synthesized and irradiated apatites in which 13CO3(2-) ions substitute hydroxyl or phosphate ions in hydroxyapatite. The 13C-couplings show that the carbon-centered radicals are CO2- --rather than CO3(3-)--the locations of which depend on the type of carbonate and the treatment of the sample.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Geoffroy M,Tochon-Danguy HJsubject
Has Abstractpub_date
1982-01-01 00:00:00pages
S99-102eissn
0171-967Xissn
1432-0827journal_volume
34 Suppl 2pub_type
杂志文章abstract::Lumbar spine bone mass and density were measured with Dual photon absorptiometry (DPA) in 60 patients with crush fractures and 60 age-matched normal women. Short-term reproducibility of bone mineral density (BMD) was 1.3% in normal women and 2.5% in osteoporotic women; long-term reproducibility in normal women was 2.2...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02553274
更新日期:1988-12-01 00:00:00
abstract::We investigated whether polymorphisms in PTHR1 are associated with bone mineral density (BMD), to determine whether the association of this gene with BMD was due to effects on attainment of peak bone mass or effects on subsequent bone loss. The PTHR1 gene, including its 14 exons, their exon-intron boundaries, and 1,50...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-007-9072-7
更新日期:2007-10-01 00:00:00
abstract::Long-term use of hydrochlorothiazide (HCTZ), a common diuretic agent for hypertension, has been associated with increased bone density and reduced hip fracture rates in patients. In this study, we sought to examine whether HCTZ has an anabolic effect on the proliferation of human osteoblasts (derived from either verte...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00369219
更新日期:1996-12-01 00:00:00
abstract::The diphosphonates dichloromethanediphosphonate (Cl2MDP) and to a minor degree 1-hydroxyethane-1,1-diphosphonate (EDHP) increased the glycogen content in cultured cartilage cells of rabbit ear. This effect was not due to different concentrations of glucose in the medium. ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02408621
更新日期:1980-01-01 00:00:00
abstract::Osteoporosis is characterized by low bone mass and a deterioration of bone architecture and likely is influenced by genetic factors. The ovariectomized (OVX) mouse is well suited for osteoporosis research, as shown to date by cross-sectional studies. Here, we investigate longitudinal changes by in vivo micro-computed ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-008-9150-5
更新日期:2008-07-01 00:00:00
abstract::Parameters of mineral metabolism were examined in 6 patients with moderately severe anticonvulsant drug-induced osteomalacia. Compared to 15 matched controls, the patients exhibited significantly reduced serum calcium, inorganic phosphate, and 25-hydroxyvitamin D concentration, elevated serum alkaline phosphatase and ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02441155
更新日期:1979-03-13 00:00:00
abstract::We studied the influence of age, gender, latitude, season, diet and ethnicity on plasma 25-hydroxyvitamin D 25 OHD, PTH, 1,25-dihydroxyvitamin D, vitamin D-binding protein, bone-specific alkaline phosphatase, and osteocalcin levels in 46 Greenlanders living in Nuuk (64 degrees N) on a traditional fare (group A), 45 Gr...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-003-0110-9
更新日期:2004-03-01 00:00:00
abstract::We compared indices of three-dimensional microstructure of iliac trabecular bone between 26 patients with vertebral compression fractures due to postmenopausal osteoporosis and 24 control subjects without vertebral fracture, who were matched for age, sex, race, menopausal status, and several densitometric and histolog...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02554913
更新日期:1985-12-01 00:00:00
abstract::Molybdenum (Mo), at high concentrations, induces changes in the epiphyseal growth plate through its effects on copper (Cu) metabolism but it is unclear whether or not Mo can induce changes independent of its effects on copper status. To this end, the effect of Mo on longitudinal bone growth was examined in rats. Dieta...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF01321835
更新日期:1993-09-01 00:00:00
abstract::Mandibular first molars of 17-day-old mouse embryos were cultured in vitro to examine the histological effects of various concentrations of parathyroid hormone (PTH) on odontogenesis of the molars. PTH did not affect the cytodifferentiation of mesenchymal cells into preodontoblasts but inhibited that of preodontoblast...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555728
更新日期:1987-01-01 00:00:00
abstract::Bruck syndrome is a rare autosomal recessive form of osteogenesis imperfecta (OI), which is mainly characterized by joint contractures and recurrent fragility fractures. Mutations in FKBP10 and PLOD2 were identified as the underlying genetic defects of Bruck syndrome. Here we investigated the phenotypes and the pathog...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-017-0360-6
更新日期:2018-03-01 00:00:00
abstract::Prior exposure to PTH markedly decreased the responsiveness of isolated, cultured bone cells to the stimulatory effect of the hormone on cyclic AMP formation. This process of desensitization developed within 30 min, persisted during prolonged incubation of the cells in PTH-free medium, and could not be attributed to e...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02408528
更新日期:1980-01-01 00:00:00
abstract::The calcium ion binding properties of a high molecular weight bovine phosphophoryn preparation have been studied at high ionic strength (0.5 M KCl as supporting electrolyte). Surprisingly, even under these conditions at which intermolecular ionic interactions are effectively screened, phosphophoryn was capable of bind...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555712
更新日期:1987-02-01 00:00:00
abstract::The effect of the configuration of porous cylindrical hydroxyapatite (HA) scaffold and laminin preparation of the scaffold on bone formation was estimated. HA scaffolds with a hollow center of 2 or 4 mm in diameter and those without a hollow center were used. The scaffolds were immersed in laminin solution or in cultu...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-008-9157-y
更新日期:2008-08-01 00:00:00
abstract::Primary cilia are responsible for sensing mechanical loading in osteocytes. However, the underlying working mechanism of cilia remains elusive. An osteocyte model is necessary to reveal the role of cilia. Furthermore, the osteocyte model should be with upregulated or downregulated primary cilium expression. Herein, we...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-020-00756-6
更新日期:2020-12-01 00:00:00
abstract::As the correlation of bone mass from childhood to adulthood is unclear, we conducted a long-term prospective observational study to determine if a pediatric bone mass scan could predict adult bone mass. We measured cortical bone mineral content (BMC [g]), bone mineral density (BMD [g/cm(2)]), and bone width (cm) in th...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-013-9802-y
更新日期:2014-02-01 00:00:00
abstract::The extracellular protein matrix of developing enamel includes a major class of proteins, the amelogenins, which are believed to be concerned in regulating enamel biomineralization. Previous studies have shown the amelogenins of the extracellular matrix to be a complex of proline-rich hydrophobic proteins which, it is...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02556044
更新日期:1989-10-01 00:00:00
abstract::Vitamin D3 deficient (D-) mice show a depressed inflammatory response and both inflammatory peritoneal macrophages and bone marrow polymorphonuclear leukocytes of D- mice exhibit a decreased spontaneous migration under agarose. The impaired phagocytic response of peritoneal macrophages from D- mice can be corrected by...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02409507
更新日期:1981-01-01 00:00:00
abstract::Discarded tissues, like human amniotic membranes and adipose tissue, were investigated for the application of Decellularized Human Amniotic Membrane (DAM) as a viable scaffold for transplantation of Adipose-derived stromal cells (ASCs) in bone regeneration of non-healing calvarial defects in rats. Amniotic membrane wa...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-020-00793-1
更新日期:2021-01-09 00:00:00
abstract::Effects of a single dose of 200 IU of nasal salmon calcitonin (SCT) on calcium metabolism and biochemical markers of bone turnover were investigated in 12 healthy male volunteers in a randomized, placebo-controlled, cross-over design. The nasal spray was given in the morning, and subsequently blood and urine samples w...
journal_title:Calcified tissue international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF01320907
更新日期:1993-10-01 00:00:00
abstract::Matrix extracellular phosphoglycoprotein (MEPE) is an inhibitor of mineralization in situ and in cell cultures where altered expression is associated with oncogenic osteomalacia and hypophosphatemic rickets. The purpose of this study was to determine whether the intact protein or the peptide(s) originating from this p...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-009-9313-z
更新日期:2010-01-01 00:00:00
abstract::Macroporous biphasic calcium phosphate (MBCP) blocks were implanted into rabbit trabecular bone and muscle, recovered 18 weeks later, and then observed and analyzed by transmission electron microscopy (TEM), electron diffraction, and electron microprobes. The results showed that (1) apatitic microcrystals appeared by ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/pl00005825
更新日期:1999-05-01 00:00:00
abstract::We compared the cytotoxic effects of alendronate (ALN) and incadronate (YM175) on isolated rabbit osteoclasts in vitro and on rats in vivo. In the in vitro experiment, each bisphosphonate was added to the culture of isolated osteoclasts at the final concentration of 3 x 10(-5), 3 x 10(-4), or 3 x 10(-3) M, and the amo...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900505
更新日期:1998-08-01 00:00:00
abstract::At 4 and 24 hours after injection of (35S)sulfate, there were 22-67% fewer silver grains on conventionally fixed sections than on sections fixed by cryotechniques. Differences were smaller when (3H) glucosamine was chosen as precursor. The number of silver grains increased between 4 and 24 hours in predentine and in a...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02557834
更新日期:1985-09-01 00:00:00
abstract::This study investigated whether bone turnover influences the response to alendronate in women with postmenopausal osteoporosis. One hundred postmenopausal osteoporotic women were randomized to receive either alendronate (10 mg/day) plus calcium (1000 mg/day) (n = 50) or calcium alone (n = 50). Vertebral and radial bon...
journal_title:Calcified tissue international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/s002239900713
更新日期:1999-11-01 00:00:00
abstract::The aim of this study was to determine whether forearm bone mineral density (BMD) measurements are affected by clinical risk factors for osteoporosis to the same extent as spine and hip BMD. The study population consisted of 1,009 female patients and volunteers, of whom 238 were premenopausal. Women were placed into s...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-006-0217-x
更新日期:2007-02-01 00:00:00
abstract::Polymorphisms in the region of the gene for the vitamin D receptor (VDR) (chromosome 12q12-14) have been associated with differences in bone mineral density (BMD) in some studies but not in others. Because linkage analysis assesses allele sharing identical-by-descent among relatives instead of the association of a par...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002230001175
更新日期:2000-12-01 00:00:00
abstract::We assessed the bone mineral density (BMD) of 16 matched sets of cadaveric proximal femurs and feet using dual-energy x-ray absorptiometry (DXA). We also estimated the femoral neck length from the DXA scans. Quantitative ultrasound densitometry was used to measure the velocity of sound and broadband ultrasound attenua...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00296338
更新日期:1995-02-01 00:00:00
abstract::The definition of osteoporosis was based for several years on bone mineral density values, which were used by most guidelines for defining treatment thresholds. The availability of tools for the estimation of fracture risk, such as FRAX™ or its adapted Italian version, DeFRA, is providing a way to grade osteoporosis s...
journal_title:Calcified tissue international
pub_type: 社论
doi:10.1007/s00223-013-9748-0
更新日期:2013-09-01 00:00:00
abstract::A positional cloning effort in French Canadian families with Paget's disease of bone (PDB) resulted in the identification of a mutation in the sequestosome1 (SQSTM1) gene in a subset of both familial and sporadic PDB cases. This was confirmed in samples of mainly United Kingdom (UK) origin. In this study, we performed...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-004-0244-4
更新日期:2004-08-01 00:00:00