1,25-dihydroxyvitamin D3 and the regulation of macrophage function.

abstract：:We have compared two components of bacterial cell walls, muramyl dipeptide (MDP) and lipopolysaccharide (LPS), for their effects on bone resorption as measured by the release of previously incorporated 45Ca. MDP is the smallest active component of peptidoglycan, whereas LPS is the active component of endotoxin. Fetal ...

journal_title：Calcified tissue international

authors： Raisz LG,Alander C,Eilon G,Whitehead SP,Nuki K

更新日期：1982-07-01 00:00:00

abstract：:A 56 year-old man with a 2-year history of transitional-cell carcinoma of the urinary bladder presented with back pain and diffuse radiological osteosclerosis. Laboratory studies revealed borderline-low ionized serum calcium, and markedly elevated serum alkaline phosphatase (ALP) activity and serum osteocalcin. Serum ...

journal_title：Calcified tissue international

authors： Liel Y,Maor E,Ariad S,Lowenthal MN

更新日期：1998-12-01 00:00:00

abstract：:Genome-wide association studies (GWAS) have demonstrated that genetic variation at the MADS box transcription enhancer factor 2, polypeptide C (MEF2C) locus is robustly associated with bone mineral density, primarily at the femoral neck. MEF2C is a transcription factor known to operate via the Wnt signaling pathway. O...

journal_title：Calcified tissue international

authors： Johnson ME,Deliard S,Zhu F,Xia Q,Wells AD,Hankenson KD,Grant SF

更新日期：2014-04-01 00:00:00

abstract：:Magnetic resonance imaging (MRI) is commonly used in the assessment of the musculoskeletal system and associated pathology. The ability of MRI to measure the signals from water and lipid protons enables quantitative measurements of bone porosity. The goal of this investigation was to demonstrate that the density and c...

journal_title：Calcified tissue international

authors： Hong J,Hipp JA,Mulkern RV,Jaramillo D,Snyder BD

更新日期：2000-01-01 00:00:00

abstract：:Osteoclasts are multinucleated cells that carry out bone resorption. Analysis of the direct effect of hormones on the bone-resorbing activity of human osteoclasts has been limited by difficulties in isolating these cells from the human skeleton. In this study, human osteoclasts formed from cultures of peripheral blood...

journal_title：Calcified tissue international

authors： Kudo O,Sabokbar A,Pocock A,Itonaga I,Athanasou NA

更新日期：2002-12-01 00:00:00

abstract：:The aim of this study was to determine whether forearm bone mineral density (BMD) measurements are affected by clinical risk factors for osteoporosis to the same extent as spine and hip BMD. The study population consisted of 1,009 female patients and volunteers, of whom 238 were premenopausal. Women were placed into s...

journal_title：Calcified tissue international

authors： Patel R,Blake GM,Fogelman I

更新日期：2007-02-01 00:00:00

abstract：:Melorheostosis is an exceptionally rare sclerosing hyperostosis that typically affects the appendicular skeleton in a limited segmental fashion. It occasionally occurs on a background of another benign generalised sclerosing bone condition, known as osteopoikilosis caused by germline mutations in LEMD3, encoding the i...

journal_title：Calcified tissue international

authors： Wordsworth P,Chan M

更新日期：2019-05-01 00:00:00

abstract：:In the past years, several epidemiological and clinical observations have underlined the importance of genetics in the pathogenesis of both female and male osteoporosis. It has been estimated that from 50 to 80% of the inter-individual variability in bone mass is genetically determined. In rare instances, osteoporosis...

journal_title：Calcified tissue international

authors： Gennari L,Brandi ML

更新日期：2001-10-01 00:00:00

abstract：:Studies of the effect of parathyroidectomy (PTX) on bone turnover in patients with the combination of primary hyperparathyroidism (PHPT) and Paget's disease (PD) are largely limited to case reports. The etiology of the combination is disputed. We report 30 patients and their biochemical (n = 17) and histomorphometric ...

journal_title：Calcified tissue international

authors： Gutteridge DH,Gruber HE,Kermode DG,Worth GK

更新日期：1999-12-01 00:00:00

abstract：:Relapse after orthodontic tooth movement is a significant problem in orthodontics. The purpose of this study was to examine the efficacy of the osteoclast inhibitor osteoprotegerin-Fc (OPG-Fc) for inhibiting postorthodontic relapse. Rat maxillary molars were moved mesially and allowed to relapse for 24 days. Low-dose ...

journal_title：Calcified tissue international

authors： Hudson JB,Hatch N,Hayami T,Shin JM,Stolina M,Kostenuik PJ,Kapila S

更新日期：2012-04-01 00:00:00

abstract：:The aim of this study was to evaluate bone resorption (BR) in rats by two methods: chronic 3H-tetracycline labeling (3HTC) and pyridinium crosslink excretion (PYDX), and compare the sensitivity of these markers in two age groups. Female Sprague-Dawley rats at 12-29 weeks of age ("mature", n = 12) and at 40-57 weeks of...

journal_title：Calcified tissue international

authors： Talbott SM,Chowdhury H,Shapses SA

更新日期：1999-04-01 00:00:00

abstract：:Amelogenins, the major protein components of the enamel extracellular matrix, are postulated to be involved in controlling the elongated and oriented growth of enamel carbonated apatite crystals. In order to clarify the functional role of amelogenin during the early stage of enamel biomineralization, octacalcium phosp...

journal_title：Calcified tissue international

authors： Iijima M,Moradian-Oldak J

更新日期：2004-06-01 00:00:00

abstract：:In order to determine whether the bacterial bone resorbing agents lipopolysaccharide (LPS) and muramyl dipeptide (MDP) interact with osteoblasts, their effect on the synthesis of collagenase and tissue inhibitor or metalloproteinases (TIMP) from monolayer cultures of mouse osteoblast-like cells was investigated. All c...

journal_title：Calcified tissue international

authors： Sismey-Durrant HJ,Atkinson SJ,Hopps RM,Heath JK

更新日期：1989-05-01 00:00:00

abstract：:Calcium deficiency is a major etiological determinant of rickets in Nigerian children and is accompanied by undermineralization of the developing bone matrix which is composed largely of type I collagen. We have assessed types I and III collagen metabolism by measuring the circulating concentrations of teh N- and C-te...

journal_title：Calcified tissue international

authors： Sharp CA,Oginni LM,Worsfold M,Oyelami OA,Risteli L,Risteli J,Davie MW

更新日期：1997-08-01 00:00:00

abstract：:It is our hypothesis that interstitial fluid flow plays a role in the bone remodeling response to mechanical loading. The fluid flow-induced expression of three proteins (collagen, osteopontin, and alkaline phosphatase) involved in bone remodeling was investigated. Rat calvarial osteoblasts subjected to pulsatile flui...

journal_title：Calcified tissue international

authors： Hillsley MV,Frangos JA

更新日期：1997-01-01 00:00:00

abstract：:The present study examined calcium phosphate precipitation in aqueous suspensions of multilamellar liposomes as a possible in vitro model for matrix vesicle mineralization. Liposomes were prepared by dispersing CHCl3-evaporated thin films of 7:2:1 and 7:1:1 molar mixtures of phosphatidylcholine, dicetyl phosphate, and...

journal_title：Calcified tissue international

authors： Eanes ED,Hailer AW,Costa JL

更新日期：1984-07-01 00:00:00

abstract：:Radiation therapy (RT) is an established treatment modality for malignant neoplasms. RT induces tissue damage that may lead to osteoradionecrosis in more severe cases. Suitable animal models to study RT-induced changes in membranous craniofacial bone are currently not available. The aim of this study was therefore to ...

journal_title：Calcified tissue international

authors： Desmons S,Heger M,Delfosse C,Falgayrac G,Sarrazin T,Delattre C,Catros S,Mordon S,Penel G

更新日期：2009-05-01 00:00:00

abstract：:Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA levels are commonly used as an internal control to normalize gene expression data based on the belief that this gene is constitutively expressed. However, GAPDH mRNA levels increased by more than 2.5-fold in tibiae of hindlimb unloaded female rats compared to L32 m...

journal_title：Calcified tissue international

authors： Maran A,Hefferan TE,Zhang M,Turner RT

更新日期：2004-02-01 00:00:00

abstract：:Humanin (HN), a mitochondrial derived peptide, plays cyto-protective role under various stress. In this study, we aimed to investigate the effects of HNGF6A, an analogue of HN, on osteoblast apoptosis and differentiation and the underlying mechanisms. Cell proliferation of murine osteoblastic cell line MC3TC-E1 was ex...

journal_title：Calcified tissue international

authors： Zhu X,Zhao Z,Zeng C,Chen B,Huang H,Chen Y,Zhou Q,Yang L,Lv J,Zhang J,Pan D,Shen J,Duque G,Cai D

更新日期：2020-05-01 00:00:00

abstract：:Until 2006 the only mutations known to cause osteogenesis imperfecta (OI) were in the two genes coding for type I collagen chains. These dominant mutations affecting the expression or primary sequence of collagen α1(I) and α2(I) chains account for over 90% of OI cases. Since then a growing list of mutant genes causing...

journal_title：Calcified tissue international

authors： Eyre DR,Weis MA

更新日期：2013-10-01 00:00:00

abstract：:Psoriatic arthritis (PsA) is an inflammatory rheumatic disorder that occurs in patients with psoriasis and predominantly affects musculoskeletal structures, skin, and nails. The etiology of PsA is not well understood but evidence supports an interplay of genetic, immunologic, and environmental factors which promote pa...

journal_title：Calcified tissue international

authors： Paine A,Ritchlin C

更新日期：2018-05-01 00:00:00

abstract：:Aging bone shows a progressive decline in mass and strength. Previous studies have suggested that bone marrow stem cells are reduced with aging and that this could be responsible, in part, for age-associated bone deficits. We measured the number of osteoprogenitor cells present in the bone marrow from adult and aged r...

journal_title：Calcified tissue international

authors： Quarto R,Thomas D,Liang CT

更新日期：1995-02-01 00:00:00

abstract：:Atomic force microscopy (AFM) was used to obtain three-dimensional images of isolated mineralites extracted from young postnatal bovine bone. The mean mineralite size is 9 nm x 6 nm x 2.0 nm, significantly shorter and thicker than the mineralites of mature bovine bone measured by the same technique. Mineralites of the...

journal_title：Calcified tissue international

authors： Tong W,Glimcher MJ,Katz JL,Kuhn L,Eppell SJ

更新日期：2003-05-01 00:00:00

abstract：:Familial hypocalciuric hypercalcemia (FHH) is often considered in the differential diagnosis of hyperparathyroidism, but is rarely diagnosed. So far, FHH has not been documented in Israel. This report presents preliminary evidence for the occurrence of FHH in Israel. ...

journal_title：Calcified tissue international

authors： Liel Y,Arie R,Vered I

更新日期：1997-07-01 00:00:00

abstract：:To assess the usefulness of the measurement of the os calcis by ultrasound, a method that probably reflects bone quality as well as density, we have studied 54 women with hip fracture of the proximal femur and a control group. Ultrasound evaluation of the os calcis [broadband ultrasound attenuation (BUA), speed of the...

journal_title：Calcified tissue international

authors： Mautalen C,Vega E,González D,Carrilero P,Otaño A,Silberman F

更新日期：1995-09-01 00:00:00

abstract：:The effect of magnesium (Mg) supplementation on bone metabolism has been studied in the normal young mouse. Weanling male mice were given Mg-supplemented drinking water (5 mM or 32 mM Mg) for 4 weeks. Mineral and skeletal changes were assessed by biochemical methods and by histomorphometric analysis of endosteal bone ...

journal_title：Calcified tissue international

authors： Marie PJ,Travers R,Delvin EE

更新日期：1983-09-01 00:00:00

abstract：:Hypophosphatemic rickets (HR) is a group of rare disorders caused by excessive renal phosphate wasting. The purpose of this cross-sectional study of 38 HR patients was to characterize the phenotype of adult HR patients. Moreover, skeletal and endodontic severity scores were defined to assess possible gender difference...

journal_title：Calcified tissue international

authors： Beck-Nielsen SS,Brusgaard K,Rasmussen LM,Brixen K,Brock-Jacobsen B,Poulsen MR,Vestergaard P,Ralston SH,Albagha OM,Poulsen S,Haubek D,Gjørup H,Hintze H,Andersen MG,Heickendorff L,Hjelmborg J,Gram J

更新日期：2010-08-01 00:00:00

abstract：:Bone injury occurs in human hemolytic disorders associated with thrombosis, such as beta-thalassemia and sickle cell disease. Exposure of rats to 2-butoxyethanol (BE) has been associated with hemolytic anemia, disseminated thrombosis, and infarction in multiple organs including bone. This rat model apparently mimics a...

journal_title：Calcified tissue international

authors： Shabat S,Nyska A,Long PH,Goelman G,Abramovitch R,Ezov N,Levin-Harrus T,Peddada S,Redlich M,Yedgar S,Nyska M

更新日期：2004-03-01 00:00:00

abstract：:The crystallinity of bone mineral at different stages of maturation has been measured by quantitative X-ray diffraction methods. Crystallinity measurements were made on tibial mid-diaphyses from 17-day embryonic chicks, newly-formed periosteal bone from embryonic chicks, and density-fractionated bone from post-hatch c...

journal_title：Calcified tissue international

authors： Bonar LC,Roufosse AH,Sabine WK,Grynpas MD,Glimcher MJ

更新日期：1983-01-01 00:00:00

abstract：:Osteoblast differentiation is predominantly regulated by the WNT/β-catenin signaling (canonical WNT pathway), which, together with bone morphogenetic proteins, acts as the master regulator of osteogenesis. The recent characterization of the canonical WNT pathway in the regulation of bone modeling and remodeling provid...

journal_title：Calcified tissue international

authors： Rossini M,Gatti D,Adami S

更新日期：2013-08-01 00:00:00