Abstract:
:In the past years, several epidemiological and clinical observations have underlined the importance of genetics in the pathogenesis of both female and male osteoporosis. It has been estimated that from 50 to 80% of the inter-individual variability in bone mass is genetically determined. In rare instances, osteoporosis in men could be inherited in a simple Mendelian pattern. Examples of this include familial osteoporotic syndromes due to mutations in the aromatase and ER alpha genes. Families have also been described in which high bone mass is inherited as an autosomal dominant trait, consistent with the effect of a single gene located on chromosome 11. However, except for these rare conditions, osteoporosis has to be considered a multifactorial disease in which genetic determinants are modulated by hormonal, environmental, and nutritional factors. The genetic effect on bone may also be gender- and site-specific, with different genes regulating bone density at different skeletal sites in males and females. To date, most of the work on the genetics of osteoporosis has focused on women. In some studies, polymorphisms at the IGF-I, VDR, COLI-alpha1, ER alpha, and aromatase gene have been recently shown to predict BMD variation and osteoporotic risk in males. These observations remain to be confirmed by other independent studies. Other candidate genes, are still awaiting mapping and identification.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Gennari L,Brandi MLdoi
10.1007/s00223-001-1049-3subject
Has Abstractpub_date
2001-10-01 00:00:00pages
200-4issue
4eissn
0171-967Xissn
1432-0827journal_volume
69pub_type
杂志文章,评审abstract::Proline biosynthetic and degradative enzymes are unevenly distributed in differentiated mammalian tissues. Activities of the synthetic enzymes are relatively high in collagenous tissues, whereas activities of the degradative enzymes are high in noncollagenous tissues. In order to further characterize tissue-specific p...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02441197
更新日期:1979-07-03 00:00:00
abstract::We compared the effects of four vitamin D metabolites, 1 alpha,25 dihydroxy vitamin D3 (1 alpha,25(OH)2D3), 1 alpha hydroxy vitamin D3 (1 alpha OH D3), 25 hydroxy vitamin D3 (25 OH D3), and 24R,25 dihydroxy vitamin D (24R,25(OH)sD3) on resorption and collagen synthesis in fetal rat bone maintained in organ culture. Re...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02408532
更新日期:1980-01-01 00:00:00
abstract::Conventional glucocorticoids exert a negative influence on calcium balance, and long-term treatment with these agents leads to osteopenia. Deflazacort is an oxazoline derivative of prednisolone with documented calcium-sparing properties when compared to prednisone on a weight basis. The purpose of the present study wa...
journal_title:Calcified tissue international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02556669
更新日期:1987-12-01 00:00:00
abstract::Results from previous quasi-static mechanical tests indicate that femurs from elderly subjects fail in vitro at forces 50% below those available in a fall from standing height. However, bone is a rate-dependent material, and it is not known whether this imbalance is present at rates of loading which occur in a fall. B...
journal_title:Calcified tissue international
pub_type: 临床试验,杂志文章
doi:10.1007/BF00310169
更新日期:1994-07-01 00:00:00
abstract::Calcium-acidic phospholipid-phosphate complexes (Ca-PL-PO4) cause hydroxyapatite (HA) deposition in vitro. The acidic phospholipids--phosphatidylserine (PS), phosphatidylinositol (PI), phosphatidylglycerol (PG), and diphosphatidylglycerol (DPG)--all form Ca-PL-PO4 complexes: Nonacidic phospholipids--sphingomyelin (SPL...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:
更新日期:1982-01-01 00:00:00
abstract::Crouzon syndrome is a debilitating congenital disorder involving abnormal craniofacial skeletal development caused by mutations in fibroblast growth factor receptor-2 (FGFR2). Phenotypic expression in humans exhibits an autosomal dominant pattern that commonly involves premature fusion of the coronal suture (craniosyn...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-013-9701-2
更新日期:2013-05-01 00:00:00
abstract::Considerable advances in oncology over recent decades have led to improved survival, while raising concerns about long-term consequences of anticancer treatments. In patients with breast or prostate malignancies, bone health is a major issue due to the high risk of bone metastases and the frequent prolonged use of hor...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/s00223-017-0369-x
更新日期:2018-02-01 00:00:00
abstract::Various studies have investigated the serum sclerostin and bone morphogenetic protein-2 (BMP-2) levels in patients with ankylosing spondylitis (AS), but the results were inconsistent. The aim of this meta-analysis was to synthetically assess the associations of serum levels of sclerostin and BMP-2 with AS. Multiple el...
journal_title:Calcified tissue international
pub_type: 杂志文章,meta分析
doi:10.1007/s00223-019-00542-z
更新日期:2019-07-01 00:00:00
abstract::Long-term use of hydrochlorothiazide (HCTZ), a common diuretic agent for hypertension, has been associated with increased bone density and reduced hip fracture rates in patients. In this study, we sought to examine whether HCTZ has an anabolic effect on the proliferation of human osteoblasts (derived from either verte...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00369219
更新日期:1996-12-01 00:00:00
abstract::Sclerostin and parathyroid hormones are strong negative and positive regulators of bone formation, respectively. The anabolic response induced by intermittent (iPTH) treatment is sclerostin status-dependent. However, the interaction between sclerostin and iPTH at the matrix level is unknown. The goal of the current st...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-015-0074-6
更新日期:2016-02-01 00:00:00
abstract::This cross-sectional, observational study was designed to identify clinical risk factors of osteoporosis and fractures in Korean women to validate the probability of osteoporosis and subsequent fractures. A total of 1541 Korean women were recruited nationally. Fracture history of any site, risk factors of osteoporosis...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-008-9182-x
更新日期:2008-12-01 00:00:00
abstract::Plasma osteocalcin (BGP), growth hormone (GH), and somatomedin C(SmC) were measured in 12 patients with acromegaly [7 clinically active (aA), 5 cured (cA)] and 9 control subjects (C). Basal plasma values for the three parameters were higher in aA than in C and in cA. No significant difference was found between cA and ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555167
更新日期:1988-07-01 00:00:00
abstract::Congenital diseases that could result in hyperphosphatemia at an early age include hyperphosphatemic familial tumoral calcinosis (HFTC)/hyperostosis-hyperphosphatemia syndrome (HHS) and congenital hypoparathyroidism/pseudohypoparathyroidism due to the insufficient activity of fibroblast growth factor (FGF) 23 and para...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/s00223-020-00659-6
更新日期:2021-01-01 00:00:00
abstract::To assess the reductions in bone mass, strength, and turnover in adjuvant-induced arthritic rats and to examine the effect of a new benzamide compound, DU-6712, on these parameters, a 28-day dosing experiment was performed using 8-week-old female Lewis rats. Arthritis was induced by injecting the adjuvant into the hin...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900472
更新日期:1998-06-01 00:00:00
abstract::This study aimed to investigate the effects of recombinant human bone morphogenetic protein (rhBMP-7) on human cancellous bone grafts (BGs) while differentiating between anabolic and catabolic events. Human BGs alone or supplemented with rhBMP-7 were harvested 14 weeks after subcutaneous implantation into NOD/Scid mic...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-019-00574-5
更新日期:2019-09-01 00:00:00
abstract::Doses of 8, 16 (low), 32, 48, 64 (medium), and 150 (high) mg/kg/day of cortisol were administered to groups of 8 growing rats each during 16 days, and their femurs were then submitted to 3-point bending tests at low strain rate. Low doses had no effect. Medium doses, previously shown to improve calcium (Ca) balance an...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00297297
更新日期:1992-01-01 00:00:00
abstract::Increased bone loss has been noted in lymphoma patients; however, the incidence of hip fracture is not known. The aim of our study was to explore the risk for hip fracture in patients with lymphoma compared with the entire Swedish population. The risk of hip fracture was determined in a retrospective population cohort...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-020-00674-7
更新日期:2020-06-01 00:00:00
abstract::In this cross-sectional study, 91 healthy premenopausal women aged 20-39 years were investigated to determine the effect of physical activities during their teenage years on their current bone mineral densities (BMD). We measured whole-body BMD (WBMD), lumbar BMD (LBMD), and radial BMD (RBMD) with dual energy X-ray ab...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02684999
更新日期:2001-01-01 00:00:00
abstract::Although radiogenic free radicals are widely used as molecular probes in biological calcified tissues, their nature and their location remain controversial. In the present study we have synthesized and irradiated apatites in which 13CO3(2-) ions substitute hydroxyl or phosphate ions in hydroxyapatite. The 13C-coupling...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:
更新日期:1982-01-01 00:00:00
abstract::Monoclonal antibody against bovine serum alpha 2HS glycoprotein was raised in mice and the localization of this glycoprotein in bovine and human teeth was examined by immunohistochemical techniques on undemineralized ground sections after surface etching with dilute HCl. Positive reactions were found in both bovine an...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555864
更新日期:1990-07-01 00:00:00
abstract::The primary objective of the present study was to evaluate the impact of physical activity and muscle strength on bone mineral density (BMD) of the tuberositas tibiae in adolescent boys. Two groups with different exercise levels were compared. The high activity group consisted of 20 subjects (age 15.9 +/- 0.3) from a ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02509438
更新日期:1996-06-01 00:00:00
abstract::Five years ago we reported results from a cross-sectional study of the effect of nutritional factors on calcium-regulating hormones and bone loss in perimenopausal women. We found an inverse correlation between serum 25-hydroxyvitamin D (25OHD) and immunoreactive parathyroid hormone (PTH), and we postulated that over ...
journal_title:Calcified tissue international
pub_type: 临床试验,杂志文章
doi:10.1007/BF00334543
更新日期:1992-09-01 00:00:00
abstract::The interaction between estrogens and androgens, with their protective effects in bone, and parathyroid hormone (PTH), a calcitropic peptide hormone, is complex but may be better understood with murine models. The purpose of this study was to characterize skeletal phenotypes of mice deficient in estrogen receptor alph...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-004-0119-8
更新日期:2004-07-01 00:00:00
abstract::The goal of this study was to find out if bone can recover after long-term administration of bisphosphonate. Disodium pamidronate (APD) was given orally by gavage to mature beagle dogs at doses of 0, 2.5, 12.5, and 25 mg/kg/day for 1 year (0.1% concentration) and the animals were allowed to recover for another year. A...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00310408
更新日期:1994-10-01 00:00:00
abstract::Dual-photon absorptiometry (153Gd) was used to measure bone mineral of the total body and major anatomical areas. Patients with osteoporosis (male = 11, female = 18) and with renal osteodystrophy (n = 17) were significantly below (20%) normal females (n = 72) and males (n = 13) at most sites. In the osteoporotic patie...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02405287
更新日期:1984-01-01 00:00:00
abstract::Postmenopausal osteoporosis induced by estrogen deficiency causes inadequate new bone formation and affects millions of women worldwide. Melatonin can improve bone mineral density at the femoral neck in postmenopausal women with osteopenia. This study aimed to investigate the mechanism of melatonin in estrogen deficie...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-018-0428-y
更新日期:2018-10-01 00:00:00
abstract::Bone loss during advancing age in women and men is partly the result of sex steroid deficiency. As the contribution of circulating sex steroids and sex hormone-binding globulin (SHBG) to bone loss remains uncertain, we sought to determine whether levels of sex steroids or SHBG predict change in bone mineral density (B...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-007-9035-z
更新日期:2007-08-01 00:00:00
abstract::There are few longitudinal data on change in bone structure and muscle mass, strength and function in later life. We report these, and consider bone-muscle interrelationships in older men and women. We studied 188 men and 166 women from the Hertfordshire Cohort Study, who underwent peripheral quantitative computed tom...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-018-0442-0
更新日期:2018-11-01 00:00:00
abstract::Quantitative ultrasound (US) measurements have been shown to be a new technique assessing bone status. This study aimed to assess a new US instrument, the DBM Sonic 1200(R) (IGEA) which permits the measurement of the speed of sound in the proximal phalanges (SOSp) of the hand. The results obtained were compared with D...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900574
更新日期:1999-01-01 00:00:00
abstract::We have previously noted that a relatively large load (150 N) is required to induce a strain on the cortex of rat vertebrae similar to that induced on weight-bearing bones by normal mechanical usage. It seems unlikely that the musculature of the tail normally imposes loads of this magnitude, and this suggests that the...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900097
更新日期:1996-08-01 00:00:00