Abstract:
:Monoclonal antibody against bovine serum alpha 2HS glycoprotein was raised in mice and the localization of this glycoprotein in bovine and human teeth was examined by immunohistochemical techniques on undemineralized ground sections after surface etching with dilute HCl. Positive reactions were found in both bovine and human peritubular dentin, whereas virtually negative staining was detected in the intertubular dentin. When the ground section was examined without surface etching, no reaction was found in any area of mineralized dentin. These results suggest that alpha 2HS glycoprotein is present mainly in the peritubular dentin associated with the mineral phase. The presence of this component in dentin may not be due simply to nonspecific binding to calcium phosphate crystals.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Takagi Y,Shimokawa H,Suzuki M,Nagai H,Sasaki Sdoi
10.1007/BF02555864subject
Has Abstractpub_date
1990-07-01 00:00:00pages
40-5issue
1eissn
0171-967Xissn
1432-0827journal_volume
47pub_type
杂志文章abstract::The feasibility of two noninvasive methods [dual photon absorptiometry (DPA) and dual energy X-ray absorptiometry (DXA)] for prediction in vivo of local variations of trabecular bone strength within the proximal tibia was evaluated in 14 cadaveric knees. Trabecular bone strength was measured using an osteopenetrometer...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900131
更新日期:1996-10-01 00:00:00
abstract::Whether the decrease of zinc content in the femoral-metaphyseal tissues of rats with skeletal unloading is involved in the alteration of bone metabolism was investigated. Skeletal unloading was designed using the model of hindlimb suspension in rats. Animals were fed for 4 days with the unloading. The metaphyseal zinc...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00310262
更新日期:1995-09-01 00:00:00
abstract::The influence of the macroscale material properties of bone on its mechanical competence has been extensively investigated, but less is known about possible contributions from bone's nanoscale material properties. These nanoscale properties, particularly the collagen network and the size and shape of hydroxyapatite mi...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-014-9913-0
更新日期:2014-11-01 00:00:00
abstract::Glycogen storage disease type 1a (Von Gierke's disease) is one of the more common glycogen storage diseases (GSD). GSD 1a patients can have severe idiopathic osteopenia, often beginning at a young age. Since calcium tracer studies offer a sensitive probe of the bone microenvironment and of calcium deposition, kinetics...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00369209
更新日期:1996-12-01 00:00:00
abstract::In order to determine whether the bacterial bone resorbing agents lipopolysaccharide (LPS) and muramyl dipeptide (MDP) interact with osteoblasts, their effect on the synthesis of collagenase and tissue inhibitor or metalloproteinases (TIMP) from monolayer cultures of mouse osteoblast-like cells was investigated. All c...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02556318
更新日期:1989-05-01 00:00:00
abstract::The solubilization of alkaline phosphatase (AP) from osteoblastic cell membranes obtained from human primary bone cell cultures was studied according to the age and sex of the donors (17 females, 11 males; age range: 2-77 years). Cell membranes were treated by non-ionic (n-octyl beta-D-glucopyranoside, OG), ionic or z...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002230050006
更新日期:2000-01-01 00:00:00
abstract::This study examined bone density among postmenopausal Buddhist nuns and female religious followers of Buddhism in southern Taiwan and related the measurements to subjects characteristics including age, body mass, physical activity, nutrient intake, and vegetarian practice. A total of 258 postmenopausal Taiwanese veget...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/pl00005812
更新日期:1997-03-01 00:00:00
abstract::The purpose of this study was to use the concept of metastable equilibrium solubility (MES) to describe the anomalous solubility behavior of carbonated apatite (CAP) in the presence of solution strontium. A CAP sample (4.8 wt% CO(3), synthesized at 70 degrees C) was prepared by precipitation. Baseline MES distribution...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-002-0035-8
更新日期:2004-01-01 00:00:00
abstract::GNAS is one of the most complex gene loci in the human genome and encodes multiple gene products including Gsα, XLαs, NESP55, A/B, and AS transcripts. XLαs, the extra-large G protein ɑ-subunit, is paternally expressed. XLɑs and Gsɑ share the common 2-13 exons with different promoters and first exons. Therefore, XLɑs c...
journal_title:Calcified tissue international
pub_type: 杂志文章,评审
doi:10.1007/s00223-020-00714-2
更新日期:2020-09-01 00:00:00
abstract::Teriparatide (TPTD) is the most widely used anabolic agent in the treatment of patients with osteoporosis although its use is restricted in many countries. A recent randomised trial confirmed that TPTD was superior to risedronate at preventing vertebral fractures over a 2-year period. There is limited information on t...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-019-00563-8
更新日期:2019-08-01 00:00:00
abstract::The effects of a series of novel phosphonates on the kinetics of mineral development in an ionophore-primed 7:2:1 phosphatidylcholine (PC): dicetylphosphate (DCP): cholesterol (Chol) liposomal model system are reported. When present at 2.5 micromol/liter or 25 micromol/liter concentrations in the solution surrounding ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02509384
更新日期:1996-05-01 00:00:00
abstract::To determine the relationships among nutrients intake, bone mass, and bone turnover in women we have investigated these issues in a population-based, cross-sectional, observational study in one county in central Sweden. A total of 175 women aged 28-74 at entry to the study were included. Dietary assessment was made by...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00298425
更新日期:1995-08-01 00:00:00
abstract::The present report compares the effects of different membrane phospholipid (PL)-cholesterol compositions on the kinetics of liposome-mediated formation of calcium phosphates from metastable solutions (2.25 mM CaCl2; 1.5 mM KH2PO4) at 22 degrees C, pH 7.4 and 240 mOsm. In most experiments, the liposomes were composed o...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00296290
更新日期:1992-03-01 00:00:00
abstract::The phorbol ester 12-O-tetradecanoyl-13-acetate (TPA) blocked the growth of, and induced the appearance of processes in the human osteosarcoma cell line U-2 OS. The phorbol ester decreased the intracellular level of alkaline phosphatase (APase) activity (as measured per mg cell protein) and caused a marked increase in...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00582169
更新日期:1992-06-01 00:00:00
abstract::Gnathodiaphyseal dysplasia (GDD; OMIM#166260) is a rare skeletal disorder which is mainly characterized by cemento-osseous lesions in mandibles, bone fragility, bowing and diaphyseal sclerosis of tubular bones. GDD is caused by point mutations in Anoctamin-5 (ANO5); however, the disease mechanisms remain unclear. Here...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-019-00528-x
更新日期:2019-06-01 00:00:00
abstract::The aim of this study was to investigate bone mineral density (BMD) and bone turnover in patients with primary knee osteoarthritis (KOA) and to compare them with generalized OA (GOA) and nonGOA patients. A total of 88 postmenopausal primary KOA patients were studied. OA was graded by using knee radiographs. BMD of the...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002230010068
更新日期:2000-05-01 00:00:00
abstract::We carried out a clinical trial of 1 alpha-hydroxycholecalciferol [1 alpha(OH)D3] at a dose of 1.0 microgram a day on 7 patients with psoriasis vulgaris. These patients had been treated by topical applications of corticosteroids before this study without improvement, and during the clinical trial, treatment of topical...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555172
更新日期:1986-12-01 00:00:00
abstract::Conventional glucocorticoids exert a negative influence on calcium balance, and long-term treatment with these agents leads to osteopenia. Deflazacort is an oxazoline derivative of prednisolone with documented calcium-sparing properties when compared to prednisone on a weight basis. The purpose of the present study wa...
journal_title:Calcified tissue international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02556669
更新日期:1987-12-01 00:00:00
abstract::A 56 year-old man with a 2-year history of transitional-cell carcinoma of the urinary bladder presented with back pain and diffuse radiological osteosclerosis. Laboratory studies revealed borderline-low ionized serum calcium, and markedly elevated serum alkaline phosphatase (ALP) activity and serum osteocalcin. Serum ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900560
更新日期:1998-12-01 00:00:00
abstract::The binding of prostaglandin E2 (PGE2) to bone cells was studied to provide direct evidence for the existence of specific receptors in bone. Bone cells were isolated by collagenase digestion of fetal and newborn rat calvaria. Isolated cells were incubated with 3H-PGE2 and collected on Millipore filters. Specific bindi...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02405038
更新日期:1983-01-01 00:00:00
abstract::Targeted disruption of the c-src gene leads to a severe form of osteopetrosis in mice [2]. As the c-src gene is expressed in all tissues and cells tested, we have analyzed fibroblasts from three individuals with malignant, congenital osteopetrosis for the expression of c-src at the protein level. No differences could ...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF01352018
更新日期:1993-07-01 00:00:00
abstract::The aim of this study was to follow the changes in bone mineral density (BMD) and biochemical markers of bone turnover in 10 children (7.5-17.5 years of age) with severe juvenile idiopathic arthritis (JIA), during a 3-year therapy with salmon calcitonin (100 IU/day 2 months on and 2 off for a year and 200 IU/day for 2...
journal_title:Calcified tissue international
pub_type: 临床试验,杂志文章
doi:10.1007/s00223-001-0008-3
更新日期:2001-07-01 00:00:00
abstract::The type IA osteogenesis imperfecta (OI) phenotype is characterized by multiple fractures, blue sclerae, and minimal skeletal deformity without dentinogenesis imperfecta. The object of this study was to determine the effect of treatment with intravenous pamidronate (30 mg) every 3 months on bone density and bone histo...
journal_title:Calcified tissue international
pub_type: 临床试验,杂志文章
doi:10.1007/s00223-001-1055-5
更新日期:2003-02-01 00:00:00
abstract::In several studies on patients with rheumatoid arthritis, an association of bone loss with a persistently high disease activity has been found. The aim of our study was to investigate the relation between disease activity and serum levels of vitamin D metabolites, parathyroid hormone (PTH), and parameters of bone turn...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900416
更新日期:1998-03-01 00:00:00
abstract::This study aimed to investigate the effects of recombinant human bone morphogenetic protein (rhBMP-7) on human cancellous bone grafts (BGs) while differentiating between anabolic and catabolic events. Human BGs alone or supplemented with rhBMP-7 were harvested 14 weeks after subcutaneous implantation into NOD/Scid mic...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-019-00574-5
更新日期:2019-09-01 00:00:00
abstract::Bone and mineral metabolism has been reported to affect the development of the ossification of the posterior longitudinal ligament (OPLL). The aim of this study was to compare bone mineral densities (BMD) and rate of osteoporosis between cervical OPLL and a matched control group. We also investigated the correlation o...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-012-9662-x
更新日期:2013-01-01 00:00:00
abstract::The orientation of nanoscale mineral platelets was quantitatively evaluated in relation to the shape of lacunae associated with partially embedded osteocytes (osteoblastic-osteocytes) on the surface of deproteinised trabecular bone of adult sheep. By scanning electron microscopy and image analysis, the mean orientatio...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-015-0072-8
更新日期:2016-02-01 00:00:00
abstract::Alkaline phosphatase is detected in both soluble and particulate fractions of rat bone. The concentration of alkaline phosphatase in the particulate fraction of rat skull cap bone and femur is high during the peak period of calcification of these bones suggesting the possibility of using it as a marker for the rate of...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555116
更新日期:1986-09-01 00:00:00
abstract::Pyrolyzed scales, fin spines, and bone from the ray-finned bony fish Polypterus (Actinopterygii) showed two mineral phases on X-ray diffraction: hydroxyapatite (HA), Ca5(PO4)3OH, and whitlockite, Ca3(PO4)2. The ratio of HA/whitlockite varied with the structure (scale, spine, bone) within each individual fish. The rela...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02441216
更新日期:1979-08-24 00:00:00
abstract::The severest long-term complications of orthopedic joint-prostheses are associated with loosening of the implant-bone interface, due to adverse reactions in bone and subsequent weakening of the connection between the two materials. Mechanical stresses, caused by joint loading, play a key role in the adaption of interf...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02406143
更新日期:1984-01-01 00:00:00