Abstract：
:The severest long-term complications of orthopedic joint-prostheses are associated with loosening of the implant-bone interface, due to adverse reactions in bone and subsequent weakening of the connection between the two materials. Mechanical stresses, caused by joint loading, play a key role in the adaption of interface bone and in the loosening process. In the present study, it is shown how local interface stress patterns can be evaluated using advanced methods of computer-based, engineering stress analyses (the Finite Element Method, FEM). The stress patterns are compared with the local bone structure and bone resorption phenomena as found in animal experiments. The results indicate that loosening and bone resorption is associated with high peak stresses at the interface in the immediate post-operative stage. In addition, there appears to be similarity between the local stress patterns and the bone morphology at the interface if resorption does not occur. Finally, it is found that implants of high local stiffness generate lower peak stresses in bone, as compared with low stiffness implants.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Huiskes R,Nunamaker Ddoi
10.1007/BF02406143subject
Has Abstractpub_date
1984-01-01 00:00:00pages
S110-7eissn
0171-967Xissn
1432-0827journal_volume
36 Suppl 1pub_type
杂志文章abstract：:The purpose of this research was to address the following question: How is the solubility of fluoride-pretreated carbonated apatite (CAP) in aqueous acidic media related to the equilibrium solution fluoride and/or the CAP adsorbed fluoride levels? A CAP sample prepared by a precipitation method at 70 degrees C contain...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-001-1069-z
更新日期：2003-03-01 00:00:00
abstract：:There is increasing evidence that 1,25 dihydroxyvitamin D3 acts directly to differentiate and activate cells of mononuclear phagocyte lineage (MNP). However, it seems possible that in bone marrow this hormone may modulate the differentiation of MNP via the factor elaborated by the stromal cells or the macrophages. We ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02556592
更新日期：1986-01-01 00:00:00
abstract：:Fracture healing is a natural process that recapitulates embryonic skeletal development. In the early phase after fracture, reactive oxygen species (ROS) are produced under inflammatory and ischemic conditions due to vessel injury and soft tissue damage, leading to cell death. Usually, such damage during the course of...
journal_title：Calcified tissue international
pub_type： 杂志文章,评审
doi：10.1007/s00223-019-00576-3
更新日期：2019-10-01 00:00:00
abstract：:The effect of ipriflavone (IP), a synthetic isoflavonoid derivative, on in vivo bone formation was studied in rat perialveolar bone by surgically producing a hole in the mandibular bone. The holes were filled either with powdered IP or with compounds containing no osteoinductive properties such as biostite and Htr (ha...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900533
更新日期：1998-10-01 00:00:00
abstract：:In the rat, prolonged administration of the luteinizing, hormone-releasing hormone agonist buserelin (25 micrograms/kg body wt/day s.c.) lowers blood estradiol, raises bone resorption, and induces osteopenia. The present study was undertaken to determine whether withdrawal of buserelin normalizes blood estradiol, slow...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555819
更新日期：1990-01-01 00:00:00
abstract：:Ectopic calcification of diseased tissues or around prosthetic implants can lead to serious disability. Therefore, calcification of implants of glutaraldehyde-cross-linked collagenous tissues and reconstituted collagen was compared with mineralization induced by demineralized bone matrix (DBM). Whereas implants of DBM...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02556366
更新日期：1988-05-01 00:00:00
abstract：:The peptide hormone calcitonin is a potent inhibitor of osteoclastic resorption, but it is unstable and poorly absorbed following oral administration. Conjugates of salmon calcitonin covalently linked to low-molecular-weight amphiphilic polymers show improved stability and absorption. The purpose of this study was to ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-002-1051-4
更新日期：2003-09-01 00:00:00
abstract：:Micro-computed tomography (microCT) has become a standard tool for the evaluation of bone morphology in preclinical studies. Unfortunately, the user-dependent definition of contour lines that separate trabecular from cortical bone is not only extremely time-consuming but may also represent a source of data bias and in...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-007-9063-8
更新日期：2007-10-01 00:00:00
abstract：:The influence of the macroscale material properties of bone on its mechanical competence has been extensively investigated, but less is known about possible contributions from bone's nanoscale material properties. These nanoscale properties, particularly the collagen network and the size and shape of hydroxyapatite mi...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-014-9913-0
更新日期：2014-11-01 00:00:00
abstract：:In the past decade there have been numerous publications reporting a significant and direct relationship between handgrip strength and bone mineral density (BMD) of the proximal femur in older adults. The present report challenges the appropriateness of the methods, and thus the conclusions used in these studies. Spec...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002239900621
更新日期：1999-04-01 00:00:00
abstract：:High PTH levels increase bone turnover and decrease bone mineral density (BMD). Low plasma 25-hydroxyvitamin D (25OHD) levels cause secondary hyperparathyroidism, but the relative contribution of low 25OHD and high PTH levels on risk of fracture is largely unknown. Within the cohort of women (n = 2,016) included in th...
journal_title：Calcified tissue international
pub_type： 杂志文章,多中心研究
doi：10.1007/s00223-010-9454-0
更新日期：2011-03-01 00:00:00
abstract：:The solubilization of alkaline phosphatase (AP) from osteoblastic cell membranes obtained from human primary bone cell cultures was studied according to the age and sex of the donors (17 females, 11 males; age range: 2-77 years). Cell membranes were treated by non-ionic (n-octyl beta-D-glucopyranoside, OG), ionic or z...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s002230050006
更新日期：2000-01-01 00:00:00
abstract：:In vitro models of osteogenesis are essential for investigating bone biology and the effects of pharmaceutical, chemical, and physical cues on bone formation. Osteogenesis takes place in a complex three-dimensional (3D) environment with cells from both mesenchymal and hematopoietic origins. Existing in vitro models of...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-011-9467-3
更新日期：2011-05-01 00:00:00
abstract：:Carboxy-terminal pyridinoline cross-linked telopeptide of type I collagen (ICTP) in serum has recently been proposed as a new biochemical marker of bone resorption. In the present study we compared serum ICTP with radiopharmaceutical and histomorphometric measurements of bone turnover in postmenopausal women with mild...
journal_title：Calcified tissue international
pub_type： 临床试验,杂志文章
doi：10.1007/BF00316286
更新日期：1994-01-01 00:00:00
abstract：:It has been suggested that oxidative stress is associated with the pathogenesis of osteoporosis. The objective of this study was to explore the association between a marker of oxidative stress and either bone turnover markers or bone mineral density (BMD) in postmenopausal women. In addition, the effects of oxidative ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-010-9393-9
更新日期：2010-09-01 00:00:00
abstract：:The present study was undertaken to determine the fluoride distribution profile in the rat femur. Male Wistar rats were divided into four groups and given water containing 0, 25, 50, and 100 ppm of fluoride, respectively, for 10 weeks. The fluoride distribution from the periosteum to the endosteum was determined in ea...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555045
更新日期：1990-03-01 00:00:00
abstract：:Non-steroidal anti-inflammatory drugs (NSAID) have been recommended to prevent of heterotopic ossification (HO) after total hip arthroplasty (THA), but debates are still ongoing. The present Bayesian network meta-analysis of randomized clinical trials (RCTs) compared all available pathways of NSAID treatment as prophy...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-020-00763-7
更新日期：2021-02-01 00:00:00
abstract：:Unfixed, undecalcified sections from closed fractures of rat metatarsals have been studied by quantitative cytochemistry from the first week after fracture to late in the fracture-healing process. Alkaline phosphatase activity appeared to be related to calcification. Glucose 6-phosphate dehydrogenase activity was asso...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02405007
更新日期：1983-01-01 00:00:00
abstract：:Osteoporosis is commonly associated with estrogen deficiency. However, the mechanisms by which the lack of this hormone causes bone loss are poorly understood. The bone structure of the oral cavity seems to be affected by estrogen deficiency, since a delayed healing process after tooth extraction has been observed aft...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-004-0013-4
更新日期：2005-02-01 00:00:00
abstract：:Limited information is available on the effect of bisphosphonates in men receiving corticosteroid therapy. We studied 184 men among the patients enrolled in two, double-blind, placebo-controlled, 1-year studies with similar protocols. The studies evaluated the effects of risedronate in patients beginning corticosteroi...
journal_title：Calcified tissue international
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00223-001-1060-8
更新日期：2001-10-01 00:00:00
abstract：:The existence of nutritional deficiency rickets among infants in sunny Riyadh was confirmed radiologically. Most of the rachitic infants were breast-fed, some received unsupplemented infant feeding formulae, and all live in an environment that is devoid of sunlight. Their mean age at the time of onset was 10.5 months....
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02405328
更新日期：1984-05-01 00:00:00
abstract：:Identifying persons with a high risk of osteoporotic fractures remains a challenge. DXA uptake in women with elevated risk of osteoporosis seems to be depending on distance to scanning facilities. This study aimed to investigate the ability of a small portable scanner in identifying women with reduced bone mineral den...
journal_title：Calcified tissue international
pub_type： 杂志文章,随机对照试验
doi：10.1007/s00223-015-0084-4
更新日期：2016-03-01 00:00:00
abstract：:Regular exercise and physical activity (PA) are known to be protective factors for maintaining bone mineral density (BMD) and preventing osteoporotic fracture. We investigated the associations between leisure-time PA and BMD in 2,903 premenopausal and 2,267 postmenopausal women in Korea. BMDs of the lumbar spine and f...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-012-9624-3
更新日期：2012-09-01 00:00:00
abstract：:We examined the role of sleep, growth hormone (GH), and parathyroid hormone [PTH(1-84)] as regulators of the diurnal rhythm of the osteoblastic bone marker, serum osteocalcin (OC). Nine normal subjects were followed with hourly blood sampling during one 24-hour period with normal sleep pattern, and one 24-hour period ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555845
更新日期：1991-12-01 00:00:00
abstract：:The demonstration of histochemical characteristics in calcifying cartilage is fraught with methodological difficulties including the distinction of mineralized from unmineralized cartilage and the demonstration of cell detail in relatively hard tissue. This study uses the decalcified bone matrix-induced enchondral (en...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555141
更新日期：1988-10-01 00:00:00
abstract：:Although several observational studies have demonstrated an association between vitamin K status and bone mineral density (BMD) in postmenopausal women, no placebo-controlled intervention trials of the effect of vitamin K1 supplementation on bone loss have been reported thus far. In the trial presented here we have in...
journal_title：Calcified tissue international
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1007/s00223-002-2084-4
更新日期：2003-07-01 00:00:00
abstract：:Anemia is commonly associated with osteoporosis and sarcopenia in older persons. However, there is a common subset of patients identified as osteosarcopenic at a higher risk of adverse outcomes. Whether these patients are also at a higher risk of anemia remains unknown. In this study, we aimed to compare hemoglobin (H...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-020-00706-2
更新日期：2020-08-01 00:00:00
abstract：:Methotrexate (MTX) is one of the most commonly prescribed drugs for autoimmune rheumatic diseases. As there is no consensus on its negative effects on bone, the purpose of this investigation was to determine the clinical spectrum of patients with stress fractures due to long-term MTX treatment (i.e., MTX osteopathy). ...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-020-00765-5
更新日期：2021-02-01 00:00:00
abstract：:The calcium ion binding properties of a high molecular weight bovine phosphophoryn preparation have been studied at high ionic strength (0.5 M KCl as supporting electrolyte). Surprisingly, even under these conditions at which intermolecular ionic interactions are effectively screened, phosphophoryn was capable of bind...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/BF02555712
更新日期：1987-02-01 00:00:00
abstract：:Icariin, the main constituent of Herba Epimedii, appears to be a promising alternative to classic drugs used to treat osteoporosis. However, the detailed molecular mechanisms of its action and the role of icariin in the cross-talk between osteoblasts and adipocytes remain unclear. The present study was designed to inv...
journal_title：Calcified tissue international
pub_type： 杂志文章
doi：10.1007/s00223-016-0138-2
更新日期：2016-08-01 00:00:00
