Abstract:
:Osteoporosis is commonly associated with estrogen deficiency. However, the mechanisms by which the lack of this hormone causes bone loss are poorly understood. The bone structure of the oral cavity seems to be affected by estrogen deficiency, since a delayed healing process after tooth extraction has been observed after ovariectomy in rats. The aim of this study was to describe the effect of the absence of estrogen on the expression and activity of matrix metalloproteinases (MMC)-2 and -9 and expression of types I and III collagens in the alveolar granulation tissue of young female rats after tooth extraction. Sixty-six, four-week-old female rats underwent bilateral ovariectomies (OVX) or sham operations. Three weeks later, both first and second mandibular molars were extracted and the animals were killed by cervical dislocation 3, 5, or 7 days after tooth extraction. The granulation tissues were collected from the extracted alveolar sockets and used for zymographic, Western blot, or reverse transcription polymerase chain reaction (RT-PCR) analysis. There was a gradual increase on the expression of all studied proteins as well as MMP-2 and -9 activities in the periods after surgery. In contrast, OVX animals showed a significant decrease in the gelatinolytic activities and expression of MMP-2 and -9 and types I and III collagens. The results presented here in suggest that the absence of estrogen may possibly contribute to the delayed alveolar wound healing by interfering with the extracellular matrix turnover.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Zecchin KG,Pereira MC,Coletta RD,Graner E,Jorge Jdoi
10.1007/s00223-004-0013-4subject
Has Abstractpub_date
2005-02-01 00:00:00pages
136-45issue
2eissn
0171-967Xissn
1432-0827journal_volume
76pub_type
杂志文章abstract::There are few studies of the effect of smoking on bone density in young women. The reported antiestrogenic effect of smoking could be a mechanism for a possible effect of smoking on bone. We measured bone mineral density (BMD) by dual-energy X-ray absorptiometry (whole body, proximal femur, lumbar spine), and serum le...
journal_title:Calcified tissue international
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journal_title:Calcified tissue international
pub_type: 杂志文章
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journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555728
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journal_title:Calcified tissue international
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doi:10.1007/pl00005815
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journal_title:Calcified tissue international
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doi:10.1007/s00223-004-0175-0
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journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02555129
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journal_title:Calcified tissue international
pub_type: 杂志文章
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journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF02405384
更新日期:1984-12-01 00:00:00
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journal_title:Calcified tissue international
pub_type: 杂志文章
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journal_title:Calcified tissue international
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journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-008-9197-3
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journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900638
更新日期:1999-06-01 00:00:00
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journal_title:Calcified tissue international
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doi:10.1007/s00223-019-00614-0
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journal_title:Calcified tissue international
pub_type: 杂志文章
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journal_title:Calcified tissue international
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journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00301601
更新日期:1995-05-01 00:00:00
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journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s002239900366
更新日期:1997-12-01 00:00:00
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journal_title:Calcified tissue international
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journal_title:Calcified tissue international
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journal_title:Calcified tissue international
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journal_title:Calcified tissue international
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