Abstract:
:There are few studies of the effect of smoking on bone density in young women. The reported antiestrogenic effect of smoking could be a mechanism for a possible effect of smoking on bone. We measured bone mineral density (BMD) by dual-energy X-ray absorptiometry (whole body, proximal femur, lumbar spine), and serum levels (mid-follicular phase) of testosterone (T), estradiol (E2), sex hormone-binding globulin (SHBG), and cortisol in 52 women (25 smokers, 27 nonsmokers) aged 20-35 years. The two groups did not differ significantly in age, height, weight, or the sum of eight skinfold thicknesses. The mean number of cigarettes smoked per day and the number of years of smoking were 16.9 and 12.9, respectively. There were no significant differences in BMD between smokers and nonsmokers at any site. For both smokers and nonsmokers, SHBG and the free androgen index (T/SHBG) made significant contributions (P less than 0.005) to the variance in BMD at all sites except the lumbar spine. The free estradiol index (E2/SHBG) contributed to whole body BMD (P less than 0.05). For all subjects, there were significant inverse relationships between SHBG and BMD (P less than 0.002), and positive relationships between T/SHBG and BMD (P less than 0.02) for all sites except the lumbar spine. These data suggest that moderate smoking in young women is not associated with low BMD at any site. However, smokers had lower free estradiol and higher SHBG, both of which have been related to increased bone loss in older women.
journal_name
Calcif Tissue Intjournal_title
Calcified tissue internationalauthors
Daniel M,Martin AD,Drinkwater DTdoi
10.1007/BF00301626subject
Has Abstractpub_date
1992-04-01 00:00:00pages
300-5issue
4eissn
0171-967Xissn
1432-0827journal_volume
50pub_type
杂志文章abstract::The purpose of this study was to determine whether human parathyroid hormone (h-PTH) enhances trabecular bone mass and connectivities that were reduced by streptozotocin (STZ)-induced diabetes in rats. Seven-month-old female Wistar rats were injected with STZ or its vehicle intraperitoneally. All vehicle-injected norm...
journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/pl00005838
更新日期:2000-03-01 00:00:00
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journal_title:Calcified tissue international
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journal_title:Calcified tissue international
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更新日期:1980-01-01 00:00:00
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journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/s00223-020-00793-1
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journal_title:Calcified tissue international
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journal_title:Calcified tissue international
pub_type: 杂志文章
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journal_title:Calcified tissue international
pub_type: 杂志文章
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journal_title:Calcified tissue international
pub_type: 杂志文章
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更新日期:1983-01-01 00:00:00
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journal_title:Calcified tissue international
pub_type: 杂志文章
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更新日期:1986-05-01 00:00:00
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journal_title:Calcified tissue international
pub_type: 杂志文章
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更新日期:2007-08-01 00:00:00
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journal_title:Calcified tissue international
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journal_title:Calcified tissue international
pub_type: 杂志文章
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更新日期:2005-11-01 00:00:00
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journal_title:Calcified tissue international
pub_type: 杂志文章
doi:10.1007/BF00298425
更新日期:1995-08-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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pub_type: 杂志文章,meta分析
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